The Induction of Mutation in Synchronously Dividing Cultures of Saccharomyces Cerevisiae by Ultraviolet Irradiation PDF Download
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Author: Carol Ann Schissler
Publisher:
ISBN:
Category : Saccharomyces cerevisiae
Languages : en
Pages : 0
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Mitotic synchrony was induced by a starvation technique in a haploid adenine-requiring strain of Saccharomyces cerevisiae. Periodic samples taken from synchronous cultures were irradiated with a constant dose of ultra-violet light and plated to determine survival rates and rates of mutation affecting adenine biosynthesis. Microscopical observation of synchronized populations showed that the budding phase coincides with the period of peak sensitivity to induced mutation. Williamson and Scopes, using a similar system, have demonstrated that DNA synthesis occurs during the time of bud formation; therefore it is proposed that increased mutability is associated with the DNA replication process.
Author: Carol Ann Schissler
Publisher:
ISBN:
Category : Saccharomyces cerevisiae
Languages : en
Pages : 0
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Book Description
Mitotic synchrony was induced by a starvation technique in a haploid adenine-requiring strain of Saccharomyces cerevisiae. Periodic samples taken from synchronous cultures were irradiated with a constant dose of ultra-violet light and plated to determine survival rates and rates of mutation affecting adenine biosynthesis. Microscopical observation of synchronized populations showed that the budding phase coincides with the period of peak sensitivity to induced mutation. Williamson and Scopes, using a similar system, have demonstrated that DNA synthesis occurs during the time of bud formation; therefore it is proposed that increased mutability is associated with the DNA replication process.
Author:
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ISBN:
Category : Medicine
Languages : en
Pages : 1020
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Category : Nuclear energy
Languages : en
Pages : 658
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Author: W. Generoso
Publisher: Springer Science & Business Media
ISBN: 1468438425
Category : Medical
Languages : en
Pages : 450
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Not many years ago most discussion of mutation induction by physical and chemical agents concentrated on the initial lesions induced in the DNA with the implicit assumption that once the lesions were made they were converted almost automatically to mutations by relatively simple processes associated with DNA replication. The discovery of a variety of enzymatic processes that can repair these lesions, the great increase in our understanding of the molecular steps involved in repair, replication, and recombination, and the increasing availability of cells with genetic defects in these pro cesses have led to the realization that mutation induction is a far more complex process than we originally thought. Repair systems can remove lesions before they can be converted to mutation, they can also convert initial lesions to secondary ones that are them selves mutagenic, and they can remove potentially lethal lesions at the expense of making mutations. The error-avoiding systems asso ciated with replication are themselves complex and may be caused to make mistakes in various ways. These different pathways for mutation production and mutation avoidance are still being worked out in prokaryotes and are less well understood in eukaryotes. This symposium shows, however, that very encouraging progress has been made in the last several years, and the progress is now accelerating.
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Category : Algology
Languages : en
Pages : 922
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Category : Agriculture
Languages : en
Pages : 1732
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Category : Nuclear energy
Languages : en
Pages : 1028
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Author: National Institutes of Health (U.S.). Division of Research Grants
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ISBN:
Category : Medicine
Languages : en
Pages : 1016
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Author: National Library of Canada
Publisher:
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Category : Dissertations, Academic
Languages : en
Pages : 266
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Author: United States. Energy Research and Development Administration
Publisher:
ISBN:
Category : Power resources
Languages : en
Pages : 716
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