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Author: Anassuya Ramachandran
Publisher:
ISBN:
Category :
Languages : en
Pages : 240
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Book Description
Author: Anassuya Ramachandran
Publisher:
ISBN:
Category :
Languages : en
Pages : 240
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Book Description
Author: Wai-Man Vivian Chan
Publisher: Open Dissertation Press
ISBN: 9781374673588
Category :
Languages : en
Pages :
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Book Description
This dissertation, "Functional Characterization of Liver Intestine-cadherin (CDH17) in Hepatocellular Carcinoma" by Wai-man, Vivian, Chan, 陳慧雯, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled Functional Characterization of Liver Intestine-Cadherin (CDH17) in Hepatocellular Carcinoma Submitted by Vivian Wai Man Chan For the degree of Master of Philosophy at the University of Hong Kong December 2006 Liver intestine-cadherin (LI-cadherin, CDH17) is a new cancer biomarker for hepatocellular carcinoma (HCC). However, the molecular mechanism of LI-cadherin on HCC pathogenesis remains unknown. The present study aims to characterize the functions of LI-cadherin and to elucidate the molecular pathway of CDH17 in HCC progression. Gene expression level of CDH17 was determined in HCC cell lines and clinical specimens by TaqMan real time Q-PCR. Protein expressions were determined by western blot and immunohistochemistry. For functional analysis, short hairpin-RNA (shRNA) constructs targeting to CDH17 exon 5 and other exons were stably transfected into HCC cell line of high metastatic potential (MHCC-97H). Alterations of tumor phenotypes were observed and determined by vitro functional assays and in vivo nude mouse model. The present findings indicate that overexpression of LI-cadherin is clinically correlated to the advanced tumor stages (III-IV) and presence of HCC venous infiltration. The metastatic HCC cell lines expressed significantly higher level of CDH17 than the primary HCC counterparts. Functional studies showed that LI-cadherin promoted HCC tumor growth in vitro iand in vivo, and be involved in tumor metastasis by cell adhesion assay and cell invasion assay. Furthermore, LI-cadherin is correlated with the altered expression and localization of β-catenin, cyclin D1 and retinoblastoma (Rb). Our results suggest that LI-cadherin may have a role in Wnt signaling pathway of HCC tumorigenesis and metastasis. ii DOI: 10.5353/th_b3889111 Subjects: Cadherins Liver - Cancer - Genetic aspects Carcinogenesis
Author: Wai-man Chan (M. Phil., Vivian)
Publisher:
ISBN:
Category : Cadherins
Languages : en
Pages : 194
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Book Description
Author: Ganji Purnachandra Nagaraju
Publisher: Springer Nature
ISBN: 3030633691
Category : Medical
Languages : en
Pages : 374
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Book Description
Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the first of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage also addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutic, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.
Author: Lawrence Miall
Publisher: John Wiley & Sons
ISBN: 1118947800
Category : Medical
Languages : en
Pages : 453
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Book Description
Paediatrics at a Glance provides an introduction to paediatrics and the problems encountered in child health as they present in primary, community and secondary care, from birth through to adolescence. Thoroughly updated to reflect changes in understanding of childhood illness over the last 5 years, the 4th edition of this best-selling textbook diagrammatically summarises the main differential diagnoses for each presenting symptom, while accompanying text covers important disorders and conditions as well as management information. Paediatrics at a Glance: • Is an accessible, user-friendly guide to the entire paediatric curriculum • Features expanded coverage of psychological issues and ethics in child health • Includes more on advances in genetics, screening and therapy of childhood illness • Contains new videos of procedures and concepts on the companion website • Includes a brand new chapter on Palliative Care - an emerging area in the specialty • Features full colour artwork throughout • Includes a companion website at www.ataglanceseries.com/paediatrics featuring interactive self-assessment case studies, MCQs, videos of the procedures and concepts covered in the book, and links to online resources Paediatrics at a Glance is the ideal companion for anyone about to start a paediatric attachment or module and will appeal to medical students, junior doctors and GP trainees as well as nursing students and other health professionals.
Author: Rachel K. Miller
Publisher: Springer
ISBN: 3319514369
Category : Science
Languages : en
Pages : 373
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Book Description
Kidney Development and Disease brings together established and young investigators who are leading authorities in nephrology to describe recent advances in three primary areas of research. The first section describes the use of animal models as powerful tools for the discovery of numerous molecular mechanisms regulating kidney development. The second section focuses on nephric cell renewal and differentiation, which lead to diverse cell fates within the developing kidney, and discusses diseases resulting from the aberrant regulation of the balance between cell fate decisions. The final section concentrates on morphogenesis of the developing kidney and its maintenance after formation as well as the diseases resulting from failures in these processes. Kidney form and function have been extensively studied for centuries, leading to discoveries related to their development and disease. Recent scientific advances in molecular and imaging techniques have broadened our understanding of nephron development and maintenance as well as the diseases related to these processes.
Author: Pallaval Veera Bramhachari
Publisher: Springer
ISBN: 9789811510441
Category : Medical
Languages : en
Pages : 0
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Book Description
This book discusses various components of the innate and adaptive immune response in combating viral infections, presenting the recent advances in our understanding of innate immunity recognition of viruses and highlighting the important role of inflammation, cytokines such as interferon, toll-like receptors and leukocytes in the initial detection of invading viruses and subsequent activation of adaptive immunity. It also summarizes the role of the adaptive immunity against viral infections through clearance of virus and establishment of memory response that protects against the recurrent infections. In addition, the book examines the role of DNA and RNA sensors in viral recognition and in controlling viral infection. Lastly, it reviews the latest developments in the development of the rational viral vaccines. As such it is a useful resource book for postgraduate and early researchers wanting to gain insights into the immune response to viral infections.
Author: Jianren Gu
Publisher: Springer Science & Business Media
ISBN: 3642287026
Category : Medical
Languages : en
Pages : 479
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Book Description
"Primary Liver Cancer: Challenges and Perspectives" presents the recent progress in basic and clinical research in Primary Liver Cancer (PLC) in China and around the world. PLC patients in China make up more than 50% of the total patients worldwide. By contributing to the book, the leading experts in the field of liver cancer in China as well as in the US share with readers their new concepts, practices, and experiences from bench to bed, from population study to individual survey, from molecular search to clinical practice, and from early diagnosis to treatment. The book is intended for researchers in the fields of epidemiology, molecular genetics, cell biology, immunology of HCC and other cancers, and clinical oncology in primary liver cancer. Jianren Gu is a Professor of molecular oncology at the Shanghai Cancer Institute, Shanghai Jiao Tong University School of Medicine and Academician of Chinese Academy of Engineering.
Author: Richard B. M. Schasfoort
Publisher: Royal Society of Chemistry
ISBN: 1782627308
Category : Science
Languages : en
Pages : 555
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Book Description
Surface plasmon resonance (SPR) plays a dominant role in real-time interaction sensing of biomolecular binding events, this book provides a total system description including optics, fluidics and sensor surfaces for a wide researcher audience.
Author: Christian Münz
Publisher: Springer
ISBN: 9783319228211
Category : Medical
Languages : en
Pages : 0
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Book Description
Epstein Barr virus (EBV) was discovered as the first human tumor virus around 50 years ago. Since its discovery in Burkitt’s lymphoma it has been associated with various other malignancies, infectious mononucleosis and even autoimmune diseases. The two book volumes on EBV summarize the first 50 years of research on this tumor virus, starting with historical perspectives on discovery, oncogenicity and immune control, reviewing the role that the virus plays in the various associated diseases and concluding with a discussion on how the immune system keeps persistent EBV infection under control in healthy EBV carriers and can be used to treat EBV associated diseases. The respective 32 chapters are written by international experts from three continents for health care providers, biomedical researchers and patients that are affected by EBV. The assembled knowledge should help to understand EBV associated diseases better and to develop EBV specific vaccination in the near future.
