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Author: Hilda Weyl Sokol
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 856
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Book Description
Author: Hilda Weyl Sokol
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 856
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Book Description
Author: David Feifel
Publisher: Elsevier Inc. Chapters
ISBN: 0128072202
Category : Medical
Languages : en
Pages : 77
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Book Description
Modeling schizophrenia in animals represents a formidable challenge because the most characteristic symptoms of this disorder, auditory hallucinations and delusional beliefs, cannot be directly modeled in animals. Furthermore, limited current understanding of the etiology and pathophysiology underlying the clinical features of this disorder greatly hinders the ability to develop valid models based on those aspects. To circumvent these issues, investigators have attempted to recreate the leading candidate biochemical, neuroanatomical, and genetic abnormalities for this disorder in animals using pharmacological, developmental, neurotoxic, genetic engineering, and other methods. The validity of these animal preparations as animal models for schizophrenia is generally based upon the extent to which they induce measurable behavioral changes that are homologous or analogous to the core clinical features or the information-processing endophenotypes (presymptom phenotypes) that are seen in schizophrenia. The utility of any animal model to serve as a screen for novel treatments is considered related to the extent to which the schizophrenia-relevant behaviors it exhibits can be ameliorated by drugs with known efficacy in schizophrenia but not by drugs known to be therapeutic for brain disorders other than schizophrenia.
Author: Registry of Comparative Pathology
Publisher:
ISBN:
Category : Diseases
Languages : en
Pages : 794
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Book Description
Author: P. Michael Conn
Publisher: Academic Press
ISBN: 0124159125
Category : Science
Languages : en
Pages : 1109
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Book Description
Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. - Organized by disease orientation for ease of searchability - Provides information on locating resources, animal alternatives and animal ethics - Covers a broad range of animal models used in research for human disease
Author:
Publisher: Elsevier
ISBN: 0080861989
Category : Medical
Languages : en
Pages : 581
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Book Description
Biochemical Basis of Functional Neuroteratology
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1492
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Book Description
Author: I.J.A. Urban
Publisher: Elsevier
ISBN: 0080862446
Category : Medical
Languages : en
Pages : 671
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Book Description
Advances in Brain Vasopressin elucidates the functions of the regulatory peptide vasopressin in the nervous system, and reviews the current status of this field at different levels. It deals with the cell biology and anatomy of the neurons that produce vasopressin in the brain, and provides an overview on the receptors of vasopressin and the signal transduction pathways that they activate, including the cellular responses that are triggered by vasopressin. Reviews are presented on the modulation of behavior induced by vasopressin in a number of different contexts, such as sex-linked and steroid-dependent behaviors, social behaviors, and learning and memory. Furthermore, the volume deals with several controversial issues in the field by presenting overlapping chapters from different research groups in order to provide the reader with current views. Highly relevant and useful, for those working on this "first" neuropeptide, and for young investigators entering the field, and in addition, shows how important a multidisciplinary approach is to unravelling the function of a neuropeptide in the brain.
Author: Mike Ludwig
Publisher: John Wiley & Sons
ISBN: 1119390885
Category : Medical
Languages : en
Pages : 462
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Book Description
Model Animals in Neuroendocrinology: From Worm to Mouse to Man offers a masterclass on the opportunities that different model animals offer to the basic understanding of neuroendocrine functions and mechanisms of action and the implications of this understanding. The authors review recent advances in the field emanating from studies involving a variety of animal models, molecular genetics, imaging technologies, and behavior assays. These studies helped unravel mechanisms underlying the development and function of neuroendocrine systems. The book highlights how studies in a variety of model animals, including, invertebrates, fish, birds, rodents and mammals has contributed to our understanding of neuroendocrinology. Model Animals in Neuroendocrinology provides students, scientists and practitioners with a contemporary account of what can be learnt about the functions of neuroendocrine systems from studies across animal taxonomy. This is the seventh volume in the Masterclass in Neuroendocrinology Series, a co-publication between Wiley and the INF (International Neuroendocrine Federation) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology.
Author: Mark A. Suckow
Publisher: Elsevier
ISBN: 0080454321
Category : Science
Languages : en
Pages : 929
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Book Description
The Laboratory Rat, Second Edition features updated information on a variety of topics including: rat genetics and genomics, both spontaneous and induced disease; state-of-the-art technology for housing and husbandry; occupational health, and experimental models. A premier source of information on the laboratory rat that will be of interest to veterinary and medical students, senior graduate, graduate students, post-docs and researchers who utilize animals in biomedical research. - At least 50% new information than first edition - Includes topics on rat genetics and genomics, occupational health, and experimental models - The premier source of information on the laboratory rat
Author: G.J. Boer
Publisher: Springer Science & Business Media
ISBN: 146158129X
Category : Science
Languages : en
Pages : 643
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Book Description
The concept for Vasopressin: Principles and Properties originated during the sum mer of 1983. From reviewing the rich and diverse literature on vasopressin, it became evident that the rapid advancements in this field made it difficult to syn thesize the information gathered from divergent scientific disciplines into a coherent view of the biological role of vasopressin. We perceived the need for a series of critical reviews delineating this recent progress. Over the past decade, major advances have been made in studies of the anatomy, physiology, phar macology, molecular biology, and behavioral activities of vasopressin. This is, in no small measure, due to the finding that vasopressin can no longer be regarded solely as a neurohypophysial hormone. Our present knowledge is that vasopressin is synthesized in also has an axonal messenger role in the nervous system and of the brain, although the functions of vasopressin in these periph sites outside of vasopressin eral sites are not well understood. In order to prepare an overview concentrating on recent studies in vertebrates, authors were selected based on their expertise and asked to review their research area, including the work from other laboratories. It was our intent to provide an updated definitive reference which would complement and extend such past texts as Neurohypophysial Hor mones and Similar Polypeptides (Handbook of Experimental Pharmacology, Vol ume XXIII, 1968) and The Pituitary Gland and Its Neuroendocrine Control (Handbook of Physiology, Section 7: Volume IV, 1974).
