The Immunological Consequences of Regulated Cell Death in Infection and Inflammation PDF Download
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Author: Bart Tummers
Publisher: Frontiers Media SA
ISBN: 2832505317
Category : Medical
Languages : en
Pages : 165
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Book Description
Author: Bart Tummers
Publisher: Frontiers Media SA
ISBN: 2832505317
Category : Medical
Languages : en
Pages : 165
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Book Description
Author: Thomas Kaufmann
Publisher: Frontiers Media SA
ISBN: 288963695X
Category :
Languages : en
Pages : 134
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Book Description
Programmed cell death (PCD) is central in maintaining the life of multicellular organisms, during development as well as in healthy adulthood or in the context of disease. The best understood form of PCD is apoptosis, a caspase mediated, immunologically silent cell death that can be initiated in probably all cell types upon aging, lack of growth support, critical damage or infection. One of the key pathways of apoptosis involves mitochondrial outer membrane permeabilization (MOMP), a process tightly regulated by members of the BCL-2 family. Whereas PCD and apoptosis were used synonymously in the past, other forms of PCD have been discovered more recently, including RIPK1/3- and MLKL-dependent necroptosis, resulting in a necrotic phenotype, and pyroptosis. Interestingly, key components of the necroptotic pathway are actively suppressed by apoptotic caspases, and this interconnection allows a switch in cell death modalities with greatly impact on the host’s immune response. Recent findings link mitochondria and/or MOMP to non-apoptotic forms of PCD, including ferroptosis and necroptosis, putting this organelle even more in the center of cellular death. This article collection highlights the exciting potential and as yet undiscovered regulation of programmed cell death that can impact the immune system and its response.
Author: S.-Y. Seong
Publisher: Frontiers Media SA
ISBN: 2889743543
Category : Medical
Languages : en
Pages : 138
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Book Description
Author: Jixin Zhong
Publisher: Frontiers Media SA
ISBN: 2889459160
Category :
Languages : en
Pages : 580
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Book Description
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author: Christian Maueröder
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: James Winkler
Publisher: Springer Science & Business Media
ISBN: 9783764357955
Category : Medical
Languages : en
Pages : 268
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Book Description
Apoptosis is a form of cell death that occurs in a controlled manner and is generally noninflammatory in nature. Apoptosis, or programmed cell death, implies a cell death that is part of a normal physiological process of pruning of unneeded cells. However, many disease conditions utilize apoptosis for pathological ends, resulting in inappropriate cell death and tissue destruction. This book starts with an introduction that reviews the general characteristics of apoptosis, its regulation and its role in physiology and disease. Next, the book focuses on three areas as they relate to inflammatory cells and diseases. The first area consists of chapters on signals for apoptosis important to inflammatory cells, namely growth factors and arachidonic acid metabolism. The next area that the book focuses on are effects at the cellular level, on cell survival versus cell death and signals critical for cell function in both normal and disease states. These topics are covered in chapters on lymphocytes, granulocytes, chondrocytes and keratinocytes. The last area that the book focuses on are events at the level of tissue and disease, looking at the evidence for altered apoptosis and/or apoptotic processes in immune and inflammatory diseases. These topics are covered in chapters on rheumatoid arthritis, osteoarthritis, lupus, psoriasis and renal disease. Together, these chapters will provide the reader with the latest insight in the role of apoptosis in inflammatory cells and diseases. This book starts with an introduction that reviews the general characteristics of apoptosis, its regulation and its role in physiology and disease. Next, the book focuses on three areas as they relate to inflammatory cells and diseases. The first area consists of chapters on signals for apoptosis important to inflammatory cells, namely growth factors and arachidonic acid metabolism. The next area that the book focuses on are effects at the cellular level, on cell survival versus cell death and signals critical for cell function in both normal and disease states. These topics are covered in chapters on lymphocytes, granulocytes, chondrocytes and keratinocytes. The last area that the book focuses on are events at the level of tissue and disease, looking at the evidence for altered apoptosis and/or apoptotic processes in immune and inflammatory diseases. These topics are covered in chapters on rheumatoid arthritis, osteoarthritis, lupus, psoriasis and renal disease. Together, these chapters will provide the reader with the latest insight in the role of apoptosis in inflammatory cells and diseases.
Author: John C. Marshall
Publisher: Springer Science & Business Media
ISBN: 9783540425892
Category : Medical
Languages : en
Pages : 458
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Book Description
This book brings together basic scientists or clinicians from a variety of different backgrounds - immunology, infectious diseases or critical care - who share a common interest in understanding the changes that occur in immune responses in sepsis. It provides an up-to-date and unrivalled synthesis of current research in this rapidly developing field.
Author: Kuo-Feng Hua
Publisher: Frontiers Media SA
ISBN: 2889716023
Category : Medical
Languages : en
Pages : 376
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Book Description
Author: Bharat B. Aggarwal
Publisher: Springer
ISBN: 3034808372
Category : Medical
Languages : en
Pages : 489
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Book Description
This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
Author: Todd Douglas
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
"Inflammation and programmed cell death are key outcomes of innate immune activation that are protective during infection, tissue damage, and metabolic stress. A network of tightly regulated molecular events is triggered by engagement of innate immune receptors, which ensures the integration of internal and external signals that dictate the appropriate signaling output. Perturbation of these regulatory mechanisms results in a predisposition to infection, cancer, and inflammatory disease. Modification of cellular substrates with linear polyubiquitin chains is one key regulatory step downstream various innate receptors that tends to induce pro-inflammatory gene expression and limit apoptotic and necroptotic cell death. These chains are synthesized uniquely by the linear ubiquitin assembly complex (LUBAC) and disassembled by the deubiquitinase OTULIN. Importantly, loss-of-function mutations in LUBAC components and OTULIN yield potentially fatal autoinflammatory disease in both mice and man. For example, mice deficient in the LUBAC adaptor Sharpin spontaneously develop chronic proliferative dermatitis (cpdm). Despite their pivotal role in homeostasis and disease, little is known about how cells control the activity of the linear ubiquitin machinery. This thesis examines the molecular events that regulate LUBAC and OTULIN function during cell death, and how these events dictate cellular fate. We first began our studies investigating cpdm mice and discovered that the danger-sensing innate receptor NLRP3 and effector proteases caspase-1/11 were key drivers of dermatitis by promoting epidermal cell death and cytokine production. We found that LUBAC-deficient keratinocytes displayed hyperactive caspase-1, which was readily modified with linear polyubiquitin upon overexpression with LUBAC. Caspases conversely cleaved HOIP, the catalytic LUBAC component, during apoptosis, impeding substrate ubiquitination and promoting cell death. Finally, we identified OTULIN as a pro-survival factor whose depletion in keratinocytes enhanced susceptibility to apoptosis and necroptosis. We found that OTULIN was cleaved during apoptosis and phosphorylated during necroptosis and described how these two events distinctly influence cell death outcome. Collectively, this thesis uncovers an inhibitory cross-regulation between LUBAC and caspase-1 and expands our understanding of how cells fine-tune cell death decisions through the post-translational modification of the linear ubiquitin machinery. These findings represent a necessary stepping-stone on the long path to the development of personalized therapeutics"--
