The Role of Protein Synthesis Initiation Factor 2 in Translational Control in Escherichia Coli

The Role of Protein Synthesis Initiation Factor 2 in Translational Control in Escherichia Coli PDF Author: Gregory Parks Owens
Publisher:
ISBN:
Category : Escherichia coli infections
Languages : en
Pages : 300

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The Role of Protein Synthesis Initiation Factor 2 in Translational Control in Escherichia Coli

The Role of Protein Synthesis Initiation Factor 2 in Translational Control in Escherichia Coli PDF Author: Gregory Parks Owens
Publisher:
ISBN:
Category : Escherichia coli infections
Languages : en
Pages : 300

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Book Description


Ribosomes Structure, Function, and Dynamics

Ribosomes Structure, Function, and Dynamics PDF Author: Marina V. Rodnina
Publisher: Springer Science & Business Media
ISBN: 3709102154
Category : Medical
Languages : en
Pages : 428

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Book Description
The ribosome is a macromolecular machine that synthesizes proteins with a high degree of speed and accuracy. Our present understanding of its structure, function and dynamics is the result of six decades of research. This book collects over 40 articles based on the talks presented at the 2010 Ribosome Meeting, held in Orvieto, Italy, covering all facets of the structure and function of the ribosome. New high-resolution crystal structures of functional ribosome complexes and cryo-EM structures of translating ribosomes are presented, while partial reactions of translation are examined in structural and mechanistic detail, featuring translocation as a most dynamic process. Mechanisms of initiation, both in bacterial and eukaryotic systems, translation termination, and novel details of the functions of the respective factors are described. Structure and interactions of the nascent peptide within, and emerging from, the ribosomal peptide exit tunnel are addressed in several articles. Structural and single-molecule studies reveal a picture of the ribosome exhibiting the energy landscape of a processive Brownian machine. The collection provides up-to-date reviews which will serve as a source of essential information for years to come.

The Role of Initiation Factor Dynamics in Translation Initiation

The Role of Initiation Factor Dynamics in Translation Initiation PDF Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Like most biological polymerization reactions, ribosome-catalyzed protein synthesis, or translation, can be divided into initiation, elongation, and termination stages. Initiation is the rate-limiting stage of translation and a critical site for translational control of gene expression. Throughout all stages of protein synthesis, the ribosome is aided by essential protein co-factors known as translation factors. I have studied the role that two translation initiation factors, IF1 and IF3, play in the mechanism and regulation of translation initiation in Escherichia coli. Specifically, I have used single-molecule fluorescence resonance energy transfer (smFRET) as a primary tool for investigating how the dynamics of IF1 and IF3 regulate the accuracy with which the translational machinery selects an initiator transfer RNA (tRNA) and the correct messenger RNA (mRNA) start codon during the initiation stage of protein synthesis.

Overexpression and Characterization of Translation Initiation Factors in Bacteria and Mammalian Cells

Overexpression and Characterization of Translation Initiation Factors in Bacteria and Mammalian Cells PDF Author: Sang-Yun Choi
Publisher:
ISBN:
Category :
Languages : en
Pages : 204

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Protein Synthesis Initiation Factor IF-2 from Escherichia Coli

Protein Synthesis Initiation Factor IF-2 from Escherichia Coli PDF Author: John Leonard Fakunding
Publisher:
ISBN:
Category :
Languages : en
Pages : 312

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Molecular Biology of the Cell

Molecular Biology of the Cell PDF Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0

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Translation Initiation: Reconstituted Systems and Biophysical Methods

Translation Initiation: Reconstituted Systems and Biophysical Methods PDF Author:
Publisher: Academic Press
ISBN: 9780123739698
Category : Science
Languages : en
Pages : 512

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Book Description
For over fifty years the Methods in Enzymology series has been the critically aclaimed laboratory standard and one of the most respected publications in the field of biochemistry. The highly relevant material makes it an essential publication for researchers in all fields of life and related sciences. This volume, the second of three on the topic of Translation Initiation includes articles written by leaders in the field.

Translational Control of Gene Expression

Translational Control of Gene Expression PDF Author: Nahum Sonenberg
Publisher: CSHL Press
ISBN: 9780879696184
Category : Gene expression
Languages : en
Pages : 1034

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Book Description
Since the 1996 publication of Translational Control, there has been fresh interest in protein synthesis and recognition of the key role of translation control mechanisms in regulating gene expression. This new monograph updates and expands the scope of the earlier book but it also takes a fresh look at the field. In a new format, the first eight chapters provide broad overviews, while each of the additional twenty-eight has a focus on a research topic of more specific interest. The result is a thoroughly up-to-date account of initiation, elongation, and termination of translation, control mechanisms in development in response to extracellular stimuli, and the effects on the translation machinery of virus infection and disease. This book is essential reading for students entering the field and an invaluable resource for investigators of gene expression and its control.

The Physiological Importance of Translational Regulation of Ribosomal Proteins in Escherichia Coli

The Physiological Importance of Translational Regulation of Ribosomal Proteins in Escherichia Coli PDF Author: James Robert Cole
Publisher:
ISBN:
Category :
Languages : en
Pages : 338

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The Mechanism of Initiation of Protein Synthesis in E. Coli

The Mechanism of Initiation of Protein Synthesis in E. Coli PDF Author: Samuel D. Bernal
Publisher:
ISBN:
Category : Escherichia coli
Languages : en
Pages : 174

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