Ultrasound Phased Array Simulations for Hyperthermia PDF Download
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Author: Xiaozheng Zeng
Publisher:
ISBN:
Category : Diagnostic ultrasonic imaging
Languages : en
Pages : 376
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Book Description
Author: Xiaozheng Zeng
Publisher:
ISBN:
Category : Diagnostic ultrasonic imaging
Languages : en
Pages : 376
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Book Description
Author: Andre Lafreniere
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Phased array ultrasound transducers (Txs) can induce electronically controllable localized hyperthermia to tissue deep within the human body. This localized heating can be applied to tumours as an adjunct therapy in multimodal oncology treatments. Magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU) systems utilize imaging techniques to monitor tissue temperature during sonication, providing feedback for control of the Tx's beam-forming. The electromagnetic environment within and near the magnetic resonance (MR) bore restricts the design of driving solutions. The arrays are normally driven by linear amplifiers and matching networks placed at a distance from the MR bore. As clinical arrays can contain over 2000 Txs, this method of driving can result in significant costs and heating. This thesis proposes a novel MRgHIFU phased array system integration, and an associated rapid design and production processes. The system's array is designed for conformal use in 3T MR head and neck hyperthermia applications. The array is powered using a high-efficiency quasi class-DE (qDE) driving method to yield equal acoustic output from all Txs without use of inductors. This allows the drivers to be placed directly within the MR bore. The driver gating signals are controlled by a field-programmable gate array (FPGA) also placed inside the MR bore. A rapid design and production process is proposed to facilitate case-by-case target oriented arrays, which yield smaller arrays that can be used as conformal devices. These conformal transducers can help facilitate treatment of targets in challenging locations, and help compensate for patient movement. A Tx casing design was developed for individual ceramics to facilitate repeated removal from various array shells. These removable Txs can be re-used in multiple arrays as they are tuned for qDE driving independent of the array geometry A series of MATLAB functions were created to find sparse array designs by running thousands 3D k-space pseudospectral heterogeneous acoustic simulations, varying the pseudo-random Tx positions, array geometry, or steering position between each simulation. The designed functions are used to sweep array geometry and randomized element positions to find a configuration that yields sufficient performance. Once an acoustically correct solution is found, it is verified by executing k-Wave thermal diffusion simulations based on the acoustic simulation's resultant pressure waves. Heating was applied for 30 minutes using a discrete PID controller based on temperature feedback. The array geometry can be exported from MATLAB for use in Autodesk Inventor to 3D print the array exactly as represented in simulation. Multiple groups of Txs were electrically characterized then binned until an appropriate qDE driving solution was achievable.
Author: Steven Gary Silverman
Publisher:
ISBN:
Category :
Languages : en
Pages : 136
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Author: Hong Wang
Publisher:
ISBN:
Category :
Languages : en
Pages : 294
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Book Description
Author: Robert J. McGough
Publisher:
ISBN:
Category :
Languages : en
Pages : 324
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Book Description
Author: Eduardo Moros
Publisher: Taylor & Francis
ISBN: 1439848920
Category : Medical
Languages : en
Pages : 375
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Book Description
The field of thermal therapy has been growing tenaciously in the last few decades. The application of heat to living tissues, from mild hyperthermia to high-temperature thermal ablation, has produced a host of well-documented genetic, cellular, and physiological responses that are being researched intensely for medical applications, particularly fo
Author: Paul Joseph Benkeser
Publisher:
ISBN:
Category :
Languages : en
Pages : 252
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Author: Alan Jeffrey Fenn
Publisher: Artech House
ISBN: 1596933801
Category : Medical
Languages : en
Pages : 241
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Book Description
From electromagnetic field theory for tissue heating... to simulations of adaptive phased array thermotherapy for deep tumors of the torso... to coverage of arrays for tumors in the head, neck, breast, and chest wall, this timely resource offers you expert guidance in this emerging area.
Author: M.Heinrich Seegenschmiedt
Publisher: Springer Science & Business Media
ISBN: 3642578586
Category : Medical
Languages : en
Pages : 479
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Book Description
Hyperthermia has been found to be of great benefit in combination with radiation therapy or chemotherapy in the management of patients with difficult and com plicated tumor problems. It has been demonstrated to increase the efficacy, of ionising radiation when used locally but also has been of help in combination with systemic chemotherapy where hyperthermia is carried out to the total body. Problems remain with regard to maximizing the effects of hyperthermia as in fluenced by blood flow, heat loss, etc. The present volume defines the current knowledge relative to hyperthermia with radiation therapy and/or chemotherapy, giving a comprehensive overview of its use in cancer management. Philadelphia/Hamburg, June 1995 L.W. BRADY H.-P. HEILMANN Preface In an attempt to overcome tumor resistance, hypoxia, or unfavorable tumor condi tions, oncological research has come to focus on gene therapy, immunotherapy, new cytotoxic agents, and increasingly sophisticated radiotherapy. Radiation research has been directed towards heavy particle therapy and modification of the radiation response by either protecting or sensitizing agents. Improved dose localization using rotational or conformal strategies has also been implemented. Recently, changes in radiation fractionation schedules have shown promise of better results. Hyperthermia in cancer therapy can be viewed similarly as another means to increase the sensitivity of tumors to radio- and chemotherapy.
Author: Lester W. Schmerr Jr.
Publisher: Springer
ISBN: 3319072722
Category : Technology & Engineering
Languages : en
Pages : 382
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Book Description
This book describes in detail the physical and mathematical foundations of ultrasonic phased array measurements. The book uses linear systems theory to develop a comprehensive model of the signals and images that can be formed with phased arrays. Engineers working in the field of ultrasonic nondestructive evaluation (NDE) will find in this approach a wealth of information on how to design, optimize and interpret ultrasonic inspections with phased arrays. The fundamentals and models described in the book will also be of significant interest to other fields, including the medical ultrasound and seismology communities. A unique feature of this book is that it presents a unified theory of imaging with phased arrays that shows how common imaging methods such as the synthetic aperture focusing technique (SAFT), the total focusing method (TFM), and the physical optics far field inverse scattering (POFFIS) imaging method are all simplified versions of more fundamental and quantitative imaging approaches, called imaging measurement models. To enhance learning, this book first describes the fundamentals of phased array systems using 2-D models, so that the complex 3-D cases normally found in practice can be more easily understood. In addition to giving a detailed discussion of phased array systems, Fundamentals of Ultrasonic Phased Arrays also provides MATLAB® functions and scripts, allowing the reader to conduct simulations of ultrasonic phased array transducers and phased array systems with the latest modeling technology.
