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Author: David Ahmad Nemazee
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805574541
Category : Medical
Languages : en
Pages : 281
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Book Description
B cells play a central role not only in adaptive immunity, but also in autoimmunity. To understand how B cells are normally prevented from reacting to self-tissue, what goes wrong in autoimmunity, and how B cells contribute to it is the aim of this book. This volume includes more than a dozen in-depth reviews by researchers specializing in various aspects of basic B cell biology that have relevance to autoimmune diseases. These up-to-date chapters present the latest information on B cell signal transduction, apoptosis, genetics and molecular biology. Also featured are chapters with special reference to particular autoimmune diseases in which B cells have been shown to play a critical role, such as type 1 diabetes, chronic graft-versus-host disease and lupus erythematosus. Further topics covered include the role of the complement system, rheumatoid factors, and anti-DNA autoantibodies as well as important related areas such as natural autoantibodies, B cell immune tolerance, Toll receptor signaling, and the immunobiology of BAFF/BLyS. Both basic researchers and clinician scientists who wish to understand the role of B lymphocytes in immune tolerance and autoimmunity will benefit from this timely publication.
Author: David Ahmad Nemazee
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805574541
Category : Medical
Languages : en
Pages : 281
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Book Description
B cells play a central role not only in adaptive immunity, but also in autoimmunity. To understand how B cells are normally prevented from reacting to self-tissue, what goes wrong in autoimmunity, and how B cells contribute to it is the aim of this book. This volume includes more than a dozen in-depth reviews by researchers specializing in various aspects of basic B cell biology that have relevance to autoimmune diseases. These up-to-date chapters present the latest information on B cell signal transduction, apoptosis, genetics and molecular biology. Also featured are chapters with special reference to particular autoimmune diseases in which B cells have been shown to play a critical role, such as type 1 diabetes, chronic graft-versus-host disease and lupus erythematosus. Further topics covered include the role of the complement system, rheumatoid factors, and anti-DNA autoantibodies as well as important related areas such as natural autoantibodies, B cell immune tolerance, Toll receptor signaling, and the immunobiology of BAFF/BLyS. Both basic researchers and clinician scientists who wish to understand the role of B lymphocytes in immune tolerance and autoimmunity will benefit from this timely publication.
Author: William Stohl
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805578512
Category : Medical
Languages : en
Pages : 321
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Book Description
The understanding of B cell biology has increased and expanded enormously in the last three decades. It is now known that B cells, in addition to just differentiating into antibody-secreting cells, serve many other vital functions. For example, their roles as antigen-presenting cells and cytokine-producing cells as well as effector cells and regulatory cells are well appreciated now. Indeed, the pathologic role of B cells in many autoimmune disorders may be largely autoantibody-independent. Today, the B cell is of considerable interest not only to immunologists but also to mainstream clinicians and scientists. The current volume covers the latest information on the functions of B cells in normal and disease states, and their therapeutic antagonism. Chapters cover cutting-edge topics from the basic to the clinical, including B cells in infection and autoimmunity, CD19-CD21 signal transduction complex, marginal zone B cell physiology and disease, B cell growth and differentiation, their role in rheumatoid arthritis, SLE treatment, the BAFF/APRIL system and B lymphocyte malignancies. This book is recommended reading for cellular and molecular immunologists as well as for rheumatologists, hematologists and clinical immunologists, and all those interested in human diseases in which B cells play an important contributory role.
Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :
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Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author: Christian Boitard
Publisher: Landes Bioscience
ISBN:
Category : Medical
Languages : en
Pages : 288
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Book Description
Author: Tomohiro Kurosaki
Publisher: Springer
ISBN: 3319261339
Category : Medical
Languages : en
Pages : 231
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Book Description
This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.
Author: Xavier Bosch
Publisher: Springer
ISBN: 9783034807050
Category : Medical
Languages : en
Pages : 0
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Book Description
This book provides a detailed overview of B-cell directed therapies in patients with rheumatic and systemic autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sjögren syndrome, ANCA-associated vasculitis and cryoglobulinemia. Organ-specific autoimmune diseases are discussed with respect to the use of B-cell directed therapies in neurological autoimmune diseases and autoimmune cytopenias. Situations in which B-cell targeted therapy may be indicated are identified, thereby offering comprehensive support for therapeutic decisions on the basis of the latest published evidence. The book also offers a valuable reference tool for rheumatologists, internists, nephrologists, immunologists, and all specialists involved in the multidisciplinary care of patients with rheumatic and systemic autoimmune diseases.
Author: Wahid Ali Khan
Publisher:
ISBN: 1789848520
Category : Microbiology
Languages : en
Pages : 218
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Book Description
The mechanism of autoantibodies cannot be explained without the detail knowledge of cytokines and interferon. These active molecules of immunology are very much dependent on each other and their function cannot be completed without their interaction towards each other. Currently, this the most updated book on this subject that helps the readers/students to upgrade their knowledge by going through chapter by chapter. Contribution by the renounced authors across the globe makes this book really unique and consider as one of the most updated textbook on this subject. This book provides a comprehensive guide to the function and types of autoantibodies and cytokines in basic and clinical field.
Author: Nicholas Chiorazzi
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 552
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Book Description
This is a collection of papers presented at the B Lymphocytes and Autoimmunity conference held on May 21-25, 1996 in Prague. The information presented includes data on B cell subset identification and development, antibody repertoire selection, tolerance induction, and antigen presentation. Each of these has a significant impact on the generation of autoantibodies and the development of autoimmune disease. A multidisciplinary discussion of the basic and clinical aspects of B cell function and autoimmunity is provided.
Author: Nadir Farid
Publisher: Elsevier
ISBN: 0323156231
Category : Science
Languages : en
Pages : 318
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Book Description
The Molecular Aspects of Autoimmunity contains a selection of the papers presented at the first of a series of biannual meetings on molecular aspects of autoimmunity held in L'Esterel, Quebec, Canada, October 30-November 2, 1988. The book contains 20 chapters and begins with a study of the expression of the Ly-1 gene and V gene families in autoantibodies. This is followed by separate chapters on the structural characteristics of human IgM autoantibodies; human IgV gene segments for autoantibodies; and the genetic basis of anti-DNA immune responses. Subsequent chapters cover topics such as the epibodies from the immune response to the acetylcholine receptor (AChR); the specificities and idiotypes of anti-histone H1 autoantibodies; T cell tolerance; and T cell antigen receptor (TCR) gene biology and the genomic composition and expressed repertoire of these genes in several autoimmune and normal mouse strains. Also discussed are MHC Class II associations with autoimmune disorders such as type 1 diabetes, rheumatoid arthritis, and thyroid disease.
Author: Min Zhang
Publisher: Open Dissertation Press
ISBN: 9781374665651
Category :
Languages : en
Pages :
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Book Description
This dissertation, "The Role of B Cell Activating Factor in B Cell Development and Autoimmunity" by Min, Zhang, 張敏, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled The Role of B Cell-Activating Factor in B Cell Development and Autoimmunity submitted by Zhang Min for the degree of Doctor of Philosophy at the University of Hong Kong in October 2006 B cell activating factor (BAFF), a member of the TNF family cytokines, has been demonstrated to enhance B cell activation and survival both in vitro and in vivo. Although dysregulated BAFF production is associated with a variety of autoimmune diseases, its function in early B cell development and autoimmunity progression remains largely unclear. To study whether BAFF is expressed in the bone marrow, we detected abundant expression of BAFF transcripts and its sister gene, APRIL, in mouse bone marrow non-lymphoid cells. The expression of BAFF receptors was found in developing B cells at various differentiation stages. Both recombinant BAFF and APRIL can significantly promote the survival of precursor B cells whereas only BAFF can - - suppress apoptosis of immature B cells in short-term cultures in vitro. These findings suggest that BAFF and APRIL, in addition to their well established role in regulating peripheral B cell growth, can modulate the survival of developing B cells in the bone marrow. To study the expression and function of BAFF in the development of autoimmune arthritis, a mouse model of collagen II (CII)-induced arthritis (CIA) for human rheumatoid arthritis was established. Elevated levels of BAFF expression were found in the peripheral blood as well as joint tissue of the CIA mice. Splenic dendritic cells from the CIA mice at the early CIA stage showed markedly increased BAFF expression, but as the disease progressed to later stages, the abundant BAFF were produced by macrophages. In cultures, recombinant BAFF suppressed apoptosis of splenic B cells from arthritic mice and enhanced the survival of plasma cells. Moreover, dendritic cell (DC)-induced B cell proliferation was specifically blocked by the soluble decoy receptor BCMA-Fc. These findings suggest that overproduction of BAFF by DCs and macrophages may play a crucial role in the pathogenesis of autoimmune arthritis. To further investigate the in vivo function of BAFF in the development of autoantibody-producing plasma cells and the progression of arthritis, recombinant BAFF was intravenously administered into CIA mice. Severe increases in disease symptoms as evaluated by clinical arthritis scores were observed in BAFF-treated CIA mice, which were accompanied by markedly increased serum levels of anti-CII antibodies. Flow cytometric analysis showed an expansion of the peripheral B compartment in BAFF-treated CIA mice, in which splenic B cells exhibited a significantly higher proliferative response to LPS and anti-IgM stimulation as well as - - a lower apoptotic incidence compared to that of the control CIA mice. Immunohistochemical studies revealed a greater accumulation of CD138+ cells with typical plasma cell morphology in the inflamed joints of the BAFF-treated CIA mice. Moreover, ELISPOT assays detected significantly increased numbers of long-lived anti-CII antibody-producing plasma cells in the joint tissue. Importantly, histopathological studies of the joints showed more pronounced damage in the BAFF-treated CIA mice. These results suggest that BAFF plays a crucial role in the generation of anti-CII antibody-producing plasma cells in CIA mice. In summary, our findings have established a pre
