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Author: Michael B. Mathews
Publisher:
ISBN: 9781621821861
Category : Genetic translation
Languages : en
Pages : 499
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Book Description
A subject collection from Cold Spring Harbor Perspectives in Biology.
Author: Michael B. Mathews
Publisher:
ISBN: 9781621821861
Category : Genetic translation
Languages : en
Pages : 499
Get Book
Book Description
A subject collection from Cold Spring Harbor Perspectives in Biology.
Author: Jacques Lapointe
Publisher: Springer Science & Business Media
ISBN: 9780306478390
Category : Science
Languages : en
Pages : 476
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Book Description
Translation Mechanisms provides investigators and graduate students with overviews of recent developments in the field of protein biosynthesis that are fuelled by the explosive and synergic growth of structural biology, genomics, and bioinformatics. The outstanding progress in our understanding of the structure, dynamics, and evolution of the prokaryotic and eukaryotic translation machinery, as well as applications in medicine and biotechnology, are described in 26 chapters covering recent discoveries on: -the subtleties of tRNA aminoacylation with natural and unnatural amino acids. -the control of mRNA stability, a key step of gene regulation. -ribosome structure and function, in the era of the atomic-crystal resolution of the ribosome. -the regulation of the biosynthesis of the translational machinery components. -the action of a variety of inhibitors of translation and the prospect for clinical studies.
Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0
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Book Description
Author: John W. B. Hershey
Publisher: Cold Spring Harbor Perspective
ISBN: 9781936113460
Category : Science
Languages : en
Pages : 0
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Book Description
The synthesis of proteins by ribosomes is a fundamental cellular process. Cells must tightly control protein synthesis to maintain homeostasis and regulate proliferation, growth, differentiation, and development. Indeed, aberrant translational control is associated with cancer, several neurologic syndromes, and genetic disorders including "ribosomopathies." Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers our current understanding of protein synthesis and its control, from the genomic level to single- molecule analysis and single-cell imaging. The contributors describe the fundamental steps in protein synthesis (initiation, elongation, and termination), the factors involved, and high- resolution structures of the translational machinery. They review the targets of translational control (e.g., initiation factors and mRNAs) and how signaling pathways modulate this machinery. The roles of the endoplasmic reticulum, the unfolded protein response, processing bodies (P-bodies), stress granules, and small RNAs (including microRNAs) are also covered. This volume includes discussion of translational deregulation in cancer and the development of therapeutic agents that target translation initiation. Thus, it is an essential reference for cell and molecular biologists, as well as developmental and neurobiologists, oncologists, virologists, and all those investigating human diseases associated with translation dysfunction.
Author: Eric Wong
Publisher: Axolotl Academic Publishing
ISBN: 0985226110
Category : Biology
Languages : en
Pages : 283
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Book Description
"Yet another cell and molecular biology book? At the very least, you would think that if I was going to write a textbook, I should write one in an area that really needs one instead of a subject that already has multiple excellent and definitive books. So, why write this book, then? First, it's a course that I have enjoyed teaching for many years, so I am very familiar with what a student really needs to take away from this class within the time constraints of a semester. Second, because it is a course that many students take, there is a greater opportunity to make an impact on more students' pocketbooks than if I were to start off writing a book for a highly specialized upper- level course. And finally, it was fun to research and write, and can be revised easily for inclusion as part of our next textbook, High School Biology."--Open Textbook Library.
Author: Armen Parsyan
Publisher: Springer
ISBN: 9401790787
Category : Medical
Languages : en
Pages : 709
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Book Description
This book, for the first time, comprehensively assembles and analyzes a large body of information on the role of the fundamental mechanism of the protein biosynthesis pathway, translation, in cancer biology. It systematically explores the function of the translation machinery and its regulation, including cell signaling, in the development, maintenance and progression of human cancer. The work presented here unveils the tremendous potential and applications of this vast and exciting branch of genetic, biochemical and molecular science in cancer medicine and drug development. Chapters contributed by experts in the field take the reader on a journey that starts with a dissection of the translation machinery and its regulation in norm and cancer. Later chapters characterize etiological and pathogenetic roles that translation plays in specific cancer types. Various aspects of diagnostic, prognostic and therapeutic significance of the translation machinery and its control in cancer are discussed. Readers will discover the importance of the process of translation and its regulatory mechanisms in physiology and cancer biology. The chapters and the numerous illustrations included here were contributed by expert scientists and clinicians from renowned academic and clinical establishments in Canada, the United States of America, the United Kingdom, Italy, France, Belgium, Spain, Germany and Australia. The book conveys information and knowledge that may interest a broad range of students and scholars ranging from basic scientists to clinicians and drug developers seeking to better understand the protein synthesis and its aberrations in cancer biology and cancer medicine.
Author: Eric Jan
Publisher: Biota Publishing
ISBN: 1615046313
Category : Science
Languages : en
Pages : 106
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Book Description
Protein synthesis is a fundamental aspect of gene expression across kingdoms. The regulation of translation is important for many biological processes including cell fate determination, development, and growth and is especially crucial to maintain cellular homeostasis during cellular stress and virus infection. Misregulation of protein translation can contribute to diseases such as diabetes, cancer, and neurodegenerative diseases. In this chapter, we highlight the basic understanding of eukaryotic translation and the major regulations that control biological events. We focus on signaling pathways that regulate overall protein synthesis and also mechanisms that control translation of specific mRNAs such as cis-acting elements within the 5' and 3 untranslated regions (UTR). Understanding these mechanisms provide insights into the fundamental gene regulations that may provide new targets for combating disease and virus infections.
Author: Michael Mathews
Publisher: CSHL Press
ISBN: 0879697679
Category : Medical
Languages : en
Pages : 932
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Book Description
Updated and broadened 3rd edition. Since the last edition was published, the structures of the bacterial and eukaryotic ribosomes have been published, adding substantially to our knowledge of the basic mechanisms of translation. Understanding of how translation is regulated, by both protein and RNA regulators, has also advanced considerable. In addition, the current manifesttion of this volume has a significant focus on the role of translational control in human development and disease.
Author:
Publisher: Elsevier
ISBN: 0080553184
Category : Science
Languages : en
Pages : 510
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Book Description
For over fifty years the Methods in Enzymology series has been the critically aclaimed laboratory standard and one of the most respected publications in the field of biochemistry. The highly relevant material makes it an essential publication for researchers in all fields of life and related sciences. This volume, the second of three on the topic of Translation Initiation includes articles written by leaders in the field.
Author: Nahum Sonenberg
Publisher: CSHL Press
ISBN: 9780879696184
Category : Gene expression
Languages : en
Pages : 1034
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Book Description
Since the 1996 publication of Translational Control, there has been fresh interest in protein synthesis and recognition of the key role of translation control mechanisms in regulating gene expression. This new monograph updates and expands the scope of the earlier book but it also takes a fresh look at the field. In a new format, the first eight chapters provide broad overviews, while each of the additional twenty-eight has a focus on a research topic of more specific interest. The result is a thoroughly up-to-date account of initiation, elongation, and termination of translation, control mechanisms in development in response to extracellular stimuli, and the effects on the translation machinery of virus infection and disease. This book is essential reading for students entering the field and an invaluable resource for investigators of gene expression and its control.
