The Origin of Chronic Inflammatory Systemic Diseases and their Sequelae

The Origin of Chronic Inflammatory Systemic Diseases and their Sequelae PDF Author: Rainer Straub
Publisher: Academic Press
ISBN: 0128033223
Category : Medical
Languages : en
Pages : 390

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Book Description
Chronic inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, inflammatory bowel diseases, and others typically stimulate a systemic response of the entire body. This response has a uniform character in many diseases because common pathways are switched on. The uniform response regulates systemic energy and water provision. However, long-term application of this program leads to typical disease sequelae such as fatigue / depressive symptoms, sleep disturbances, anorexia, malnutrition, muscle wasting – cachexia, cachectic obesity, insulin resistance, dyslipidemia, alterations of steroid hormone axes, disturbances of the hypothalamic-pituitary-gonadal axis, elevated sympathetic tone, hypertension, volume expansion, decreased parasympathetic tone, inflammation–related anemia, bone loss, hypercoagulability, circadian rhythms of symptoms, and disease exacerbation by stress . The Origin of Chronic Inflammatory Systemic Diseases and Their Sequelae demonstrates concepts of neuroendocrine immunology, energy and water regulation, and evolutionary medicine in order to show that the uniform response that regulates systemic energy and water provision, has been positively selected for acute physiological responses and short-lived disease states, but is a misguided program in chronic inflammatory diseases and aging. Offers a broad conceptual framework with a strong clinical link, written in an easy to grasp style and demonstrating the link to aging research Describes the important principles derived from basic immunology that are used to explain pathogenesis of chronic inflammatory systemic diseases with a focus on autoimmunity Defines the bioenergetics and energy regulation of the body explaining common response pathways typical for systemic inflammation Makes use of evolutionary medicine theory to demonstrate the uniformity of the systemic response Explains the appearance of typical disease sequelae on the basis of the three pillars: neuroendocrine immunology, energy regulation, and evolutionary medicine theory Contains color figures and tables that explain the field to newcomers

The Origin of Chronic Inflammatory Systemic Diseases and their Sequelae

The Origin of Chronic Inflammatory Systemic Diseases and their Sequelae PDF Author: Rainer Straub
Publisher: Academic Press
ISBN: 0128033223
Category : Medical
Languages : en
Pages : 390

Get Book

Book Description
Chronic inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, inflammatory bowel diseases, and others typically stimulate a systemic response of the entire body. This response has a uniform character in many diseases because common pathways are switched on. The uniform response regulates systemic energy and water provision. However, long-term application of this program leads to typical disease sequelae such as fatigue / depressive symptoms, sleep disturbances, anorexia, malnutrition, muscle wasting – cachexia, cachectic obesity, insulin resistance, dyslipidemia, alterations of steroid hormone axes, disturbances of the hypothalamic-pituitary-gonadal axis, elevated sympathetic tone, hypertension, volume expansion, decreased parasympathetic tone, inflammation–related anemia, bone loss, hypercoagulability, circadian rhythms of symptoms, and disease exacerbation by stress . The Origin of Chronic Inflammatory Systemic Diseases and Their Sequelae demonstrates concepts of neuroendocrine immunology, energy and water regulation, and evolutionary medicine in order to show that the uniform response that regulates systemic energy and water provision, has been positively selected for acute physiological responses and short-lived disease states, but is a misguided program in chronic inflammatory diseases and aging. Offers a broad conceptual framework with a strong clinical link, written in an easy to grasp style and demonstrating the link to aging research Describes the important principles derived from basic immunology that are used to explain pathogenesis of chronic inflammatory systemic diseases with a focus on autoimmunity Defines the bioenergetics and energy regulation of the body explaining common response pathways typical for systemic inflammation Makes use of evolutionary medicine theory to demonstrate the uniformity of the systemic response Explains the appearance of typical disease sequelae on the basis of the three pillars: neuroendocrine immunology, energy regulation, and evolutionary medicine theory Contains color figures and tables that explain the field to newcomers

Diseases of the Chest, Breast, Heart and Vessels 2019-2022

Diseases of the Chest, Breast, Heart and Vessels 2019-2022 PDF Author: Juerg Hodler
Publisher: Springer
ISBN: 3030111490
Category : Medical
Languages : en
Pages : 238

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Book Description
This open access book focuses on diagnostic and interventional imaging of the chest, breast, heart, and vessels. It consists of a remarkable collection of contributions authored by internationally respected experts, featuring the most recent diagnostic developments and technological advances with a highly didactical approach. The chapters are disease-oriented and cover all the relevant imaging modalities, including standard radiography, CT, nuclear medicine with PET, ultrasound and magnetic resonance imaging, as well as imaging-guided interventions. As such, it presents a comprehensive review of current knowledge on imaging of the heart and chest, as well as thoracic interventions and a selection of "hot topics". The book is intended for radiologists, however, it is also of interest to clinicians in oncology, cardiology, and pulmonology.

Periodontitis and Systemic Diseases

Periodontitis and Systemic Diseases PDF Author: Josefine Hirschfeld
Publisher: Quintessenz Verlag
ISBN: 3868675574
Category : Medical
Languages : en
Pages : 502

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Book Description
The association between periodontitis and systemic diseases has become a hot topic in recent years. This comprehensive book reviews the clinical evidence and biological plausibility of the many systemic diseases that have been linked to periodontitis. Edited by Dr Josefine Hirschfeld and Prof Iain L.C. Chapple, experts in each field discuss the mechanisms at work, citing the available key literature and clearly summarising current knowledge and understanding of the associations between periodontitis and diabetes mellitus, cardiovascular diseases, chronic kidney disease, inflammatory bowel diseases, rheumatoid arthritis, respiratory diseases, pregnancy and fertility, malignancy, neurodegenerative diseases, stress and depression, and autoimmunity. Each chapter critically appraises the existing evidence, providing comprehensive, contemporary and well-considered insights into the clinical evidence and biological plausibility of each condition, as well as the limitations of existing studies and how these can be overcome in the future. Periodontitis and Systemic Diseases: Clinical Evidence and Biological Plausibility is an indispensable reference for both clinicians and researchers.

Contemporary Oral Medicine

Contemporary Oral Medicine PDF Author: Camile S. Farah
Publisher: Springer
ISBN: 9783319723013
Category : Medical
Languages : en
Pages : 0

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Book Description
This book, written by world authorities in the field, is a comprehensive, up-to-date guide to the specialty of Oral Medicine, which is concerned with the diagnosis, prevention, and predominantly non-surgical management of medically related disorders and conditions affecting the oral and maxillofacial region. The pathophysiology, clinical presentation, diagnostic evaluation, and treatment of all relevant diseases and disorders are described with the aid of a wealth of clinical cases and illustrations that enable the reader to appreciate the diversity and potential complexity of Oral Medicine. In addition to the wide-ranging coverage of oral conditions, separate sections are devoted to bone and cutaneous pathology and to orofacial pain and its management, in addition to dental sleep medicine. The clinician who treats Oral Medicine patients will find this book to be an excellent aid to optimal management grounded in a sound knowledge of basic science and the dental and medical aspects of each disorder. In addition, it will serve as an outstanding textbook for undergraduate and postgraduate students.

Textbook of Clinical Otolaryngology

Textbook of Clinical Otolaryngology PDF Author: Abdulsalam Al-Qahtani
Publisher: Springer Nature
ISBN: 303054088X
Category : Medical
Languages : en
Pages : 759

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Book Description
This textbook provides a comprehensive overview of the state of the art in otolaryngology, discussing all the newly advances in the subspecialties of head and neck, plastics, otology, laryngology, rhinology and pediatrics, and also addressing topics like allergy, sleep medicine, trauma, and the fundamentals of systemic diseases that frequently manifest in the head and neck region. The book is divided into 9 sections, presenting the recent literature concerning all the subspecialties in otolaryngology and providing the information necessary for readers to gain an understanding of the field of otolaryngology. Each chapter includes definitions, key points and take-home messages, to aid learning. Throughout the book, tips and key features are highlighted with boxes, tables and figures, which the reader can refer back to for quick revision. Above all, the book enables medical students, residents and junior specialists in the field of ENT to develop their learning and surgical skills.

The Infectious Etiology of Chronic Diseases

The Infectious Etiology of Chronic Diseases PDF Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309089948
Category : Medical
Languages : en
Pages : 235

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Book Description
In recent years, a number of chronic diseases have been linked, in some cases definitively, to an infectious etiology: peptic ulcer disease with Helicobacter pylori, cervical cancer with several human papillomaviruses, Lyme arthritis and neuroborreliosis with Borrelia burgdorferi, AIDS with the human immunodeficiency virus, liver cancer and cirrhosis with hepatitis B and C viruses, to name a few. The proven and suspected roles of microbes does not stop with physical ailments; infections are increasingly being examined as associated causes of or possible contributors to a variety of serious, chronic neuropsychiatric disorders and to developmental problems, especially in children. The Infectious Etiology of Chronic Diseases: Defining the Relationship, Enhancing the Research, and Mitigating the Effects, summarizes a two-day workshop held by the Institute of Medicine's Forum on Microbial Threats to address this rapidly evolving field. Participants explored factors driving infectious etiologies of chronic diseases of prominence, identified difficulties in linking infectious agents with chronic outcomes, and discussed broad-based strategies and research programs to advance the field.

Oxford Handbook of Cardiology

Oxford Handbook of Cardiology PDF Author: Punit Ramrakha
Publisher: OUP Oxford
ISBN: 0191629987
Category : Medical
Languages : en
Pages : 876

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Book Description
Cardiovascular disease remains the major cause of morbidity and mortality throughout developed countries and is also rapidly increasing in developing countries. Cardiovascular medicine and the specialty of cardiology continue to expand, and the remit of the cardiologist is forever broader with the development of new sub-specialties. The Oxford Handbook of Cardiology provides a comprehensive but concise guide to all modern cardiological practice with an emphasis on practical clinical management in many different contexts. This second edition addresses all the key advances made in the field since the previous edition, including interventional cardiology, electrophysiology, and pharmacology. It expands the remit to medical students and the more junior doctor while retaining the level of detail required by more senior practitioners within the field.

Uncommon Causes of Stroke

Uncommon Causes of Stroke PDF Author: Julien Bogousslavsky
Publisher: Cambridge University Press
ISBN: 9780521771450
Category : Medical
Languages : en
Pages : 418

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Book Description
An essential resource for diagnosis and treatment of stroke patients outside the usual clinical categories.

Guideline: Sugars Intake for Adults and Children

Guideline: Sugars Intake for Adults and Children PDF Author: World Health Organization
Publisher: World Health Organization
ISBN: 9241549025
Category : Health & Fitness
Languages : en
Pages : 59

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Book Description
This guideline provides updated global, evidence-informed recommendations on the intake of free sugars to reduce the risk of NCDs in adults and children, with a particular focus on the prevention and control of unhealthy weight gain and dental caries. The recommendations in this guideline can be used by policy-makers and programme managers to assess current intake levels of free sugars in their countries relative to a benchmark. They can also be used to develop measures to decrease intake of free sugars, where necessary, through a range of public health interventions. Examples of such interventions and measures that are already being implemented by countries include food and nutrition labelling, consumer education, regulation of marketing of food and non-alcoholic beverages that are high in free sugars, and fiscal policies targeting foods and beverages that are high in free sugars. This guideline should be used in conjunction with other nutrient guidelines and dietary goals, in particular those related to fats and fatty acids (including saturated fatty acids and trans-fatty acids), to guide development of effective public health nutrition policies and programmes to promote a healthy diet.

Interventional Inflammatory Bowel Disease: Endoscopic Management and Treatment of Complications

Interventional Inflammatory Bowel Disease: Endoscopic Management and Treatment of Complications PDF Author: Bo Shen
Publisher: Academic Press
ISBN: 0128113898
Category : Medical
Languages : en
Pages : 380

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Book Description
Interventional Inflammatory Bowel Diseases: Endoscopic Management and Treatment of Complications covers the preparation, principle, techniques, and damage control of complications in endoscopic therapy, providing the ultimate guidance in endoscopic management of IBD. With contributions from a panel of international leading experts in the field, perspectives are included from GI pathologists, GI radiologists, gastroenterologists, advanced endoscopists, IBD specialists and colorectal surgeons. Recommendations from experts are also included within each chapter. By bridging medical and surgical treatment modalities for IBD, this is the perfect reference for GI researchers, medical students, therapeutic GI endoscopists, IBD specialists, surgeons and advanced health care providers. Incorporates state-of-the-art of research in the area of therapeutic endoscopy in Crohn’s Disease and Ulcerative Colitis Makes the connection between the understanding of the complex nature and disease course of IBD with corresponding advanced endoscopic procedures Explores endoscopic treatment as the missing link between medical and surgical treatment for complex Crohn’s Disease and Ulcerative Colitis Contains access to videos demonstrating important procedural concepts