The Effects of Hormones on the Growth of Carcinogen-induced Rat Mammary Carcinoma in Vitro PDF Download
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Author: Gloria M. Calaf De Iturri
Publisher:
ISBN:
Category : Growth
Languages : en
Pages : 412
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Book Description
Author: Gloria M. Calaf De Iturri
Publisher:
ISBN:
Category : Growth
Languages : en
Pages : 412
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Book Description
Author: James L. Clark
Publisher:
ISBN:
Category : Breast
Languages : en
Pages : 126
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Author: James Edward Richards
Publisher:
ISBN:
Category :
Languages : en
Pages : 394
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Book Description
Author: Benjamin S. Leung
Publisher: Springer Science & Business Media
ISBN: 9401180458
Category : Medical
Languages : en
Pages : 296
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Book Description
The concept that hormones influence tumor growth originated in 1889 with the proposal of Albert Schinzinger who suggested that breast cancer is related to the ovaries. Several years later, Sir George Beatson observed that remission of disseminated breast cancer could be achieved in premenopausal patients by performing bilateral oophorectomy. As a result of the contri butions of Hedley Atkins, Charles Huggins and others, additive and ablative hormonal therapies have been widely used for the treatment of advanced breast cancers for several decades. Model systems to study the effects of hormones on growth and regression of breast tumors have been available for many years; however, the complexities of the hormonal environment have rendered in vivo studies difficult in man and experimental animals. Recently, the availability of long-term cultures of breast cancer cells has stimulated many investigators to use these cell lines to unravel the mechanisms of hormone action. Because of the extreme diversity and complexity of advances regarding the endocrinology of the breast and breast cancers, a multi-authored review was deemed necessary. It has been gratifying to receive contributions from many noted scholars. In Volume I of this monograph, the influence of steroid hormones and their antagonists upon normal and neoplastic tissues of the mammary gland are presented. In Volume II, the effects of peptide and other hormones are reviewed.
Author: Eldon E. Cassell
Publisher:
ISBN:
Category : Carcinogens
Languages : en
Pages : 144
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Author: Matthew J. van Zwieten
Publisher: Springer
ISBN:
Category : Health & Fitness
Languages : en
Pages : 308
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Author: Benjamin S. Leung
Publisher: Springer London
ISBN:
Category : Medical
Languages : en
Pages : 328
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Author: Gijsbertus S. Bunnik
Publisher:
ISBN: 9789070639167
Category :
Languages : en
Pages : 183
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Author: Jonathan J. Li
Publisher: Springer Science & Business Media
ISBN: 146139208X
Category : Medical
Languages : en
Pages : 338
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Book Description
In the past decade there has been a growing public interest and resurgence in research in the field of hormonal carcinogenesis. This is due to the widespread use of therapeutic hormonal agents worldwide and to the increasing awareness of the causal association of hormones, both endogenous and exogenously administered, and a variety of human cancers. These associations include estrogens in uterine, cervical, vaginal, liver, testicular, prostatic, and possible breast cancers; progesterone and progestational hormones in breast cancer; androgens and anabolic steroids in hepatic and prostatic cancers. Additionally, gonadotrophins playa role in the etiology of ovarian and testicular cancers and thyroid-stimulating hormones in thyroid cancers. Therefore, hormonal carcinogenesis encompasses the study of both natural and synthetic hormonal agents, including growth factors and other peptide and protein factors, which contribute substantially to the etiology of both human and animal neoplasms, benign or malignant. Hormones may be involved in all aspects of neoplastic transformation, including initiation, promotion, and progression, and the inhibition of these processes. There are a number of important issues in women's health that need to be addressed. More than 40 million U. S. women are menopausal, and these women have a life expectancy of over 30 years after the menopause. When these figures are multiplied worldwide, the numbers become staggering. After the menopause, estrogen replacement therapy (ERT) is the choice of most women in industrialized countries.
Author: Jonathan J. Li
Publisher: Springer Science & Business Media
ISBN: 0387237615
Category : Medical
Languages : en
Pages : 562
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Book Description
It has been over a decade since the First International Symposium on Hormonal Carcinogenesis convened in 199 1. Since then, the field has rapidly expanded with considerable progress in both breast and prostate cancers; while ovarian and endometrial cancer have been hampered, in part, due to the absence of suitable hormone-mediated animal models. While knock-out, transgenic, and cell-culture systems have been extremely useful in identifying specific genelprotein alterations and the ensuing pathways affected, the precise molecular mechanisms whereby sex hormones elicit their oncogenic effects still remain elusive. Moreover, despite the considerable progress made in breast cancer research, the exact role of progestins in the presence or absence of estrogen in breast growth, differentiation, and malignant transformation is lacking. Elucidating the incipient molecular alterations in earlylpre-invasive lesions elicited by these hormones is a growing important focus of this field. The main purpose of these Symposia has been to address vital questions that impact our understanding of the causation, dependency, progression, resistance, and prevention of hormonally-associated cancers. We are indebted to the Scientific Advisory Board members who worked with us reviewing and offering suggestions to finalize the scientific program. We offer special thanks for the guidance and support of Dr. Gerald Mueller. His wisdom played an indispensable role in maintaining the excellence of these Symposia. We also acknowledge the numerous external reviewers that worked diligently to revise and improve the quality of the manuscripts. We are very grateful to Ms. Tandria Price.
