Vascular-Targeted Therapies in Oncology

Vascular-Targeted Therapies in Oncology PDF Author: Dietmar W. Siemann
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 384

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Book Description
Vascular-Targeted Therapies in Oncology provides an interesting insight to the current status and future potential of vascular-disrupting approaches in cancer management. Emphasis is placed on target development, preclinical assessment, and the use of such targeted approaches in combination with conventional treatment regimens and the current clinical status of these therapies.

Vascular-Targeted Therapies in Oncology

Vascular-Targeted Therapies in Oncology PDF Author: Dietmar W. Siemann
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 384

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Book Description
Vascular-Targeted Therapies in Oncology provides an interesting insight to the current status and future potential of vascular-disrupting approaches in cancer management. Emphasis is placed on target development, preclinical assessment, and the use of such targeted approaches in combination with conventional treatment regimens and the current clinical status of these therapies.

Targeted Therapies in Oncology

Targeted Therapies in Oncology PDF Author: Giuseppe Giaccone
Publisher: CRC Press
ISBN: 1420020587
Category : Medical
Languages : en
Pages : 426

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Book Description
Targeted therapy is one of the most burgeoning areas of development in cancer research. Increasing knowledge in tumor formation and growth at the molecular level has generated a broad array of therapeutic options, including signal transduction inhibition, anti-angiogenic and anti-vascular agents, cell cycle inhibitors, telomerase and telomere inter

Targeted Therapies in Oncology, Second Edition

Targeted Therapies in Oncology, Second Edition PDF Author: Giuseppe Giaccone
Publisher: CRC Press
ISBN: 1842145452
Category : Medical
Languages : en
Pages : 500

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Book Description
Since the last edition of this book, major advances have been made in our understanding of key pathways that control tumor progression. This has led to the development of new anticancer agents that have the ability to block the activity of proteins involved in neoplastic cell development and proliferation. Targeted Therapies in Oncology, Second Edition provides a concise timely panorama of existing targeted therapies and progress into future anticancer treatments. These therapies notably include: Targeted agents of immune checkpoints Signal-transduction inhibitors Antiangiogenic agents Vascular-disrupting agents Apoptosis modulators Stem cell inhibitors Tumor profiling for drug development The book emphasizes the biology behind this new class of drugs as well as the clinical achievements obtained. The contributors to this volume stand at the cutting edge of cancer research and treatment around the world.

Vascular Disruptive Agents for the Treatment of Cancer

Vascular Disruptive Agents for the Treatment of Cancer PDF Author: Tim Meyer
Publisher: Springer Science & Business Media
ISBN: 1441966099
Category : Medical
Languages : en
Pages : 258

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Book Description
Angiogenesis (formation of new vessels from pre-existing ones) is a crucial early event in the process of tumor development. New vessels supply the tumor with nutrients that are needed for further local growth and enable distant metastases (Folkman 1995). Judah Folkman (1971) highlighted the potential therapeutic imp- cations of tumor angiogenesis. He hypothesized that if tumor angiogenesis is inhibited, then tumor growth and metastasis will be impaired greatly or even impossible. The subsequent quest for endogenous and exogenous inhibitors of angiogenesis has yielded a variety of promising therapeutic agents that block one or more angiogenic pathways, a few of which have been approved by the FDA (e. g. , bevacizumab, sorafenib, sunitinib) for use as single agents or in combination with chemotherapy in specific populations of cancer patients (Sessa et al. 2008). There has also been a dramatic expansion in the exploration of novel anti-angiogenic agents pre-clinically and in clinical trials (Ferrara 2002). Some of the most promising data comes from the development of agents that inhibit one of the key growth factors involved in tumor angiogenesis – vascular endothelial growth factor (VEGF) (Ferrara et al. 2003). Bevacizumab is a monoclonal antibody against VEGF that was the first an- angiogenic agent that improved significantly the overall survival of patients with colorectal and non-squamous non-small cell lung cancer (Ferrara et al. 2005). Various agents that target tumor angiogenesis are currently under investigation in different cancer types in many clinical trials (Ferrara and Kerbel 2005).

Vascular Disruptive Agents for the Treatment of Cancer

Vascular Disruptive Agents for the Treatment of Cancer PDF Author:
Publisher:
ISBN: 9781441966100
Category :
Languages : en
Pages : 268

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Book Description


Hepatocellular Carcinoma

Hepatocellular Carcinoma PDF Author: Yujin Hoshida
Publisher: Springer
ISBN: 3030215407
Category : Medical
Languages : en
Pages : 366

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Book Description
This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.

Vascular-targeted Combination Therapies for the Treatment of Cancer

Vascular-targeted Combination Therapies for the Treatment of Cancer PDF Author: Andrea Brett Weiss
Publisher:
ISBN: 9789462950856
Category : Cancer
Languages : en
Pages : 291

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Book Description


Targeted Cancer Therapy

Targeted Cancer Therapy PDF Author: Razelle Kurzrock
Publisher: Springer Science & Business Media
ISBN: 1603274243
Category : Medical
Languages : en
Pages : 447

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Book Description
Emerging technologies in target identification, drug discovery, molecular markers, and imaging are rapidly changing the face of cancer. This book provides a foundation of knowledge in targeted cancer therapeutics. The treatment of cancer is increasingly being individualized, based on an understanding of underlying biologic mechanisms. Poised to change the landscape in oncology, this volume provides a state-of-the-art overview. It will be valuable to practicing and academic physicians, fellows, residents and students, as well as basic scientists, interested in the cancer field.

Anti-Angiogenesis Strategies in Cancer Therapies

Anti-Angiogenesis Strategies in Cancer Therapies PDF Author: Shaker Mousa
Publisher: Academic Press
ISBN: 0128026731
Category : Medical
Languages : en
Pages : 212

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Book Description
Anti-angiogenesis Strategies in Cancer Therapeutics provides a detailed look at the current status and future directions in the discovery and development of novel anti-angiogenesis strategies in oncology. This book highlights the different mechanisms involved in the modulation of angiogenesis, including inflammation, thrombosis, and microRNA, and shows how nanotechnology can further enhance the potential of existing and new anti-angiogenesis approaches. Written for industry scientists, researchers, oncologists, hematologists, and professors and students in the field, this comprehensive book covers all aspects of anti-angiogenesis strategies and their differences. Covers important preclinical models and clinical trials in the discovery and development of novel anti-angiogenesis agents Reviews FDA-approved anti-angiogenesis agents Illustrates the value of nanotechnology in improving the utility of anti-angiogenesis agents Offers insight into the development of novel anti-angiogenesis agents and future direction in this area

Molecular Targeting in Oncology

Molecular Targeting in Oncology PDF Author: Howard L. Kaufman
Publisher: Springer Science & Business Media
ISBN: 1597453374
Category : Medical
Languages : en
Pages : 719

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Book Description
This book presents an overview of the development of targeted therapies for the treatment of cancer with an emphasis on clinical application. The volume covers the complexity of the rapidly developing area of targeted therapies for the treatment of patients with cancer. It is structured in a way so readers may begin with chapters that most interest them and work through the rest of the chapters in the order of their choice.