The Use of Ultrasound to Create Tissue Hyperthermia to Support the Treatment of Cancer PDF Download
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Author: Adam H. Aitkenhead
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Author: Adam H. Aitkenhead
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Author: Leopold J. Anghileri
Publisher: CRC Press
ISBN: 1000012689
Category : Medical
Languages : en
Pages : 390
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First published in 1986, Hyperthermia in Cancer Treatment is a most useful guide to the relationship between Hyperthermia, and the ways in which it is used for the control of cancer. Well-structured and comprehensive, this book is a must-read for any students of Oncology or professionals in their respective fields
Author:
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 296
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Author: Chun-Yen Lai
Publisher:
ISBN: 9781303153822
Category :
Languages : en
Pages :
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Ultrasound-induced mild hyperthermia is a promising cancer therapy strategy as high duty cycle ultrasound waves are utilized to induce a temperature of -42°C to increase cell membrane permeability and drug delivery efficiency. Ultrasound is noninvasive, provides spatial selectivity, and is free of ionizing radiation, thus localized thermal therapy is accomplished without concerns occurring in surgery, radiotherapy or chemotherapy. Tight control of ultrasound-induced mild hyperthermia is crucial in order to maximize therapeutic effect in a local area while minimizing unwanted thermal effects on the surrounding healthy tissue. In this dissertation, an advanced ultrasound mild hyperthermia system is established on a clinical scanner, to which modified software, a custom transducer, and an external temperature feedback system are integrated to perform a controlled thermal therapy. The motivation of this study is to develop an image-guided drug delivery system using ultrasound-induced mild hyperthermia. A dual-mode linear array transducer incorporating two 1.54-MHz therapeutic arrays and one 5.5-MHz imaging array was used in the study, in which single-beam and scanned-beam insonation were investigated and simulated. Agarose-based phantom models were established and functionalized for purposes, such as thermometry, visualization of drug release, and phantom design. Low temperature sensitive liposomes (LTSLs) were synthesized to encapsulate near-infrared fluorescence dye for drug release examination in various environments (phantom or solution), to which a simulation tool was developed to simulate drug delivery. An algorithm for ultrasound thermometry was developed in this study, facilitating thermal dose control in a broad region of interest. An approach to achieve more accurate ultrasound thermometry was studied by characterizing the tissue dependent thermal strain parameter and associating the parameter with computed tomography (CT) radiodensity. Finally, ultrasound-induced mild hyperthermia and cancer drugs were combined to perform tumor therapy on a mouse bearing breast cancer xenografts, and therapeutic effects and systemic toxicity were analyzed. Overall, three contributions are described in this work. First, the development of ultrasound-induced mild hyperthermia provides the capability to apply thermal therapy both in vitro and in vivo. Single-beam and scanned-beam insonation were characterized for delivering energy along a single line-of-sight and within a defined region of interest, respectively, allowing flexible planning of tumor treatment. The combination of scanned-beam insonation and drug delivery in a tumor model demonstrated therapeutic efficacy, while systemic toxicity and recurrence of tumors were not observed. Second, tissue-mimicking phantoms were created to test delivery. By incorporating LTSLs in the phantom, the three-dimensional (3-D) drug release profile was visualized using an optical imaging system. The simulation tool developed based on the finite-difference time-domain (FDTD) algorithm was validated by the phantom model and thus provided the ability to predict the kinetics of drug release. Third, the algorithm developed for ultrasound thermometry was shown to be practical for in vivo use. Using phantoms consisting of varied fat concentrations, the relationship between the tissue dependent thermal strain parameter and CT radiodensity was determined. Taken together, the contributions facilitate creation of a novel integrated ultrasound system capable of modern cancer therapy.
Author: Andras Szasz
Publisher: Springer Science & Business Media
ISBN: 9048194989
Category : Medical
Languages : en
Pages : 575
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Book Description
Oncothermia is the next generation medical innovation that delivers selective, controlled and deep energy for cancer treatment. The basic principles for oncothermia stem from oncological hyperthermia, the oldest approach to treating cancer. Nevertheless, hyperthermia has been wrought with significant controversy, mostly stemming from shortcomings of controlled energy delivery. Oncothermia has been able to overcome these insufficiencies and prove to be a controlled, safe and efficacious treatment option. This book is the first attempt to elucidate the theory and practice of oncothermia, based on rigorous mathematical and biophysical analysis, not centered on the temperature increase. It is supported by numerous in-vitro and in-vivo findings and twenty years of clinical experience. This book will help scientists, researchers and medical practitioners in understanding the scientific and conceptual underpinnings of oncothermia and will add another valuable tool in the fight against cancer. Professor Andras Szasz is the inventor of oncothermia and the Head of St Istvan University's Biotechnics Department in Hungary. He has published over 300 papers and lectured at various universities around the world. Dr. Oliver Szasz is the managing director of Oncotherm, the global manufacturer and distributor of medical devices for cancer treatment used in Europe & Asia since the late 1980s. Dr. Nora Szasz is currently a management consultant in healthcare for McKinsey & Co.
Author: Ferenc A. Jolesz
Publisher: CRC Press
ISBN: 1420019937
Category : Medical
Languages : en
Pages : 217
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Book Description
MRI-Guided Focused Ultrasound Surgery will be the first publication on this new technology, and will present a variety of current and future clinical applications in tumor ablation treatment. This source helps surgeons and specialists evaluate, analyze, and utilize MRI-guided focused ultrasound surgery - bridging the gap between phase 3 clinical tr
Author: John Grisham
Publisher: Focused Ultrasound Foundation
ISBN: 1495179419
Category : Medical
Languages : en
Pages : 66
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Book Description
John Grisham says THE TUMOR is the most important book he has ever written. In this short book, he provides readers with a fictional account of how a real, new medical technology could revolutionize the future of medicine by curing with sound. THE TUMOR follows the present day experience of the fictional patient Paul, an otherwise healthy 35-year-old father who is diagnosed with a malignant brain tumor. Grisham takes readers through a detailed account of Paul’s treatment and his family’s experience that doesn’t end as we would hope. Grisham then explores an alternate future, where Paul is diagnosed with the same brain tumor at the same age, but in the year 2025, when a treatment called focused ultrasound is able to extend his life expectancy. Focused ultrasound has the potential to treat not just brain tumors, but many other disorders, including Parkinson’s, Alzheimer’s, hypertension, and prostate, breast and pancreatic cancer. For more information or to order a free hardcopy of the book, please visit The Focused Ultrasound Foundation’s website www.fusfoundation.org. Here you will find a video of Grisham on the TEDx stage with the Foundation’s chairman and a Parkinson’s patient who brings the audience to its feet sharing her incredible story of a focused ultrasound “miracle.” Readers will get a taste of the narrative they expect from Grisham, but this short book will also educate and inspire people to be hopeful about the future of medical innovation.
Author: Vincent T. DeVita
Publisher: Lippincott Williams & Wilkins
ISBN: 9780781744508
Category : Medical
Languages : en
Pages : 3144
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Book Description
Examines molecular biologic techniques including proteomics, genomics, targeted therapies, RNA interference, cDNA arrays, and tissue arrays. This book contains sections discussing bioinformatics and societal issues in oncology, including regulatory issues, telemedicine, and international differences in oncology.
Author: F. Kristian Storm
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 600
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Author: M.Heinrich Seegenschmiedt
Publisher: Springer Science & Business Media
ISBN: 3642578586
Category : Medical
Languages : en
Pages : 479
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Hyperthermia has been found to be of great benefit in combination with radiation therapy or chemotherapy in the management of patients with difficult and com plicated tumor problems. It has been demonstrated to increase the efficacy, of ionising radiation when used locally but also has been of help in combination with systemic chemotherapy where hyperthermia is carried out to the total body. Problems remain with regard to maximizing the effects of hyperthermia as in fluenced by blood flow, heat loss, etc. The present volume defines the current knowledge relative to hyperthermia with radiation therapy and/or chemotherapy, giving a comprehensive overview of its use in cancer management. Philadelphia/Hamburg, June 1995 L.W. BRADY H.-P. HEILMANN Preface In an attempt to overcome tumor resistance, hypoxia, or unfavorable tumor condi tions, oncological research has come to focus on gene therapy, immunotherapy, new cytotoxic agents, and increasingly sophisticated radiotherapy. Radiation research has been directed towards heavy particle therapy and modification of the radiation response by either protecting or sensitizing agents. Improved dose localization using rotational or conformal strategies has also been implemented. Recently, changes in radiation fractionation schedules have shown promise of better results. Hyperthermia in cancer therapy can be viewed similarly as another means to increase the sensitivity of tumors to radio- and chemotherapy.
