Addressing Feasibility of Using Microdialysis to Monitor Adenosine in Arctic Ground Squirrel (Spermophilus Parryii) PDF Download
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Author: Bongchu Chi
Publisher:
ISBN:
Category : Arctic ground squirrel
Languages : en
Pages : 76
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Book Description
"Both hibernation and anapyrexia are important physiological adaptations. In addition, there is a strong relationship between survival rate and hypothermia during metabolic trauma. Evidence shows that adenosine might be one of the mediators, both of hibernation and anapyrexia. Adenosine is an inhibitory neuromodulator that suppresses neuronal activity when energy stores are low. This inhibitory activity makes adenosine a good candidate for neuroprotection via the suppression of neural activity during metabolic trauma. The main objective of this study was to investigate the feasibility of using microdialysis to monitor extracellular adenosine in the brains of Arctic ground squirrels (AGS), Spermophilus parryii, throughout hibernation. To investigate this feasibility, the basal level of adenosine concentration in AGS was collected using an in vivo microdialysis method. Samples then were analyzed by high performance liquid chromatography (HPLC). Also, the effects of adding an adenosine transporter inhibitor, S-(p-Nitrobenzyl)-6-thioinosine (NBTI), on extracellular adenosine concentration and body temperature (Tb) of AGS were observed. The results of this study indicate that it is not feasible to observe extracellular adenosine concentrations in AGS during hibernation using these techniques"--Leaf iii.
Author: Bongchu Chi
Publisher:
ISBN:
Category : Arctic ground squirrel
Languages : en
Pages : 76
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Book Description
"Both hibernation and anapyrexia are important physiological adaptations. In addition, there is a strong relationship between survival rate and hypothermia during metabolic trauma. Evidence shows that adenosine might be one of the mediators, both of hibernation and anapyrexia. Adenosine is an inhibitory neuromodulator that suppresses neuronal activity when energy stores are low. This inhibitory activity makes adenosine a good candidate for neuroprotection via the suppression of neural activity during metabolic trauma. The main objective of this study was to investigate the feasibility of using microdialysis to monitor extracellular adenosine in the brains of Arctic ground squirrels (AGS), Spermophilus parryii, throughout hibernation. To investigate this feasibility, the basal level of adenosine concentration in AGS was collected using an in vivo microdialysis method. Samples then were analyzed by high performance liquid chromatography (HPLC). Also, the effects of adding an adenosine transporter inhibitor, S-(p-Nitrobenzyl)-6-thioinosine (NBTI), on extracellular adenosine concentration and body temperature (Tb) of AGS were observed. The results of this study indicate that it is not feasible to observe extracellular adenosine concentrations in AGS during hibernation using these techniques"--Leaf iii.
Author: Robert C. Roach
Publisher: Springer
ISBN: 0306480727
Category : Medical
Languages : en
Pages : 372
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Book Description
The International Hypoxia Symposium convenes biannually to bring together international experts from many fields to explore the state of the art in normal and pathophysiological responses to hypoxia. Representatives from five continents and 32 countries joined together in February 2003 for four days in the dramatic mountains of Banff, Alberta. As editors of the Proceedings of the International Hypoxia Symposia, we strive to maintain a 26 six year tradition of presenting a stimulating blend of clinical and basic science papers focused on hypoxia. Topics covered in 2003 include hibernation and hypoxia, hypoxia and fetal development and new advances in high altitude pathophysiology, oxidative stress and membrane damage, hypoxic regulation of blood flow, heat shock proteins in hypoxia, and future directions in hypoxia research. In 2003 we also had the privilege ofhonoring John W. Severinghaus as a friend, colleague, mentor and inspiration to many in the field. Tom Hornbein's personal tribute to John Severinghaus is the first chapter in this volume, followed by an entertaining update of the history of the discovery of oxygen written by John Severinghaus.
Author: Peter D. Le Roux
Publisher: Saunders
ISBN: 9781437701678
Category : Medical
Languages : en
Pages : 0
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Book Description
Ideal for neurosurgeons, neurologists, neuroanesthesiologists, and intensivists, Monitoring in Neurocritical Care helps you use the latest technology to more successfully detect deteriorations in neurological status in the ICU. This neurosurgery reference offers in-depth coverage of state-of-the-art management strategies and techniques so you can effectively monitor your patients and ensure the best outcomes. Understand the scientific basis and rationale of particular monitoring techniques and how they can be used to assess neuro-ICU patients. Make optimal use of the most advanced technology, including transcranial Doppler sonography, transcranial color-coded sonography, measurements of jugular venous oxygen saturation, near-infrared spectroscopy, brain electrical monitoring techniques, and intracerebral microdialysis and techniques based on imaging. Apply multimodal monitoring for a more accurate view of brain function, and utilize the latest computer systems to integrate data at the bedside. Access practical information on basic principles, such as quality assurance, ethics, and ICU design. Seamlessly search the full text of Monitoring in Neurocritical Care online at www.expertconsult.com.
Author: X. J. Musacchia
Publisher: Elsevier Publishing Company
ISBN:
Category : Medical
Languages : en
Pages : 664
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Book Description
Author: E. Carafoli
Publisher: Springer Science & Business Media
ISBN: 9783540671756
Category : Science
Languages : en
Pages : 214
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Book Description
With contributions by numerous experts
Author: Barry G. Lovegrove
Publisher:
ISBN: 9780620414821
Category : Hibernation
Languages : en
Pages : 424
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Book Description
Author: Philippe Jeanteur
Publisher: Springer Science & Business Media
ISBN: 3540344497
Category : Science
Languages : en
Pages : 265
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Book Description
Splicing of primary RNA transcript is a quasi-systematic step of gene expression in higher organisms. This is the first book to highlight the medical implications, i.e. diseases, caused by alternative splicing. Alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences. The book also outlines possible targets for therapy.
Author: Charles Peirson Lyman
Publisher:
ISBN:
Category : Mammals
Languages : en
Pages : 0
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Book Description
Author: Dennis J. McGinty
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 464
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Book Description
Author: Josef Krieglstein
Publisher: Elsevier Science & Technology
ISBN:
Category : Medical
Languages : en
Pages : 478
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Book Description
