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Author: A.N. Worden
Publisher: Springer Science & Business Media
ISBN: 9400932014
Category : Medical
Languages : en
Pages : 309
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Book Description
Reproduction and fetal development in humans and experimental animals may be adversely affected by a wide range of drugs and environmental agents. They may be toxic in the parental generation leading to impaired germ cell formation, loss of reproductive poten tial and infertility following chronic exposure. Deviant fetal development occurs as a consequence of cellular damage at sensi tive stages in development. Changes seen range from intrauterine mortality and structural malformation to growth retardation with physiological and behavioural defects. Concepts on the mechanism of action of teratogens are discussed with reference to some better-known agents. Presently, regulatory authorities prefer whole animal studies in predictive safety evaluation of substances to which a pregnant woman may be exposed. Tests are conducted over one or more generations and are designed to study the influence of test com pounds upon general reproductive performance, fertility, fetal development and perinatal and postnatal behaviour. Experiments are designed to permit compounds to be tested under conditions resembling expected human exposure. Small rodents and rabbits are preferred species on account of their convenience as laboratory animals and the available knowledge regarding their reproductive behaviour, fetal development and known sensitivity to human teratogens.
Author: A.N. Worden
Publisher: Springer Science & Business Media
ISBN: 9400932014
Category : Medical
Languages : en
Pages : 309
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Book Description
Reproduction and fetal development in humans and experimental animals may be adversely affected by a wide range of drugs and environmental agents. They may be toxic in the parental generation leading to impaired germ cell formation, loss of reproductive poten tial and infertility following chronic exposure. Deviant fetal development occurs as a consequence of cellular damage at sensi tive stages in development. Changes seen range from intrauterine mortality and structural malformation to growth retardation with physiological and behavioural defects. Concepts on the mechanism of action of teratogens are discussed with reference to some better-known agents. Presently, regulatory authorities prefer whole animal studies in predictive safety evaluation of substances to which a pregnant woman may be exposed. Tests are conducted over one or more generations and are designed to study the influence of test com pounds upon general reproductive performance, fertility, fetal development and perinatal and postnatal behaviour. Experiments are designed to permit compounds to be tested under conditions resembling expected human exposure. Small rodents and rabbits are preferred species on account of their convenience as laboratory animals and the available knowledge regarding their reproductive behaviour, fetal development and known sensitivity to human teratogens.
Author: D.V. Parke
Publisher: Springer Science & Business Media
ISBN: 9400941390
Category : Medical
Languages : en
Pages : 226
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Book Description
A. N. WORDEN, D. V. PARKE AND J. MARKS THE BACKGROUND There is nothing new about the fact that chemical substances derived either from natural products or by synthetic means .. can give rise to toxicity in animals and human beings, and that they must be subjected to controls. The earliest writings speak of such toxicity and, from the times of ancient Egypt and in the Old Tes tament, controls have existed[l]. In the Middle Ages Paracelsus (1493-1541) noted that "All things are poisons, for there is nothing without poisonous qualities. It is only the dose which makes a thing a poison", and hence he stressed the importance of dose relative to toxic reactions [ 2] . Most of the early controls concentrated on substances that were to be deliberately administered to the human subject in the form of medicines. Legislation for many centuries was mainly con cerned with regulating the activities of apothecaries and physicians. The Royal College of Physicians, for example, was originally established to control the activities of physicians within London. Among the controls which it exerted was that over the use of medicinal substances. Such controls were, however, poor, based as they were on hearsay evidence of toxicity. For many centuries no means existed for the accurate determination of toxicity.
Author: Sarfaraz K. Niazi
Publisher: CRC Press
ISBN: 1000458164
Category : Medical
Languages : en
Pages : 620
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Book Description
Before now, biological systems could only be expressed in terms of linear relationships, however, as knowledge grows and new techniques of analysis on biological systems is made available, we are realizing the non-linearity of these systems. The concepts and techniques of nonlinear analysis allow for more realistic and accurate models in science. The Future of Pharmaceuticals: A Nonlinear Analysis provides an opportunity to understand the non-linearity of biological systems and its application in various areas of science, primarily pharmaceutical sciences. This book will benefit professionals in pharmaceutical industries, academia, and policy who are interested in an entirely new approach to how we will treat disease in the future. Key Features: Addresses a new approach of nonlinear analysis. Applies a theory of projection to chalk out the future, instead of basing on linear evolution. Provides an opportunity to better understand the non-linearity in biological systems and its applications in various areas of science, primarily pharmaceutical sciences. Helps change the thought process for those looking for answers to their questions which they do not find in the linear relationship approach. Encourages a broader perspective for the creative process of drug development.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 254
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Book Description
Author: John McDaniel
Publisher: Routledge
ISBN: 0429560389
Category : Computers
Languages : en
Pages : 452
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Book Description
This edited text draws together the insights of numerous worldwide eminent academics to evaluate the condition of predictive policing and artificial intelligence (AI) as interlocked policy areas. Predictive and AI technologies are growing in prominence and at an unprecedented rate. Powerful digital crime mapping tools are being used to identify crime hotspots in real-time, as pattern-matching and search algorithms are sorting through huge police databases populated by growing volumes of data in an eff ort to identify people liable to experience (or commit) crime, places likely to host it, and variables associated with its solvability. Facial and vehicle recognition cameras are locating criminals as they move, while police services develop strategies informed by machine learning and other kinds of predictive analytics. Many of these innovations are features of modern policing in the UK, the US and Australia, among other jurisdictions. AI promises to reduce unnecessary labour, speed up various forms of police work, encourage police forces to more efficiently apportion their resources, and enable police officers to prevent crime and protect people from a variety of future harms. However, the promises of predictive and AI technologies and innovations do not always match reality. They often have significant weaknesses, come at a considerable cost and require challenging trade- off s to be made. Focusing on the UK, the US and Australia, this book explores themes of choice architecture, decision- making, human rights, accountability and the rule of law, as well as future uses of AI and predictive technologies in various policing contexts. The text contributes to ongoing debates on the benefits and biases of predictive algorithms, big data sets, machine learning systems, and broader policing strategies and challenges. Written in a clear and direct style, this book will appeal to students and scholars of policing, criminology, crime science, sociology, computer science, cognitive psychology and all those interested in the emergence of AI as a feature of contemporary policing.
Author: Federation of European Chemical Societies
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 614
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Book Description
Reviews the current status of risk assessment procedures as they relate to the environment.
Author:
Publisher:
ISBN:
Category : Biological models
Languages : en
Pages : 564
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Book Description
Author: Corwin Hansch
Publisher:
ISBN:
Category : Biopharmaceutics
Languages : en
Pages : 786
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Book Description
Author: Ronald W. Estabrook
Publisher:
ISBN:
Category : Allergy
Languages : en
Pages : 638
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Book Description
Author: Alix Fano
Publisher: Zed Books
ISBN:
Category : Social Science
Languages : en
Pages : 266
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Book Description
For the last 150 years, industrial, agricultural and household chemicals have been tested on animals for the alleged purpose of protecting the public from their dangerous effects. Through a meticulous analysis of the technical and scientific problems that have plagued animal tests for decades, this book reveals that using animals as human surrogates is not only unethical, it is bad science.
