The Clinical Value of Fluorescence Imaging in Head and Neck Cancer PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download The Clinical Value of Fluorescence Imaging in Head and Neck Cancer PDF full book. Access full book title The Clinical Value of Fluorescence Imaging in Head and Neck Cancer by . Download full books in PDF and EPUB format.
Author:
Publisher:
ISBN: 9789464163599
Category :
Languages : en
Pages : 0
Get Book Here
Book Description
English summary The main objective for curative oncologic surgery is to remove tumor tissue in conjunction with tumor-free margins. The essence for surgeons hereby lies in distinguishing healthy from diseased tissue to ensure satisfying prognosis. Today, surgeons make this important distinction based on tissue palpation and visual appearance, occasionally followed by frozen section analysis (FSA) – a technique that has substantial flaws, especially in complex surgery such as the head and neck. This might in part explain the high rates of tumor-positive margins and subsequent suboptimal overall survival rates afflicted with surgical head and neck oncology. The past decades, intraoperative imaging techniques utilizing near-infrared (NIR) fluorescence have been developed to aid surgeons in distinguishing tumor from healthy adjacent tissue. These real-time imaging techniques provide an essential step towards improving surgical outcome through enhanced tumor visualization and thereby increase patient survival. The first targeted fluorescent agents have been evaluated in multiple early phase trials and are now entering large scale clinical testing. It is now that we can start to monitor where the true clinical capacity of this technique lies. This thesis aims to lay a clinical foundation and explore the future possibilities of intraoperative fluorescence-guidance for surgical head and neck oncology. By providing an overview of various in situ and ex vivo imaging strategies, the work aims to illustrate the clinical possibilities and subsequently smoothen the transition of fluorescence imaging into today’s clinic.
Author:
Publisher:
ISBN: 9789464163599
Category :
Languages : en
Pages : 0
Get Book Here
Book Description
English summary The main objective for curative oncologic surgery is to remove tumor tissue in conjunction with tumor-free margins. The essence for surgeons hereby lies in distinguishing healthy from diseased tissue to ensure satisfying prognosis. Today, surgeons make this important distinction based on tissue palpation and visual appearance, occasionally followed by frozen section analysis (FSA) – a technique that has substantial flaws, especially in complex surgery such as the head and neck. This might in part explain the high rates of tumor-positive margins and subsequent suboptimal overall survival rates afflicted with surgical head and neck oncology. The past decades, intraoperative imaging techniques utilizing near-infrared (NIR) fluorescence have been developed to aid surgeons in distinguishing tumor from healthy adjacent tissue. These real-time imaging techniques provide an essential step towards improving surgical outcome through enhanced tumor visualization and thereby increase patient survival. The first targeted fluorescent agents have been evaluated in multiple early phase trials and are now entering large scale clinical testing. It is now that we can start to monitor where the true clinical capacity of this technique lies. This thesis aims to lay a clinical foundation and explore the future possibilities of intraoperative fluorescence-guidance for surgical head and neck oncology. By providing an overview of various in situ and ex vivo imaging strategies, the work aims to illustrate the clinical possibilities and subsequently smoothen the transition of fluorescence imaging into today’s clinic.
Author: Robert Hermans
Publisher: Springer Science & Business Media
ISBN: 3642178685
Category : Medical
Languages : en
Pages : 415
Get Book Here
Book Description
Imaging is crucial in the multidisciplinary approach to head and neck cancer management. The rapid technological development of recent years makes it necessary for all members of the multidisciplinary team to understand the potential applications, limitations, and advantages of existing and evolving imaging technologies. It is equally important that the radiologist has sufficient clinical background knowledge to understand the clinical significance of imaging findings. This book provides an overview of the findings obtained using different imaging techniques during the evaluation of head and neck neoplasms, both before and after therapy. All anatomic areas in the head and neck are covered, and the impact of imaging on patient management is discussed in detail. The authors are recognized experts in the field, and numerous high-quality images are included. This second edition provides information on the latest imaging developments in this area, including the application of PET-CT and diffusion-weighted magnetic resonance imaging.
Author: David Pertzborn
Publisher:
ISBN:
Category :
Languages : de
Pages : 0
Get Book Here
Book Description
Head and neck cancer is a global health problem with an average of 890,000 new cases and 450,000 deaths per year. Despite ongoing research into diagnosis and treatment options, the overall five-year survival rate has not significantly increased in the last decades. One major challenge lies in the heterogeneity and complexity of head and neck cancers, which comprise a diverse group of tumors that arise from different cell types and anatomical locations in the head and neck region. In case of surgical treatment, up to now the main challenge is a reliable intraoperative assessment and the complete resection of the tumor. Currently used intraoperative in vivo imaging devices are lacking the ability to clearly define the tumor margins. In this work I analyzed head and neck squamous cell carcinomas (HNSCC) and salivary gland carcinomas (SGC) and combined novel spectral and molecular imaging methods with deep learning based data analysis to overcome clinical challenges in treatment and diagnosis of HNSCC and SGC. The two imaging methods were matrix assisted laser desorption/ionization imaging (MALDI) and hyperspectral imaging (HSI). MALDI imaging aims to provide a label- free, spatially resolved measurement of the abundance of biomolecules by using the difference in their mass-to-charge ratio. This leads to a mass spectrum for each location of a given sample. HSI on the other hand measures the interaction of a sample with a broad light spectrum ranging from the visible to the infrared. This thesis is based on three studies. In the first two studies, I was able to show that complex medical problems in head and neck cancer diagnosis and treatment can be addressed by combining novel imaging techniques with deep learning based data analysis. In the third one, I helped to show, that there is no tumor specific uptake of ICG by combining and analyzing fluorescence microscopy and classical histopathological data.
Author: Mitsuo Kusano
Publisher: Springer
ISBN: 4431555285
Category : Medical
Languages : en
Pages : 453
Get Book Here
Book Description
This book presents a comprehensive overview and outlook for the future of indocyanine green (ICG) fluorescence navigation surgery, which is attracting clinical interest as a safe and less invasive procedure not only in detecting cerebral vessels, coronary arteries, and biliary trees, but also in identifying sentinel lymph nodes in cancer. The book starts with the characteristics of ICG and photodynamic cameras/endoscopes, followed by detailed descriptions of the applications of ICG fluorescence imaging in various areas such as ocular surgery, neurosurgery, cardiovascular surgery, and plastic surgery. It also covers identifying sentinel lymph nodes in breast cancer as well as cancers of the gastrointestinal tract, and provides valuable information for hepato-biliary-pancreatic surgeons, such as identifying tattooing of liver segments and bile leakage. Written entirely by experts in their respective areas, ICG Fluorescence Imaging and Navigation Surgery offers an essential resource for surgeons operating on cancers and vascular disorders in the brain and cardiovascular systems and in plastic surgery.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
Get Book Here
Book Description
Author:
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 222
Get Book Here
Book Description
Author: N. Kokudo
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318022934
Category : Medical
Languages : en
Pages : 134
Get Book Here
Book Description
Indocyanine green (ICG) fluorescence has been used for imaging purposes for more than half a century; First employed by ophthalmologists for visualizing the retinal artery in the late 1960s, the application of ICG fluorescence imaging has since been continuously expanded. Recently, advances in imaging technologies have led to renewed attention regarding the use of ICG in the field of hepatobiliary surgery, as a new tool for visualizing the biliary tree and liver tumors.
Author: Prashanth Panta
Publisher: Springer
ISBN: 3319612557
Category : Medical
Languages : en
Pages : 314
Get Book Here
Book Description
This monograph equips clinicians with the knowledge required to detect oral cancer at the earliest possible stage while simultaneously inspiring researchers to work on novel methods of detection. All the methods employed in the oral cancer context are considered, from simple ones like oral screening to more complex emerging optical methods and biomarker identification strategies. Individual chapters focus on conventional oral screening and application of vital stains, optical methods like white light based fluorescence-reflectance imaging, narrow band imaging, direct-oral-microscopy, and more advanced methods like optical coherence tomography, an in-vivo optical biopsy technique, and photo-acoustic imaging that allows visualization of deeper tissue changes. Novel electrical methods like bio-impedance assessment, occult biophysical methods like crystallization test, and the most promising salivary biomarkers and point-of-care opportunities are covered. Helpful information is also provided on essential topics including, oral potentially malignant disorders, biological aspects and molecular mechanisms underlying oral cancer progression, global epidemiology, concept of diagnostic delays, traditional imaging, and classic histopathology and microscopic features. The newer techniques are currently of active research interest, and can soon become powerful chair-side tools with potential to reduce diagnostic delays and improve survival.
Author: Giuliano Mariani
Publisher: Springer Science & Business Media
ISBN: 0387383271
Category : Medical
Languages : en
Pages : 319
Get Book Here
Book Description
This multidisciplinary textbook is designed to be the standard on the subject and is geared for use by physicians who are involved in the care and/or diagnosis of cancer patients. Comprehensive coverage is provided on all aspects of radioguided surgery. Practical information is readily accessible and throughout there is an emphasis on improved decision making. Tables present the indications, performance, and interpretation of procedures at a glance. A wealth of illustrations, including a full-color insert, enhances the application of new concepts.
Author: Sylvain Gioux
Publisher:
ISBN: 9781628414011
Category : Imaging systems in medicine
Languages : en
Pages : 277
Get Book Here
Book Description
'Proceedings of SPIE' offers access to the latest innovations in research and technology and are among the most cited references in patent literature.
