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Author: Daniel R. Brooks
Publisher: University of Chicago Press
ISBN: 022663258X
Category : Science
Languages : en
Pages : 423
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Book Description
The contemporary crisis of emerging disease has been a century and a half in the making. Human, veterinary, and crop health practitioners convinced themselves that disease could be controlled by medicating the sick, vaccinating those at risk, and eradicating the parts of the biosphere responsible for disease transmission. Evolutionary biologists assured themselves that coevolution between pathogens and hosts provided a firewall against disease emergence in new hosts. Most climate scientists made no connection between climate changes and disease. None of these traditional perspectives anticipated the onslaught of emerging infectious diseases confronting humanity today. As this book reveals, a new understanding of the evolution of pathogen-host systems, called the Stockholm Paradigm, explains what is happening. The planet is a minefield of pathogens with preexisting capacities to infect susceptible but unexposed hosts, needing only the opportunity for contact. Climate change has always been the major catalyst for such new opportunities, because it disrupts local ecosystem structure and allows pathogens and hosts to move. Once pathogens expand to new hosts, novel variants may emerge, each with new infection capacities. Mathematical models and real-world examples uniformly support these ideas. Emerging disease is thus one of the greatest climate change–related threats confronting humanity. Even without deadly global catastrophes on the scale of the 1918 Spanish Influenza pandemic, emerging diseases cost humanity more than a trillion dollars per year in treatment and lost productivity. But while time is short, the danger is great, and we are largely unprepared, the Stockholm Paradigm offers hope for managing the crisis. By using the DAMA (document, assess, monitor, act) protocol, we can “anticipate to mitigate” emerging disease, buying time and saving money while we search for more effective ways to cope with this challenge.
Author: Daniel R. Brooks
Publisher: University of Chicago Press
ISBN: 022663258X
Category : Science
Languages : en
Pages : 423
Get Book Here
Book Description
The contemporary crisis of emerging disease has been a century and a half in the making. Human, veterinary, and crop health practitioners convinced themselves that disease could be controlled by medicating the sick, vaccinating those at risk, and eradicating the parts of the biosphere responsible for disease transmission. Evolutionary biologists assured themselves that coevolution between pathogens and hosts provided a firewall against disease emergence in new hosts. Most climate scientists made no connection between climate changes and disease. None of these traditional perspectives anticipated the onslaught of emerging infectious diseases confronting humanity today. As this book reveals, a new understanding of the evolution of pathogen-host systems, called the Stockholm Paradigm, explains what is happening. The planet is a minefield of pathogens with preexisting capacities to infect susceptible but unexposed hosts, needing only the opportunity for contact. Climate change has always been the major catalyst for such new opportunities, because it disrupts local ecosystem structure and allows pathogens and hosts to move. Once pathogens expand to new hosts, novel variants may emerge, each with new infection capacities. Mathematical models and real-world examples uniformly support these ideas. Emerging disease is thus one of the greatest climate change–related threats confronting humanity. Even without deadly global catastrophes on the scale of the 1918 Spanish Influenza pandemic, emerging diseases cost humanity more than a trillion dollars per year in treatment and lost productivity. But while time is short, the danger is great, and we are largely unprepared, the Stockholm Paradigm offers hope for managing the crisis. By using the DAMA (document, assess, monitor, act) protocol, we can “anticipate to mitigate” emerging disease, buying time and saving money while we search for more effective ways to cope with this challenge.
Author: Joshua Busby
Publisher: Cambridge University Press
ISBN: 1108832466
Category : Political Science
Languages : en
Pages : 349
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Book Description
Busby explains how climate change can affect security outcomes, including violent conflict and humanitarian emergencies. Through case studies from sub-Saharan Africa, the Middle East, and South Asia, the book develops a novel argument explaining why climate change leads to especially bad security outcomes in some places but not in others.
Author: Robert Lefkowitz
Publisher: Simon and Schuster
ISBN: 1643136399
Category : Biography & Autobiography
Languages : en
Pages : 304
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Book Description
The rollicking memoir from the cardiologist turned legendary scientist and winner of the Nobel Prize that revels in the joy of science and discovery. Like Richard Feynman in the field of physics, Dr. Robert Lefkowitz is also known for being a larger-than-life character: a not-immodest, often self-deprecating, always entertaining raconteur. Indeed, when he received the Nobel Prize, the press corps in Sweden covered him intensively, describing him as “the happiest Laureate.” In addition to his time as a physician, from being a "yellow beret" in the public health corps with Dr. Anthony Fauci to his time as a cardiologist, and his extraordinary transition to biochemistry, which would lead to his Nobel Prize win, Dr. Lefkowitz has ignited passion and curiosity as a fabled mentor and teacher. But it's all in a days work, as Lefkowitz reveals in A Funny Thing Happened on the Way to Stockholm, which is filled to the brim with anecdotes and energy, and gives us a glimpse into the life of one of today's leading scientists.
Author: Daniel Rirdan
Publisher: Daniel Rirdan
ISBN: 1470135884
Category : Science
Languages : en
Pages : 495
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Book Description
From climate change to land degradation to fossil fuel shortages, we are faced with an impending calamity that threatens to bankrupt the planetary ecosystem and with it much of the manmade world. This book offers a plan that truly goes the distance: a highly detailed, planetary-wide blueprint that lays out a new course for our technological and industrial engines. It calls for sweeping adjustments in the way every person thinks and lives.--Inside front cover.
Author: J.H. Erik Andriessen
Publisher: Springer Science & Business Media
ISBN: 354028365X
Category : Business & Economics
Languages : en
Pages : 397
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Book Description
Dear Reader This is a book about mobile virtual work. It aims at clarifying the basic concepts and showing present practices and future challenges. The roots of the book are in the collaboration of few European practitioners and - searchers, who met each other under the umbrella of the Swedish SALTSA programme (see next page) in January 2002 in Stockholm. The group was first called ‘ICT, Mobility and Work Organisation’ but redefined itself quickly as ‘Mobile Virtual Cooperative Work’ group. The change of the name reflects the development of reasoning in the group. We could not find much material on mobile work, certainly not systematic studies, - though a growing interest in mobile technologies and services could be found. Practices of telework and virtual organizations were better known, but we were convinced that the combination with mobile work was so- thing different and new. Our main target became to understand what it was all about. The next step was an expert meeting in October 2004 at Rånäs Castle again in Sweden. A wider group of experts was invited to present their views on mobile virtual work and ideas about book chapters from different perspectives of working life. Some of the expertise could be found through the network of the AMI@Work family created by the New Working En- ronments unit of the European Commission’s Information Society Dir- torate-General. Also close collaboration was developed with the related MOSAIC program.
Author: Bernhard Strauss
Publisher: MIT Press
ISBN: 0262045214
Category : Science
Languages : en
Pages : 433
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Book Description
Leading scientists argue for a new paradigm for cancer research, proposing a complex systems view of cancer supported by empirical evidence. Current consensus in cancer research explains cancer as a disease caused by specific mutations in certain genes. After dramatic advances in genome sequencing, never before have we known so much about the individual cancer cell--and yet never before has it been so unclear what to do with this knowledge. In this volume, leading researchers argue for a new theory framework for understanding and treating cancer. The contributors propose a complex systems view of cancer, presenting conceptual building blocks for a new research paradigm supported by empirical evidence. The contributors first discuss the new research framework in terms of theoretical foundations and then take up the relevance of a systems approach, reviewing such topics as nonlinearity, recurrence after treatment, the cellular attractor concept, network theory, and non-coding DNA--the "dark matter" of our genome. They address the temporality of cancer progression, drawing on evolutionary theory and clinical experience. Finally, they cover the dominant role of the tissue microenvironment in cancer, analyzing topics including altered metabolic pathways, the disease-defining influence on metastasis, and the interconnectedness of different environmental niches across levels of organization.
Author: Claudia Card
Publisher: Oxford University Press
ISBN: 0199881790
Category : Philosophy
Languages : en
Pages : 299
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Book Description
What distinguishes evils from ordinary wrongs? Is hatred a necessarily evil? Are some evils unforgivable? Are there evils we should tolerate? What can make evils hard to recognize? Are evils inevitable? How can we best respond to and live with evils? Claudia Card offers a secular theory of evil that responds to these questions and more. Evils, according to her theory, have two fundamental components. One component is reasonably foreseeable intolerable harm -- harm that makes a life indecent and impossible or that makes a death indecent. The other component is culpable wrongdoing. Atrocities, such as genocides, slavery, war rape, torture, and severe child abuse, are Cards paradigms because in them these key elements are writ large. Atrocities deserve more attention than secular philosophers have so far paid them. They are distinguished from ordinary wrongs not by the psychological states of evildoers but by the seriousness of the harm that is done. Evildoers need not be sadistic:they may simply be negligent or unscrupulous in pursuing their goals. Cards theory represents a compromise between classic utilitarian and stoic alternatives (including Kants theory of radical evil). Utilitarians tend to reduce evils to their harms; Stoics tend to reduce evils to the wickedness of perpetrators: Card accepts neither reduction. She also responds to Nietzsches challenges about the worth of the concept of evil, and she uses her theory to argue that evils are more important than merely unjust inequalities. She applies the theory in explorations of war rape and violence against intimates. She also takes up what Primo Levi called the gray zone, where victims become complicit in perpetrating on others evils that threaten to engulf themselves. While most past accounts of evil have focused on perpetrators, Card begins instead from the position of the victims, but then considers more generally how to respond to -- and live with -- evils, as victims, as perpetrators, and as those who have become both.
Author: Johan Rockstrom
Publisher: Yale University Press
ISBN: 0300218362
Category : Business & Economics
Languages : en
Pages : 208
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Book Description
We have entered the Anthropocene - the era of massive human impacts on the planet - and the actions of over seven billion residents threaten to destabilize Earth's natural systems, with consequences for human societies. The authors combine the latest science with storytelling and photography to create a new narrative for humanity's future and reject the notion that economic growth and human prosperity can only be achieved at the expense of the environment
Author: Thomas Hale
Publisher: John Wiley & Sons
ISBN: 0745670105
Category : Political Science
Languages : en
Pages : 223
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Book Description
The issues that increasingly dominate the 21st century cannot be solved by any single country acting alone, no matter how powerful. To manage the global economy, prevent runaway environmental destruction, reign in nuclear proliferation, or confront other global challenges, we must cooperate. But at the same time, our tools for global policymaking - chiefly state-to-state negotiations over treaties and international institutions - have broken down. The result is gridlock, which manifests across areas via a number of common mechanisms. The rise of new powers representing a more diverse array of interests makes agreement more difficult. The problems themselves have also grown harder as global policy issues penetrate ever more deeply into core domestic concerns. Existing institutions, created for a different world, also lock-in pathological decision-making procedures and render the field ever more complex. All of these processes - in part a function of previous, successful efforts at cooperation - have led global cooperation to fail us even as we need it most. Ranging over the main areas of global concern, from security to the global economy and the environment, this book examines these mechanisms of gridlock and pathways beyond them. It is written in a highly accessible way, making it relevant not only to students of politics and international relations but also to a wider general readership.
Author: Michael J. Wade
Publisher: University of Chicago Press
ISBN: 022612973X
Category : Science
Languages : en
Pages : 269
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Book Description
Across the globe, populations of plants and animals live in clusters, but maintain a connectivity a population of populations. There are naturally occurring metapopulations, such as clusters of groupers spread across coral reefs, and there are metapopulations humans have helped create by fragmenting landscapes: stands of trees separated by roads, prairies separated by agricultural farms. As the dynamics of landscape change have accelerated, and understanding of how metapopulations functions has played a critical role in ecology and evolutionary biology. Adaptation in Metapopulations synthesizes the role of genetic interactions in adaptive evolution and their influence on the effectiveness of different types of selection. Drawing on extensive field work and lab experiments, cohered with a strong conceptual arc, the work also integrates molecular and organismal biology, as Wade explores adaptation at multiple scales, and shows how evolutionary dynamics scale from the gene to the metapopulation. "
