Author: Tracy Kidder
Publisher: Hachette UK
ISBN: 0316204552
Category : Computers
Languages : en
Pages : 222
Book Description
Tracy Kidder's "riveting" (Washington Post) story of one company's efforts to bring a new microcomputer to market won both the Pulitzer Prize and the National Book Award and has become essential reading for understanding the history of the American tech industry. Computers have changed since 1981, when The Soul of a New Machine first examined the culture of the computer revolution. What has not changed is the feverish pace of the high-tech industry, the go-for-broke approach to business that has caused so many computer companies to win big (or go belly up), and the cult of pursuing mind-bending technological innovations. The Soul of a New Machine is an essential chapter in the history of the machine that revolutionized the world in the twentieth century. "Fascinating...A surprisingly gripping account of people at work." --Wall Street Journal
The Soul of A New Machine
Company of One
Author: Paul Jarvis
Publisher: Mariner Books
ISBN: 1328972356
Category : Business & Economics
Languages : en
Pages : 273
Book Description
What if the real key to a richer and more fulfilling career was not to create and scale a new start-up, but rather, to be able to work for yourself, determine your own hours, and become a (highly profitable) and sustainable company of one? Suppose the better--and smarter--solution is simply to remain small? This book explains how to do just that. Company of One is a refreshingly new approach centered on staying small and avoiding growth, for any size business. Not as a freelancer who only gets paid on a per piece basis, and not as an entrepreneurial start-up that wants to scale as soon as possible, but as a small business that is deliberately committed to staying that way. By staying small, one can have freedom to pursue more meaningful pleasures in life, and avoid the headaches that result from dealing with employees, long meetings, or worrying about expansion. Company of One introduces this unique business strategy and explains how to make it work for you, including how to generate cash flow on an ongoing basis. Paul Jarvis left the corporate world when he realized that working in a high-pressure, high profile world was not his idea of success. Instead, he now works for himself out of his home on a small, lush island off of Vancouver, and lives a much more rewarding and productive life. He no longer has to contend with an environment that constantly demands more productivity, more output, and more growth. In Company of One, Jarvis explains how you can find the right pathway to do the same, including planning how to set up your shop, determining your desired revenues, dealing with unexpected crises, keeping your key clients happy, and of course, doing all of this on your own.
Publisher: Mariner Books
ISBN: 1328972356
Category : Business & Economics
Languages : en
Pages : 273
Book Description
What if the real key to a richer and more fulfilling career was not to create and scale a new start-up, but rather, to be able to work for yourself, determine your own hours, and become a (highly profitable) and sustainable company of one? Suppose the better--and smarter--solution is simply to remain small? This book explains how to do just that. Company of One is a refreshingly new approach centered on staying small and avoiding growth, for any size business. Not as a freelancer who only gets paid on a per piece basis, and not as an entrepreneurial start-up that wants to scale as soon as possible, but as a small business that is deliberately committed to staying that way. By staying small, one can have freedom to pursue more meaningful pleasures in life, and avoid the headaches that result from dealing with employees, long meetings, or worrying about expansion. Company of One introduces this unique business strategy and explains how to make it work for you, including how to generate cash flow on an ongoing basis. Paul Jarvis left the corporate world when he realized that working in a high-pressure, high profile world was not his idea of success. Instead, he now works for himself out of his home on a small, lush island off of Vancouver, and lives a much more rewarding and productive life. He no longer has to contend with an environment that constantly demands more productivity, more output, and more growth. In Company of One, Jarvis explains how you can find the right pathway to do the same, including planning how to set up your shop, determining your desired revenues, dealing with unexpected crises, keeping your key clients happy, and of course, doing all of this on your own.
It Doesn’t Have to Be Crazy at Work
Author: Jason Fried
Publisher: HarperCollins
ISBN: 0008323453
Category : Self-Help
Languages : en
Pages : 147
Book Description
Jason Fried and David Heinemeier Hansson, the authors of the New York Times bestseller Rework, are back with a manifesto to combat all your modern workplace worries and fears.
Publisher: HarperCollins
ISBN: 0008323453
Category : Self-Help
Languages : en
Pages : 147
Book Description
Jason Fried and David Heinemeier Hansson, the authors of the New York Times bestseller Rework, are back with a manifesto to combat all your modern workplace worries and fears.
Dreaming in Code
Author: Scott Rosenberg
Publisher: Crown Currency
ISBN: 1400082471
Category : Business & Economics
Languages : en
Pages : 415
Book Description
Our civilization runs on software. Yet the art of creating it continues to be a dark mystery, even to the experts. To find out why it’s so hard to bend computers to our will, Scott Rosenberg spent three years following a team of maverick software developers—led by Lotus 1-2-3 creator Mitch Kapor—designing a novel personal information manager meant to challenge market leader Microsoft Outlook. Their story takes us through a maze of abrupt dead ends and exhilarating breakthroughs as they wrestle not only with the abstraction of code, but with the unpredictability of human behavior— especially their own.
Publisher: Crown Currency
ISBN: 1400082471
Category : Business & Economics
Languages : en
Pages : 415
Book Description
Our civilization runs on software. Yet the art of creating it continues to be a dark mystery, even to the experts. To find out why it’s so hard to bend computers to our will, Scott Rosenberg spent three years following a team of maverick software developers—led by Lotus 1-2-3 creator Mitch Kapor—designing a novel personal information manager meant to challenge market leader Microsoft Outlook. Their story takes us through a maze of abrupt dead ends and exhilarating breakthroughs as they wrestle not only with the abstraction of code, but with the unpredictability of human behavior— especially their own.
Restoring the Soul of Business
Author: Rishad Tobaccowala
Publisher: HarperChristian + ORM
ISBN: 1400210666
Category : Business & Economics
Languages : en
Pages : 256
Book Description
From old-fashioned bricks-and-mortars to cutting-edge startups, businesses are moving into uncharted territory as they determine how to move from an analog past to a digital future effectively. How can you make sure not to leave human instinct behind? Businesses are leaving behind traditional meetings in favor of virtual ones, transitioning from surveys and studies to analytics and algorithms. The startling and often unacknowledged truth is that?the promise of digital transformation can only be realized when we find a way to balance it with the promise of people.?In the end, it’s the people that matter, and companies must never forget the soul that drives them. In Restoring the Soul of Business, business leader Rishad Tobaccowala?teaches you to: Understand how to unleash the significant benefit that can be realized by combining emotion and data, human and machine, analog and digital. Spot the warning signs of data-blinded companies: cold cultures with little human interaction, poor innovation stemming from discouraged employees who don’t contribute ideas, and poor customer service due to automated, robotic processes. Explore how organizations of various sizes and from different industries have successfully reoriented their thinking on how to fuse technology and humanity. Gain skills to become an expert in connections critical to growth and success, including the connection between being creative and using technology. Everyone working in an organization will find penetrating observations and guidance about how and why establishing the proper balance between human intuition and creativity and data-driven insights can lead to increased revenue, profitability, retention—and even joy—in their careers and business. Restoring the Soul of Business provides practical tools and techniques that every organization can and should implement, and challenges you to move forward with the kind of balance that capitalizes transformation and produces one great success after another.
Publisher: HarperChristian + ORM
ISBN: 1400210666
Category : Business & Economics
Languages : en
Pages : 256
Book Description
From old-fashioned bricks-and-mortars to cutting-edge startups, businesses are moving into uncharted territory as they determine how to move from an analog past to a digital future effectively. How can you make sure not to leave human instinct behind? Businesses are leaving behind traditional meetings in favor of virtual ones, transitioning from surveys and studies to analytics and algorithms. The startling and often unacknowledged truth is that?the promise of digital transformation can only be realized when we find a way to balance it with the promise of people.?In the end, it’s the people that matter, and companies must never forget the soul that drives them. In Restoring the Soul of Business, business leader Rishad Tobaccowala?teaches you to: Understand how to unleash the significant benefit that can be realized by combining emotion and data, human and machine, analog and digital. Spot the warning signs of data-blinded companies: cold cultures with little human interaction, poor innovation stemming from discouraged employees who don’t contribute ideas, and poor customer service due to automated, robotic processes. Explore how organizations of various sizes and from different industries have successfully reoriented their thinking on how to fuse technology and humanity. Gain skills to become an expert in connections critical to growth and success, including the connection between being creative and using technology. Everyone working in an organization will find penetrating observations and guidance about how and why establishing the proper balance between human intuition and creativity and data-driven insights can lead to increased revenue, profitability, retention—and even joy—in their careers and business. Restoring the Soul of Business provides practical tools and techniques that every organization can and should implement, and challenges you to move forward with the kind of balance that capitalizes transformation and produces one great success after another.
A Truck Full of Money
Author: Tracy Kidder
Publisher:
ISBN: 0812995244
Category : Biography & Autobiography
Languages : en
Pages : 289
Book Description
"One man's quest to recover from great success"--Front cover.
Publisher:
ISBN: 0812995244
Category : Biography & Autobiography
Languages : en
Pages : 289
Book Description
"One man's quest to recover from great success"--Front cover.
Soul Machine: The Invention of the Modern Mind
Author: George Makari
Publisher: W. W. Norton & Company
ISBN: 0393248690
Category : Psychology
Languages : en
Pages : 547
Book Description
A brilliant and comprehensive history of the creation of the modern Western mind. Soul Machine takes us back to the origins of modernity, a time when a crisis in religious authority and the scientific revolution led to searching questions about the nature of human inner life. This is the story of how a new concept—the mind—emerged as a potential solution, one that was part soul and part machine, but fully neither. In this groundbreaking work, award-winning historian George Makari shows how writers, philosophers, physicians, and anatomists worked to construct notions of the mind as not an ethereal thing, but a natural one. From the ascent of Oliver Cromwell to the fall of Napoleon, seminal thinkers like Hobbes, Locke, Diderot, and Kant worked alongside often-forgotten brain specialists, physiologists, and alienists in the hopes of mapping the inner world. Conducted in a cauldron of political turmoil, these frequently shocking, always embattled efforts would give rise to psychiatry, mind sciences such as phrenology, and radically new visions of the self. Further, they would be crucial to the establishment of secular ethics and political liberalism. Boldly original, wide-ranging, and brilliantly synthetic, Soul Machine gives us a masterful, new account of the making of the modern Western mind.
Publisher: W. W. Norton & Company
ISBN: 0393248690
Category : Psychology
Languages : en
Pages : 547
Book Description
A brilliant and comprehensive history of the creation of the modern Western mind. Soul Machine takes us back to the origins of modernity, a time when a crisis in religious authority and the scientific revolution led to searching questions about the nature of human inner life. This is the story of how a new concept—the mind—emerged as a potential solution, one that was part soul and part machine, but fully neither. In this groundbreaking work, award-winning historian George Makari shows how writers, philosophers, physicians, and anatomists worked to construct notions of the mind as not an ethereal thing, but a natural one. From the ascent of Oliver Cromwell to the fall of Napoleon, seminal thinkers like Hobbes, Locke, Diderot, and Kant worked alongside often-forgotten brain specialists, physiologists, and alienists in the hopes of mapping the inner world. Conducted in a cauldron of political turmoil, these frequently shocking, always embattled efforts would give rise to psychiatry, mind sciences such as phrenology, and radically new visions of the self. Further, they would be crucial to the establishment of secular ethics and political liberalism. Boldly original, wide-ranging, and brilliantly synthetic, Soul Machine gives us a masterful, new account of the making of the modern Western mind.
Devices of the Soul
Author: Steve Talbott
Publisher: "O'Reilly Media, Inc."
ISBN: 0596515235
Category : Computers
Languages : en
Pages : 300
Book Description
"Self-forgetfulness is the reigning temptation of the technological era. This is why we so readily give our assent to the absurd proposition that a computer can add two plus two, despite the obvious fact that it can do nothing of the sort--not if we have in mind anything remotely resembling what we do when we add numbers. In the computer's case, the mechanics of addition involve no motivation, no consciousness of the task, no mobilization of the will, no metabolic activity, no imagination. And its performance brings neither the satisfaction of accomplishment nor the strengthening of practical skills and cognitive capacities." In this insightful book, author Steve Talbott, software programmer and technical writer turned researcher and editor for The Nature Institute, challenges us to step back and take an objective look at the technology driving our lives. At a time when 65 percent of American consumers spend more time with their PCs than they do with their significant others, according to a recent study, Talbott illustrates that we're forgetting one important thing--our Selves, the human spirit from which technology stems. Whether we're surrendering intimate details to yet another database, eschewing our physical communities for online social networks, or calculating our net worth, we freely give our power over to technology until, he says, "we arrive at a computer's-eye view of the entire world of industry, commerce, and society at large...an ever more closely woven web of programmed logic." Digital technology certainly makes us more efficient. But when efficiency is the only goal, we have no way to know whether we're going in the right or wrong direction. Businesses replace guiding vision with a spreadsheet's bottom line. Schoolteachers are replaced by the computer's dataflow. Indigenous peoples give up traditional skills for the dazzle and ease of new gadgets. Even the Pentagon's zeal to replace "boots on the ground" with technology has led to the mess in Iraq. And on it goes. The ultimate danger is that, in our willingness to adapt ourselves to technology, "we will descend to the level of the computational devices we have engineered--not merely imagining ever new and more sophisticated automatons, but reducing ourselves to automatons." To transform our situation, we need to see it in a new and unaccustomed light, and that's what Talbott provides by examining the deceiving virtues of technology--how we're killing education, socializing our machines, and mechanizing our society.Once you take this eye-opening journey, you will think more clearly about how you consume technology and how you allow it to consume you. "Nothing is as rare or sorely needed in our tech-enchanted culture right now as intelligent criticism of technology, and Steve Talbott is exactly the critic we've been waiting for: trenchant, sophisticated, and completely original. Devices of the Soul is an urgent and important book." --Michael Pollan, author of The Omnivore's Dilemma: A Natural History of Four Meals and The Botany of Desire: A Plant's Eye View of the World "Steve Talbott is a rare voice of clarity, humanity, and passion in a world enthralled by machines and calculation. His new book, Devices of the Soul, lays out a frightening and at the same time inspiring analysis of what computers and computer-like thinking are doing to us, our children, and the future of our planet. Talbott is no Luddite. He fully understands and appreciates the stunning power of technology for both good and evil. His cool and precise skewering of the fuzzy thinking and mindless enthusiasm of the technology true believers is tempered by his modesty, the elegance of his writing, and his abiding love for the world of nature and our capacity for communion with it. " --Edward Miller, Former editor, Harvard Education Letter "Those who care about the healthy and wholesome lives of children can gain much from Steve Talbott's wisdom. He examines the need to help children spend more time touching nature and real life and less touching keyboards. He eloquently questions the assumption that speeding up learning is a good thing. Is, after all, a sped-up life a well-lived life? Most importantly, he reminds all of us that technology is just one part of life and ought not to overshadow the life of self and soul." --Joan Almon, Coordinator, Alliance for Childhood "One of the most original and provocative writers of our time, Steve Talbott offers a rich assortment of insightful reflections on the nature of our humanity, challenging our own thinking and conventional wisdom about advances in technology." --Dorothy E. Denning, Department of Defense Analysis, Naval Postgraduate School, Monterey, CA "Are you experiencing growing unease as computational metaphors have seized our discourse? Steve Talbott offers immediate relief. You are not losing your mind! Chapter after chapter, he shows how to draw on the powers of technology without losing your soul or breaking your heart." --Peter Denning, Past President of ACM, Monterey, California "Steve Talbott is a rare writer whose words can alter one's entire perception of the world. He is our most original and perceptive defender of the wholeness of life against the onslaught of mechanism. Devices of the Soul is written with Talbott's typical grace and clarity. It displays a quality hardly found anymore in our high tech culture--wisdom. " --Lowell Monke, Associate Professor of Education, Wittenberg University
Publisher: "O'Reilly Media, Inc."
ISBN: 0596515235
Category : Computers
Languages : en
Pages : 300
Book Description
"Self-forgetfulness is the reigning temptation of the technological era. This is why we so readily give our assent to the absurd proposition that a computer can add two plus two, despite the obvious fact that it can do nothing of the sort--not if we have in mind anything remotely resembling what we do when we add numbers. In the computer's case, the mechanics of addition involve no motivation, no consciousness of the task, no mobilization of the will, no metabolic activity, no imagination. And its performance brings neither the satisfaction of accomplishment nor the strengthening of practical skills and cognitive capacities." In this insightful book, author Steve Talbott, software programmer and technical writer turned researcher and editor for The Nature Institute, challenges us to step back and take an objective look at the technology driving our lives. At a time when 65 percent of American consumers spend more time with their PCs than they do with their significant others, according to a recent study, Talbott illustrates that we're forgetting one important thing--our Selves, the human spirit from which technology stems. Whether we're surrendering intimate details to yet another database, eschewing our physical communities for online social networks, or calculating our net worth, we freely give our power over to technology until, he says, "we arrive at a computer's-eye view of the entire world of industry, commerce, and society at large...an ever more closely woven web of programmed logic." Digital technology certainly makes us more efficient. But when efficiency is the only goal, we have no way to know whether we're going in the right or wrong direction. Businesses replace guiding vision with a spreadsheet's bottom line. Schoolteachers are replaced by the computer's dataflow. Indigenous peoples give up traditional skills for the dazzle and ease of new gadgets. Even the Pentagon's zeal to replace "boots on the ground" with technology has led to the mess in Iraq. And on it goes. The ultimate danger is that, in our willingness to adapt ourselves to technology, "we will descend to the level of the computational devices we have engineered--not merely imagining ever new and more sophisticated automatons, but reducing ourselves to automatons." To transform our situation, we need to see it in a new and unaccustomed light, and that's what Talbott provides by examining the deceiving virtues of technology--how we're killing education, socializing our machines, and mechanizing our society.Once you take this eye-opening journey, you will think more clearly about how you consume technology and how you allow it to consume you. "Nothing is as rare or sorely needed in our tech-enchanted culture right now as intelligent criticism of technology, and Steve Talbott is exactly the critic we've been waiting for: trenchant, sophisticated, and completely original. Devices of the Soul is an urgent and important book." --Michael Pollan, author of The Omnivore's Dilemma: A Natural History of Four Meals and The Botany of Desire: A Plant's Eye View of the World "Steve Talbott is a rare voice of clarity, humanity, and passion in a world enthralled by machines and calculation. His new book, Devices of the Soul, lays out a frightening and at the same time inspiring analysis of what computers and computer-like thinking are doing to us, our children, and the future of our planet. Talbott is no Luddite. He fully understands and appreciates the stunning power of technology for both good and evil. His cool and precise skewering of the fuzzy thinking and mindless enthusiasm of the technology true believers is tempered by his modesty, the elegance of his writing, and his abiding love for the world of nature and our capacity for communion with it. " --Edward Miller, Former editor, Harvard Education Letter "Those who care about the healthy and wholesome lives of children can gain much from Steve Talbott's wisdom. He examines the need to help children spend more time touching nature and real life and less touching keyboards. He eloquently questions the assumption that speeding up learning is a good thing. Is, after all, a sped-up life a well-lived life? Most importantly, he reminds all of us that technology is just one part of life and ought not to overshadow the life of self and soul." --Joan Almon, Coordinator, Alliance for Childhood "One of the most original and provocative writers of our time, Steve Talbott offers a rich assortment of insightful reflections on the nature of our humanity, challenging our own thinking and conventional wisdom about advances in technology." --Dorothy E. Denning, Department of Defense Analysis, Naval Postgraduate School, Monterey, CA "Are you experiencing growing unease as computational metaphors have seized our discourse? Steve Talbott offers immediate relief. You are not losing your mind! Chapter after chapter, he shows how to draw on the powers of technology without losing your soul or breaking your heart." --Peter Denning, Past President of ACM, Monterey, California "Steve Talbott is a rare writer whose words can alter one's entire perception of the world. He is our most original and perceptive defender of the wholeness of life against the onslaught of mechanism. Devices of the Soul is written with Talbott's typical grace and clarity. It displays a quality hardly found anymore in our high tech culture--wisdom. " --Lowell Monke, Associate Professor of Education, Wittenberg University
House
Author: Tracy Kidder
Publisher: HMH
ISBN: 0547526172
Category : House & Home
Languages : en
Pages : 355
Book Description
The Pulitzer Prize–winning author brings “clarity, intelligence and grace” to the tale of building a home in this New York Times Bestseller (The New York Times Book Review). It’s 1983 and Jonathan and Judith Souweine are ready to build their forever home on a four-acre lot just outside of Amherst, Massachusetts. A lawyer and a psychologist, neither has much experience with the process. In this New York Times bestseller, Tracy Kidder leads readers through the grand adventure of building the American dream. In his portrayal, constructing a staircase or applying a coat of paint becomes a riveting tale of conflicting wills, the strength and strain of relationships, and pride in craftsmanship. With drama, sensitivity, and insight, the Pulitzer Prize-winning author of The Soul of the New Machine takes us from blueprints to moving day. In the process, he sheds new light on objects usually taken for granted and creates a vivid cast of characters you will not soon forget. “Tracy Kidder has done it again. . . . What might seem like ordinary work takes on an extraordinary, unpredictable life of its own. The subject is fascinating, the book a remarkable piece of craftsmanship in itself.” —Chicago Tribune Book World “Kidder makes us feel with a splendid intensity the complex web of relationships and emotions that inevitably comes into play in the act of bringing a work of architecture to fruition.” —The New York Times Book Review
Publisher: HMH
ISBN: 0547526172
Category : House & Home
Languages : en
Pages : 355
Book Description
The Pulitzer Prize–winning author brings “clarity, intelligence and grace” to the tale of building a home in this New York Times Bestseller (The New York Times Book Review). It’s 1983 and Jonathan and Judith Souweine are ready to build their forever home on a four-acre lot just outside of Amherst, Massachusetts. A lawyer and a psychologist, neither has much experience with the process. In this New York Times bestseller, Tracy Kidder leads readers through the grand adventure of building the American dream. In his portrayal, constructing a staircase or applying a coat of paint becomes a riveting tale of conflicting wills, the strength and strain of relationships, and pride in craftsmanship. With drama, sensitivity, and insight, the Pulitzer Prize-winning author of The Soul of the New Machine takes us from blueprints to moving day. In the process, he sheds new light on objects usually taken for granted and creates a vivid cast of characters you will not soon forget. “Tracy Kidder has done it again. . . . What might seem like ordinary work takes on an extraordinary, unpredictable life of its own. The subject is fascinating, the book a remarkable piece of craftsmanship in itself.” —Chicago Tribune Book World “Kidder makes us feel with a splendid intensity the complex web of relationships and emotions that inevitably comes into play in the act of bringing a work of architecture to fruition.” —The New York Times Book Review
Breath from Salt
Author: Bijal P. Trivedi
Publisher: BenBella Books
ISBN: 1948836629
Category : Medical
Languages : en
Pages : 744
Book Description
Recommended by Bill Gates and included in GatesNotes "Elaborating on the science as well as the business behind the fight against cystic fibrosis, Trivedi captures the emotions of the families, doctors, and scientists involved in the clinical trials and their 'weeping with joy' as new drugs are approved, and shows how cystic fibrosis, once a 'death sentence,' became, for many, a manageable condition. This is a rewarding and challenging work." —Publishers Weekly Cystic fibrosis was once a mysterious disease that killed infants and children. Now it could be the key to healing millions with genetic diseases of every type—from Alzheimer's and Parkinson's to diabetes and sickle cell anemia. In 1974, Joey O'Donnell was born with strange symptoms. His insatiable appetite, incessant vomiting, and a relentless cough—which shook his tiny, fragile body and made it difficult to draw breath—confounded doctors and caused his parents agonizing, sleepless nights. After six sickly months, his salty skin provided the critical clue: he was one of thousands of Americans with cystic fibrosis, an inherited lung disorder that would most likely kill him before his first birthday. The gene and mutation responsible for CF were found in 1989—discoveries that promised to lead to a cure for kids like Joey. But treatments unexpectedly failed and CF was deemed incurable. It was only after the Cystic Fibrosis Foundation, a grassroots organization founded by parents, formed an unprecedented partnership with a fledgling biotech company that transformative leaps in drug development were harnessed to produce groundbreaking new treatments: pills that could fix the crippled protein at the root of this deadly disease. From science writer Bijal P. Trivedi, Breath from Salt chronicles the riveting saga of cystic fibrosis, from its ancient origins to its identification in the dank autopsy room of a hospital basement, and from the CF gene's celebrated status as one of the first human disease genes ever discovered to the groundbreaking targeted genetic therapies that now promise to cure it. Told from the perspectives of the patients, families, physicians, scientists, and philanthropists fighting on the front lines, Breath from Salt is a remarkable story of unlikely scientific and medical firsts, of setbacks and successes, and of people who refused to give up hope—and a fascinating peek into the future of genetics and medicine.
Publisher: BenBella Books
ISBN: 1948836629
Category : Medical
Languages : en
Pages : 744
Book Description
Recommended by Bill Gates and included in GatesNotes "Elaborating on the science as well as the business behind the fight against cystic fibrosis, Trivedi captures the emotions of the families, doctors, and scientists involved in the clinical trials and their 'weeping with joy' as new drugs are approved, and shows how cystic fibrosis, once a 'death sentence,' became, for many, a manageable condition. This is a rewarding and challenging work." —Publishers Weekly Cystic fibrosis was once a mysterious disease that killed infants and children. Now it could be the key to healing millions with genetic diseases of every type—from Alzheimer's and Parkinson's to diabetes and sickle cell anemia. In 1974, Joey O'Donnell was born with strange symptoms. His insatiable appetite, incessant vomiting, and a relentless cough—which shook his tiny, fragile body and made it difficult to draw breath—confounded doctors and caused his parents agonizing, sleepless nights. After six sickly months, his salty skin provided the critical clue: he was one of thousands of Americans with cystic fibrosis, an inherited lung disorder that would most likely kill him before his first birthday. The gene and mutation responsible for CF were found in 1989—discoveries that promised to lead to a cure for kids like Joey. But treatments unexpectedly failed and CF was deemed incurable. It was only after the Cystic Fibrosis Foundation, a grassroots organization founded by parents, formed an unprecedented partnership with a fledgling biotech company that transformative leaps in drug development were harnessed to produce groundbreaking new treatments: pills that could fix the crippled protein at the root of this deadly disease. From science writer Bijal P. Trivedi, Breath from Salt chronicles the riveting saga of cystic fibrosis, from its ancient origins to its identification in the dank autopsy room of a hospital basement, and from the CF gene's celebrated status as one of the first human disease genes ever discovered to the groundbreaking targeted genetic therapies that now promise to cure it. Told from the perspectives of the patients, families, physicians, scientists, and philanthropists fighting on the front lines, Breath from Salt is a remarkable story of unlikely scientific and medical firsts, of setbacks and successes, and of people who refused to give up hope—and a fascinating peek into the future of genetics and medicine.