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Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309175267
Category : Medical
Languages : en
Pages : 134
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Book Description
Xenotransplantation involves the transplantation of cells, tissues, and whole organs from one species to another. Interest in animal-to-human xenotransplants has been spurred by the continuing shortage of donated human organs and by advances in knowledge concerning the biology of organ and tissue rejection. The scientific advances and promise, however, raise complex questions that must be addressed. This book considers the scientific and medical feasibility of xenotransplantation and explores the ethical and public policy issues surrounding the possibility of renewed clinical trials. The volume focuses on the science base of xenotransplantation, public health risks of infectious disease transmission, and ethical and public policy issues, including the views of patients and their families.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309175267
Category : Medical
Languages : en
Pages : 134
Get Book Here
Book Description
Xenotransplantation involves the transplantation of cells, tissues, and whole organs from one species to another. Interest in animal-to-human xenotransplants has been spurred by the continuing shortage of donated human organs and by advances in knowledge concerning the biology of organ and tissue rejection. The scientific advances and promise, however, raise complex questions that must be addressed. This book considers the scientific and medical feasibility of xenotransplantation and explores the ethical and public policy issues surrounding the possibility of renewed clinical trials. The volume focuses on the science base of xenotransplantation, public health risks of infectious disease transmission, and ethical and public policy issues, including the views of patients and their families.
Author: David K. C. Cooper
Publisher: Springer Nature
ISBN: 3030491277
Category : Medical
Languages : en
Pages : 313
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Book Description
This title provides an illuminating examination of the current state of xenotransplantation – grafting or transplanting organs or tissues between members of different species – and how it might move forward into the clinic. To be sure, this is a critical topic, as a major problem that remains worldwide is an inadequate supply of organs from deceased human donors, severely limiting the number of organ transplants that can be performed each year. Based on presentations given at a major conference on xenotransplantation, this title includes important views from many leading experts who were invited to present their data and opinions on how xenotransplantation can advance into the clinic. Attention was concentrated on pig kidney and heart transplantation as it is in regard to these organs that most progress has been made. Collectively, these chapters effectively highlight the many advantages of xenotransplantation to patients with end-stage organ failure, thereby encouraging the mapping of a concrete pathway to clinical xenotransplantation. The book is organized across 22 chapters, beginning with background information on clinical and experimental xenotransplantation. Following this are discussions addressing how pigs can be genetically engineered for their organs to be resistant to the human immune response through deletion of pig xenoantigens, and the insertion of ‘protective’ human transgenes. Subsequent chapters analyze complications that arise in practice, comparing allotransplant and xenotransplant rejection. The selection of the ideal patients for the first clinical trials is discussed. Finally, the book concludes with an analysis on the regulatory, economic, and social aspects of this research, including FDA perspectives and the sensitive, psychosocial factors regarding allotransplantation and xenotransplantation. A major and timely addition to the literature, Clinical Xenotransplantation will be of great interest to all researchers, physicians, and academics from other disciplines with an interest in xenotransplantation.
Author: Sara Fovargue
Publisher: Cambridge University Press
ISBN: 1139503987
Category : Law
Languages : en
Pages : 307
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Book Description
Some developing biotechnologies challenge accepted legal and ethical norms because of the risks they pose. Xenotransplantation (cross-species transplantation) may prolong life but may also harm the xeno-recipient and the public due to its potential to transmit infectious diseases. These trans-boundary diseases emphasise the global nature of advances in health care and highlight the difficulties of identifying, monitoring and regulating such risks and thereby protecting individual and public health. Xenotransplantation raises questions about how uncertainty and risk are understood and accepted, and exposes tensions between private benefit and public health. Where public health is at risk, a precautionary approach informed by the harm principle supports prioritising the latter, but the issues raised by genetically engineered solid organ xenotransplants have not, as yet, been sufficiently discussed. This must occur prior to their clinical introduction because of the necessary changes to accepted norms which are needed to appropriately safeguard individual and public health.
Author: Sheila A. M. McLean
Publisher: Routledge
ISBN: 1351142704
Category : Law
Languages : en
Pages : 495
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Book Description
Originally published in 2005. One of the leading causes of death is organ failure, that is, when one or other of the organs that run the machine we call the body gives out. However, whereas with a machine spare parts can usually replace faulty parts, in the case of humans the supply of these is limited as it is dependent on organs being obtained from living or dead donors. Due to the limitations of supply, increasing attention is being paid to alternative schemes for obtaining organs. One of these possibilities is xenotransplantation: using organs from animals. In this book, the authors examine the legal and ethical issues surrounding xenotransplantation and consider the implications for the future. As they point out, xenotransplantation represents a major deviation from standard medical practice and the possibility of transplantation of large segments of tissue, or whole organs, from animals into humans poses an entirely novel set of considerations - ethical, legal and scientific - which it is necessary to evaluate and understand.
Author: David K. C. Cooper M.D.
Publisher: Oxford University Press
ISBN: 0195351827
Category : Medical
Languages : en
Pages : 299
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Book Description
The plight of a patient waiting months, sometimes years, for an organ transplant is one of the most heart-wrenching predicaments confronting medicine today. But the current critical shortage of human donor organs has had one positive consequence: it has stimulated promising new research into the field of xenotransplantation--the transplantation of organs from one animal species to another. In Xeno: The Promise of Transplanting Animal Organs Into Humans, David Cooper and Robert Lanza explore what may become one of the greatest medical advances of the 21st century. As scientists genetically engineer animal organs to evade the problems of rejection, we can expect a tremendous increase in xenotransplantation. This book recounts the several historical attempts to transplant animal organs into humans, and draws attention to the immense potential and promise of this form of therapy. The problems which remain, and recent breakthroughs in overcoming rejection and in "humanizing" pig organs for transplantation, are fully discussed. The authors also provide a fascinating consideration of the social and ethical questions posed by such procedures. Which patients should be the first to be offered this new form of therapy? Will transplanted animal organs transfer infectious viruses to the human recipient, and will they then be passed on to the community at large? Can society afford the major increase in healthcare expenditure that will result from our ability to provide a limitless number of donor organs? With profound implications for human health and longevity in the next millennium, Xeno is essential reading for anyone interested in the future of medicine.
Author: Carolyn Wilson
Publisher: Springer Science & Business Media
ISBN: 3642555411
Category : Medical
Languages : en
Pages : 261
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Book Description
Xenotransplantation could have an impact on at least three aspects of medicine. The first is as a means of overcoming a severe shortage of human donor organs for the treatment of organ failure. The second aspect relates to the possibility that a xenogeneic organ would not be susceptible to infection by a "human" virus and thus the xenograft might resist injury caused by such viruses. The third and, as of yet, unexplored aspect relates to a means of delivering genes for therapeutic purposes thus overcoming some of the limitations of "conventional" gene therapy.
Author: Martine Rothblatt
Publisher: Taylor & Francis
ISBN: 1351772511
Category : Business & Economics
Languages : en
Pages : 198
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Book Description
This title was first published in 2003. Xenotransplantation - the transplantation of animal organs into humans - poses a fascinating moral dilemma. Should this ability to extend the lives of millions of older people be permitted given that it might trigger a new pandemic similar to AIDS? This study examines the moral dilemma from a combination of humanistic, legalistic, bioethical, economical and technological perspectives. The first part of the book demonstrates that xenografts are the only realistic near-term technological answer to the organ shortage problem. The balance of the book is devoted to assessing whether doctrines such as the 'right to health care' trump the moral and ethical conundrums posed by xenotransplantation. The book concludes with a 'geoethical' solution that proposes authorization of xenotransplantation subject to the prior implementation of a new international organization for epidemiology and basic health care. It also suggests that the costs of operating such an organization could be covered by a global tax on xenografts.
Author: David K. C. Cooper
Publisher:
ISBN: 9781536139457
Category : MEDICAL
Languages : en
Pages : 0
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Book Description
There is a critical and continuing shortage of organs and cells from deceased human donors for the purposes of transplantation into patients with terminal organ failure. The use of organs and cells from pigs i.e., cross-species transplantation, or xenotransplantation could resolve this problem. Recollections of Pioneers in Xenotransplantation Research is a collection of reminiscences by surgeons and scientists who, over the past 50 years, have made major contributions to research into achieving successful transplantation of pig organs and cells into primates. It records the personal work of 22 researchers from North America, Asia, Europe, and Australasia who developed this field, which will have an immense impact on the future medical care of patients with such diverse conditions as heart and kidney failure, diabetes, corneal blindness, and Parkinsons disease. A pig organ transplanted into a human or nonhuman primate is rejected within minutes. To overcome this immunological barrier, pigs have been genetically-engineered to protect their tissues from the primate immune response. Today, life-supporting organs from pigs with up to six genetic modifications have functioned for more than a year in nonhuman primates, and the blood sugar of diabetic monkeys has been controlled for more than two years by the transplantation of insulin-producing pancreatic islet cells from pigs. Clinical trials of pig islet and corneal transplantation have already been undertaken, and trials of organ transplants are currently being planned. The pioneering researchers who contributed to the early development of this field highlight their own roles, and record their personal recollections of the other scientists and surgeons with whom they collaborated. They do not confine themselves to the scientific progress they made, but comment on the roles of industry and academia in moving the field forward. Recollections of Pioneers in Xenotransplantation Research will be of interest to physicians, scientists, and the lay person with an interest in transplantation or in the care of patients with life-threatening diseases, but also to those interested to understand the potential of genetic-engineering in science and medicine. The book provides a historical record of the research that has contributed to an advance in medicine that has been called the next great medical revolution. Within a few years, this new form of therapy is likely to impact every family in the developed world.
Author: Brigitte E. S. Jansen
Publisher: Dr Brigitte Jansen
ISBN: 3899758633
Category :
Languages : en
Pages : 193
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Book Description
Author: Shuji Miyagawa
Publisher: BoD – Books on Demand
ISBN: 1789856639
Category : Technology & Engineering
Languages : en
Pages : 157
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Book Description
Recently, remarkable progress has been made in the area of preclinical xenotransplantation experiments. Surprisingly, a heterotopic heart from the gene-editing pig continued to beat for almost 2.5 years, when implanted in the monkey abdomen, and a pig life-supporting kidney could also function for over 1.3 years in monkeys. Concerning islets, islets from gene-editing pigs could work for more than one year in monkeys. It is noteworthy that one group reported a survival of adult wild-type pig islets of over 600 days. On the other hand, the progress in these preclinical trials strongly affected not only the xenotransplantation study itself but regeneration studies to use pigs as a scaffold to foster human induced pluripotent stem cells.
