Biological, Diagnostic and Therapeutic Advances in Alzheimer's Disease PDF Download
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Author: Ghulam Md Ashraf
Publisher: Springer Nature
ISBN: 9811396361
Category : Medical
Languages : en
Pages : 293
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Book Description
This book discusses the latest research into the highly prevalent neurodevelopmental disease most commonly associated with aging: Alzheimer’s disease (AD). Even after years of research, Alzheimer’s disease is still far from being cured. It presents a range of common symptoms in the form of behavioral and cognitive impairments. This book describes the symptoms and the biology behind them. The contents covers latest findings on the genetics involved and various factors and pathways influencing disease development. It also covers various non-pharmacological therapies like immunotherapy, use of natural products, and employing nanotechnology in both the detection and treatment of AD. This book also highlights the role of diet and nutrition in healthy aging. Given its scope, it offers a valuable asset for researchers and clinicians alike.
Author: Ghulam Md Ashraf
Publisher: Springer Nature
ISBN: 9811396361
Category : Medical
Languages : en
Pages : 293
Get Book
Book Description
This book discusses the latest research into the highly prevalent neurodevelopmental disease most commonly associated with aging: Alzheimer’s disease (AD). Even after years of research, Alzheimer’s disease is still far from being cured. It presents a range of common symptoms in the form of behavioral and cognitive impairments. This book describes the symptoms and the biology behind them. The contents covers latest findings on the genetics involved and various factors and pathways influencing disease development. It also covers various non-pharmacological therapies like immunotherapy, use of natural products, and employing nanotechnology in both the detection and treatment of AD. This book also highlights the role of diet and nutrition in healthy aging. Given its scope, it offers a valuable asset for researchers and clinicians alike.
Author: M.C. Carrillo
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805598033
Category : Medical
Languages : en
Pages : 200
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Book Description
Expanding knowledge on genetic and epigenetic risk factors is rapidly enhancing our understanding of the complex molecular interactions and systems involved in the pathogenesis of Alzheimer’s disease. In this publication, leading experts discuss emerging novel conceptual models of the disease along with advances in the development of surrogate markers that will not only improve the accuracy of diagnostic technologies but also improve the prospects of developing disease-modifying interventions. The novel framework of the disease presented here highlights research on biological markers as well as efforts to validate technologies for early and accurate detection. It also introduces notion of a complex systems dysfunction that extends beyond prevailing ideas derived from the ‘amyloid’ or ‘tau’ hypotheses.This outstanding publication provides researchers, clinicians, students and other professionals interested in neurodegenerative disorders with a comprehensive update on current trends and future directions in therapy development, with special focus on advances in clinical trial designs.
Author: Elena Poole
Publisher: American Medical Publishers
ISBN: 9781639276585
Category : Health & Fitness
Languages : en
Pages : 0
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Book Description
Alzheimer's disease (AD) refers to a type of neurologic condition, which causes the brain to shrink and brain cells to die over time. AD is the most frequent form of dementia in which a progressive loss in social, cognitive and behavioral abilities occurs that impairs a person's capacity to operate independently. The primary symptom of AD is forgetting recent events or discussions. A person with AD will have severe memory impairment, while losing the capacity to perform daily tasks, as the disease progress. Drug development for AD relies heavily on biomarkers and they can also be used to facilitate diagnosis, safety monitoring, demonstrating target engagement and supporting the modification of disease. AD is incurable due to its multifactorial and complex nature. Biomarkers aid in characterizing the baseline state, a therapy response or a disease process. This book is compiled in such a manner, that it will provide in-depth knowledge about the assessment and management of Alzheimer's disease. It presents researches and studies performed by experts across the globe.
Author: Thimmaiah Govindaraju
Publisher: Royal Society of Chemistry
ISBN: 1839162740
Category : Medical
Languages : en
Pages : 695
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Book Description
Alzheimer’s disease is an increasingly common form of dementia and despite rising interest in discovery of novel treatments and investigation into aetiology, there are no currently approved treatments that directly tackle the causes of the condition. Due to its multifactorial pathogenesis, current treatments are directed against symptoms and even precise diagnosis remains difficult as the majority of cases are diagnosed symptomatically and usually confirmed only by autopsy. Alzheimer’s Disease: Recent Findings in Pathophysiology, Diagnostic and Therapeutic Modalities provides a comprehensive overview from aetiology and neurochemistry to diagnosis, evaluation and management of Alzheimer's disease, and latest therapeutic approaches. Intended to provide an introduction to all aspects of the disease and latest developments, this book is ideal for students, postgraduates and researchers in neurochemistry, neurological drug discovery and Alzheimer’s disease.
Author: Robert Becker
Publisher: Springer Science & Business Media
ISBN: 1461241162
Category : Medical
Languages : en
Pages : 571
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Book Description
Author: Khalid Iqbal
Publisher: Wiley
ISBN: 9780471969648
Category : Medical
Languages : en
Pages : 0
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Book Description
The past 15 years have witnessed a remarkable increase in our knowledge of the neurobiology of Alzheimer?s disease, and as new findings occur, the need for sharing and evaluating the information becomes even more important. An indispensable and detailed volume, this book is a nucleus of the latest information, covering all aspects of the neurobiology of Alzheimer?s disease, its treatment and psychosocial aspects. Over the past two years, since the publication of the last volume, major advances have been made towards understanding the aetiology and the pathogenesis of this disease. These include the discoveries of the genes whose mutations associate with Alzheimer?s disease in familial cases; the mechanisms of neuronal degeneration and identification of specific steps in the neurodegenerative process that provide targets for therapeutic intervention. This volume also presents advances in the generation of cellular and animal models of ß-amyloid and tau pathology, the two hallmark lesions of Alzheimer?s disease. The chapters in this book are at the cutting edge of Alzheimer?s disease research and will be of enormous value not only to Alzheimer?s disease researchers, but also to neurobiologists, clinicians and caregivers.
Author: Gary Fiskum
Publisher: Springer Science & Business Media
ISBN: 9780306452987
Category : Science
Languages : en
Pages : 500
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Book Description
Proceedings of the Fifteenth Washington International Spring Symposium held at The George Washington University, Washington, D.C., May 15-17, 1995
Author: Elias K. Michaelis
Publisher: Academic Press
ISBN: 0123948169
Category : Medical
Languages : en
Pages : 400
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Book Description
"Providing a cross-section of current research, treatments and potential clinical developments, this volume of Advances in Pharmacology is an essential resource for biologists, pharmacologists and those engaged with Alzheimer's research."--P. [4] of cover.
Author: Ezio Giacobini
Publisher: Birkhauser
ISBN: 9783764338794
Category : Alzheimer's Disease
Languages : en
Pages : 613
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Book Description
A truly comprehensive and international overview of therapy development in Alzheimer disease research and practice. The 91 research papers report on the use of cholinesterase inhibitors in the later stages of clinical development, muscarinic and nicotinic agents, neuromodulators, and nerve and growth factors. In depth treatments are given to antioxidant and anti-inflammatory therapies, as well as potential treatments. In addition to the technical discussions of drug development, specialists analyze drug development guidelines, bioethics, legal aspects relating to Alzheimer research, behavioral treatments, and the activities of the Nancy and Ronald Reagan Foundation. Annotation copyrighted by Book News, Inc., Portland, OR
Author: Magisetty Obulesu
Publisher: Academic Press
ISBN: 0128167394
Category : Medical
Languages : en
Pages : 80
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Book Description
Alzheimer’s Disease Theranostics discusses the latest information on recent theranostic avenues for both the diagnosis and treatment of Alzheimer’s patients. It presents the pros and cons of the probable mechanistic role of nanoparticles in crossing the blood-brain barrier and improving disease symptoms. Finally, it highlights the merits of existing maneuvers and suggests perspectives to aid in future developments. Despite the difficulty of drug delivery to the brain, there are some nanoparticulate platforms demonstrating promise in treating neurodegenerative disorders such as Alzheimer’s disease. Manifold theranostic maneuvers include antioxidants, natural bioactive compounds, gene therapy, and nanotechnological approaches, all of which are discussed in this important work. Examines various theranostic applications for the diagnosis and treatment of Alzheimer’s disease Features a comprehensive overview of nanoparticle therapeutics in the area and use of antioxidants Assesses the common challenges and lessons learned from blood-brain barrier challenges, viral vector approaches and mitochondria-targeted therapeutics
