The Nonparametric Least-squares Method for Estimating Monotone Functions with Interval-censored Observations PDF Download
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Author: Gang Cheng
Publisher:
ISBN:
Category : Estimation theory
Languages : en
Pages : 159
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Book Description
The theory of modern empirical process is applied to prove the consistency of the proposed NPLSE. Simulation studies are extensively carried out to provide numerical evidence for the validity of the NPLSE. The proposed estimation method is applied to two real scientific applications. For the first application, California Partners' Study, we estimate the distribution function of HIV transmission time between two partners. In the second application, the NPLSEs of the mean functions of tumor growth are estimated for tumors with different stages at diagnosis based on the data from a cancer surveillance program, the SEER program. An ad-hoc nonparametric statistic is designed to test the difference between two monotone functions under this context. In this dissertation, we also propose a numerical algorithm, the projected Newton-Raphson algorithm, to compute the non- and semi-parametric estimate for the M-estimation problems subject to linear equality or inequality constraints. By combining the Newton-Raphson algorithm and the dual method for strictly convex quadratic programming, the projected Newton-Raphson algorithm shows the desired convergence rate. Compared to the well-known iterative convex minorant algorithm, the projected Newton-Raphson algorithm achieves much quicker convergence when computing the non- and semi-parametric maximum likelihood estimate of panel count data.
Author: Gang Cheng
Publisher:
ISBN:
Category : Estimation theory
Languages : en
Pages : 159
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Book Description
The theory of modern empirical process is applied to prove the consistency of the proposed NPLSE. Simulation studies are extensively carried out to provide numerical evidence for the validity of the NPLSE. The proposed estimation method is applied to two real scientific applications. For the first application, California Partners' Study, we estimate the distribution function of HIV transmission time between two partners. In the second application, the NPLSEs of the mean functions of tumor growth are estimated for tumors with different stages at diagnosis based on the data from a cancer surveillance program, the SEER program. An ad-hoc nonparametric statistic is designed to test the difference between two monotone functions under this context. In this dissertation, we also propose a numerical algorithm, the projected Newton-Raphson algorithm, to compute the non- and semi-parametric estimate for the M-estimation problems subject to linear equality or inequality constraints. By combining the Newton-Raphson algorithm and the dual method for strictly convex quadratic programming, the projected Newton-Raphson algorithm shows the desired convergence rate. Compared to the well-known iterative convex minorant algorithm, the projected Newton-Raphson algorithm achieves much quicker convergence when computing the non- and semi-parametric maximum likelihood estimate of panel count data.
Author: Ding-Geng (Din) Chen
Publisher: CRC Press
ISBN: 1466504250
Category : Mathematics
Languages : en
Pages : 435
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Book Description
Interval-Censored Time-to-Event Data: Methods and Applications collects the most recent techniques, models, and computational tools for interval-censored time-to-event data. Top biostatisticians from academia, biopharmaceutical industries, and government agencies discuss how these advances are impacting clinical trials and biomedical research. Divided into three parts, the book begins with an overview of interval-censored data modeling, including nonparametric estimation, survival functions, regression analysis, multivariate data analysis, competing risks analysis, and other models for interval-censored data. The next part presents interval-censored methods for current status data, Bayesian semiparametric regression analysis of interval-censored data with monotone splines, Bayesian inferential models for interval-censored data, an estimator for identifying causal effect of treatment, and consistent variance estimation for interval-censored data. In the final part, the contributors use Monte Carlo simulation to assess biases in progression-free survival analysis as well as correct bias in interval-censored time-to-event applications. They also present adaptive decision making methods to optimize the rapid treatment of stroke, explore practical issues in using weighted logrank tests, and describe how to use two R packages. A practical guide for biomedical researchers, clinicians, biostatisticians, and graduate students in biostatistics, this volume covers the latest developments in the analysis and modeling of interval-censored time-to-event data. It shows how up-to-date statistical methods are used in biopharmaceutical and public health applications.
Author: Aaron Kenji Aragaki
Publisher:
ISBN:
Category :
Languages : en
Pages : 336
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Book Description
Author: Jianguo Sun
Publisher: Springer
ISBN: 0387371192
Category : Mathematics
Languages : en
Pages : 310
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Book Description
This book collects and unifies statistical models and methods that have been proposed for analyzing interval-censored failure time data. It provides the first comprehensive coverage of the topic of interval-censored data and complements the books on right-censored data. The focus of the book is on nonparametric and semiparametric inferences, but it also describes parametric and imputation approaches. This book provides an up-to-date reference for people who are conducting research on the analysis of interval-censored failure time data as well as for those who need to analyze interval-censored data to answer substantive questions.
Author: Jerald F. Lawless
Publisher: John Wiley & Sons
ISBN: 1118031253
Category : Mathematics
Languages : en
Pages : 662
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Book Description
Praise for the First Edition "An indispensable addition to any serious collection on lifetime data analysis and . . . a valuable contribution to the statistical literature. Highly recommended . . ." -Choice "This is an important book, which will appeal to statisticians working on survival analysis problems." -Biometrics "A thorough, unified treatment of statistical models and methods used in the analysis of lifetime data . . . this is a highly competent and agreeable statistical textbook." -Statistics in Medicine The statistical analysis of lifetime or response time data is a key tool in engineering, medicine, and many other scientific and technological areas. This book provides a unified treatment of the models and statistical methods used to analyze lifetime data. Equally useful as a reference for individuals interested in the analysis of lifetime data and as a text for advanced students, Statistical Models and Methods for Lifetime Data, Second Edition provides broad coverage of the area without concentrating on any single field of application. Extensive illustrations and examples drawn from engineering and the biomedical sciences provide readers with a clear understanding of key concepts. New and expanded coverage in this edition includes: * Observation schemes for lifetime data * Multiple failure modes * Counting process-martingale tools * Both special lifetime data and general optimization software * Mixture models * Treatment of interval-censored and truncated data * Multivariate lifetimes and event history models * Resampling and simulation methodology
Author: Thomas Kailath
Publisher: Hutchinson Ross Publishing Company
ISBN:
Category : Mathematics
Languages : en
Pages : 344
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Book Description
A survey of the field; Mathematical foundations of least-squares prediction theory; Wiener-hopf equations and optimum filters; State-space models and recursive filters.
Author: Li Ding
Publisher:
ISBN:
Category :
Languages : en
Pages : 182
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Book Description
Author:
Publisher:
ISBN:
Category : Aeronautics
Languages : en
Pages : 938
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Book Description
Author: Mikhail S. Nikulin
Publisher: John Wiley & Sons
ISBN: 1786300001
Category : Mathematics
Languages : en
Pages : 160
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Book Description
This book is devoted to the problems of construction and application of chi-squared goodness-of-fit tests for complete and censored data. Classical chi-squared tests assume that unknown distribution parameters are estimated using grouped data, but in practice this assumption is often forgotten. In this book, we consider modified chi-squared tests, which do not suffer from such a drawback. The authors provide examples of chi-squared tests for various distributions widely used in practice, and also consider chi-squared tests for the parametric proportional hazards model and accelerated failure time model, which are widely used in reliability and survival analysis. Particular attention is paid to the choice of grouping intervals and simulations. This book covers recent innovations in the field as well as important results previously only published in Russian. Chi-squared tests are compared with other goodness-of-fit tests (such as the Cramer-von Mises-Smirnov, Anderson-Darling and Zhang tests) in terms of power when testing close competing hypotheses.
Author: Vilijandas Bagdonavicius
Publisher: John Wiley & Sons
ISBN: 1118602137
Category : Mathematics
Languages : en
Pages : 162
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Book Description
This book concerns testing hypotheses in non-parametric models. Generalizations of many non-parametric tests to the case of censored and truncated data are considered. Most of the test results are proved and real applications are illustrated using examples. Theories and exercises are provided. The incorrect use of many tests applying most statistical software is highlighted and discussed.
