The Cellular and Molecular Mechanisms of Ischemia-reperfusion Induced Lung Injury PDF Download
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Author: Hyunhee Kim
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Hyunhee Kim
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Jonathan A. Cardella
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Lung transplantation has emerged as a therapeutic modality for patients with end-stage lung disease. However ischemia reperfusion injury remains a significant clinical problem, occurring in 20% of patients. Many cell culture models have been developed to study ischemia-reperfusion (I/R) injury, however none are specific to the conditions of lung preservation and transplantation. We designed a cell culture model that mimics the conditions of clinical lung transplantation, where preservation is aerobic and hypothermic. Human pulmonary epithelial cells (A549 cell line), were preserved in 100% O2 at 4°C for varying periods in Low Potassium Dextran Glucose solution, simulating ischemia, followed by the reintroduction of warm (37°C) Dulbecco's Modified Eagle Medium plus 10% fetal bovine serum to simulate reperfusion. Cultures were assayed for cell attachment and viability. Sequential extension of ischemic times to 24 h showed a time-dependent loss of cells. There was a further decrease in cell number following simulated reperfusion. Cell detachment was due mainly to cell death, as determined by cell viability assays. The effects of chemical components in the preservation solution and various gas mixtures during ischemia. were examined using this model system. Because this model closely mimics I/R injury in lung transplantation, it could be used to study cellular and molecular mechanisms related to this clinical situation.
Author: Dipak K. Das
Publisher: CRC Press
ISBN: 9780849345555
Category : Medical
Languages : en
Pages : 534
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Book Description
Pathophysiology of Reperfusion Injury presents the first integrated summary of the important areas of reperfusion injury. By covering reperfusion injury in the heart, lungs, liver, kidneys, and small bowel, the book demonstrates the interrelationships of these various aspects and concludes that they are all part of a natural and integrated whole. The leading investigators in the field address the potential biochemical, cellular, and molecular mechanisms of reperfusion injury, which will benefit all researchers working in this field.
Author: Chunheng Mo
Publisher: Frontiers Media SA
ISBN: 2832543251
Category : Science
Languages : en
Pages : 123
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Book Description
Organ fibrosis seriously threatens human health. Globally, more than 30% of the diseases that cause disability and death are due to organ fibrosis. However, there have been so far only a few effective treatments for organ fibrosis. Idiopathic pulmonary fibrosis (IPF) is progressive, lethal fibrotic lung disease. Approximately, 10/100,000 people globally suffer from pulmonary fibrosis, and the incidence is on the rise. The median survival for patients is only 3-5 years. Currently there is no effective treatment for lung fibrosis. Therefore, new insights into lung fibrosis and therapeutic strategy should be explored and developed. This Research Topic aims to deepen the understanding and research on the pathogenesis of lung fibrosis to develop effective treatments. Studies have shown that effective lung repair and regeneration are critical biological processes for the restoration of original physiological function of lung after injury. The intrinsic ability of regeneration and repair is often suppressed in lung with chronic injury or the diseased organs, leading to fibrosis and loss of function. Targeting key pathways in the process of lung regeneration can promote the repair of the impaired lung and alleviate fibrosis in animal models. How to induce regeneration and repair of the impaired organ to alleviate fibrosis is a frontier research topic. Hence, this Research Topic focuses on the cellular and molecular mechanisms of lung regeneration, repair, and fibrosis. Moreover, this topic will also focus on the study of lung development to provide new insights into the pathogenesis of lung injury and fibrosis.
Author: Dipak Kumar Das
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 532
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Book Description
This volume provides presentations on many aspects of reperfusion injury. Every vital organ undergoing ischaemic insult, transplantation or vascular surgery, is subject to reperfusion and thus to the likelihood of injury. This text describes the mechanisms of such injury, from pathophysiology to molecular aspects, in the brain, heart, lung, liver, kidney, intestines and joints. It also discusses the possible direction of future research in this relatively new area.
Author: Charles G. Cochrane
Publisher:
ISBN:
Category : Cellular immunity
Languages : en
Pages : 270
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Author: Robert Fitridge
Publisher: University of Adelaide Press
ISBN: 1922064009
Category : Medical
Languages : en
Pages : 589
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Book Description
New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
![Molecular Mechanisms of Ventilator-induced Lung Injury [microform]: Biotrauma PDF](https://books.google.com/books/content/images/frontcover/YTJ1tgAACAAJ?fife=w80-h100)
Author: Lorraine N. Tremblay
Publisher: National Library of Canada = Bibliothèque nationale du Canada
ISBN: 9780612415218
Category :
Languages : en
Pages : 392
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Author: Bo Gao
Publisher: Frontiers Media SA
ISBN: 283250471X
Category : Science
Languages : en
Pages : 259
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Author: Pierce A. Grace
Publisher: Wiley-Blackwell
ISBN: 9780632050215
Category : Medical
Languages : en
Pages : 400
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Book Description
Ischaemia-Reperfusion Injury is concerned with the consequences of interrupting and restoring blood flow to tissues. Many common clinical conditions are caused by interruption of blood flow to tissues (eg, ischaemic heart disease, peripheral vascular disease, stroke); blood flow is also interrupted deliberately in many surgical procedures (eg, cardiac surgery, arterial surgery, transplant surgery, limb surgery with tourniquet). In treating such conditions or after performing such operations the aim of the clinician is to restore the blood supply to the ischaemic tissue. Paradoxically, restoration of blood flow to ischaemic tissues can lead to further tissue damage with the potential for severe local and systemic injury. This book focuses on the clinical, pathological and biochemical processes involved in ischaemia-reperfusion injury and gives an overview of the strategies that may be adopted to mitigate or prevent such injury. This book will be of interest to both clinicians and scientists who have to deal with or have interest in this difficult but important problem.
