Application of Novel Statistical and Machine-learning Methods to High-dimensional Clinical Cancer and (Multi-)Omics data PDF Download
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Author: Chao Xu
Publisher: Frontiers Media SA
ISBN: 2889714365
Category : Science
Languages : en
Pages : 136
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Book Description
Author: Chao Xu
Publisher: Frontiers Media SA
ISBN: 2889714365
Category : Science
Languages : en
Pages : 136
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Book Description
Author: Angelo Facchiano
Publisher: Frontiers Media SA
ISBN: 2889637522
Category :
Languages : en
Pages : 175
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Book Description
Author: Hongda Liu
Publisher: Frontiers Media SA
ISBN: 2832554741
Category : Medical
Languages : en
Pages : 535
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Book Description
More and more medical centers are now combining high-resolution CT scans well with deep learning and artificial intelligence for lung cancer screening, resulting in significantly improved diagnostic sensitivity. Furthermore, the increased molecular alterations in lung cancer were demonstrated not only in tumor tissue, but also in other body organs. For example, circulating tumor DNA combined with next-generation sequencing is now becoming a popular method for lung cancer diagnosis and therapeutic monitoring. Therefore, the first focus of this topic is on such achievements in early diagnosis of lung cancer, especially non-invasive tests such as liquid biopsy.
Author: Ching-Chang Ko
Publisher: Springer Nature
ISBN: 3030718816
Category : Medical
Languages : en
Pages : 186
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Book Description
This book reviews all aspects of the use of machine learning in contemporary dentistry, clearly explaining its significance for dental imaging, oral diagnosis and treatment, dental designs, and dental research. Machine learning is an emerging field of artificial intelligence research and practice in which computer agents are employed to improve perception, cognition, and action based on their ability to “learn”, for example through use of big data techniques. Its application within dentistry is designed to promote personalized and precision patient care, with enhancement of diagnosis and treatment planning. In this book, readers will find up-to-date information on different machine learning tools and their applicability in various dental specialties. The selected examples amply illustrate the opportunities to employ a machine learning approach within dentistry while also serving to highlight the associated challenges. Machine Learning in Dentistry will be of value for all dental practitioners and researchers who wish to learn more about the potential benefits of using machine learning techniques in their work.
Author: Brandon K. K. Fields
Publisher: Frontiers Media SA
ISBN: 2832556418
Category : Medical
Languages : en
Pages : 119
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Book Description
Increasing interest in the development and validation of quantitative imaging biomarkers for oncologic imaging has in recent years inspired a surge in the field of artificial intelligence and machine learning. Initial results showed promise in identifying potential markers of treatment response, malignant potential, and prognostic predictors, among others; however, while many of these early algorithms showed the optimistic ability to separate pathologic states on “in-house” datasets, it was often the case that these classifiers generalized poorly on external validation sets and thus were of limited utility in the clinical setting. This issue was additionally compounded by the frequent use of data filtering and feature selection techniques in many studies to further bolster the machine learning results in limited case scenarios, thereby biasing the overall fit and further reducing generalizability.
Author: Claudio Carini
Publisher: CRC Press
ISBN: 0429576730
Category : Medical
Languages : en
Pages : 659
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Book Description
"The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.
Author: Stephanie K. Ashenden
Publisher: Academic Press
ISBN: 0128204494
Category : Computers
Languages : en
Pages : 266
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Book Description
The Era of Artificial Intelligence, Machine Learning and Data Science in the Pharmaceutical Industry examines the drug discovery process, assessing how new technologies have improved effectiveness. Artificial intelligence and machine learning are considered the future for a wide range of disciplines and industries, including the pharmaceutical industry. In an environment where producing a single approved drug costs millions and takes many years of rigorous testing prior to its approval, reducing costs and time is of high interest. This book follows the journey that a drug company takes when producing a therapeutic, from the very beginning to ultimately benefitting a patient's life. This comprehensive resource will be useful to those working in the pharmaceutical industry, but will also be of interest to anyone doing research in chemical biology, computational chemistry, medicinal chemistry and bioinformatics. - Demonstrates how the prediction of toxic effects is performed, how to reduce costs in testing compounds, and its use in animal research - Written by the industrial teams who are conducting the work, showcasing how the technology has improved and where it should be further improved - Targets materials for a better understanding of techniques from different disciplines, thus creating a complete guide
Author: Sweet Ping Ng
Publisher: Frontiers Media SA
ISBN: 2832533973
Category : Medical
Languages : en
Pages : 216
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Book Description
Author: Victor Jin
Publisher: Frontiers Media SA
ISBN: 2889634485
Category :
Languages : en
Pages : 154
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Book Description
Multisource heterogenous omics data can provide unprecedented perspectives and insights into cancer studies, but also pose great analytical problems for researchers due to the vast amount of data produced. This Research Topic aims to provide a forum for sharing ideas, tools and results among researchers from various computational cancer biology fields such as genetic/epigenetic and genome-wide studies.
Author: Steven Piantadosi
Publisher: Springer Nature
ISBN: 3319526367
Category : Medical
Languages : en
Pages : 2573
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Book Description
This is a comprehensive major reference work for our SpringerReference program covering clinical trials. Although the core of the Work will focus on the design, analysis, and interpretation of scientific data from clinical trials, a broad spectrum of clinical trial application areas will be covered in detail. This is an important time to develop such a Work, as drug safety and efficacy emphasizes the Clinical Trials process. Because of an immense and growing international disease burden, pharmaceutical and biotechnology companies continue to develop new drugs. Clinical trials have also become extremely globalized in the past 15 years, with over 225,000 international trials ongoing at this point in time. Principles in Practice of Clinical Trials is truly an interdisciplinary that will be divided into the following areas: 1) Clinical Trials Basic Perspectives 2) Regulation and Oversight 3) Basic Trial Designs 4) Advanced Trial Designs 5) Analysis 6) Trial Publication 7) Topics Related Specific Populations and Legal Aspects of Clinical Trials The Work is designed to be comprised of 175 chapters and approximately 2500 pages. The Work will be oriented like many of our SpringerReference Handbooks, presenting detailed and comprehensive expository chapters on broad subjects. The Editors are major figures in the field of clinical trials, and both have written textbooks on the topic. There will also be a slate of 7-8 renowned associate editors that will edit individual sections of the Reference.
