The Guide to Investigation of Mouse Pregnancy PDF Download
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Author: B. Anne Croy
Publisher: Academic Press
ISBN: 0123947944
Category : Science
Languages : en
Pages : 829
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Book Description
The Guide to Investigation of Mouse Pregnancy is the first publication to cover the mouse placenta or the angiogenic tree the mother develops to support the placenta. This much-needed resource covers monitoring of the cardiovascular system, gestational programming of chronic adult disease, epigenetic regulation, gene imprinting, and stem cells. Offering detailed and integrated information on how drugs, biologics, stress, and manipulations impact pregnancy in the mouse model, this reference highlights techniques used to analyze mouse pregnancy. Joining the ranks of much referenced mouse resources, The Guide to Investigation of Mouse Pregnancy is the only manual providing needed content on pregnancy in animal models for translational medicine and research. - Provides instruction on how to collect pre-clinical data on pregnancy in mouse models for eventual use in human applications - Describes the angiogenic tree the mother's uterus develops to support pregnancy and the monitoring of pregnancy-induced cardiovascular changes - Educates readers on placental cell lineages, decidual development including immune cells, epigenetic regulation, gene imprinting, stem cells, birth and lactation - Discusses how stress, environmental toxicants and other manipulations impact upon placental function and pregnancy success
Author: B. Anne Croy
Publisher: Academic Press
ISBN: 0123947944
Category : Science
Languages : en
Pages : 829
Get Book Here
Book Description
The Guide to Investigation of Mouse Pregnancy is the first publication to cover the mouse placenta or the angiogenic tree the mother develops to support the placenta. This much-needed resource covers monitoring of the cardiovascular system, gestational programming of chronic adult disease, epigenetic regulation, gene imprinting, and stem cells. Offering detailed and integrated information on how drugs, biologics, stress, and manipulations impact pregnancy in the mouse model, this reference highlights techniques used to analyze mouse pregnancy. Joining the ranks of much referenced mouse resources, The Guide to Investigation of Mouse Pregnancy is the only manual providing needed content on pregnancy in animal models for translational medicine and research. - Provides instruction on how to collect pre-clinical data on pregnancy in mouse models for eventual use in human applications - Describes the angiogenic tree the mother's uterus develops to support pregnancy and the monitoring of pregnancy-induced cardiovascular changes - Educates readers on placental cell lineages, decidual development including immune cells, epigenetic regulation, gene imprinting, stem cells, birth and lactation - Discusses how stress, environmental toxicants and other manipulations impact upon placental function and pregnancy success
Author: Brad Bolon
Publisher: CRC Press
ISBN: 1420070096
Category : Medical
Languages : en
Pages : 446
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Book Description
Pathology of the Developing Mouse provides, in so far as feasible, one complete reference on the design, analysis, and interpretation of abnormal findings that may be detected in developing mice before and shortly after birth. In particular, this book is designed specifically to be not only a "how to do" manual for developmental pathology expe
Author: Felice Petraglia
Publisher: Cambridge University Press
ISBN: 1316516660
Category : Health & Fitness
Languages : en
Pages : 219
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Book Description
Summarizes the role of hormones in pregnancy and how to manage gestational disorders in patients.
Author: Gillian Morriss-Kay
Publisher: Elsevier
ISBN: 0443237387
Category : Science
Languages : en
Pages : 668
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Book Description
Kaufman's Atlas of Mouse Development Supplement, Second Edition continues the stellar reputation of the original Atlas by providing updated, in-depth anatomical content and morphological views of organ systems. The book explores the developmental origins of the organ systems, following the original atlas as a continuation of the standard in the field for developmental biologists and researchers across biological and biomedical sciences studying mouse development. In this new edition, each chapter has been updated to include the latest research, along with while new chapters on the functional aspects of mouse and human heart development, the immune system, and the inner ear. These additions ensure an up-to-date resource for all biomedical scientists who use the mouse as a model species for understanding the normal and abnormal development of human systems. - Offers in-depth anatomy and morphological views of organ systems and their developmental origins - Includes the latest techniques for visualizing gene expression and other functional aspects of tissue and organ development - Explores the links between mouse and human developmental processes - Features high-quality color images to help readers visualize key developmental processes and structures
Author: John P. Sundberg
Publisher: John Wiley & Sons
ISBN: 1119624576
Category : Medical
Languages : en
Pages : 564
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Book Description
An updated and comprehensive reference to pathology in every organ system in genetically modified mice The newly revised and thoroughly updated Second Edition of Pathology of Genetically Engineered and Other Mutant Mice delivers a comprehensive resource for pathologists and biomedical scientists tasked with identifying and understanding pathologic changes in genetically modified mice. The book is organized by body system, includes descriptions and explanations of a wide range of findings, as well as hundreds of color photographs illustrating both common and rare lesions that may be found in genetically engineered and wild type mice. The book is written by experienced veterinary and medical pathologists working in veterinary medical colleges, medical colleges, and research institutes. Covering the latest discoveries in mouse pathology resulting from advancements in biotechnology research over the last 30 years, this singular and accessible resource is a must-read for veterinary and medical pathologists and researchers working with genetically engineered and other mice. Readers will also benefit from: A thorough introduction to mouse pathology and mouse genetic nomenclature, as well as databases useful for analysis of mutant mice An exploration of concepts related to validating animal models, including the Cinderella Effect Practical discussions of basic necropsy methods and grading lesions for computational analyses Concise diagnostic approaches to the respiratory tract, the oral cavity and GI tract, the cardiovascular system, the liver and pancreas, the skeletal system, and other tissues As a one-stop and up to date reference on mouse pathology, Pathology of Genetically Engineered and Other Mutant Mice is an essential book for veterinary and medical pathologists, as well as for scientists, researchers, and toxicologists whose work brings them into contact with genetically modified mice.
Author: Rana Dajani
Publisher: Frontiers Media SA
ISBN: 2832505260
Category : Science
Languages : en
Pages : 220
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Book Description
Author: Martin Flajnik
Publisher: Lippincott Williams & Wilkins
ISBN: 1975142527
Category : Medical
Languages : en
Pages : 3597
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Book Description
Selected as a Doody's Core Title for 2022! Defining the field of immunology for 40 years, Paul’s Fundamental Immunology continues to provide detailed, authoritative, up-to-date information that uniquely bridges the gap between basic immunology and the disease process. The fully revised 8th edition maintains the excellence established by Dr. William E. Paul, who passed away in 2015, and is now under new editorial leadership of Drs. Martin F. Flajnik, Nevil J. Singh, and Steven M. Holland. It’s an ideal reference and gold standard text for graduate students, post-doctoral fellows, basic and clinical immunologists, microbiologists and infectious disease physicians, and any physician treating diseases in which immunologic mechanisms play a role.
Author: Virginia Hayssen
Publisher: JHU Press
ISBN: 1421423162
Category : Science
Languages : en
Pages : 369
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Book Description
A fascinating look at the diverse reproductive strategies of numerous female mammals, from hyenas to goats, kangaroos to whales. Newborn mammals can weigh as little as a dime or as much as a motorcycle. Some receive milk for only a few days, whereas others nurse for years. Humans typically have only one baby at a time following nine months of pregnancy, but other mammals have twenty or more young after only a few weeks in utero. What causes this incredible reproductive diversity? In Reproduction in Mammals, Virginia Hayssen and Teri J. Orr present readers with a fascinating examination of the varied reproductive strategies of a broad spectrum of mammals, from marsupials to whales. This unique book's comprehensive coverage gathers stories from many taxa into a single, cohesive perspective that centers on the reproductive lives of females. The authors shed light on a number of intriguing questions, including • do bigger moms have bigger babies? • do primates have longer pregnancies than other groups? • does habitat influence animals' reproductive patterns? • do carnivores typically produce larger litters than prey species? The book opens with the authors' definition of what constitutes a female perspective and an examination of the evolution of reproduction in mammals. It then outlines the typical individual mammalian female: her genetics, anatomy, and physiology. Taking a nuanced approach, Hayssen and Orr describe the female reproductive cycle and explore female mammals' interactions with males and offspring. Readers will come away from this thought-provoking book with an understanding of not only how reproduction fits into the lives of female mammals but also how biology has affected the enormously diverse reproductive patterns of the phenotypes we observe today.
Author: Demba Sarr
Publisher: Frontiers Media SA
ISBN: 2889662403
Category : Science
Languages : en
Pages : 150
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Book Description
Pregnancy is a physiologically and immunologically challenging health state. Immunological and physiological changes throughout the course of pregnancy make pregnant women usually susceptible to infection with microbial agents. Infections with pathogens during pregnancy can have devastating consequences to both the fetus and his/her mother. These infections are linked with adverse pregnancy outcomes. Infections with parasites, viruses, or bacteria can be associated with maternal anemia, abortion, intrauterine growth retardation, preterm delivery, fetal morbidity and high risk of mortality during the first years of life. Despite these significant consequences and complications associated with infections by microbial pathogens during the course of gestation, very little is known about the underlying mechanisms of the pathogenesis and immunopathology of infections during pregnancy. The Research Topic proposed here in, will focus on microbial infections during pregnancy. Studies and review papers addressing the pregnant host/fetus/pathogen interactions, the host/fetus immunological response against infections during gestation, trans-placental transfer of infections during pregnancy are welcome. Topics related to model systems used to mirror the biology in human, the pathogenesis and molecular pathways as well as the mechanisms of the disease at the maternofetal interface including the placenta, the amniotic fluid, and the fetal membranes will be considered making the scope and interest of the topic relatively broad. There is a growing number of pathogens associated with pregnancy. In most cases, women are more susceptible to infections with these pathogens when they become pregnant in comparison to their non-pregnant counterparts. Unfortunately, vertical transmission occurs in most cases but the underlying mechanisms are still unknown. The placenta has always been considered as a barrier against congenital infections but studies have indicated that microbial pathogens breach this barrier. The amniotic fluid, and the fetal membranes are also important components of vertical transmission because of their non-sterile state even in most healthy pregnancies. During pregnancy, infections by malaria or toxoplasmosis as well as other viral or bacterial pathogens lead to an uncontrolled inflammatory response recognized as a significant cause for preterm delivery and intra uterine growth retardation leading to low birth weight, a risk factor to infant morbidity and mortality. To successfully prevent, treat, eradicate or educate about microbial infections during pregnancy, we must understand the molecular mechanisms by which they cause poor birth outcomes including how vertical transmission occurs at the maternofetal interface.
Author: Silas Boye Nissen
Publisher: Niels Bohr Institute, Faculty of Science, University of Copenhagen
ISBN:
Category : Science
Languages : en
Pages : 319
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Book Description
Part 1: How are the incredible diversity and robustness compatible with animal morphologies? Based on apical-basal and planar cell polarities’ ubiquity, I suggest a 3D mathematical model: Point particles represent cells having zero, one, or two unit-arrows representing polarities. I test the model abilities on preimplantation development, sea urchin gastrulation, mammalian neurulation, organoid folding, and tubulogenesis. I find that a minimal, versatile toolbox, including cellular polarities, captures the emergence of diverse and robust animal morphologies. Part 2: How are deep convective events spatially organized in the tropical atmosphere? Here, I test the importance of atmospheric cold pools for organizing convection. I suggest a 2D mathematical model: Points expand into circles representing cold pools. When circles meet, a convective event occurs, and a new circle forms. I find this model captures convective scale increase and initial stages of convective self-aggregation. The latter is crucial due to its link to tropical cyclogenesis.
