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Author: Abdelwahed Barkaoui
Publisher: BoD – Books on Demand
ISBN: 1837680140
Category : Technology & Engineering
Languages : en
Pages : 157
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Book Description
Dive into the intricate realm of osteoporosis through the lens of biomechanics with Biomechanical Insights into Osteoporosis. This pioneering volume offers a comprehensive exploration of this debilitating condition, providing an in-depth understanding of its biomechanical foundations and implications. Osteoporosis, characterized by reduced bone mineral density and heightened susceptibility to fractures, stands as a global health challenge. This book brings together leading experts in the field, who rigorously analyze the multifaceted aspects of osteoporosis, offering invaluable knowledge for researchers, clinicians, and students alike. Key Highlights: •Biomechanical Foundations: Gain profound insights into the biomechanical basis of bone fractures and fracture osteosynthesis in small animals. Explore the fundamental principles that shape our understanding of osteoporotic biomechanics. •Non-Glucocorticoid Drug-Induced Osteoporosis: Investigate the mechanisms, risk factors, and therapeutic approaches for osteoporosis induced by medications other than glucocorticoids. •Vascular Remodeling and Bone Destruction: Discover the common pathogenetic links between vascular remodeling and bone tissue destruction in postmenopausal women with arterial hypertension. This holistic perspective illuminates bone health dynamics. •Genetic Targets and Future Directions: Explore promising genetic targets that have the potential to revolutionize osteoporosis treatment. Get a glimpse into the future of research and treatment strategies. •Biomarkers and Metabolism: Delve into the latest research progress surrounding bone mineral density and bone metabolism biomarkers, offering valuable insights into diagnostics and monitoring. •Impact of Diseases and Medical Treatments: Understand the intricate interplay between diseases and medical treatments on bone mineral density. Gain a comprehensive understanding of how various factors influence skeletal health. This book represents a significant milestone in deciphering the complexities of osteoporosis from a biomechanical perspective. Join us in this scientific journey to explore the fascinating facets of osteoporosis. Biomechanical Insights into Osteoporosis is an essential resource for anyone seeking a deeper understanding of this critical health issue and the biomechanical aspects that underlie it.
Author: Abdelwahed Barkaoui
Publisher: BoD – Books on Demand
ISBN: 1837680140
Category : Technology & Engineering
Languages : en
Pages : 157
Get Book Here
Book Description
Dive into the intricate realm of osteoporosis through the lens of biomechanics with Biomechanical Insights into Osteoporosis. This pioneering volume offers a comprehensive exploration of this debilitating condition, providing an in-depth understanding of its biomechanical foundations and implications. Osteoporosis, characterized by reduced bone mineral density and heightened susceptibility to fractures, stands as a global health challenge. This book brings together leading experts in the field, who rigorously analyze the multifaceted aspects of osteoporosis, offering invaluable knowledge for researchers, clinicians, and students alike. Key Highlights: •Biomechanical Foundations: Gain profound insights into the biomechanical basis of bone fractures and fracture osteosynthesis in small animals. Explore the fundamental principles that shape our understanding of osteoporotic biomechanics. •Non-Glucocorticoid Drug-Induced Osteoporosis: Investigate the mechanisms, risk factors, and therapeutic approaches for osteoporosis induced by medications other than glucocorticoids. •Vascular Remodeling and Bone Destruction: Discover the common pathogenetic links between vascular remodeling and bone tissue destruction in postmenopausal women with arterial hypertension. This holistic perspective illuminates bone health dynamics. •Genetic Targets and Future Directions: Explore promising genetic targets that have the potential to revolutionize osteoporosis treatment. Get a glimpse into the future of research and treatment strategies. •Biomarkers and Metabolism: Delve into the latest research progress surrounding bone mineral density and bone metabolism biomarkers, offering valuable insights into diagnostics and monitoring. •Impact of Diseases and Medical Treatments: Understand the intricate interplay between diseases and medical treatments on bone mineral density. Gain a comprehensive understanding of how various factors influence skeletal health. This book represents a significant milestone in deciphering the complexities of osteoporosis from a biomechanical perspective. Join us in this scientific journey to explore the fascinating facets of osteoporosis. Biomechanical Insights into Osteoporosis is an essential resource for anyone seeking a deeper understanding of this critical health issue and the biomechanical aspects that underlie it.
Author: G. Lowet
Publisher: IOS Press
ISBN: 9789051993271
Category : Biomechanics
Languages : en
Pages : 234
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Book Description
This book focuses on the structure of bone, and its consequences for the mechanical behaviour of the bone structure. The first part of this book focuses on the development of models to predict the adaptation of bone due to changes on the mechanical loading situation (such as provoked by an implant). But far more important than the computer power presently available, the incorporation of knowledge on the biological processes have led to new kinds of models. Next to the development of models itself, the issue of model validation though comparison with clinical data is a main issue addressed in the papers of this symposium. The second part, dealing with the relationship between bone architecture and competence of bone, focuses on the morphology of trabecular bone structure. This work is mainly carried out in the context of research on osteoporosis, and look for the relation between bone structure and fracture risk. The last part is devoted to ultrasound research in bone biomechanics. Several methods have been described for the in vitro and in vivo measurement of ultrasound velocity and attenuation, both on cortical and on trabecular bone. The reader will not only discover the state-of-the-art when reading though this book. This book can give a taste of the fascinating perspectives the research in bone biomechanics still have to offer, even after more than 100 years.
Author: Sarah Kathleen Easley
Publisher:
ISBN:
Category :
Languages : en
Pages : 210
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Book Description
Anti-fracture therapies for the treatment of osteoporosis have been shown clinically to reduce the incidence of fracture; however, standard clinical measurements of bone density cannot sufficiently explain these large reductions. Therefore, the overall goal of this research is to develop a better understanding of the mechanisms through which anti-fracture therapies improve bone strength -- a critical determinant of fracture risk -- which should lead to improved assessment of treatment efficacy. Combining the latest advances in micro-computed tomography and high-resolution micro-CT-based finite element modeling, we used repeated measures and parameter variations to isolate specific biomechanical effects of various bone characteristics that can be altered by disease and treatment. Specifically, we found that simulated microcavities in trabecular bone from a wide range of bone volume fraction and microarchitecture reduced the strength and altered the relationship between strength and bone volume fraction. While this effect was greater in low-density bone and when the microcavities were targeted to regions of high tissue strain, an appreciable biomechanical effect persisted for all types of bone. Since previous work with antiresorptive-treated canine bone did not find such an effect, questions remain regarding accurate representation of the morphology and micromechanics of actual resorption-induced cavities. Despite these uncertainties, our results provide new insight into the clinical relevance of stress risers caused by resorption cavities, suggesting that antiresorptive therapies may be most effective via mitigation of stress risers in a subset of patients with low bone volume fraction and high bone turnover. Studying vertebrae from treated rats revealed that any treatment-induced changes in intra-specimen variations in tissue mineralization, as detected by quantitative micro-CT, had a negligible biomechanical effect at the whole bone level and in isolated trabecular bone. Intra-specimen variations in tissue mineralization did have a role in general biomechanical behavior, but this role was remarkably uniform across the four different treatment groups: sham control, ovariectomized (OVX), OVX+PTH, and OVX+raloxifene. Finite element results showed that biomechanical treatment effects were dominated by treatment-induced changes in geometry and microarchitecture. This research also produced an efficient pre-clinical framework for characterizing bone quality which should provide considerable insight into the mechanisms of biomechanical effects in a broad range of bone research applications, including aging, diseases, and pharmaceutical and genetic therapy. The approach takes advantage of the hierarchical structure of bone by evaluating the most biomechanically relevant characteristics at each physical scale to isolate the source of bone quality effects and prescribing subsequent analysis only when such effects are found. Using this framework, we found that neither ovariectomy nor PTH treatment had a net effect on bone quality of rat vertebrae during compressive loading suggesting that the observed changes in vertebral strength were primarily due to changes in bone quantity. In closure, this dissertation research has increased knowledge regarding the mechanisms through which osteoporosis therapies improve bone strength without appreciably increasing bone mass. Further, it provides new methods for pre-clinical assessment of treatment efficacy. This dissertation also outlines areas of research to further advance our understanding of the effects of disease and drug therapies on bone biomechanics in human bone.
Author: Harry K. Genant
Publisher: Springer Science & Business Media
ISBN: 3642804403
Category : Medical
Languages : en
Pages : 562
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Book Description
The diagnosis of osteoporosis and the determination of fracture risk has always been a challenge for radiologists, epidemiologists, and clinicians as well as oth er researchers and health care professionals working in the field. It is bone min eral density that is closely related to bone fragility, and the advent of techniques to quantitatively assess bone density has been welcomed. It has reduced the sub jectivity inherent to conventional radiologic assessment of osteoporosis. The on going technical process has made various techJ)iques to assess bone density wide ly available. However, these measurement techniques have also incurred some crit icism because bone densitometry has sometimes been applied without specific indications and without appropriate clinical ramifications. The purpose of this text is to provide a perspective on the current status of bone densitometry and ist relevance to osteoporosis diagnosis and management. Therefore, this book will give the reader an introduction to the nature of osteo porosis, its pathophysiology and epidemiology, and the clinical consequences of performing bone densitometry. Aside from standard bone densitometry, newer technologies such as quantitative ultrasound techniques, magnetic resonance imaging and bone structure analysis are discussed in the context of diagnosing osteoporosis.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309072840
Category : Business & Economics
Languages : en
Pages : 511
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Book Description
Every year workers' low-back, hand, and arm problems lead to time away from jobs and reduce the nation's economic productivity. The connection of these problems to workplace activities-from carrying boxes to lifting patients to pounding computer keyboards-is the subject of major disagreements among workers, employers, advocacy groups, and researchers. Musculoskeletal Disorders and the Workplace examines the scientific basis for connecting musculoskeletal disorders with the workplace, considering people, job tasks, and work environments. A multidisciplinary panel draws conclusions about the likelihood of causal links and the effectiveness of various intervention strategies. The panel also offers recommendations for what actions can be considered on the basis of current information and for closing information gaps. This book presents the latest information on the prevalence, incidence, and costs of musculoskeletal disorders and identifies factors that influence injury reporting. It reviews the broad scope of evidence: epidemiological studies of physical and psychosocial variables, basic biology, biomechanics, and physical and behavioral responses to stress. Given the magnitude of the problem-approximately 1 million people miss some work each year-and the current trends in workplace practices, this volume will be a must for advocates for workplace health, policy makers, employers, employees, medical professionals, engineers, lawyers, and labor officials.
Author: Hideaki E. Takahashi
Publisher: Springer Nature
ISBN: 9811656134
Category : Medical
Languages : en
Pages : 569
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Book Description
This edited book describes what fragile bone is, how the condition is assessed, and how it can be treated. It is intended for multi-professional trainees and practitioners in health and social care fields who care for and treat the elderly. Chapters within the book provide the latest advances in cell and molecular biology, morphology, radiology, and the biomechanics of bone in health and disease. The basic concept of “Remodeling” and “Modeling” is described for better understanding of the mechanisms of osteoporosis. Methods of identifying and assessing osteoporosis are described, as are risk factors for bone fracture and non-unions. Furthermore, the effects of various drugs used to treat osteoporosis at both material and structural levels of bone and their cost effectiveness are described. Operative treatments for fracture that maintain or improve the quality of life of patients are included Treatment of Osteoporotic Fracture and Systemic Skeletal Disorders attempts to provide a holistic and translational view of the pathogenesis and treatment of osteoporosis and some other musculoskeletal diseases, with an overview of treatment modalities in various clinical settings.
Author: Eric S. Orwoll
Publisher: Academic Press
ISBN: 0080923461
Category : Medical
Languages : en
Pages : 764
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Book Description
Since the publication of the first edition, the U.S. Surgeon General released the first-ever report on bone health and osteoporosis in October 2004. This report focuses even more attention on the devastating impact osteoporosis has on millions of lives. According to the National Osteoporosis Foundation, 2 million American men have osteoporosis, and another 12 million are at risk for this disease. Yet despite the large number of men affected, the lack of awareness by doctors and their patients puts men at a higher risk that the condition may go undiagnosed and untreated. It is estimated that one-fifth to one-third of all hip fractures occur in men. This second edition brings on board John Bilezikian and Dirk Vanderschueren as editors with Eric Orwoll. The table of contents is more than doubling with 58 planned chapters. The format is larger – 8.5 x 11. This edition of Osteoporosis in Men brings together even more eminent investigators and clinicians to interpret developments in this growing field, and describe state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy. Brings together more eminent investigators and clinicians to interpret developments in this growing field Describes state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy There is no book on the market that covers osteoporosis in men as comprehensively as this book
Author: Xiaodu Wang
Publisher: Springer Nature
ISBN: 3031025792
Category : Science
Languages : en
Pages : 219
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Book Description
This eight-chapter monograph intends to present basic principles and applications of biomechanics in bone tissue engineering in order to assist tissue engineers in design and use of tissue-engineered products for repair and replacement of damaged/deformed bone tissues. Briefly, Chapter 1 gives an overall review of biomechanics in the field of bone tissue engineering. Chapter 2 provides detailed information regarding the composition and architecture of bone. Chapter 3 discusses the current methodologies for mechanical testing of bone properties (i.e., elastic, plastic, damage/fracture, viscoelastic/viscoplastic properties). Chapter 4 presents the current understanding of the mechanical behavior of bone and the associated underlying mechanisms. Chapter 5 discusses the structure and properties of scaffolds currently used for bone tissue engineering applications. Chapter 6 gives a brief discussion of current mechanical and structural tests of repair/tissue engineered bone tissues. Chapter 7 summarizes the properties of repair/tissue engineered bone tissues currently attained. Finally, Chapter 8 discusses the current issues regarding biomechanics in the area of bone tissue engineering. Table of Contents: Introduction / Bone Composition and Structure / Current Mechanical Test Methodologies / Mechanical Behavior of Bone / Structure and Properties of Scaffolds for Bone Tissue Regeneration / Mechanical and Structural Evaluation of Repair/Tissue Engineered Bone / Mechanical and Structural Properties of Tissues Engineered/Repair Bone / Current Issues of Biomechanics in Bone Tissue Engineering
Author: Ignac Fogelman
Publisher: Springer
ISBN: 3642024009
Category : Medical
Languages : en
Pages : 1046
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Book Description
This book, written by authors with national and international reputations in the field, covers all aspects of radionuclide and hybrid bone imaging. Introductory sections present the basic science and consider the current status and limitations of conventional radiological techniques. The underlying principles of PET-CT and SPECT-CT are carefully explained, and the value of different PET and SPECT tracers, assessed. The role of single- and dual-modality approaches in the imaging of benign bone diseases and malignancies is then discussed in detail in a series of well-illustrated chapters. The pathologies addressed include metabolic bone disease, arthritis, bone and joint infections, primary bone and soft tissue tumors, and metastases from breast and prostate cancer. A further section considers the role of bone scintigraphy in the pediatric patient, and the closing chapters focus on miscellaneous subjects, including bone densitometry and radionuclide targeted therapy.
Author:
Publisher: BoD – Books on Demand
ISBN: 1789851211
Category : Medical
Languages : en
Pages : 114
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Book Description
I have taught a variety of courses in biomechanics, introductory and advanced, at multiple universities in Canada. I have not been able to find or use an appropriate textbook for students whose background is not biomedical engineering. It should be noted that there are many outstanding books on biomechanics; however, they are usually not very introductory or the topics covered are too detailed, which makes it impossible for those audiences to make effective use of the book. The present book is an attempt to fill this gap. No previous familiarity of anatomy, biology, or physiology is expected, and in fact every chapter begins with a review of the relevant necessary background. Each chapter then highlights identification and explanation of the indispensable aspects of the associated biomechanics issues.
