Chemical Mixtures and Combined Chemical and Nonchemical Stressors PDF Download
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Author: Cynthia V. Rider
Publisher: Springer
ISBN: 3319562347
Category : Medical
Languages : en
Pages : 554
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Book Description
In this book, both basic and advanced concepts are discussed for considering mixtures from initial exposure characterization through evaluation of risk associated with combined exposures. This book will provide an introduction to key issues and multiple options for evaluating both the toxicity of mixtures as well as the risk associated with exposure to mixtures. Additionally, promising tools adapted from other disciplines will be discussed in the context of mixtures toxicology and risk assessment. Finally, the discussion will move beyond chemical mixtures to address incorporating non-chemical stressors into toxicity studies and cumulative risk assessments. Although exposure to multiple chemical and non-chemical stressors is the rule, not the exception, consideration of mixtures in toxicology and risk assessment continues to be a significant challenge. This book will be an essential resource for researchers and professionals in the fields of toxicology, epidemiology, exposure science, risk assessment, and statistics.
Author: Cynthia V. Rider
Publisher: Springer
ISBN: 3319562347
Category : Medical
Languages : en
Pages : 554
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Book Description
In this book, both basic and advanced concepts are discussed for considering mixtures from initial exposure characterization through evaluation of risk associated with combined exposures. This book will provide an introduction to key issues and multiple options for evaluating both the toxicity of mixtures as well as the risk associated with exposure to mixtures. Additionally, promising tools adapted from other disciplines will be discussed in the context of mixtures toxicology and risk assessment. Finally, the discussion will move beyond chemical mixtures to address incorporating non-chemical stressors into toxicity studies and cumulative risk assessments. Although exposure to multiple chemical and non-chemical stressors is the rule, not the exception, consideration of mixtures in toxicology and risk assessment continues to be a significant challenge. This book will be an essential resource for researchers and professionals in the fields of toxicology, epidemiology, exposure science, risk assessment, and statistics.
Author: Cornelis A. M. van Gestel
Publisher: CRC Press
ISBN: 1439830096
Category : Medical
Languages : en
Pages : 312
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Book Description
In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology an
Author: Harold Zeliger
Publisher: William Andrew
ISBN: 0815519842
Category : Technology & Engineering
Languages : en
Pages : 627
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Book Description
This book considers how exposure to toxic mixtures affects the different physiological systems and organs, including the respiratory, cardiovascular, immunological, musculoskeletal, nervous and reproductive systems, as well as the various organs, including the kidneys, liver and skin.The author evaluates various sources of exposure, including air, water, and soil pollution; in utero exposure; chemicals contained in foods, cosmetics, and domestic cleaning products; adhesives and paints; industrial chemicals; pesticides; electromagnetic radiation; and chemicals ingested or inhaled during the use of alcohol, tobacco and narcotics.The book also examines the interplay between exposure to these mixtures and the prevalence of various diseases and conditions, including autism, attention deficit hyperactivity disorder (ADHD), developmental neurotoxicology, multiple chemical sensitivity (MSC), chronic fatigue syndrome (CFS), fibromyalgia (FM), Gulf war syndrome, cancer and cancer clusters. The author also discusses how exposure to these mixtures yields the above diseases and conditions in different populations: fetuses, infants, pre-adolescent children, adolescents and adults.Finally, the book addresses the profound policy implications for formulation, labeling and use of chemical products, and it proposes more stringent exposure limits and warning requirements in light of the newly recognized toxic effects that are directly attributable to the mixture of toxic lipophilic and hydrophilic chemicals. Addresses chemical mixtures, while most literature only deals with single chemicals exposure Explains why certain toxicological effects are observed Discusses diagnosis and treatment of injuries resulting from exposure Explores consequences of effects on product formulation, use, handling and required warnings Provides guidelines for safer development of personal care, cosmetic, industrial and consumer use products
Author: Raymond S.H. Yang
Publisher: Elsevier
ISBN: 1483289400
Category : Science
Languages : en
Pages : 745
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Book Description
Although toxicologic studies in the laboratory often focus on a single chemical, in the larger world, mixtures of chemicals are routinely encountered. Toxicology of Chemical Mixtures examines the mechanisms of interactions and health effects stemming from chemical mixtures in the environment. Toxicologists, pharmacologists, environmental scientists, and professionals involved in environmental clean-ups will benefit from its content. Emphasis is on low-level, long-term exposure. Some of the issues addressed include Target organ toxicities in response to chemical mixture exposures Risk assessment and experimental approaches Case studies and special pollution problems Special pollution problems
Author: Patrick Sullivan
Publisher: Elsevier
ISBN: 0080466478
Category : Technology & Engineering
Languages : en
Pages : 569
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Book Description
Any professional examination of existing or potential new toxins in a population must account for those already present from past problems and natural conditions.Toxic Legacy provides extensive information on the occurrence of chemical hazards and their potential dangers in combinations in the food, water and air in cities around the United States. The book illustrates consumer preferences for specific food and water products, as well as particular diets and discusses the toxicity and risks associated with our exposure to synthetic chemicals. The authors offer unique guidance to environmental engineers, scientists, process engineers, and planners and specify what steps can be taken to limit exposure to complex chemical mixtures. Includes strategies for minimizing our exposure to chemical mixtures Provides detailed analysis of hazards associated with exposure to chemical mixtures from multiple sources Presents chemical data on the food, water and air for 36 metropolitan areas in the United States
Author: J. K. Pollak
Publisher:
ISBN: 9780867587753
Category : Toxicology
Languages : en
Pages : 77
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Book Description
Author: Carl F. Cranor
Publisher: Oxford University Press
ISBN: 0190635762
Category : Philosophy
Languages : en
Pages : 265
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Book Description
The world is awash in chemicals created by fellow citizens, but we know little to nothing about them. Understanding whether even the most prevalent ones are toxic would take decades. Many people have tragically suffered serious diseases and premature death, including children during development. Why has this occurred? Many factors contribute, but two important ones are the laws permitting this and the manner in which science has been used to identify and assess whether or not products are toxic. Both are the outcome of legislative, corporate, and judicial choices. Congress created laws that in fact keep public health officials and the wider population in the dark about the toxicity of virtually all substances other than prescription drugs and pesticides. Facing considerable ignorance about toxic substances, impartially motivated scientists seeking to protect the public health are constrained by the natural pace of studies to reveal toxic effects. Corporate pressures on public health officials and scientific obstruction substantially heighten the barriers to protecting the public. When people have suffered serious as well as life-threatening diseases likely traceable to toxic substances, judicial errors barring relevant science in the personal injury (tort) law can and have frustrated redress of injustices. Under both public health law and the tort law, there are possibilities for improved approaches, provided public leaders make different and better choices. This book describes these issues and suggests how we could be better protected from myriad toxic substances in our midst.
Author: Committee on Methods for the In Vivo Toxicity Testing of Complex Mixtures
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 248
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Book Description
Addresses the problem of identifying and classifying complex mixtures, investigating the effects of exposure, and the research problems inherent in testing their toxicity to human being. Case studies are presented. Annotation(c) 2003 Book News, Inc., Portland, OR (booknews.com).
Author: John C. Lipscomb
Publisher: Elsevier Inc. Chapters
ISBN: 0128060441
Category : Medical
Languages : en
Pages : 34
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Book Description
Humans are exposed to chemicals through voluntary and involuntary actions; to natural and synthetic chemicals all day, every day. Single chemical risk assessments are complex in and of themselves, and the assessment of chemical mixtures exponentially increases the complexity for toxicologists, regulators, and the public. Chemicals produce effects in biological systems which may or may not be related to their toxicity; some effects may be adaptive or may not be a direct part of their mode or mechanism of toxic action. These terms are commonly used and may be distinguished based on the level of detail implied. Mode of action usually describes the effect of a toxicant at the cellular or organ level, while mechanism of action implies an understanding of the interaction of the toxicant at the molecular level. Chemicals can have the same mode of action, but act via different mechanisms. Components in a chemical mixture are characterized by mode and/or mechanism for the purpose of grouping, described later.
Author:
Publisher: DIANE Publishing
ISBN: 1428902295
Category :
Languages : en
Pages : 209
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Book Description
