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Author: Senta Jorinde Raasveld
Publisher:
ISBN: 9789465060989
Category :
Languages : en
Pages : 0
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Book Description
"Transfusion has been a topic of interest for centuries. Nowadays, it is one of the key treatments in patients admitted to the intensive care unit (ICU). Researchers have tried to find the optimal indications for transfusion in different settings (e.g., trauma vs. non-trauma), subpopulations (e.g., sepsis, post-cardiothoracic surgery) as well as the specifics of transfusion itself (e.g., blood vs. components, storage times). In the past decades, there has been increasing attention to the potential downsides of transfusion. These include patient -level factors, such as short- and long-term side-effects, as well as system-level factors such as donor shortages and increasing healthcare costs. This has led to different international non-inferiority randomized trials investigating whether it is safe to apply a restrictive transfusion policy. Overall, this has resulted in guidelines moving towards a more restrictive transfusion policy in ICU patients. While these data are important for the patient population as a whole, the individual patient may benefit from a personalized approach. The work in this thesis forms an epidemiological overview of transfusion practices in two domains: on one hand, the global mixed population in the ICU; on the other hand, patients supported with extracorporeal membrane oxygenation (ECMO). The different presented studies each highlighted a different aspect of transfusion. By focusing on actual transfusion behavior, we aimed to improve our understanding of how clinical studies and guideline recommendations are translated into clinical practice. Ultimately, the goal of this work was to provide a foundation for future research, implementation and education."--
Author: Senta Jorinde Raasveld
Publisher:
ISBN: 9789465060989
Category :
Languages : en
Pages : 0
Get Book Here
Book Description
"Transfusion has been a topic of interest for centuries. Nowadays, it is one of the key treatments in patients admitted to the intensive care unit (ICU). Researchers have tried to find the optimal indications for transfusion in different settings (e.g., trauma vs. non-trauma), subpopulations (e.g., sepsis, post-cardiothoracic surgery) as well as the specifics of transfusion itself (e.g., blood vs. components, storage times). In the past decades, there has been increasing attention to the potential downsides of transfusion. These include patient -level factors, such as short- and long-term side-effects, as well as system-level factors such as donor shortages and increasing healthcare costs. This has led to different international non-inferiority randomized trials investigating whether it is safe to apply a restrictive transfusion policy. Overall, this has resulted in guidelines moving towards a more restrictive transfusion policy in ICU patients. While these data are important for the patient population as a whole, the individual patient may benefit from a personalized approach. The work in this thesis forms an epidemiological overview of transfusion practices in two domains: on one hand, the global mixed population in the ICU; on the other hand, patients supported with extracorporeal membrane oxygenation (ECMO). The different presented studies each highlighted a different aspect of transfusion. By focusing on actual transfusion behavior, we aimed to improve our understanding of how clinical studies and guideline recommendations are translated into clinical practice. Ultimately, the goal of this work was to provide a foundation for future research, implementation and education."--
Author: Nicole P. Juffermans
Publisher: Springer
ISBN: 3319087355
Category : Medical
Languages : en
Pages : 185
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Book Description
Due to a high incidence of anemia, critically ill patients are frequently transfused, with up to 40% of patients receiving a transfusion during their stay in the Intensive Care Unit. It has become increasingly clear that there is an association between transfusion and adverse outcomes, underlining the need for a careful assessment of the risks and benefits of a blood transfusion. In the last decade, there have been several large clinical trials that have studied red blood cell transfusion triggers in various ICU patient populations, allowing us to take a personalized approach to transfusion. Moreover, ICU patients often suffer from coagulopathy. Recent studies have addressed the effectiveness of fresh frozen plasma and platelets to prevent or treat bleeding. Aiming at a personalized therapy approach in transfusion practice, this book is the first to offer a comprehensive summary of transfusion triggers for red blood cells in specific ICU patient populations and specific conditions. In addition, it discusses evidence for triggers for plasma and platelets and outlines the most common adverse effects of transfusion in the ICU. Transfusion in the Intensive Care Unit is a practical handbook that can be used in everyday practice to guide transfusion and thus will serve as a valuable resource for physicians, fellows and residents working in Intensive Care, Anesthesiology and Cardiac Surgery.
Author: Debora Simmons
Publisher: Elsevier Health Sciences
ISBN: 1455700223
Category : Medical
Languages : en
Pages : 142
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Book Description
This issue of Critical Care Nursing Clinics, Guest Edited by Debora Simmons, RN, MSN, CCRN, CCNS, will feature such article topics as: Cause Mapping Critical Events; Blood Bank Safety in the ICU; Patient Safety in Perinatal Care; High Risk Drugs in Critical Areas; Enteral Feeding Tubing Misconnections; Safe Practices for Enteral Nutrition; Negotiating Safety; Device Complexity and Human Factors; Decreasing Risk; Delirium in ICU; and Voice of the Patient.
Author: Nicolaus Kröger
Publisher:
ISBN: 9781013273674
Category : Medical
Languages : en
Pages : 688
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Book Description
This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
Author: Hans Gombotz
Publisher: Thieme
ISBN: 3132004510
Category : Medical
Languages : en
Pages : 443
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Book Description
Patient Blood Management (PBM) is an innovative clinical concept that aims to reduce the need for allogenic blood transfusions, cut health-care costs, and avert or correct the risk factors related to blood transfusion, thus minimizing the rate of side effects and complications. This comprehensive hands-on volume offers a three-point approach for the implementation of PBM to improve patient outcome, focusing on how to prevent or treat anemia, reduce blood loss, and increase anemia tolerance. The book also goes beyond preoperative PBM, with detailed accounts of coagulation disorder management and the administration of coagulation products and platelet concentrates. Special Features: Presents a clear three-pillar strategy for the application of PBM: diagnosis and treatment of anemia, reduction of peri-interventional blood loss, and optimization of the tolerance to anemia in the everyday clinical setting Covers issues such as PBM during surgery, requirements for modern transfusion medicine, ordering blood products, the role of pre-anesthesia clinics, benchmarking processes, and potential implications of PBM in the public health sector Overview of research in PBM including landmark studies and current clinical trials Boxes in each chapter highlighting key information, core statements, and summaries A multidisciplinary and international team of contributors experienced in PBM Patient Blood Management is a guide for clinicians and residents whose patients are at risk for anemia, coagulation disorders, or severe blood loss. Anesthesiologists, surgeons, and specialists involved in the use of blood and blood products can use the book for quick reference or to learn more about a leading-edge concept for optimizing patient safety and improving outcome.
Author: Deborah A. Sesok-Pizzini
Publisher: Springer
ISBN: 3319427644
Category : Medical
Languages : en
Pages : 135
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Book Description
This book provides a concise yet comprehensive review of neonatal transfusion medicine. The text covers major areas of the field, including chapters dedicated to pre transfusion testing, manufacturing, standards and storage; blood product administration; special congenital and acquired disorders in the neonate; hemolytic disease of the newborn; intrauterine transfusions; adverse reactions; and ECMO. The volume features contributions from a diverse group of experts in the field and include pathologists, anesthesiologists, neonatologists, a pediatric hematologist and oncologist, and a high-risk obstetrician. These authors contribute their unique expertise and perspectives to the practice of neonatal transfusion medicine and allow the reader to experience an in depth introduction to each of the chapter topics. Neonatal Transfusion Practices is a valuable, go-to reference that addresses some of the more frequent questions asked by clinicians and professionals who have limited exposure to neonatal transfusion practices. /div
Author: Hunter B. Moore
Publisher: Springer Nature
ISBN: 3030536068
Category : Medical
Languages : en
Pages : 802
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Book Description
The first edition of this publication was aimed at defining the current concepts of trauma induced coagulopathy by critically analyzing the most up-to-date studies from a clinical and basic science perspective. It served as a reference source for any clinician interested in reviewing the pathophysiology, diagnosis, and management of the coagulopathic trauma patient, and the data that supports it. By meticulously describing the methodology of most traditional as well as state of the art coagulation assays the reader is provided with a full understanding of the tests that are used to study trauma induced coagulopathy. With the growing interest in understanding and managing coagulation in trauma, this second edition has been expanded to 46 chapters from its original 35 to incorporate the massive global efforts in understanding, diagnosing, and treating trauma induced coagulopathy. The evolving use of blood products as well as recently introduced hemostatic medications is reviewed in detail. The text provides therapeutic strategies to treat specific coagulation abnormalities following severe injury, which goes beyond the first edition that largely was based on describing the mechanisms causing coagulation abnormalities. Trauma Induced Coagulopathy 2nd Edition is a valuable reference to clinicians that are faced with specific clinical challenges when managing coagulopathy.
Author: Elso
Publisher:
ISBN: 9780965675659
Category :
Languages : en
Pages :
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Book Description
Author: Chaim Hershko
Publisher: Springer Science & Business Media
ISBN: 1461505933
Category : Science
Languages : en
Pages : 275
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Book Description
Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. However, normal iron physiology offers little protec tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant develop ments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload (Chapters 1-5).
Author: Clifford S. Deutschman
Publisher: Elsevier Health Sciences
ISBN: 1437737897
Category : Medical
Languages : en
Pages : 743
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Book Description
Evidence-Based Practice of Critical Care, edited by Drs. Clifford S. Deutschman and Patrick J. Neligan, provides objective data and expert guidance to help answer the most important questions challenging ICU physicians today. It discusses the clinical options, examines the relevant research, and presents expert recommendations on everything from acute organ failure to prevention issues. An outstanding source for "best practices" in critical care medicine, this book is a valuable framework for translating evidence into practice. Gain valuable evidence-based recommendations on key topics such as acute organ failure, infection, sepsis and inflammation, and prevention issues pointing the way to the most effective approaches. Get an overview of each question, an outline of management options, a review of the relevant evidence, areas of uncertainty, existing management guidelines, and authors’ recommendations. Navigate a full range of challenges from routine care to complicated and special situations. Find the information you need quickly with tables that summarize the available literature and recommended clinical approaches.
