New Non-opioid Analgesics: Understanding Molecular Mechanisms on the Basis of Patch-clamp and chemical Studies PDF Download
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Author: Boris V. Krylov
Publisher: Bentham Science Publishers
ISBN: 1608059308
Category : Science
Languages : en
Pages : 211
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Book Description
The monograph is a summary of methods used to study pain receptors and the results obtained in some experiments designed to study the effect of non-opioid analgesics. The molecular mechanisms of nociceptive information control in primary sensory nociceptive neurons are described based on investigations of the membrane signaling cascade (opioid-like receptor → Na+,K+-ATPase → NaV1.8 channel) observed by the authors. Based on this data, the authors conclude that the modulation of NaV1.8 channels responsible for the coding of noxious signals can be carried out due to two novel targeting mechanisms. The first of these is the activation of opioid-like receptors; the second is the activation of Na+/K+-ATPase as a signal transducer. The development of a novel class of analgesics that trigger these mechanisms should lead to a successful solution to the problem of chronic pain relief. Chapters of the monograph cover the general methods used in studying nociceptive pain (including the patch-clamp method), and the mechanism behind the binding of different ligands to these receptors such gamma-pyrones, gamma-pyridines and cardiotonic steroids. This monograph is a valuable reference for neuroscientists, pharmacologists and allied researchers studying pain receptors for the development of safe and effective analgesics.
Author: Boris V. Krylov
Publisher: Bentham Science Publishers
ISBN: 1608059308
Category : Science
Languages : en
Pages : 211
Get Book Here
Book Description
The monograph is a summary of methods used to study pain receptors and the results obtained in some experiments designed to study the effect of non-opioid analgesics. The molecular mechanisms of nociceptive information control in primary sensory nociceptive neurons are described based on investigations of the membrane signaling cascade (opioid-like receptor → Na+,K+-ATPase → NaV1.8 channel) observed by the authors. Based on this data, the authors conclude that the modulation of NaV1.8 channels responsible for the coding of noxious signals can be carried out due to two novel targeting mechanisms. The first of these is the activation of opioid-like receptors; the second is the activation of Na+/K+-ATPase as a signal transducer. The development of a novel class of analgesics that trigger these mechanisms should lead to a successful solution to the problem of chronic pain relief. Chapters of the monograph cover the general methods used in studying nociceptive pain (including the patch-clamp method), and the mechanism behind the binding of different ligands to these receptors such gamma-pyrones, gamma-pyridines and cardiotonic steroids. This monograph is a valuable reference for neuroscientists, pharmacologists and allied researchers studying pain receptors for the development of safe and effective analgesics.
Author: Ilia V. Rogachevskii
Publisher: Frontiers in Pain Science
ISBN: 9781608059317
Category : Medical
Languages : en
Pages : 212
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Book Description
The monograph is a summary of methods used to study pain receptors and the results obtained in some experiments designed to study the effect of non-opioid analgesics. The molecular mechanisms of nociceptive information control in primary sensory nociceptive neurons are described based on investigations of the membrane signaling cascade (opioid-like receptor ? Na+,K+-ATPase ? NaV1.8 channel) observed by the authors. Based on this data, the authors conclude that the modulation of NaV1.8 channels responsible for the coding of noxious signals can be carried out due to two novel targeting mechanisms. The first of these is the activation of opioid-like receptors; the second is the activation of Na+/K+-ATPase as a signal transducer. The development of a novel class of analgesics that trigger these mechanisms should lead to a successful solution to the problem of chronic pain relief.Chapters of the monograph cover the general methods used in studying nociceptive pain (including the patch-clamp method), and the mechanism behind the binding of different ligands to these receptors such gamma-pyrones, gamma-pyridines and cardiotonic steroids.This monograph is a valuable reference for neuroscientists, pharmacologists and allied researchers studying pain receptors for the development of safe and effective analgesics.
Author: James E. Barrett
Publisher: Springer Nature
ISBN: 3030353621
Category : Medical
Languages : en
Pages : 466
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Book Description
Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.
Author: Brian Cox
Publisher: Royal Society of Chemistry
ISBN: 1849735085
Category : Science
Languages : en
Pages : 385
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Book Description
Ion channel drug discovery is a rapidly evolving field fuelled by recent, but significant, advances in our understanding of ion channel function combined with enabling technologies such as automated electrophysiology. The resurgent interest in this target class by both pharmaceutical and academic scientists was clearly highlighted by the over-subscribed RSC/BPS 'Ion Channels as Therapeutic Targets' symposium in February 2009. This book builds on the platform created by that meeting, covering themes including advances in screening technology, ion channel structure and modelling and up-to-date case histories of the discovery of modulators of a range of channels, both voltage-gated and non-voltage-gated channels. The editors have built an extensive network of contacts in the field through their first-hand scientific experience, collaborations and conference participation and the organisation of the meeting at Novartis, Horsham, increased the network enabling the editors to draw on the experience of eminent researchers in the field. Interest and investment in ion channel modulation in both industrial and academic settings continues to grow as new therapeutic opportunities are identified and realised for ion channel modulation. This book provides a reference text by covering a combination of recent advances in the field, from technological and medicinal chemistry perspectives, as well as providing an introduction to the new 'ion channel drug discoverer'. The book has contributions from highly respected academic researchers, industrial researchers at the cutting edge of drug discovery and experts in enabling technology. This combination provides a complete picture of the field of interest to a wide range of readers.
Author: Dale Purves
Publisher: Sinauer Associates Incorporated
ISBN: 9780878937257
Category : Medical
Languages : en
Pages : 773
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Book Description
Neuroscience is a comprehensive textbook created primarily for medical and premedical students; it emphasises the structure of the nervous system, the correlation of structure and function, and the structure/function relationships particularly pertinent to the practice of medicine. Although not primarily about pathology, the book includes the basis of a variety of neurological disorders. It could serve equally well as a text for undergraduate neuroscience courses in which many of the students are premeds. Being both comprehensive and authoritative, it is also appropriate for graduate and professional use. The new edition offers a host of new features including a new art program and the completely revised Sylvius for Neuroscience: Visual Glossary of Human Neuroanatomy, an interactive CD-ROM reference guide to the human nervous system. Major changes to the new edition also include: additional neuroanatomical content, including two appendices-(1) The Brainstem and Cranial Nerves and (2) Vascular Supply, the Meninges, and the Ventricular System; and updated and new boxes on neurological and psychiatric diseases.
Author: Mark I. Johnson
Publisher: OUP Oxford
ISBN: 0191654167
Category : Medical
Languages : en
Pages : 273
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Book Description
Transcutaneous electrical nerve stimulation (TENS) is a technique that delivers mild electrical currents across the intact surface of the skin to reduce pain. TENS is used by practitioners throughout the world to manage painful conditions and TENS equipment can be purchased by the general public so that they can self-administer treatment. There are thousands of experimental and clinical research studies published on TENS and related techniques yet there is uncertainty about the best way to administer TENS in clinical practice. This is because currents used during TENS can be administered in a variety of ways and the findings of research studies have been inconclusive. This book provides guidance on how best to use TENS based on an evaluation of current research evidence. The book covers what TENS is, how it works, and safe and appropriate clinical techniques for many conditions including chronic low back pain, osteoarthritis and cancer pain. It also offers solutions to the problems faced by researchers when trying to design clinical trials on TENS. Accessibility written, Transcutaneous Electrical Nerve Stimulation (TENS) provides a comprehensive coverage of research issues and findings about TENS and will be essential reading for healthcare professionals, practitioners and students.
Author: David S. Goodsell
Publisher: Springer
ISBN: 3319325108
Category : Science
Languages : en
Pages : 179
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Book Description
This book will take an evidence-based approach to current knowledge about biomolecules and their place in our lives, inviting readers to explore how we know what we know, and how current gaps in knowledge may influence the way we approach the information. Biomolecular science is increasingly important in our everyday life, influencing the choices we make about our diet, our health, and our wellness. Often, however, information about biomolecular science is presented as a list of immutable facts, discouraging critical thought. The book will introduce the basic tools of structural biology, supply real-life examples, and encourage critical thought about aspects of biology that are still not fully understood.
Author:
Publisher: Academic Press
ISBN: 0128033274
Category : Science
Languages : en
Pages : 393
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Book Description
Current Topics in Membranes is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading. This volume offers an up to date presentation of current knowledge in the field of Lipid Domains. - Written by leading experts - Contains original material, both textual and illustrative, that should become a very relevant reference material - The material is presented in a very comprehensive manner - Both researchers in the field and general readers should find relevant and up-to-date information
Author: R. Wayne Albers
Publisher: Academic Press
ISBN: 0080959016
Category : Science
Languages : en
Pages : 1121
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Book Description
Basic Neurochemistry, Eighth Edition, is the updated version of the outstanding and comprehensive classic text on neurochemistry. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from intracellular trafficking, stem cells, adult neurogenesis, regeneration, and lipid messengers. It contains expanded coverage of all major neurodegenerative and psychiatric disorders, including the neurochemistry of addiction, pain, and hearing and balance; the neurobiology of learning and memory; sleep; myelin structure, development, and disease; autism; and neuroimmunology. - Completely updated text with new authors and material, and many entirely new chapters - Over 400 fully revised figures in splendid color - 61 chapters covering the range of cellular, molecular and medical neuroscience - Translational science boxes emphasizing the connections between basic and clinical neuroscience - Companion website at http://elsevierdirect.com/companions/9780123749475
Author: Daniel Johnston
Publisher: MIT Press
ISBN: 0262293498
Category : Medical
Languages : en
Pages : 709
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Book Description
with simulations and illustrations by Richard Gray Problem solving is an indispensable part of learning a quantitative science such as neurophysiology. This text for graduate and advanced undergraduate students in neuroscience, physiology, biophysics, and computational neuroscience provides comprehensive, mathematically sophisticated descriptions of modern principles of cellular neurophysiology. It is the only neurophysiology text that gives detailed derivations of equations, worked examples, and homework problem sets (with complete answers). Developed from notes for the course that the authors have taught since 1983, Foundations of Cellular Neurophysiology covers cellular neurophysiology (also some material at the molecular and systems levels) from its physical and mathematical foundations in a way that is far more rigorous than other commonly used texts in this area.
