Auditory Brainstem Response Latency in Noise as a Marker of Cochlear Synaptopathy PDF Download
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Author: Golbarg Mehraei
Publisher:
ISBN:
Category :
Languages : en
Pages : 117
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Book Description
Communication in environments with multiple competing sound sources can be challenging, even for listeners with normal hearing thresholds (NHT). This difficulty in "normal" listeners is thought to arise from central sites of the auditory system with the assumption that sound encoding at the auditory nerve (AN) is robust. Despite this assumption, growing evidence from animal and human studies suggests that acoustic exposure, too modest to elevate hearing thresholds, can nonetheless cause "hidden hearing loss" that interferes with coding of supra-threshold sound. In animal studies, such noise exposure leads to cochlear synaptopathy (death of auditory nerve fibers or ANFs); however, there is no clinical test of synaptopathy in humans. In animals, synaptopathy reduces the amplitude of auditory brainstem response (ABR) wave-I. Unfortunately, ABR wave-I is difficult to measure in humans, limiting its clinical use. Here, using behavioral, otoacoustic, and electrophysiological measures in humans and mice in conjunction with computational models of sound processing by the auditory periphery and brainstem, we show that the effect of masking noise on the latency of the more robust ABR wave-V mirrors changes in ABR wave-I amplitude. In our human cohort, the effect of noise on wave-V latency predicts perceptual temporal sensitivity. Further, we show evidence that ABR wave-V latency in forward masking may be affected by ANF loss and is predictive of a listener's performance in a perceptual task related to speech intelligibility in noise. Our results suggest that measures of the effects of masking on ABR wave-V latency can be used to diagnose ANF survival in humans.
Author: Golbarg Mehraei
Publisher:
ISBN:
Category :
Languages : en
Pages : 117
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Book Description
Communication in environments with multiple competing sound sources can be challenging, even for listeners with normal hearing thresholds (NHT). This difficulty in "normal" listeners is thought to arise from central sites of the auditory system with the assumption that sound encoding at the auditory nerve (AN) is robust. Despite this assumption, growing evidence from animal and human studies suggests that acoustic exposure, too modest to elevate hearing thresholds, can nonetheless cause "hidden hearing loss" that interferes with coding of supra-threshold sound. In animal studies, such noise exposure leads to cochlear synaptopathy (death of auditory nerve fibers or ANFs); however, there is no clinical test of synaptopathy in humans. In animals, synaptopathy reduces the amplitude of auditory brainstem response (ABR) wave-I. Unfortunately, ABR wave-I is difficult to measure in humans, limiting its clinical use. Here, using behavioral, otoacoustic, and electrophysiological measures in humans and mice in conjunction with computational models of sound processing by the auditory periphery and brainstem, we show that the effect of masking noise on the latency of the more robust ABR wave-V mirrors changes in ABR wave-I amplitude. In our human cohort, the effect of noise on wave-V latency predicts perceptual temporal sensitivity. Further, we show evidence that ABR wave-V latency in forward masking may be affected by ANF loss and is predictive of a listener's performance in a perceptual task related to speech intelligibility in noise. Our results suggest that measures of the effects of masking on ABR wave-V latency can be used to diagnose ANF survival in humans.
Author: Dianne Hamilton Meyer
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Jens Blauert
Publisher: Springer Nature
ISBN: 3030003868
Category : Science
Languages : en
Pages : 815
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Book Description
Sound, devoid of meaning, would not matter to us. It is the information sound conveys that helps the brain to understand its environment. Sound and its underlying meaning are always associated with time and space. There is no sound without spatial properties, and the brain always organizes this information within a temporal–spatial framework. This book is devoted to understanding the importance of meaning for spatial and related further aspects of hearing, including cross-modal inference. People, when exposed to acoustic stimuli, do not react directly to what they hear but rather to what they hear means to them. This semiotic maxim may not always apply, for instance, when the reactions are reflexive. But, where it does apply, it poses a major challenge to the builders of models of the auditory system. Take, for example, an auditory model that is meant to be implemented on a robotic agent for autonomous search-&-rescue actions. Or think of a system that can perform judgments on the sound quality of multimedia-reproduction systems. It becomes immediately clear that such a system needs • Cognitive capabilities, including substantial inherent knowledge • The ability to integrate information across different sensory modalities To realize these functions, the auditory system provides a pair of sensory organs, the two ears, and the means to perform adequate preprocessing of the signals provided by the ears. This is realized in the subcortical parts of the auditory system. In the title of a prior book, the term Binaural Listening is used to indicate a focus on sub-cortical functions. Psychoacoustics and auditory signal processing contribute substantially to this area. The preprocessed signals are then forwarded to the cortical parts of the auditory system where, among other things, recognition, classification, localization, scene analysis, assignment of meaning, quality assessment, and action planning take place. Also, information from different sensory modalities is integrated at this level. Between sub-cortical and cortical regions of the auditory system, numerous feedback loops exist that ultimately support the high complexity and plasticity of the auditory system. The current book concentrates on these cognitive functions. Instead of processing signals, processing symbols is now the predominant modeling task. Substantial contributions to the field draw upon the knowledge acquired by cognitive psychology. The keyword Binaural Understanding in the book title characterizes this shift. Both books, The Technology of Binaural Listening and the current one, have been stimulated and supported by AABBA, an open research group devoted to the development and application of models of binaural hearing. The current book is dedicated to technologies that help explain, facilitate, apply, and support various aspects of binaural understanding. It is organized into five parts, each containing three to six chapters in order to provide a comprehensive overview of this emerging area. Each chapter was thoroughly reviewed by at least two anonymous, external experts. The first part deals with the psychophysical and physiological effects of Forming and Interpreting Aural Objects as well as the underlying models. The fundamental concepts of reflexive and reflective auditory feedback are introduced. Mechanisms of binaural attention and attention switching are covered—as well as how auditory Gestalt rules facilitate binaural understanding. A general blackboard architecture is introduced as an example of how machines can learn to form and interpret aural objects to simulate human cognitive listening. The second part, Configuring and Understanding Aural Space, focuses on the human understanding of complex three-dimensional environments—covering the psychological and biological fundamentals of auditory space formation. This part further addresses the human mechanisms used to process information and interact in complex reverberant environments, such as concert halls and forests, and additionally examines how the auditory system can learn to understand and adapt to these environments. The third part is dedicated to Processing Cross-Modal Inference and highlights the fundamental human mechanisms used to integrate auditory cues with cues from other modalities to localize and form perceptual objects. This part also provides a general framework for understanding how complex multimodal scenes can be simulated and rendered. The fourth part, Evaluating Aural-scene Quality and Speech Understanding, focuses on the object-forming aspects of binaural listening and understanding. It addresses cognitive mechanisms involved in both the understanding of speech and the processing of nonverbal information such as Sound Quality and Quality-of- Experience. The aesthetic judgment of rooms is also discussed in this context. Models that simulate underlying human processes and performance are covered in addition to techniques for rendering virtual environments that can then be used to test these models. The fifth part deals with the Application of Cognitive Mechanisms to Audio Technology. It highlights how cognitive mechanisms can be utilized to create spatial auditory illusions using binaural and other 3D-audio technologies. Further, it covers how cognitive binaural technologies can be applied to improve human performance in auditory displays and to develop new auditory technologies for interactive robots. The book concludes with the application of cognitive binaural technologies to the next generation of hearing aids.
Author: James Wilbur Hall
Publisher: Allyn & Bacon
ISBN:
Category : Education
Languages : en
Pages : 896
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Book Description
A book such as this one is needed but does not exist. There is no book with a scope encompassing all clinically important auditory evoked responses.
Author: Colleen G. Le Prell
Publisher: Springer Science & Business Media
ISBN: 1441995234
Category : Science
Languages : en
Pages : 377
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Book Description
Exposure to loud noise continues to be the largest cause of hearing loss in the adult population. The problem of NIHL impacts a number of disciplines. US standards for permissible noise exposure were originally published in 1968 and remain largely unchanged today. Indeed, permissible noise exposure for US personnel is significantly greater than that allowed in numerous other countries, including for example, Canada, China, Brazil, Mexico, and the European Union. However, there have been a number of discoveries and advances that have increased our understanding of the mechanisms of NIHL. These advances have the potential to impact how NIHL can be prevented and how our noise standards can be made more appropriate.
Author: Nina Kraus
Publisher: Springer
ISBN: 331947944X
Category : Medical
Languages : en
Pages : 306
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Book Description
This volume will cover a variety of topics, including child language development; hearing loss; listening in noise; statistical learning; poverty; auditory processing disorder; cochlear neuropathy; attention; and aging. It will appeal broadly to auditory scientists—and in fact, any scientist interested in the biology of human communication and learning. The range of the book highlights the interdisciplinary series of questions that are pursued using the auditory frequency-following response and will accordingly attract a wide and diverse readership, while remaining a lasting resource for the field.
Author: Debra L. Franzone
Publisher:
ISBN:
Category : Audiometry, Evoked response
Languages : en
Pages : 116
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Book Description
Author: Brian C. J. Moore
Publisher: John Wiley & Sons
ISBN: 9780470518182
Category : Medical
Languages : en
Pages : 344
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Book Description
Since the first edition was published in 1998, considerable advances have been made in the fields of pitch perception and speech perception. In addition, there have been major changes in the way that hearing aids work, and the features they offer. This book will provide an understanding of the changes in perception that take place when a person has cochlear hearing loss so the reader understands not only what does happen, but why it happens. It interrelates physiological and perceptual data and presents both this and basic concepts in an integrated manner. The goal is to convey an understanding of the perceptual changes associated with cochlear hearing loss, of the difficulties faced by the hearing-impaired person, and the limitations of current hearing aids.
Author: Kirstin Elizabeth Beach
Publisher:
ISBN:
Category :
Languages : en
Pages : 142
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Book Description
Author: Yvonne Satterblom Sininger
Publisher:
ISBN:
Category : Auditory evoked response
Languages : en
Pages : 246
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Book Description
