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Author: S Narasimha Murthy
Publisher: CRC Press
ISBN: 1439811296
Category : Medical
Languages : en
Pages : 303
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Book Description
Discussing existing techniques, ongoing research, new approaches, and basic concepts in the treatment of nail diseases, Topical Nail Products and Ungual Drug Delivery summarizes the current knowledge and represents a jumping-off point for creating novel techniques of drug delivery across the nail. A growing area of pharmaceutical research, the search for efficient delivery techniques that can cross the nail barrier has yielded several effective strategies, brought together in this book. Topics Include Nail anatomy, physiology, diseases, and treatment Permeability of the nail plate Topical nail formulations Approaches to enhance ungual and trans-ungual drug delivery In vitro and in vivo models to evaluate topical nail formulations Nail sampling techniques Bioengineering of the nail Trans-ungual iontophoresis Pharmacokinetics of drugs in the nail apparatus Onychopharmacokinetics: proposed model insight Photodynamic therapy of nail diseases The nail as a surrogate for investigating drug use
Author: S Narasimha Murthy
Publisher: CRC Press
ISBN: 1439811296
Category : Medical
Languages : en
Pages : 303
Get Book Here
Book Description
Discussing existing techniques, ongoing research, new approaches, and basic concepts in the treatment of nail diseases, Topical Nail Products and Ungual Drug Delivery summarizes the current knowledge and represents a jumping-off point for creating novel techniques of drug delivery across the nail. A growing area of pharmaceutical research, the search for efficient delivery techniques that can cross the nail barrier has yielded several effective strategies, brought together in this book. Topics Include Nail anatomy, physiology, diseases, and treatment Permeability of the nail plate Topical nail formulations Approaches to enhance ungual and trans-ungual drug delivery In vitro and in vivo models to evaluate topical nail formulations Nail sampling techniques Bioengineering of the nail Trans-ungual iontophoresis Pharmacokinetics of drugs in the nail apparatus Onychopharmacokinetics: proposed model insight Photodynamic therapy of nail diseases The nail as a surrogate for investigating drug use
Author: Dimitris Rigopoulos
Publisher: John Wiley & Sons
ISBN: 1119226538
Category : Medical
Languages : en
Pages : 243
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Book Description
The definitive guide to one of the world’s most prevalent dermatologic conditions Onychomycosis is a fungal nail disease that accounts for 40% of all nail disorders, affecting 1 out of 10 people at some stage in their lives. Compiled by leading dermatologists with expert knowledge of the condition, Onychomycosis: Diagnosis and Effective Management provides a clear and clinically focused reference tool for those looking to treat patients expediently and successfully. This in-depth guide covers all aspects of disease management, from differential diagnosis and lab analysis to topical and systemic treatments. Designed to be a functional and accessible resource, the text also highlights key learning points, with real-life case studies and helpful take-home messages included in each chapter. Coverage of recent innovations and cutting-edge methods ensure the content is relevant to today’s dermatologists, while thorough explanations of routine techniques, prognostic factors, and epidemiology make this is an excellent handbook for anyone studying the disease for the first time. The book features: A complete guide to the diagnosis and treatment of this common disorder Key learning points, case studies, and take-home messages to aid quick and easy consultation Insights from world-renowned dermatological experts from North America and Europe Over 70 illustrations Onychomycosis is a reliable, easy-to-use companion for trainees and experienced specialists alike, and an invaluable asset to any clinic treating nail conditions.
Author: Abraham J. Domb
Publisher: Springer Science & Business Media
ISBN: 1461494346
Category : Medical
Languages : en
Pages : 700
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Book Description
The concept of focal controlled drug delivery has been applied for treating illnesses that are localized to a certain tissue or organ. These delivery systems are applied directly to the diseased site and deliver a desired dose for an extended time period while minimizing systemic distribution of toxic drug. Controlled drug delivery systems have been focused on oral extended release formulations and on systemic delivery of small drugs and peptides. Despite the upsurge of interest in focal targeted drug delivery, there is currently no single reference text on the subject. By comparison, there are numerous authored and edited books on oral, systemic and transdermal drug delivery or books on biodegradable polymers as drug carriers. Thus, the aim of Focal Drug Delivery is to bring together leading experts and researchers in the field to provide an authoritative account of the essential pharmaceutical, technological, physiological and biological sciences underpinning the topic. In addition, the book will review advances in treatment options for diseases localized at a certain tissue or organ.
Author: Robert L. Bronaugh
Publisher: CRC Press
ISBN: 9781420000948
Category : Science
Languages : en
Pages : 992
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Book Description
Since publication of the Second Edition in 1989, numerous innovations have occurred that affect the way scientists look at issues in the field of percutaneous absorption. Focusing on recent advances as well as updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption, Third Edition provides thorough coverage of the skin's role as an important portal of entry for chemicals into the body. Assembles the work of nearly 80 experts-30 more than the Second Edition-into a unified, comprehensive volume that contains the latest ideas and research! Complete with nearly 600 drawings, photographs, equations, and tables and more than 1600 bibliographic citations of pertinent literature, Percutaneous Absorption, Third Edition details the applied biology of percutaneous penetration factors that affect skin permeation, such as age, vehicles, metabolism, hydration of skin, and chemical structure in vivo and in vitro techniques for measuring absorption, examining factors influencing methodology such as animal models, volatility of test compound, multiple dosage, and artificial membranes procedures for use in transdermal delivery, exploring topics such as effects of penetration enhancers on absorption, optimizing absorption, and the topical delivery of drugs to muscle tissue And presents new chapters on mathematical models cutaneous metabolism prediction of percutaneous absorption in vitro absorption methodology dermal decontamination concentration of chemicals in skin transdermal drug delivery mechanisms of absorption safety evaluation of cosmetics absorption of drugs and cosmetic ingredients nail penetration Emphasizes human applications-particularly useful for pharmacists, pharmacologists, dermatologists, cosmetic scientists, biochemists, toxicologists, public health officials, manufacturers of cosmetic and toiletry products, and graduate students in these disciplines! An invaluable reference source for readers who need to keep up with the latest developments in the field, Percutaneous Absorption, Third Edition is also an excellent experimental guide for laboratory personnel.
Author: Robert Baran
Publisher: John Wiley & Sons
ISBN: 0470694831
Category : Medical
Languages : en
Pages : 656
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Book Description
This new edition brings together five leading authorities in nail surgery in this well established and definitive textbook. The entire text is extended in this edition, and particular emphasis is placed on the advances in treatments that have taken place in recent years. Considerable strides have been made in the treatment of fungal diseases (onychomycoses) with the appearance of new therapeutic agents. There is also much greater coverage of nail surgery to reflect the increasing involvement of the dermatologist in this field. The section on nail tumours has also been expanded. Drs Baran and Dawber have been joined by David de Berker, Eckhart Haneke and Antonella Tosti on the editorial team. This move is representative of the major European contribution to the field of nail surgery in recent years. Significant contribution has come from Dr Elvin Zook, the eminent American hand surgeon, who has helped to ensure that the book is as relevant in North America as it is in Europe.
Author: Heather A.E. Benson
Publisher: CRC Press
ISBN: 1482235404
Category : Medical
Languages : en
Pages : 479
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Book Description
Cosmetics are the most widely applied products to the skin and include creams, lotions, gels and sprays. Their formulation, design and manufacturing ranges from large cosmetic houses to small private companies. This book covers the current science in the formulations of cosmetics applied to the skin. It includes basic formulation, skin science, advanced formulation, and cosmetic product development, including both descriptive and mechanistic content with an emphasis on practical aspects. Key Features: Covers cosmetic products/formulation from theory to practice Includes case studies to illustrate real-life formulation development and problem solving Offers a practical, user-friendly approach, relying on the work of recognized experts in the field Provides insights into the future directions in cosmetic product development Presents basic formulation, skin science, advanced formulation and cosmetic product development
Author: Rajeshree Harshadrai Khengar
Publisher:
ISBN:
Category : Drug delivery systems
Languages : en
Pages : 470
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Book Description
Introduction: The physical hardness and chemical stability of the human nail is reported to be related to its high disulphide bond content and prevents the effective topical treatment of nail disorders such as onychomycosis. Oral therapy of onychomycosis is associated with a number of side-effects including liver toxicity. A strong clinical demand exists to develop a topical medicine that can effectively penetrate the nail plate in order to treat the growing number of patients with a fungal nail infection. The slow progress in this field is mainly due to the lack of an accepted model that can be used to assess nail permeability parameters. Recently the potential for chemical agents to act as penetration enhancers (PEs) and increase topical nail permeability has been reported. The main aims of this thesis were to identify a suitable method to screen potential chemical nail PEs in vitro, to investigate the effects of topically applied chemical agents as nail PEs on nail permeability and to investigate the influence of redox chemistry on human nail disulphide bonds and nail barrier function. Method: Three different screening methods to identify potential PEs were first assessed. A human nail swelling screen based on water uptake was selected and used to identify the potential nail PE activity of a variety of compounds. Permeability studies of model penetrants were performed in vitro using the ChubTur® diffusion cell to assess the effect of chemical agents identified in the nail swelling screen on barrier function. Potentiometry and differential pulse voltammetry were used to assess the electrochemical nature of potential nail PEs and the influence of the redox environment on the nail barrier. The novel nail PEs identified in this work were finally assessed using the microbiological TurChub® assay with Candida albicans as a marker clinically relevant to onychomycosis.
Author: Robert Baran
Publisher: CRC Press
ISBN: 1482257351
Category : Medical
Languages : en
Pages : 594
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Book Description
This text documents the science that lies behind the expanding field of cosmetic dermatology so that clinicians can practice with confidence and researchers can be fully aware of the clinical implications of their work. New chapters have been added to this edition on photodamage, actinic keratoses, UV lamps, hidradenitis suppurativa, age-related changes in male skin, changes in female hair with aging, nonabltaive laser rejuvenation, and cryolipolysis, and chapters have been updated throughout to keep this at the forefront of work and practice. The Series in Cosmetic and Laser Therapy is published in association with the Journal of Cosmetic and Laser Therapy. Print Versions of this book also include access to the ebook version.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 3
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Book Description
Author: N. Zaias
Publisher: Springer Science & Business Media
ISBN: 9401178461
Category : Medical
Languages : en
Pages : 255
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Book Description
The primary intent of this book is to familiarize the medical practitioner with the "nail unit" in a way which will render, correctly and more easily, the diagnosis of nail diseases. At the same time, it serves to encourage the treatment and corrective measures of the ab normalities, if possible, based on anatomical and physiological knowledge. The chapters on anatomy, regeneration, and nail formation are basic to the author's in tent. The content ofthe references quoted represents information which is proven and not controversial material. In addition, my own material not previously published is included. I would like to introduce the anatomical concept that the nail unit consists of four dif ferent epithelial structures, each with its own characteristics, yet all interrelated. These four constituents are the Proximal Nail Fold (PNF), the Matrix (M), the Nail Bed (NB) and the Hyponychium (HYP). A disease may occur in any number of or all nail unit structures. A clear understanding of the anatomy, histology, and tissue kinetics of each constituent will be necessary and is the key factor in interpreting the abnormal findings of each of these constituents as disease occurs. It follows, therefore, that treatment and Cor rective measures should include the knowledge of not only the nail but also of its relation ship to the bony phalanx and the digit.
