The Designs, Syntheses and Medical Applications of Mesoporous Silica Nanoparticle Based Drug Delivery Systems PDF Download
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Author: Zongxi Li
Publisher:
ISBN:
Category :
Languages : en
Pages : 208
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Book Description
The work covered in this thesis focuses on the development of mesoporous silica nanoparticle-based platforms for the controlled delivery of therapeutic agents. The first part of the thesis discusses the physical chemical properties of mesoporous silica nanoparticles, including the studies on their uptake and release capacities and the physical states of the encapsulated cargo molecules using spectroscopic methods. The second part of the thesis describes the organic functionalizations of the mesoporous silica nanoparticles with novel cyclodextrin-based nanogate systems, achieving pH and redox responsive controlled release mechanisms, as well as cargo size selectivity for the release from a dual-loaded system. In the third part of this thesis, several examples of the biomedical applications of the mesoporous silica nanoparticle based drug delivery systems are shown. This includes the in vitro delivery of small interference RNA to shutdown endogenous and exogenous gene expressions in cells using the polyethyleneimine coated nanoparticles, the in vivo delivery of anti-cancer therapeutic to achieve tumor suppression effects on mice models, and the in vivo delivery of anti-microbial therapeutic to achieve animal protection from anthrax lethal toxins. A combination of all these areas of research demonstrate the advancement of the mesoporous silica nanoparticle based drug delivery system towards utilization within living organisms, and realization of medicine on the nanoscale.
Author: Zongxi Li
Publisher:
ISBN:
Category :
Languages : en
Pages : 208
Get Book Here
Book Description
The work covered in this thesis focuses on the development of mesoporous silica nanoparticle-based platforms for the controlled delivery of therapeutic agents. The first part of the thesis discusses the physical chemical properties of mesoporous silica nanoparticles, including the studies on their uptake and release capacities and the physical states of the encapsulated cargo molecules using spectroscopic methods. The second part of the thesis describes the organic functionalizations of the mesoporous silica nanoparticles with novel cyclodextrin-based nanogate systems, achieving pH and redox responsive controlled release mechanisms, as well as cargo size selectivity for the release from a dual-loaded system. In the third part of this thesis, several examples of the biomedical applications of the mesoporous silica nanoparticle based drug delivery systems are shown. This includes the in vitro delivery of small interference RNA to shutdown endogenous and exogenous gene expressions in cells using the polyethyleneimine coated nanoparticles, the in vivo delivery of anti-cancer therapeutic to achieve tumor suppression effects on mice models, and the in vivo delivery of anti-microbial therapeutic to achieve animal protection from anthrax lethal toxins. A combination of all these areas of research demonstrate the advancement of the mesoporous silica nanoparticle based drug delivery system towards utilization within living organisms, and realization of medicine on the nanoscale.
Author:
Publisher: Academic Press
ISBN: 0128155205
Category : Science
Languages : en
Pages : 185
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Book Description
Cancer Therapy and Diagnosis, Part B, Volume 44 in The Enzymes series highlights new advances in the field, with this new volume presenting interesting chapters on Mesoporous silica nanoparticle synthesis, Periodic mesoporous organosilica, Nanovalves and other nanomachine-equipped nanoparticles and controlled release, Two-photon light control and photodynamic therapy, Biodegradable PMO nanoparticles, Cationic mesoporous silica and protein delivery, Drug loading, stimuli-responsive delivery and cancer treatment, Animal models and cancer therapy, siRNA delivery and TWIST shutdown for ovarian cancer treatment, and TBC (mesoporous silica nanoparticles and cancer therapy or biodistribution of MSN). Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in The Enzymes series Updated release includes the latest information on Cancer Therapy and Diagnosis
Author: Yu Chen
Publisher: Springer
ISBN: 3662486229
Category : Technology & Engineering
Languages : en
Pages : 100
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Book Description
This thesis reports on essential advances in the design, synthesis and biomedical applications of multifunctional Mesoporous Silica Nanoparticles (MSNs). It provides several examples of multifunctional MSN-based drug delivery nanosystems and demonstrates successful synergistic cancer therapies combining MSNs and high-intensity focused ultrasound. The book will especially be of interest to researchers and graduate students in the fields of biomaterials, biology, chemistry, medicine and the life sciences who are working to develop new methods and technologies to combat cancer.
Author: Luigi Pasqua
Publisher: Smithers Rapra Technology
ISBN: 9781847355072
Category : Biomedical engineering
Languages : en
Pages : 168
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Book Description
This book provides an insightful understanding of the mesoporous silica structure and its special properties. The details of synthesis and modification strategies are discussed by reviewing the open literature. The discussion concerning the potential of mesoporous silica in modern biomedical applications will be related to a critical analysis in the field of material science. This book will help the reader rapidly develop the necessary tools to follow the design of the different mesoporous silica-based devices presented in the various studies. The structure of the different devices is examined in detail and the relationship between the structure and the expected activity are discussed. It will also assist in the ability to design new therapeutic devices in a field where the applications seem to be without limits.
Author: Pieter Stroeve
Publisher: World Scientific
ISBN: 9813201061
Category : Technology & Engineering
Languages : en
Pages : 391
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Book Description
With the alarming increase in cancer diagnoses and genetic illnesses, traditional drug agents and their delivery media need to be re-evaluated to address a quickly evolving field. With newer smart materials for the controlled release of macromolecules, peptides, genetic material, etc. further complications arise, such as material performance, synthesis, functionalization and targeting, biological identity, and biocompatibility.The book provides a comprehensive overview of the recent developments on 'smart' targeting and drug delivery systems with a variety of carriers like nanoparticles, membranes, and hydrogels. It contains detailed descriptions on the recent trends in this field in the ongoing battle with catastrophic diseases like cancer. This field of research has been in its infancy and continues to face growth, and with it, further challenges and difficulties along the way toward maturity, which are accurately introduced in this book.
Author: Anupam Das Talukdar
Publisher: Elsevier
ISBN: 0323904149
Category : Technology & Engineering
Languages : en
Pages : 672
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Book Description
Advances in Nanotechnology-Based Drug Delivery Systems covers the core concepts and latest research regarding the use of nanoscale materials for the development and application of drug delivery systems. The book introduces the reader to nanotechnology in drug delivery, covering the synthesis, encapsulation techniques, characterization and key properties of nanoscale drug delivery systems. Later chapters review the broad range of target applications, including site-specific delivery of drugs for cardiovascular disease, cancer, bacterial infection, bone regeneration. and much more. This book helps translate advanced research into a clinical setting, analyzing the toxicity and health and safety challenges associated with utilizing nanotechnology in biomedicine. This will be a useful reference for those interested in nano-sized drug delivery in biomedicine, including academics and researchers in materials science, biomedical engineering, pharmaceutical science and related disciplines. Provides a clear introduction to nanotechnology in drug delivery, covering key principles, synthesis, characterization and unique properties of nanoscale materials for drug delivery systems“/li> Discusses preclinical, clinical and patented nano-drug delivery systems, enabling the reader to grasp the current state-of-the-art and market Covers a broad range of targets for nanoscale drug delivery systems, such as in neurological disorders, oral disease, renal disease, cancer, skin protection, and much more
Author: Carmen Alvarez-Lorenzo
Publisher: Royal Society of Chemistry
ISBN: 1849738785
Category : Medical
Languages : en
Pages : 419
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Book Description
Smart Materials for Drug Delivery brings together the recent findings in the area and provides a critical analysis of the different materials available and how they can be applied to advanced drug delivery systems.
Author: Mariela A. Agotegaray
Publisher: Springer
ISBN: 3319501585
Category : Technology & Engineering
Languages : en
Pages : 93
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Book Description
This brief offers a comprehensive discussion of magnetic targeted drug delivery of silica-coated nanodevices. Focusing on the latest trend in pharmaceutical applications of these nanodevices, a multidisciplinary overview is displayed, from synthesis and design to pharmacokenetics, biodistribution and toxicology. Chapters include design of silica-coated magnetic nanodevices; techniques for drug loading with features applicable to biological systems; synthesis, characterization and the assessment of biomedical issues with both in vitro and in vivo experiments. Applications in the treatment of different localized diseases are also addressed in order to present the potential use of these nanosystems as global, commercially available therapeutics.
Author: Valentina Cauda
Publisher: MDPI
ISBN: 3039439391
Category : Science
Languages : en
Pages : 204
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Book Description
Mesoporous materials are capturing great interest thanks to their exceptional surface area, uniform and tunable pore size, ease surface functionalization, thus enabling broad series of intervention in the field of nanomedicine. Since many years, these aspects foster a deep investigation on mesoporous nanoparticles, to design and fabricate biocompatible, smart and stimuli-responsive nanotools for controlled drug- or gene-delivery, theranostics applications, in particular for cancer therapy, and tissue engineering. This Book is thus dedicated to the most recent advances in the field, collecting research papers and reviews. It spans from the synthesis and characterization of the mesoporous material, especially those made of silica, silicon and bioactive glasses, to their functionalization with smart gate-keepers, reporter molecules or targeting ligands, up to their in-vitro applications in the nanomedicine field.
Author: Yasser Shahzad
Publisher: CRC Press
ISBN: 9781003168584
Category : Medical
Languages : en
Pages : 416
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Book Description
After the drug discovery and development process, designing suitable formulations to safely deliver the optimum dose, while avoiding side effects, has been a constant challenge, especially when drugs are very toxic and have poor solubility and undesirable clearance profiles. With recent advances in synthetic technologies, nanoparticles can be custom-made from a variety of advanced materials to mimic the bioenvironment and can be equipped with various targeting and imaging moieties for site-specific delivery and real-time imaging. Drug Delivery Using Nanomaterials covers advancements in the field of nanoparticle-based drug-delivery systems, along with all the aspects needed for a successful and marketable nanoformulation. FEATURES Offers a general overview of the entire process involved in the synthesis and characterization of pharmaceutical nanoparticles Covers a broad range of synthetic materials for developing nanoformulations customized for specific disease states, target organs, and drugs Every chapter sequentially builds, providing a progressive pathway from classical nanoparticles to the more advanced to be used as a full drug product by consumers Provides information in a bottom-up manner in that definitions and explanations of relevant background information serve as a framework for understanding advanced concepts This user-friendly reference is aimed at materials engineers, chemical engineers, biomedical engineers, pharmaceutical scientists, chemists, and others working on advanced drug delivery, from academia as well as industry.
