The regulation of HMG-CoA reductase by reversible phosphorylation PDF Download
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Author: Paul Robert Clarke
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Paul Robert Clarke
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Benjamin Preiss
Publisher: Elsevier
ISBN: 0323155146
Category : Nature
Languages : en
Pages : 343
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Book Description
Regulation of HMG-CoA Reductase is a nine-chapter text that focuses on the research developments in the regulation of HMG-CoA reductase enzyme and cholesterol biosynthesis. This book deals first with the role of cholesterol in the regulation of its own biosynthesis and the work involving compactin and related competitive inhibitors of HMG-CoA reductase. The subsequent chapters examine the reversible phosphorylation of HMG-CoA reductase in hormonal and other short-term physiological changes and the structure and properties of the enzyme, including evidence for modulation of enzyme activity and structure unrelated to phosphorylation. These topics are followed by discussions on the regulation of reductase in the biosynthesis of ubiquinone, dolichols, and isopentenyl-tRNA and the regulation of reductase activity in extrahepatic tissues. This text further explores the contributions made through the use of cultured cells and their genetic manipulation, with emphasis on the great potential of this approach. The concluding chapters address the status of the low-density lipoprotein pathway and related mechanisms. These chapters also consider the regulation of human hepatic HMG-CoA reductase and the special problems inherent in work with human tissues. Enzyme scientists and researchers and graduate students will find this book invaluable.
Author: Philip Cohen
Publisher: Elsevier-North-Holland Biomedical Press
ISBN:
Category : Science
Languages : en
Pages : 300
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Author: Thomas S. Ingebritsen
Publisher:
ISBN:
Category :
Languages : en
Pages : 12
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Author: Helen Hsin-I. Cheng
Publisher:
ISBN:
Category :
Languages : en
Pages : 398
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Author: Edward Bittar
Publisher: Elsevier
ISBN: 0080528740
Category : Science
Languages : en
Pages : 415
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Book Description
This volume illustrates the extent to which the traditional distinction between biochemical and physiological processes is being obliterated by molecular biology. It can hardly be doubted that the revolution in cell and molecular biology is leading to core knowledge that provides an outline of the integrative and reductionist approach. We view this as the beginning of a new era, that of the integration of learning. As in the preceding volumes, the choice of topics has been deliberate not only because of the need to keep the volume within reasonable bounds but also because of the need to avoid information over-load. Several relevant topics are dealt with in other modules; for example, the role of G proteins in transmembrane signalling is covered in the Membranes and Cell Signalling module (i.e., Volume 7). Omissions are of course inevitable but they are minor. A case in point is the subject of phosphatases, the treatment of which does not take into account calcineurin. One of the key functions of this Ca2+ -activated protein phosphatase that is also regulated by calmodulin is to desphosphorylate voltage-dependent Ca2+ channels. The mere recognition of such omissions before or after consulting textbooks and journals should be a spur to a more complete discussion by the student of the subject in a small group teaching setting.
Author: N. B. Myant
Publisher: Butterworth-Heinemann
ISBN: 148328123X
Category : Science
Languages : en
Pages : 925
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Book Description
The Biology of Cholesterol and Related Steroids focuses on the study of sterols in relation to living organisms. The publication first takes a look at the analysis of sterols and related steroids and the distribution of sterols and related steroids in nature, as well as the processes of extraction and separation and presence of sterols in plants, fungi, vertebrates, and invertebrates. The text then ponders on biosynthesis of sterols and metabolism of cholesterol. Topics include formation of fatty acid esters of cholesterol, steroid hormones, biosynthetic pathway to sterols, reaction mechanisms, and comparative aspects of sterol synthesis. The manuscript examines the developmental aspects of cholesterol metabolism and sterols in biological membranes. The book also reviews cholesterol synthesis in animal tissues, sterol metabolism in isolated cells, and epidemiology of the plasma cholesterol. Discussions focus on selection of statistical populations, genetic influences, regulation of sterol synthesis, general aspects of sterol metabolism, and removal of cell cholesterol in vivo. The publication is a dependable source of data for biochemists and readers interested in the biology of cholesterol and steroids.
Author: Keith N. Frayn
Publisher: John Wiley & Sons
ISBN: 1118685334
Category : Medical
Languages : en
Pages : 385
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Book Description
The important Third Edition of this successful book conveys a modern and integrated picture of metabolism and metabolic regulation. Explaining difficult concepts with unequalled clarity, author Keith Frayn provides the reader with an essential guide to the subject. Covering topics such as energy balance, body weight regulation and how the body copes with extreme situations, this book illustrates how metabolic regulation allows the human body to adapt to many different conditions. Changes throughout the new edition include: Extensive chapter updates Clear and accessible 2-color diagrams Q&A sections online at www.wiley.com/go/fraynto facilitate learning Frayn has written a book which will continue to be an extremely valuable tool for scientists, practitioners and students working and studying across a broad range of allied health sciences including medicine, biochemistry, nutrition, dietetics, sports science and nursing.
Author: Paul D. Boyer
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 536
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Book Description
Conteúdo: Structure and control.
Author: N Myant
Publisher: Elsevier
ISBN: 0323148875
Category : Science
Languages : en
Pages : 480
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Book Description
Cholesterol Metabolism, LDL, and the LDL Receptor focuses on the cholesterol biochemistry and lipoprotein metabolism. This book is organized into 10 chapters that describe the coordinated actions of three regulated processes, namely, the intracellular synthesis of cholesterol, its esterification by ACAT, and the receptor-mediated uptake of low-density lipoprotein (LDL), for optimal level of free cholesterol. The first five chapters explore the various aspects of cholesterol biology, including discussions on the interaction of ligands with their cell-surface receptors; the role of coated pits in the endocytosis of receptor-bound ligands; and the recycling of receptors through the interior of the cell. These chapters also examine the regulation of gene expression encoding inducible proteins and the use of natural and synthetic mutations in studies of the functions of the separate domains of a multifunctional protein. A chapter describes the cloning of the apoB gene, the receptor-binding domain of apoB-100, and the unusual mode of derivation of apoB-48. Considerable chapters are devoted to LDL receptor and its pathway. The concluding chapter deals with the clinical consequences of genetic dysfunction of the LDL receptor, with particular emphasis on the diagnostic and treatment approaches of familial hypercholesterolemia that are based wholly or in part on knowledge of the LDL receptor or its gene. This book is an indispensable guide for biologists, physiologists, and clinicians who are interested in the epidemiological field of cholesterol and heart attacks.
