Ototoxicity

Ototoxicity PDF Author: Peter S. Roland
Publisher: PMPH-USA
ISBN: 9781550092639
Category : Aminoglycosides
Languages : en
Pages : 236

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Book Description
CD-ROM features complete text and full-color illustrations in searchable PDF files.

Ototoxicity

Ototoxicity PDF Author: Peter S. Roland
Publisher: PMPH-USA
ISBN: 9781550092639
Category : Aminoglycosides
Languages : en
Pages : 236

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Book Description
CD-ROM features complete text and full-color illustrations in searchable PDF files.

Aminoglycoside Ototoxicity

Aminoglycoside Ototoxicity PDF Author: Stephen A. Lerner
Publisher: Little, Brown Medical Division
ISBN:
Category : Medical
Languages : en
Pages : 488

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Book Description


Cellular Mechanisms in Ototoxicity

Cellular Mechanisms in Ototoxicity PDF Author: Peter S. Steyger
Publisher: Frontiers Media SA
ISBN: 2889454835
Category :
Languages : en
Pages : 292

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Book Description
The auditory perception of sounds (environmental, vocal or music) is one of the 5 principal senses consciously monitored by our brains, and is crucial for many human endeavors as well as quality of life. Loss of optimal performance in this principal sensory system leads to loss of effective communication and intimacy, as well as increased risk of isolation, depression, cognitive decline, and greater vulnerability to predators. The vestibular system ensures that individuals remain upright and effectively monitor their posture within their spatial surroundings, move effectively, and remain focused on visual targets during motion. The loss of vestibular sensitivity results in postural instability, falls, inability to observe the environment during motion, and a debilitating incapacity to function effectively. The sensory cells for both auditory and vestibular systems are located within the inner ear of the temporal bulla. There are many causes of auditory and vestibular deficits, including congenital (or genetic) events, trauma, aging and loud sound exposures. Ototoxicity refers to damage of the auditory or vestibular structures or functions, as the result of exposure to certain pharmaceuticals, chemicals, and/or ionizing radiation exposure that damage the inner ear. Ototoxicity is a major contributor to acquired hearing loss and vestibular deficits, and is entirely preventable. In 2009, the United States Department of Defense initiated the Hearing Center of Excellence (HCE), headquartered in San Antonio, Texas, in response to the prevalence of acquired auditory and vestibular deficits in military and veteran populations. The knowledge shared in this eBook supports the HCE’s mandate to improve aural protection of military and civilian populations worldwide. The last few years have seen significant advances in understanding the cellular mechanisms underlying ototoxic drug-induced hearing loss and vestibular deficits. In this eBook, we present some of these advances and highlight gaps where further research is needed. Selected articles discuss candidate otoprotective agents that can ameliorate the effects of ototoxicity in the context of how they illustrate cellular mechanisms of ototoxicity. Our goal in illustrating these advances in mechanisms of ototoxicity is to accelerate the development of clinical therapies that prevent or reverse this debilitating disorder.

Aminoglycoside Ototoxicity Following Middle Ear Injection

Aminoglycoside Ototoxicity Following Middle Ear Injection PDF Author: Michael D. Rudnick
Publisher:
ISBN:
Category : Aminoglycosides
Languages : en
Pages : 28

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Book Description


Therapy in Nephrology and Hypertension E-Book

Therapy in Nephrology and Hypertension E-Book PDF Author: Christopher S. Wilcox
Publisher: Elsevier Health Sciences
ISBN: 1437711243
Category : Medical
Languages : en
Pages : 1161

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Book Description
Thoroughly revised, the new edition of this companion to Brenner & Rector’s The Kidney equips you with today’s guidance to effectively manage renal and hypertension patients. International authorities emphasize the specifics of treatment while presenting field-tested advice on the best therapeutic strategies available. New chapters reflect the latest evidence impacting current clinical issues, while a new design helps you reference the information more easily. Presents the most comprehensive text available on nephrology and hypertension treatment for a convenient single source that is easy to consult. Features the evidence-based guidance of leading authorities for making more informed clinical decisions. Offers in-depth discussions and referenced coverage of key trials to help you analyze the results and the evidence provided. Provides treatment algorithms and tables of commonly used drugs in each chapter for quick-access expert advice on arriving at the best and most appropriate treatment regimen. Offers new chapters on erectile and sexual dysfunction, transplant immunology and immunosuppression, dietary salt restriction, and systematic vasculitis and pauci-immune glomerulonephritis that reflect new evidence impacting current clinical issues. Presents the contributions of newly assigned section editors—authorities in their subspecialty fields—who offer you the benefit of their practice-proven expertise. Provides rationales for the therapies presented to help you choose the most effective treatment for each patient.

Mechanisms of Aminoglycoside Ototoxicity and Strategies for Prevention

Mechanisms of Aminoglycoside Ototoxicity and Strategies for Prevention PDF Author: Peter S. Steyger
Publisher:
ISBN:
Category : Aminoglycosides
Languages : en
Pages : 242

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Book Description


Drug-Induced Liver Injury

Drug-Induced Liver Injury PDF Author:
Publisher: Academic Press
ISBN: 0128173173
Category : Medical
Languages : en
Pages : 290

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Book Description
Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series

Ototoxicity

Ototoxicity PDF Author: Donald Henderson
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 464

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Book Description
This work presents an integrated look at research suggesting that many ototoxic and ototraumatic reactions in the inner ear from drugs and trauma (noise) can be prevented or reduced with pharmacological interventions. The papers, by international authorities, address both the basic science background and the clinical applications of new therapies involving neurotrophins, free-radical scavengers, and other compounds that reduce the risk of hearing loss. A contextual framework is provided by three tutorial papers on free-radical scavengers, neurotrophins, and the role of the kidney in ototoxic reactions.

The Aminoglycosides, Microbiology, Clinical Use, and Toxicology

The Aminoglycosides, Microbiology, Clinical Use, and Toxicology PDF Author: Andrew Whelton
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 664

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Book Description


Antimicrobial Therapy in Veterinary Medicine

Antimicrobial Therapy in Veterinary Medicine PDF Author: Steeve Giguère
Publisher: John Wiley & Sons
ISBN: 111867507X
Category : Medical
Languages : en
Pages : 49

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Book Description
The Fifth Edition of Antimicrobial Therapy in Veterinary Medicine, the most comprehensive reference available on veterinary antimicrobial drug use, has been thoroughly revised and updated to reflect the rapid advancements in the field of antimicrobial therapy. Encompassing all aspects of antimicrobial drug use in animals, the book provides detailed coverage of virtually all types of antimicrobials relevant to animal health. Now with a new chapter on antimicrobial therapy in zoo animals, Antimicrobial Therapy in Veterinary Medicine offers a wealth of invaluable information for appropriately prescribing antimicrobial therapies and shaping public policy. Divided into four sections covering general principles of antimicrobial therapy, classes of antimicrobial agents, special considerations, and antimicrobial drug use in multiple animal species, the text is enhanced by tables, diagrams, and photos. Antimicrobial Therapy in Veterinary Medicine is an essential resource for anyone concerned with the appropriate use of antimicrobial drugs, including veterinary practitioners, students, public health veterinarians, and industry and research scientists.