The Crystal Structure of T4 Lysozyme and the Evolution of Protein Structure PDF Download
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Author: Stephen James Remington
Publisher:
ISBN:
Category : Bacteriophage T4
Languages : en
Pages : 232
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Book Description
Author: Stephen James Remington
Publisher:
ISBN:
Category : Bacteriophage T4
Languages : en
Pages : 232
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Book Description
Author: David L. Veenstra
Publisher:
ISBN:
Category : Molecular structure
Languages : en
Pages : 334
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Book Description
Author: Jason Frederick Cellitti
Publisher:
ISBN:
Category :
Languages : en
Pages : 344
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Book Description
Author: Prerna Prem Chaudhary
Publisher:
ISBN:
Category : Bacteriophage T4
Languages : en
Pages : 250
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Book Description
Author: Hadeer Abdel Karim ELsayed ELHabashy
Publisher:
ISBN:
Category : Molecular biology
Languages : en
Pages : 164
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Book Description
Abstract: The idea of developing a Bio-molecular mechanical device has attracted the attention of many research groups due to its promising Nano and Bio- technological applications such as flow-control valves, switches and bio-sensors. T4 Lysozyme protein is an enzyme, which has been extensively studied. This protein provides a wealth of information regarding the structure/function relationship of proteins at atomic resolution. An engineered variant of T4 Lysozyme has been reported to trigger a large scale translocation of an engineered helix (∼ 2nm), upon the addition of an external ligand. The design was based on the duplication of a surface helix, followed by manipulating the stability of an adjacent loop, which caused the duplicated helix to switch between two conformations. The purpose of this study is to investigate the dynamics of the engineered motion for potential Nano and Biotechnological applications. Many wild type and mutant static crystal structures of T4 Lysozyme have been shown to display a range of about 50 degrees in hinge bending motion between the N- and C-terminal domains of the protein, indicating intrinsic flexibility. The present molecular dynamics simulations detect similar motion in the engineered protein, within 100 nanosecond time scale. A preliminary mathematical model (solvent free) describing the hinge bending motion and the impact force is constructed. However, in the nanosecond time scale, the engineered triggered motion (the helical trans location) was partially detected only when bond constraints were significantly relaxed.
Author: Harold A. Scheraga
Publisher: Academic Press
ISBN: 1483258971
Category : Technology & Engineering
Languages : en
Pages : 320
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Book Description
Protein Structure deals with the chemistry and physics of biologically important molecules—the proteins—particularly the determination of the structure of various proteins, their thermodynamics, their kinetics, and the mechanisms of different reactions of individual proteins. The book approaches the study of protein structure in two ways: firstly, by determining the general features of protein structure, the overall size, and shape of the molecule; and secondly, by investigating the molecule internally along with the various aspects of the internal configuration of protein molecules. It describes in detail experimental methods for determining protein structure in solution, such as the hydrodynamic method, the thermodynamic optical method, and the electrochemical method. The book then explains the results of experiments carried out on insulin, lysozyme, and ribonuclease. The text notes that the experiments, carried out on native and denatured proteins as well as on derivatives prepared by chemical modification (e.g., by methylation, iodination, acetylation, etc.), can lead to greater understanding of secondary and tertiary structures of proteins of known sequence. The book is suitable for biochemists, micro-biologists, cellular researchers, or investigators involved in protein structure and other biological sciences related to muscle physiologists, geneticists, enzymologists, or immunologists.
Author: Dale L. Oxender
Publisher: Alan R. Liss
ISBN:
Category : Science
Languages : en
Pages : 362
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Author: Daniel Chasman
Publisher: CRC Press
ISBN: 0824748166
Category : Medical
Languages : en
Pages : 534
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Book Description
This text offers in-depth perspectives on every aspect of protein structure identification, assessment, characterization, and utilization, for a clear understanding of the diversity of protein shapes, variations in protein function, and structure-based drug design. The authors cover numerous high-throughput technologies as well as computational methods to study protein structures and residues. A valuable reference, this book reflects current trends in the effort to solve new structures arising from genome initiatives, details methods to detect and identify errors in the prediction of protein structural models, and outlines challenges in the conversion of routine processes into high-throughput platforms.
Author: M. Vijayan
Publisher: Universities Press
ISBN: 9788173712548
Category : Molecular biology
Languages : en
Pages : 828
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Book Description
Prof. G.N. Ramachandran Has Been Among The Foremost Biophysicists And Structural Biologists Of Our Times, And The Most Outstanding Scientist To Have Worked In Independent India. His Contributions Pertaining To Collagen, Methods Of Structural Analysis, Computer Modelling And Conformational Analysis, And Three-Dimensional Image Reconstruction Have Had A High Global Impact. This Volume In Honour Of Gnr Consists Of Articles At The Cutting Edge Of Structural Biology Contributed By Leading Scientists, Including Two Noble Laureates. It Is Intended To Be A Window To Modern Structural Biology And A Showcase Of The Indian Effort In This Area.
Author: Robert Cassels
Publisher:
ISBN:
Category : Lysozyme
Languages : en
Pages : 358
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Book Description
