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Author: John Finch
Publisher: Icon Books
ISBN: 1848316704
Category : Science
Languages : en
Pages : 458
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Book Description
In Cambridge in the 1950s, several research groups funded by the Medical Research Council were producing exciting results. In the Biochemistry Department, Sanger determined the amino acid sequence of insulin, and was awarded a Nobel Prize for this in 1958. At the Cavendish Laboratory, in the MRC Unit for the Study of the Molecular Structure of Biological Systems, Watson and Crick solved the structure of DNA, and Perutz and Kendrew produced the first three-dimensional maps of protein structures – haemoglobin and myoglobin – for which all four were later awarded Nobel Prizes. This made it timely to create, in 1962, a new Laboratory of Molecular Biology in Cambridge by amalgamating these groups with other MRC-funded groups from London. The Laboratory has become one of the most successful in its field, and the number of Nobel Prizes awarded over the years to scientists at LMB has risen to thirteen. This book follows the development of LMB, through the people who moved into the new Laboratory and their research. It describes events and personalities that have given the Laboratory a friendly, family atmosphere, while continuing to be scientifically productive.
Author: John Finch
Publisher: Icon Books
ISBN: 1848316704
Category : Science
Languages : en
Pages : 458
Get Book Here
Book Description
In Cambridge in the 1950s, several research groups funded by the Medical Research Council were producing exciting results. In the Biochemistry Department, Sanger determined the amino acid sequence of insulin, and was awarded a Nobel Prize for this in 1958. At the Cavendish Laboratory, in the MRC Unit for the Study of the Molecular Structure of Biological Systems, Watson and Crick solved the structure of DNA, and Perutz and Kendrew produced the first three-dimensional maps of protein structures – haemoglobin and myoglobin – for which all four were later awarded Nobel Prizes. This made it timely to create, in 1962, a new Laboratory of Molecular Biology in Cambridge by amalgamating these groups with other MRC-funded groups from London. The Laboratory has become one of the most successful in its field, and the number of Nobel Prizes awarded over the years to scientists at LMB has risen to thirteen. This book follows the development of LMB, through the people who moved into the new Laboratory and their research. It describes events and personalities that have given the Laboratory a friendly, family atmosphere, while continuing to be scientifically productive.
Author: George G. Brownlee
Publisher: Cambridge University Press
ISBN: 1316124053
Category : Science
Languages : en
Pages : 315
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Book Description
Considered 'the father of genomics', Fred Sanger (1918–2013) paved the way for the modern revolution in our understanding of biology. His pioneering methods for sequencing proteins, RNA and, eventually, DNA earned him two Nobel Prizes. He remains one of only four scientists (and the only British scientist) ever to have achieved that distinction. In this, the first full biography of Fred Sanger to be published, Brownlee traces Sanger's life from his birth in rural Gloucestershire to his retirement in 1983 from the Medical Research Council's Laboratory of Molecular Biology in Cambridge. Along the way, he highlights the remarkable extent of Sanger's scientific achievements and provides a real portrait of the modest man behind them. Including an extensive transcript of a rare interview of Sanger by the author, this biography also considers the wider legacy of Sanger's work, including his impact on the Human Genome Project and beyond.
Author: Erling Norrby
Publisher: World Scientific
ISBN: 9813144661
Category : Science
Languages : en
Pages : 580
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Book Description
The present book discusses the prizes in physiology or medicine 1963-65. The 1963 prize recognized milestone discoveries in the field of neurosciences, the way electrical impulses are generated and spread in nerves. The impressive developments of insights into tantalizing brain functions, like consciousness and memory, is discussed in the perspective of prizes both before and after the 1963 prize. The prize in 1964 marked the advanced biochemical venture that led to a full understanding of the synthesis of cholesterol, a central molecule for providing flexibility of the membranes of the trillions of cell in our body. The importance of this molecule for the appearance of cardiovascular diseases and the possibilities to prevent them is presented in the light of other prizes earlier and later in this field. The 1965 prize recognized three impressive French intellectuals, Lwoff, Monod and Jacob. Their contributions allowed the full maturation of the initial phase of the emerging field of molecular biology. The comprehension of the information flow from DNA via RNA to proteins was the source of a revolution of life sciences and of medicine.
Author: Erling Norrby
Publisher: World Scientific
ISBN: 9814522007
Category : Medical
Languages : en
Pages : 470
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Book Description
Each year the Nobel Prizes in the natural sciences reveal amazing discoveries. Nominations are kept secret for 50 years after the awards have been made. Covering the awards from 1960 to 1962, this book reveals discoveries relating to the control of infectious diseases and the advent of organ transplant organs, as well as advances in molecular biology.
Author: Erling Norrby
Publisher: World Scientific
ISBN: 9811261342
Category : Science
Languages : en
Pages : 459
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Book Description
The present book discusses the Nobel Prizes in physiology or medicine from 1969 to 1971. The 1969 prize recognized Max Delbrück, Alfred Hershey and Salvador Luria. Their pioneering studies of viruses infecting bacteria, bacteriophages, from the mid-1940s through the 1950s laid the foundation for the wide field of molecular biology. The nature of the gene was finally understood. Insights into the biochemistry of the critical information molecules, the nucleic acids, opened wide vistas for interpreting their expression and the interaction of their product with other gene products.The contact between the endings of a nerve and a target cell, the synapse, has always stirred the imagination of scientists. A number of the insights gained have been highlighted by Nobel Prizes in physiology or medicine. In 1970 the prize recognized Bernard Katz, Ulf von Euler and Julius Axelrod. They had revealed how signaling substances in the nerve terminals were stored in packages, released by membrane fusion and inactivated or reused by particular metabolic events.The recipient of the 1971 Nobel Prize in physiology or medicine was a single scientist, Earl Sutherland. He had identified critical molecules in cells that allow signals elicited at their surface via a number of internal steps to influence the expression of specific genes in the nucleus. The new kind of information transmitting molecules were referred to as 'secondary messengers'. They represent a critical part of a highly complex network of signaling controlling the operative conditions of the cell by adjustments of the so-called intermediary metabolism.The widening insights into functions of specialized cells and their complex interactions have led to the development of many kinds of remedies.
Author: Joe S. Jeffers
Publisher: Springer
ISBN: 3319547097
Category : Science
Languages : en
Pages : 94
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Book Description
In this Brief, Joe Jeffers uncovers the life and works of two-time Nobel Laureate Frederick Sanger. Following Sanger’s early life to retirement, Jeffers describes how this celebrated British biochemist became the first person to determine the amino acid sequence of a protein for which he was awarded the Nobel Prize in 1958. Highlighting Sanger’s remarkable career, Jeffers describes Sanger’s later change in research direction to investigate deoxyribonucleic acids (DNA), work for which Sanger also received the Nobel Prize jointly with Paul Berg and Walter Gilbert in 1980. Joe Jeffers conducted twelve interviews with Sanger over the period of 1999-2009 and he has also spoken to more than 40 of Sanger’s colleagues and family members. This brief provides a rigorous yet concise view of Sanger on a personal and scientific level and is suitable for biochemists, historians or the interested layperson.
Author: Paul M. Wassarman
Publisher:
ISBN: 0199732043
Category : Biography & Autobiography
Languages : en
Pages : 369
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Book Description
A Place in History: The Biography of John C. Kendrew is the story of the influential 20th century scientific pioneer and winner of the 1962 Nobel Prize in chemistry.
Author: John Meurig Thomas
Publisher: Oxford University Press, USA
ISBN: 0198854501
Category : Nature
Languages : en
Pages : 321
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Book Description
This is a history of the personalities and single-minded devotion of four Nobel laureates who played a pivotal role in the creation of a new and prevalent branch of biology. This led to major medical advances in one of the greatest centres of scientific research: the Laboratory of Molecular Biology in Cambridge, which they helped to establish.
Author: Howard Markel
Publisher: W. W. Norton & Company
ISBN: 1324002247
Category : Science
Languages : en
Pages : 526
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Book Description
An NPR Best Book of the Year An authoritative history of the race to unravel DNA’s structure, by one of our most prominent medical historians. James Watson and Francis Crick’s 1953 discovery of the double helix structure of DNA is the foundation of virtually every advance in our modern understanding of genetics and molecular biology. But how did Watson and Crick do it—and why were they the ones who succeeded? In truth, the discovery of DNA’s structure is the story of five towering minds in pursuit of the advancement of science, and for almost all of them, the prospect of fame and immortality: Watson, Crick, Rosalind Franklin, Maurice Wilkins, and Linus Pauling. Each was fascinating and brilliant, with strong personalities that often clashed. Howard Markel skillfully re-creates the intense intellectual journey, and fraught personal relationships, that ultimately led to a spectacular breakthrough. But it is Rosalind Franklin—fiercely determined, relentless, and an outsider at Cambridge and the University of London in the 1950s, as the lone Jewish woman among young male scientists—who becomes a focal point for Markel. The Secret of Life is a story of genius and perseverance, but also a saga of cronyism, misogyny, anti-Semitism, and misconduct. Drawing on voluminous archival research, including interviews with James Watson and with Franklin’s sister, Jenifer Glynn, Markel provides a fascinating look at how science is done, how reputations are undone, and how history is written, and revised. A vibrant evocation of Cambridge in the 1950s, Markel also provides colorful depictions of Watson and Crick—their competitiveness, idiosyncrasies, and youthful immaturity—and compelling portraits of Wilkins, Pauling, and most cogently, Rosalind Franklin. The Secret of Life is a lively and sweeping narrative of this landmark discovery, one that finally gives the woman at the center of this drama her due.
Author: Gareth Williams
Publisher: Simon and Schuster
ISBN: 1643132830
Category : Science
Languages : en
Pages : 607
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Book Description
Unraveling the Double Helix covers the most colorful period in the history of DNA, from the discovery of "nuclein" in the late 1860s to the publication of James Watson's The Double Helix in 1968. These hundred years included the establishment of the Nobel Prize, antibiotics, x-ray crystallography, the atom bomb and two devastating world wars—events which are strung along the thread of DNA like beads on a necklace. The story of DNA is a saga packed with awful mistakes as well as brilliant science, with a wonderful cast of heroes and villains. Surprisingly, much of it is unfamiliar. The elucidation of the double helix was one of the most brilliant gems of twentieth century science, but some of the scientists who paved the way have been airbrushed out of history. James Watson and Francis Crick solved a magnificent mystery, but Gareth Williams shows that their contribution was the last few pieces of a gigantic jigsaw puzzle assembled over several decades.The book is comprehensive in scope, covering the first century of the history of DNA in its entirety, including the eight decades that have been neglected by other authors. It also explores the personalities of the main players, the impact of their entanglement with DNA, and what unique qualities make great scientists tick.
