The Crossroads Between Immunological Disorders and Neuropsychiatric Diseases. A Case for Schizophrenia PDF Download
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Author: Silvia Sánchez-Ramón
Publisher: Frontiers Media SA
ISBN: 2889713563
Category : Science
Languages : en
Pages : 157
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Book Description
Author: Silvia Sánchez-Ramón
Publisher: Frontiers Media SA
ISBN: 2889713563
Category : Science
Languages : en
Pages : 157
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Book Description
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1796
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Author: Mohammadreza Shalbafan
Publisher: Frontiers Media SA
ISBN: 2832550568
Category : Medical
Languages : en
Pages : 708
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Book Description
The COVID-19 outbreak has impacted many areas of our lives, including mental health. Lockdown and physical distancing measures have been one major effective intervention to counter the spread of the virus and reduce the impact of the disease. However, they have negatively impacted mental well-being and behaviors, either triggering the onset of new psychiatric symptoms and diseases or amplifying pre-existing ones. The pandemic and lockdown measures have also been associated with reduced access to treatment and facilities all over the world, further worsening mental health outcomes. The impact on mental health, although universal, varied between nations. Cultural and societal variables, including norms, values, religion, and stigma have played an important role in shaping COVID-19-related mental health symptoms, including anxiety, depression, grief, psychosis, and addiction. These sociocultural factors have also molded how mental health interventions are tailored and provided. Highlighting the intertwining relationship between the pandemic, mental health, and sociocultural factors are essential to managing emerging mental health symptoms adequately.
Author: Karl Bechter
Publisher: Frontiers Media SA
ISBN: 2889459500
Category :
Languages : en
Pages : 189
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Book Description
Growing evidence derived from cerebrospinal fluid (CSF), neuropathological, imaging, genetic, and epidemiological studies link neuroinflammation and immune dysregulation to a subset of individuals with a variety of severe mental disorders (SMDs), including affective and non-affective psychotic disorders. Further, the recent discoveries of neuronal surface antibodies (NSAs) in autoimmune encephalitis (AE) presenting with diverse neuropsychiatric disorders such as psychosis and cognitive decline, among many others, provides further support to the notion that CNS autoimmunity and neuroinflammation can contribute to the neurobiology of psychiatric disturbances. Further, these immune mechanisms may contribute to a subset of patients currently diagnosed as having treatment-resistant SMDs such as schizophrenia and major depressive disorder. Additionally, mounting data indicate that various infections can serve as an immunological trigger of aberrant immune responses, presumably by causing release of excess neural antigen, thereby giving rise to NSAs or aberrant immune cellular responses to give rise to primary or secondary psychiatric disorders such as schizophrenia and those associated with AE, respectively. Collectively, these findings support the “mild encephalitis” hypothesis of SMD. The significant overlap among AE-associated psychosis, systemic autoimmune disorder-associated psychosis, and psychotic disorders associated with pathological processes involving inflammation and immune dysregulation has also prompted some authors to adopt the term “autoimmune psychosis” (AP). This term reflects that this psychosis subtype is mechanistically linked to complex neuroimmune and inflammatory signalling abnormalities that can be responsive to early immunomodulatory treatment. It also suggests that a subset of AP might represent an incomplete or “forme fruste” subtype of AE presenting with dominant or pure psychiatric symptoms mimicking primary psychiatric illnesses. Because data indicate that delayed diagnosis and treatment may lead to permanent sequelae, early recognition of AP utilizing neurodiagnostic workup (e.g., CSF analysis, neuroimaging, and EEG) and its early treatment with appropriate immunotherapy are paramount to a meaningful recovery. This eBook will provide an overview of the current knowledge and research areas from epidemiology, risk factors and diagnosis to the management of these conditions, in this rapidly emerging field, helping to bridge the gaps in knowledge that currently exist in the disciplines of Psychiatry, Neurology, and Neuroimmunology.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309049393
Category : Medical
Languages : en
Pages : 636
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Book Description
The understanding of how to reduce risk factors for mental disorders has expanded remarkably as a result of recent scientific advances. This study, mandated by Congress, reviews those advances in the context of current research and provides a targeted definition of prevention and a conceptual framework that emphasizes risk reduction. Highlighting opportunities for and barriers to interventions, the book draws on successful models for the prevention of cardiovascular disease, injuries, and smoking. In addition, it reviews the risk factors associated with Alzheimer's disease, schizophrenia, alcohol abuse and dependence, depressive disorders, and conduct disorders and evaluates current illustrative prevention programs. The models and examination provide a framework for the design, application, and evaluation of interventions intended to prevent mental disorders and the transfer of knowledge about prevention from research to clinical practice. The book presents a focused research agenda, with recommendations on how to develop effective intervention programs, create a cadre of prevention researchers, and improve coordination among federal agencies.
Author: Błażej Misiak
Publisher: Frontiers Media SA
ISBN: 2889457974
Category :
Languages : en
Pages : 115
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Book Description
Major psychiatric disorders, including schizophrenia, bipolar disorder and major depression represent complex phenotypes with imprecise diagnostic boundaries. It has been found that these disorders can be characterized by a number of peripheral immune-inflammatory alterations, including, i.e. elevated levels of pro-inflammatory cytokines, increased levels of specific and non-specific antibodies or abnormal counts of lymphocyte subpopulations. Although it has been found that major psychiatric disorders share similar dysregulations of immune-inflammatory response, recent studies have also clearly demonstrated that some differences can be indicated. Interestingly, certain immune-inflammatory disturbances appear to be state markers, since they occur in acute relapse and normalize following pharmacological treatment, while the rest represents trait markers that remain stable regardless of treatment. It is also important to note that peripheral immune-inflammatory markers have been associated with psychopathological manifestation of major psychiatric disorders, response to treatment and long-term outcomes. However, it remains unclear what is the origin of peripheral inflammation in psychiatric disorders. To date, several mechanisms have been proposed, including the gut-brain axis dysregulation, infections in the neurodevelopmental period or immunogenetic factors. This eBook summarizes current evidence from studies investigating peripheral inflammation in schizophrenia, bipolar disorder, major depression and post-traumatic stress disorder as well as it provides future directions for the field.
Author: Norbert Müller
Publisher: Springer
ISBN: 331913602X
Category : Medical
Languages : en
Pages : 408
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Book Description
Psychiatric disorders are one of the most dramatic burdens for humankind. The role of immune dysfunction in the pathophysiology of these disorders has emerged during the last years, because there has been tremendous progress in psychoneuroimmunological research. Many results are presented here by pioneers in the field. The book addresses various effects of the immune system on the pathophysiology and course of psychiatric disorders and highlights the possible future impact on treatment decisions of various psychiatric disorders, including schizophrenia and depression. The contributions cover the role of in utero immune challenges on the development of schizophrenia, the role of infections, and autoimmune diseases and mild immune activation in the development of depression and schizophrenia, the influence of immune responses in other disorders such as Tourette's, Alzheimer's, and OCD, the connections between mental and physical pain as well as between anti-inflammatory and antipsychotic drugs.
Author: Dick F. Swaab
Publisher: Elsevier
ISBN: 0128199741
Category : Science
Languages : en
Pages : 520
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Book Description
The Human Hypothalamus: Neuropsychiatric Disorders, Volume 181 in the Handbook of Clinical Neurology series, provides comprehensive summaries of recent research on the brain and nervous system as they relate to clinical neurology. This volume identifies the neurobiology and neurophysiology of disorders relating to the hypothalamus and provides treatment information for these disorders. Disorders covered include neuropsychiatric, neurodegenerative, periodic, and autoimmune disorders. Coverage includes Alzheimer’s, Parkinson’s, epilepsy, sleep, pain, depression, anxiety, OCD, PTSD, schizophrenia, autism, aggressions, addiction, and more. Summarizes research on how the hypothalamus relates to neurological disorders Contains neuropsychiatric, neurodegenerative, periodic and autonomic disorders Includes the neurobiology of, and treatment for, each disorder Covers depression, anxiety, OCD, PTSD, schizophrenia, autism, aggression, addiction, and more Provides coverage of sleep and pain
Author: Angela Woods
Publisher: Oxford University Press
ISBN: 0199583951
Category : Literary Criticism
Languages : en
Pages : 271
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Book Description
Schizophrenia has been one of psychiatry's most contested diagnostic categories. The Sublime object of Psychiatry studies representations of schizophrenia across a wide range of disciplines and discourses: biological and phenomenological psychiatry, psychoanalysis, critical psychology, antipsychiatry, and postmodern philosophy.
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 536
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Book Description
