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Author: Trevor John Parry
Publisher:
ISBN: 9781109703887
Category :
Languages : en
Pages : 41
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Book Description
The RNA polymerase II core promoter is a diverse and complex region of DNA that contains the transcription start site. Core promoter elements are conserved DNA sequences within the core promoter that direct transcription to the start site and function in the regulation of gene expression. Here I describe the TCT motif, a newly discovered core promoter element that encompasses the transcription start site and is conserved among the ribosomal protein genes. Mutational analysis of three ribosomal protein gene promoters, RpLP1, RpS12, and RpS15, demonstrates the importance of this DNA element. A severe down-regulation of transcription is seen when the wild-type sequence is mutated, with positions 3-5 (+3 to +5 relative to the +1 transcription start site) being the most important. I also show that the TCT does not work synergistically with other previously characterized core promoter elements, and the RpLP1 promoter is not bound by Transcription Factor IID (TFIID). The TCT is a necessary core promoter element for the transcription of the ribosomal protein genes. Its inability to work synergistically with other known promoter elements, along with its inability to bind TFIID, may suggest a parallel mechanism of RNA polymerase II transcription for the ribosomal protein genes that is independent of the mechanism used for all previously studied genes.
Author: Trevor John Parry
Publisher:
ISBN: 9781109703887
Category :
Languages : en
Pages : 41
Get Book Here
Book Description
The RNA polymerase II core promoter is a diverse and complex region of DNA that contains the transcription start site. Core promoter elements are conserved DNA sequences within the core promoter that direct transcription to the start site and function in the regulation of gene expression. Here I describe the TCT motif, a newly discovered core promoter element that encompasses the transcription start site and is conserved among the ribosomal protein genes. Mutational analysis of three ribosomal protein gene promoters, RpLP1, RpS12, and RpS15, demonstrates the importance of this DNA element. A severe down-regulation of transcription is seen when the wild-type sequence is mutated, with positions 3-5 (+3 to +5 relative to the +1 transcription start site) being the most important. I also show that the TCT does not work synergistically with other previously characterized core promoter elements, and the RpLP1 promoter is not bound by Transcription Factor IID (TFIID). The TCT is a necessary core promoter element for the transcription of the ribosomal protein genes. Its inability to work synergistically with other known promoter elements, along with its inability to bind TFIID, may suggest a parallel mechanism of RNA polymerase II transcription for the ribosomal protein genes that is independent of the mechanism used for all previously studied genes.
Author:
Publisher: ScholarlyEditions
ISBN: 1481608517
Category : Medical
Languages : en
Pages : 76
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Book Description
DNA-Directed RNA Polymerases—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about DNA-Directed RNA Polymerases in a concise format. The editors have built DNA-Directed RNA Polymerases—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about DNA-Directed RNA Polymerases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of DNA-Directed RNA Polymerases—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author: Fumiaki Uchiumi
Publisher: BoD – Books on Demand
ISBN: 1789855179
Category : Medical
Languages : en
Pages : 202
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Book Description
Transcription is the most fundamental nuclear event, by which the information of nucleotide sequences on DNA is transcribed into RNA by multiple proteins, including RNA polymerases. Transcription determines the functions of proteins and the behaviour of cells, appropriately responding to environmental changes.This book is intended for scientists, especially those who are interested in the future prospect of gene expression and control in medicine and industry. This book consists of 9 chapters, divided into four parts. Each chapter is written by experts both in the basic and applied scientific field. A collection of articles presented by active and laboratory-based investigators provides evidence from the research, giving us a rigid platform to discuss "Gene Expression and Control."
Author: J. Robin Harris
Publisher: Springer Nature
ISBN: 3030281515
Category : Science
Languages : en
Pages : 657
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Book Description
This book follows on from Volume 83 in the SCBI series (“Macromolecular Protein Complexes”), and addresses several important topics (such as the Proteasome, Anaphase Promoting Complex, Ribosome and Apoptosome) that were not previously included, together with a number of additional exciting topics in this rapidly expanding field of study. Although the first SCBI Protein Complex book focused on soluble protein complexes, the second (Vol. 87)addressed Membrane Complexes, and the third (Vol. 88) put the spotlight on Viral Protein and Nucleoprotein Complexes, a number of membrane, virus and even fibrillar protein complexes have been be considered for inclusion in the present book. A further book is also under preparation that follows the same pattern, in an attempt to provide a thorough coverage of the subject. Chapter 9 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Author: Isil Aksan Kurnaz
Publisher: CRC Press
ISBN: 1482260905
Category : Medical
Languages : en
Pages : 334
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Book Description
Although designed for undergraduates with an interest in molecular biology, biotechnology, and bioengineering, this book-Techniques in Genetic Engineering-IS NOT: a laboratory manual; nor is it a textbook on molecular biology or biochemistry. There is some basic information in the appendices about core concepts such as DNA, RNA, protein, genes, and
Author: J.R. Kinghorn
Publisher: Springer Science & Business Media
ISBN: 9780751400588
Category : Medical
Languages : en
Pages : 284
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Book Description
The filamentous fungi are perhaps unique in the diversity of their metabolic activities. This includes biosynthetic as well as degradative activities, many is to provide an of which are of industrial interest. The objective of this text up-to-date and broad review which emphasizes the genetic and molecular biological contribution in the field of fungal biotechnology. This text begins with an overview of the tools and methodologies involved which, to a large extent, have been developed in the model filamentous fungus Aspergillus nidulans and subsequently have been extended to commercially important fungi. This is followed by a chapter which provides a compilation of genes isolated from commercial fungi and their present status with respect to structure, function and regulation. Chapters 3 and 4 highlight the degradative powers of filamentous fungi. First, a discussion of what is known regarding the molecular genetics of fungi and the genes and enzymes involved in the beverage and food industries. This has an oriental flavour, reflecting the tremendous importance of fungi in traditional Chinese and Japanese food production. An account of lignocellulose degradation by filamentous fungi follows, illustrating the potential of fungi to utilize this substance as a renewable energy source. The ability of fungi to produce high-value foreign proteins is reviewed in chapters 5 and 6. Chymosin production, in particular, represents a good example of high-level yields being obtained, such as to warrant commercial production.
Author: Ibrokhim Y. Abdurakhmonov
Publisher: BoD – Books on Demand
ISBN: 1789232686
Category : Medical
Languages : en
Pages : 190
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Book Description
Bioinformatics has evolved significantly in the era of post genomics and big data. Huge advancements were made toward storing, handling, mining, comparing, extracting, clustering and analysis as well as visualization of big macromolecular data using novel computational approaches, machine and deep learning methods, and web-based server tools. There are extensively ongoing world-wide efforts to build the resources for regional hosting, organized and structured access and improving the pre-existing bioinformatics tools to efficiently and meaningfully analyze day-to-day increasing big data. This book intends to provide the reader with updates and progress on genomic data analysis, data modeling and network-based system tools.
Author: Vladimir Vapnik
Publisher: Springer Science & Business Media
ISBN: 1475732643
Category : Mathematics
Languages : en
Pages : 324
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Book Description
The aim of this book is to discuss the fundamental ideas which lie behind the statistical theory of learning and generalization. It considers learning as a general problem of function estimation based on empirical data. Omitting proofs and technical details, the author concentrates on discussing the main results of learning theory and their connections to fundamental problems in statistics. This second edition contains three new chapters devoted to further development of the learning theory and SVM techniques. Written in a readable and concise style, the book is intended for statisticians, mathematicians, physicists, and computer scientists.
Author: Nello Cristianini
Publisher: Cambridge University Press
ISBN: 9780521856034
Category : Computers
Languages : en
Pages : 200
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Book Description
Where did SARS come from? Have we inherited genes from Neanderthals? How do plants use their internal clock? The genomic revolution in biology enables us to answer such questions. But the revolution would have been impossible without the support of powerful computational and statistical methods that enable us to exploit genomic data. Many universities are introducing courses to train the next generation of bioinformaticians: biologists fluent in mathematics and computer science, and data analysts familiar with biology. This readable and entertaining book, based on successful taught courses, provides a roadmap to navigate entry to this field. It guides the reader through key achievements of bioinformatics, using a hands-on approach. Statistical sequence analysis, sequence alignment, hidden Markov models, gene and motif finding and more, are introduced in a rigorous yet accessible way. A companion website provides the reader with Matlab-related software tools for reproducing the steps demonstrated in the book.
Author: Supratim Choudhuri
Publisher: Elsevier
ISBN: 0124105106
Category : Science
Languages : en
Pages : 238
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Book Description
Bioinformatics for Beginners: Genes, Genomes, Molecular Evolution, Databases and Analytical Tools provides a coherent and friendly treatment of bioinformatics for any student or scientist within biology who has not routinely performed bioinformatic analysis. The book discusses the relevant principles needed to understand the theoretical underpinnings of bioinformatic analysis and demonstrates, with examples, targeted analysis using freely available web-based software and publicly available databases. Eschewing non-essential information, the work focuses on principles and hands-on analysis, also pointing to further study options. - Avoids non-essential coverage, yet fully describes the field for beginners - Explains the molecular basis of evolution to place bioinformatic analysis in biological context - Provides useful links to the vast resource of publicly available bioinformatic databases and analysis tools - Contains over 100 figures that aid in concept discovery and illustration
