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Author: William R. Jacobs, Jr.
Publisher: John Wiley & Sons
ISBN: 1555819567
Category : Medical
Languages : en
Pages : 742
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Book Description
Can today's innovative practices and molecular tools tame this ancient disease? One third of the world's population is infected with tuberculosis (TB), with about 10 million new cases annually. To combat TB and its agent, Mycobacterium tuberculosis, the World Health Organization launched The End TB Strategy, which aims to slash the suffering and cost of TB by 2035. This makes the second edition of Tuberculosis and the Tubercle Bacillus, edited by Jacobs, McShane, Mizrahi, and Orme, an extremely valuable resource for scientists and clinicians. The editors have gathered their colleagues from around the world to present the latest on the molecular biology of M. tuberculosis and related species, the host-pathogen interactions that enable invasion, and the host's immune response to M. tuberculosis infection. The basic, clinical, and translational research presented in this book supports the goals of WHO's End TB Strategy by driving toward the development of effective vaccines, rapid molecular diagnostics, and anti-TB drugs. Creating an effective tuberculosis vaccine. Understand the innate and adaptive immune response to M. tuberculosis infection, its study in established animal models, and how this information is being used to develop new vaccines against TB. Formulating new antituberculosis drugs. Learn the challenges and methods for evaluating new drugs in preclinical trials with a focus on drugs that work against "persisters" and those that act on the electron transport complex and ATP synthase of M. tuberculosis. Overcoming the challenges of diagnosing tuberculosis. Review new diagnostic tools that are simple, rapid, affordable, specific, sensitive, and safe, including molecular-based diagnostic methods such as GeneXpert MTB/RIF. Using molecular, genomic, and bioinformatics tools to understand the biology and evolution of Mycobacterium. Explore current research on the molecular mechanisms that M. tuberculosis uses to evade the immune system, enter a state of nonreplicating persistence, and become reactivated. The second edition of Tuberculosis and the Tubercle Bacillus presents the latest research on a microorganism that is exquisitely well adapted to its human host. This pathogen continues to confound scientists, clinicians, and public health specialists, who will all find much valuable information in this comprehensive set of reviews.
Author: William R. Jacobs, Jr.
Publisher: John Wiley & Sons
ISBN: 1555819567
Category : Medical
Languages : en
Pages : 742
Get Book Here
Book Description
Can today's innovative practices and molecular tools tame this ancient disease? One third of the world's population is infected with tuberculosis (TB), with about 10 million new cases annually. To combat TB and its agent, Mycobacterium tuberculosis, the World Health Organization launched The End TB Strategy, which aims to slash the suffering and cost of TB by 2035. This makes the second edition of Tuberculosis and the Tubercle Bacillus, edited by Jacobs, McShane, Mizrahi, and Orme, an extremely valuable resource for scientists and clinicians. The editors have gathered their colleagues from around the world to present the latest on the molecular biology of M. tuberculosis and related species, the host-pathogen interactions that enable invasion, and the host's immune response to M. tuberculosis infection. The basic, clinical, and translational research presented in this book supports the goals of WHO's End TB Strategy by driving toward the development of effective vaccines, rapid molecular diagnostics, and anti-TB drugs. Creating an effective tuberculosis vaccine. Understand the innate and adaptive immune response to M. tuberculosis infection, its study in established animal models, and how this information is being used to develop new vaccines against TB. Formulating new antituberculosis drugs. Learn the challenges and methods for evaluating new drugs in preclinical trials with a focus on drugs that work against "persisters" and those that act on the electron transport complex and ATP synthase of M. tuberculosis. Overcoming the challenges of diagnosing tuberculosis. Review new diagnostic tools that are simple, rapid, affordable, specific, sensitive, and safe, including molecular-based diagnostic methods such as GeneXpert MTB/RIF. Using molecular, genomic, and bioinformatics tools to understand the biology and evolution of Mycobacterium. Explore current research on the molecular mechanisms that M. tuberculosis uses to evade the immune system, enter a state of nonreplicating persistence, and become reactivated. The second edition of Tuberculosis and the Tubercle Bacillus presents the latest research on a microorganism that is exquisitely well adapted to its human host. This pathogen continues to confound scientists, clinicians, and public health specialists, who will all find much valuable information in this comprehensive set of reviews.
Author: Stewart T. Cole
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 618
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Book Description
- Reviews state-of-the-art corpus of knowledge in this critical area of global health research- Provides clinical and epidemiological features of the disease-causing strains of Mycobacterium tuberculosis- Explores the genetics, genomics, cell structure, and metabolism of M. tuberculosis- Examines various animal models and their roles in vaccine development and testing- Features contributors who are world leaders in the field of tuberculosis research.
Author: Peter D. O. Davies
Publisher: CRC Press
ISBN: 0429586493
Category : Medical
Languages : en
Pages : 482
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Book Description
Completely updated and revised, Clinical Tuberculosis continues to provide the TB practitioner-whether in public health, laboratory science or clinical practice-with a synoptic and definitive account of the latest methods of diagnosis, treatment and control of this challenging and debilitating disease.New in the Fifth Edition:Gamma interferon-based
Author: Robert Koch
Publisher:
ISBN: 9781330538036
Category : Medical
Languages : en
Pages : 118
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Book Description
Excerpt from Aetiology of Tuberculosis Dr. Koch's treatise on the AEtiology of Tubercolosis, has been translated with the authorization of the author, and is presented to the medical and veterinary professions of the United States as the most remarkable work on the subject. It is reprinted from the American Veterinary Review, and the translation is due to the Massachusetts State Veterinary Medical Association, who recognized its importance and undertook the labor of the work. The present edition is due to the demand for the treatise in its entirety, and although it is issued without the illustrations of the costly German edition, it will be found of the greatest advantage to all investigations in the subject. That the bacillus of Koch is the cause of tubercular disease; that to these are due all the different lesions of the various tissues in which it is found implanted; and that it is then invariably present, though, perhaps at times, difficult to discover, to color, or to isolate; and that, unless it is there, tuberculosis does not exist - all this is proved beyond question or doubt in Koch's "AEtiology." The modes of development, the processes of the biological studies which are required for the investigation; everything discoverable, In fact, connected with this bacillus, are minutely, carefully, and thoroughly described and presented by the author to the inquiring student. With this work properly appreciated and well studied, there is no longer any reason for error of diagnosis in that fatal affection. The lesions are in many instances so characteristic that any error can scarcely be possible, and yet how frequently may it happen that lesions, of the lungs, for instance, often peculiar, may be of a tuberculous aspect and yet entirely different in their nature! The pseudo-tubercules of the lungs, sometimes encountered, have no doubt in some instances led to a diagnosis of alleged phthisis, which would have been of an entirely different nature had the teachings of the author been followed, and the truth discerned, which the absence of the bacilli would have made certain, if it had but been rightly interpreted. "AEtiology of tuberculosis," which has filled so important a place among German scientific authorities, may now perform the same good office for English-speaking veterinarians, and by such of us as may unfortunately have much to do with this disease in the United States, we hope it will be recognized as an instructor and assistant beyond any possibility of rivalry or cavil, or chance of supercedure. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works."
Author: George P. Kubica
Publisher:
ISBN:
Category : Medical bacteriology
Languages : en
Pages : 96
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Book Description
Author: Barry R. Bloom
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 664
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Book Description
The authors discuss fundamental questions about the biology, genetics, mechanisms of pathogenicity, mechanisms of resistance, and drug development strategies that are likely to provide important new knowledge about TB and new interventions to prevent and treat this disease.
Author: M. Monir Madkour
Publisher: Springer Science & Business Media
ISBN: 3642189377
Category : Medical
Languages : en
Pages : 974
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Book Description
A comprehensive textbook on tuberculosis that covers all aspects of the disease: epidemiology, microbiology, diagnosis, treatment, control and prevention. The main part of the book comprises very detailed and richly illustrated clinical chapters. The copious images are the advantage of this book. Chapters on new methods and treatments and on animal tuberculosis are included. The material is based on a wealth of experience in tuberculosis as seen in endemic countries such as Saudi Arabia that enjoy free access to advanced investigative and therapeutic facilities. This coexistence of endemicity of the disease and state-of-the-art facilities is rare in poor and developing countries or in rich and developed nations. This multidisciplinary volume is ideal for all clinicians, laboratory and research workers, epidemiologists, university teachers and students, health care planners and international organizations involved in world health and infectious disease.
Author: Dorothee Heemskerk
Publisher: Springer
ISBN: 3319191322
Category : Medical
Languages : en
Pages : 71
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Book Description
This work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.
Author: W. Arber
Publisher: Springer
ISBN: 9783642661037
Category : Medical
Languages : en
Pages : 0
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Book Description
The processes involved in herpesvirus replication, latency, and oncogenic transformation, have, in general, been rather poorly defined. A primary reason for this is the size and complexity of the herpesvirus genome. Undoubtedly, a better understanding of the functions of the viral genome in infected and transformed cells will be achieved through studies with temperature-sensitive (ts) mutants of herpesviruses since, theoretically, any essential gene function can be affected by mutants of this type. A. The Herpesviruses A consideration of the genetic analysis of members of the herpesvirus group necessitates a description, albeit brief, of the properties of the group and, most importantly, of their genetic material. The herpesviruses comprise a group of relatively large (100-150 nm), enveloped viruses. The envelope surrounds an icosahedral capsid enclosing a core which contains double stranded DNA (ROIZMAN, 1969). The group is thus defined on the basis of a common virion morphology. In addition to a common structure, members of the group share a number of biological properties such as a similar replicative cycle, the ability to cause latent and chronic infections, and the ability to induce antigenic modifications of infected cell membranes. Several herpes viruses have been associated recently with malignancies in man and animals (KLEIN, 1972). Herpesviruses are ubiquitous and have been described in over 30 different species (HUNT and MELENDEZ, 1969; WILDY, 1971; FARLEY et aI. , 1972; KAZAMA and SCHORNSTEIN, 1972; NAHMIAS et aI. , 1972; ROlZMAN et aI. , 1973). Their widespread occurrence in nature suggests a common ancestor.
Author: Mamadou Daffé
Publisher:
ISBN: 9781555814687
Category : Bacterial cell walls
Languages : en
Pages : 0
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Book Description
Explains the unique characteristics that cause this large group of bacteria responsible for tuberculosis and leprosy to function differently; serves as a valuable reference for those working in the areas of biochemistry, genetics, genomics, and immunology.
