Cellular Factors Involved in Early Steps of Retroviral Replication PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Cellular Factors Involved in Early Steps of Retroviral Replication PDF full book. Access full book title Cellular Factors Involved in Early Steps of Retroviral Replication by John A T Young. Download full books in PDF and EPUB format.
Author: John A T Young
Publisher:
ISBN: 9783642190131
Category :
Languages : en
Pages : 256
Get Book Here
Book Description
Author: John A.T. Young
Publisher: Springer Science & Business Media
ISBN: 9783540008446
Category : Medical
Languages : en
Pages : 266
Get Book Here
Book Description
The articles in this volume provide a comprehensive overview of our current understanding of the roles played by cellular factors in the early steps of retroviral replication. A better understanding of these functions will provide critical new insights into retrovirus-host cell interactions and is likely to prove useful for the future development of effective antiretroviral therapies.
Author: John A T Young
Publisher:
ISBN: 9783642190131
Category :
Languages : en
Pages : 256
Get Book Here
Book Description
Author: Leslie Parent
Publisher: Academic Press
ISBN: 0128111933
Category : Science
Languages : en
Pages : 622
Get Book Here
Book Description
Retrovirus-Cell Interactions provides an up-to-date review of the interactions between retroviruses and the cells they infect, offering a comprehensive understanding of how retroviruses hijack cellular factors to facilitate virus replication. Drugs targeting viral enzymes have been developed to treat HIV; the next challenge is to inhibit virus-cell interactions as next generation treatment strategies. Organized according to the retrovirus' replication cycle, this book does not focus exclusively on HIV, but rather includes important findings in other retroviral systems, including animal retroviruses, retrotransposons, and endogenous retroelements to allow broad comparisons on important commonalities and differences. Provides a valuable starting point for people who want to develop a detailed understanding of retroviral replication Includes future-thinking strategies, such as next-generation treatment and anti-retroviral therapeutics Features important commonalities and differences among retroviral systems
Author: Shannon Beth Seidel
Publisher:
ISBN: 9781267470218
Category :
Languages : en
Pages : 143
Get Book Here
Book Description
Retroviruses are relevant human pathogens affecting the lives of tens of millions of people globally each year and resulting in nearly 2 million deaths annually. Understanding the process of retrovirus infection has wide benefits including the identification of therapeutic targets to treat HIV/AIDS and better understanding of cellular pathways disrupted in diseases, such as cancer and AIDS. Here, I first present my role in a collaborative project that led to the identification of over 200 cellular factors with potentially important roles in the early stages of retrovirus infection. We identified these factors through a genome-wide siRNA screen and through characterization of interactions between host and virus proteins. Additionally, I present my work on ZASC1, a host cell transcription factor that binds to the promoter regions of both HIV-1 and MLV and regulates virus gene expression in cultured established cell lines. I generated a ZASC1 knockout mouse model, showing that this gene is non-essential to development and reproduction. This mouse model was used to characterize the role of ZASC1 in retrovirus replication and disease pathogenesis. I showed that ZASC1 influences myeloid cell differentiation in this compartment and that this transcription factor is required for efficient early Mo-MuLV infection in the bone marrow compartment. Through studies of Mo-MuLV pathogenesis in the ZASC1 knockout mouse model, I show that despite this early defect, tumorigenesis is not regulated by ZASC1.
Author: Clarissa A. Dirks
Publisher:
ISBN:
Category :
Languages : en
Pages : 240
Get Book Here
Book Description
Author: James Gregory Greger (Jr)
Publisher:
ISBN:
Category :
Languages : en
Pages : 194
Get Book Here
Book Description
Author: Shari Marie Kaiser
Publisher:
ISBN: 9781109911923
Category :
Languages : en
Pages : 129
Get Book Here
Book Description
Retroviruses are undoubtedly one of the most elegant entities of the world. With modest genomes and intricate architecture, retroviruses are able to invade a species, establish a domicile, evade the immune system and rapidly evolve to successfully replicate in a specialized niche of the host. To establish a productive infection, retroviruses heavily rely on the host factors to successfully complete their replication cycle. Yet, as the retrovirus directs coordination and utilization of various host proteins for its own benefit, it simultaneously must evade interactions with the host antiviral and immune proteins that are in place to limit virus replication.
Author: Maarten Alexander Nicolaas Rits
Publisher:
ISBN:
Category :
Languages : en
Pages : 169
Get Book Here
Book Description
Author: John A.T. Young
Publisher: Springer Science & Business Media
ISBN: 364219012X
Category : Medical
Languages : en
Pages : 250
Get Book Here
Book Description
The articles in this volume provide a comprehensive overview of our current understanding of the roles played by cellular factors in the early steps of retroviral replication. A better understanding of these functions will provide critical new insights into retrovirus-host cell interactions and is likely to prove useful for the future development of effective antiretroviral therapies.
Author: Bryan Cullen
Publisher: Oxford University Press
ISBN: 9780199633821
Category : Gene Expression Regulation.
Languages : en
Pages : 220
Get Book Here
Book Description
The first book to specifically cover the molecular biology of retroviruses - of immense importance since the high profile of HIV. International contributors provide detailed reviews of the latest knowledge. An excellent text for both medical and non-medical researchers, it also serves as an illuminating introduction for scientists active in other areas.
