Author: Jack R. Lancaster
Publisher: Wiley-VCH
ISBN:
Category : Science
Languages : en
Pages : 368

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Book Description

Author: Deborah Zamble
Publisher: Royal Society of Chemistry
ISBN: 1788010582
Category : Science
Languages : en
Pages : 396

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Book Description
Metal ions play key roles in biology. Many are essential for catalysis, for electron transfer and for the fixation, sensing, and metabolism of gases. Others compete with those essential metal ions or have toxic or pharmacological effects. This book is structured around the periodic table and focuses on the control of metal ions in cells. It addresses the molecular aspects of binding, transport and storage that ensure balanced levels of the essential elements. Organisms have also developed mechanisms to deal with the non-essential metal ions. However, through new uses and manufacturing processes, organisms are increasingly exposed to changing levels of both essential and non-essential ions in new chemical forms. They may not have developed defenses against some of these forms (such as nanoparticles). Many diseases such as cancer, diabetes and neurodegeneration are associated with metal ion imbalance. There may be a deficiency of the essential metals, overload of either essential or non-essential metals or perturbation of the overall natural balance. This book is the first to comprehensively survey the molecular nature of the overall natural balance of metal ions in nutrition, toxicology and pharmacology. It is written as an introduction to research for students and researchers in academia and industry and begins with a chapter by Professor R J P Williams FRS.

Author: Robert P. Hausinger
Publisher: Springer Science & Business Media
ISBN: 1475794355
Category : Science
Languages : en
Pages : 286

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Book Description
In this timely monograph, the author summarizes the rapidly growing body of knowledge regarding nickel by providing a balanced discussion of its harmful and beneficial effects. Coverage includes a history of nickel; the chemistry of nickel, descriptions of the four known enzymes which contain nickel; and nickel metabolism in microbes, plants, and animals. Taken as a whole, Dr. Hausinger's work will highlight key features of this important element and help define future research.

Author: Robert R. Crichton
Publisher: Elsevier
ISBN: 0080556221
Category : Science
Languages : en
Pages : 383

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Book Description
The importance of metals in biology, the environment and medicine has become increasingly evident over the last twenty five years. The study of the multiple roles of metal ions in biological systems, the rapidly expanding interface between inorganic chemistry and biology constitutes the subject called Biological Inorganic Chemistry. The present text, written by a biochemist, with a long career experience in the field (particularly iron and copper) presents an introduction to this exciting and dynamic field. The book begins with introductory chapters, which together constitute an overview of the concepts, both chemical and biological, which are required to equip the reader for the detailed analysis which follows. Pathways of metal assimilation, storage and transport, as well as metal homeostasis are dealt with next. Thereafter, individual chapters discuss the roles of sodium and potassium, magnesium, calcium, zinc, iron, copper, nickel and cobalt, manganese, and finally molybdenum, vanadium, tungsten and chromium. The final three chapters provide a tantalising view of the roles of metals in brain function, biomineralization and a brief illustration of their importance in both medicine and the environment.Relaxed and agreeable writing style. The reader will not only fiind the book easy to read, the fascinating anecdotes and footnotes will give him pegs to hang important ideas on.Written by a biochemist. Will enable the reader to more readily grasp the biological and clinical relevance of the subject.Many colour illustrations. Enables easier visualization of molecular mechanismsWritten by a single author. Ensures homgeneity of style and effective cross referencing between chapters

Author: Michael J. Maroney
Publisher: MDPI
ISBN: 303928066X
Category : Science
Languages : en
Pages : 238

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Book Description
The chemistry of nickel in biological systems has been intensely investigated since the discovery of the essential role played by this transition metal in the enzyme urease, ca. 1975. Since then, several nickel-dependent enzymes have been discovered and characterized at the molecular level using structural, spectroscopic, and kinetic methods, and insight into reaction mechanisms has been elaborated using synthetic and computational models. The dual role of nickel as both an essential nutrient and as a toxin has prompted efforts to understand the molecular mechanisms of nickel toxicology and to uncover the means by which cells select nickel from among a pool of different and more readily available metal ions and thus regulate the intracellular chemistry of nickel. This latter effort highlights the importance of proteins involved in the extra- and intra-cellular sensing of nickel, the roles of nickel-selective proteins for import and export, and nickel-responsive transcription factors, all of which are important for regulating nickel homeostasis. In this Special Issue, the contributing authors have covered recent advances in many of these aspects of nickel biochemistry, including toxicology, bacterial pathogenesis, carcinogenesis, computational and synthetic models, nickel trafficking proteins, and enzymology.

Author: Wolfgang Kaim
Publisher: John Wiley & Sons
ISBN: 0470975237
Category : Science
Languages : en
Pages : 436

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Book Description
The field of Bioinorganic Chemistry has grown significantly in recent years; now one of the major sub-disciplines of Inorganic Chemistry, it has also pervaded other areas of the life sciences due to its highly interdisciplinary nature. Bioinorganic Chemistry: Inorganic Elements in the Chemistry of Life, Second Edition provides a detailed introduction to the role of inorganic elements in biology, taking a systematic element-by-element approach to the topic. The second edition of this classic text has been fully revised and updated to include new structure information, emerging developments in the field, and an increased focus on medical applications of inorganic compounds. New topics have been added including materials aspects of bioinorganic chemistry, elemental cycles, bioorganometallic chemistry, medical imaging and therapeutic advances. Topics covered include: Metals at the center of photosynthesis Uptake, transport, and storage of essential elements Catalysis through hemoproteins Biological functions of molybdenum, tungsten, vanadium and chromium Function and transport of alkaline and alkaline earth metal cations Biomineralization Biological functions of the non-metallic inorganic elements Bioinorganic chemistry of toxic metals Biochemical behavior of radionuclides and medical imaging using inorganic compounds Chemotherapy involving non-essential elements This full color text provides a concise and comprehensive review of bioinorganic chemistry for advanced students of chemistry, biochemistry, biology, medicine and environmental science.

Author: Dieter Rehder
Publisher: OUP Oxford
ISBN: 9780199655199
Category : Science
Languages : en
Pages : 0

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Book Description
Bioinorganic Chemistry provides a broad overview of this dynamic field, reviewing the key chemical elements that have important biological function, and exploring how the chemistry of these elements is central to the function of biological systems.

Author: Astrid Sigel
Publisher: John Wiley & Sons
ISBN: 0470028122
Category : Science
Languages : en
Pages : 728

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Book Description
Helmut Sigel, Astrid Sigel and Roland K.O. Sigel, in close cooperation with John Wiley & Sons, launch a new Series “Metal Ions in Life Sciences”. The philosophy of the Series is based on the one successfully applied to a previous series published by another publisher, but the move from “biological systems” to “life sciences” will open the aims and scope and allow for the publication of books touching on the interface between chemistry, biology, pharmacology, biochemistry and medicine. Volume 2 focuses on the vibrant research area concerning nickel as well as its complexes and their role in Nature. With more than 2,800 references and over 130 illustrations, it is an essential resource for scientists working in the wide range from inorganic biochemistry all the way through to medicine. In 17 stimulating chapters, written by 47 internationally recognized experts, Nickel and Its Surprising Impact in Nature highlights critically the biogeochemistry of nickel, its role in the environment, in plants and cyanobacteria, as well as for the gastric pathogen Helicobacter pylori, for gene expression and carcinogenensis. In addition, it covers the complex-forming properties of nickel with amino acids, peptides, phosphates, nucleotides, and nucleic acids. The volume also provides sophisticated insights in the recent progress made in understanding the role of nickel in enzymes such as ureases, hydrogenases, superoxide dismutases, acireductone dioxygenases, acetyl-coenzyme A synthases, carbon monoxide dehydrogenases, methyl-coenzyme M reductases...and it reveals the chaperones of nickel metabolism.

Author: Peter W. Jolly
Publisher: Springer Science & Business Media
ISBN: 3662075334
Category : Science
Languages : en
Pages : 394

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Book Description
This volume starts the updating of the information on organonickel chemistry, one of the most active areas of modern organometallic chemistry. It covers all mononuclear compounds containing one nickel-to-carbon bond. The main part is devoted to the family of planar NiII compounds, RNi(D)2X, which within 20 years has increased from about 250 to more than 1000 members. This research interest has been stimulated by the fact that many compounds insert various unsaturated species into the Ni-C bond to create new organonickel species. Moreover, these compounds are important as intermediates in many catalytic processes involving organic halides. Compounds containing h*2-bonded heteroalkene molecules including the C1 fragments CO2 and CS2, and related metallocyclic compounds are also emphasized in this volume. These types of compounds play an important role in a number of nickel-catalyzed co-oligomerization reactions involving unsaturated organic compounds. Most of the compounds are well-characterized by modern spectroscopic techniques. The various types of compounds are in most cases confirmed by X-ray diffraction. The author of these volumes, a member of the M lheim group, has made many contributions of his own and is eminently qualified to critically review this area of research.

Author: Douglas M. Considine
Publisher: Springer Science & Business Media
ISBN: 1475769180
Category : Technology & Engineering
Languages : en
Pages : 3529

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Book Description
Advancements in science and engineering have occurred at a surprisingly rapid pace since the release of the seventh edition of this encyclopedia. Large portions of the reference have required comprehensive rewriting and new illustrations. Scores of new topics have been included to create this thoroughly updated eighth edition. The appearance of this new edition in 1994 marks the continuation of a tradition commenced well over a half-century ago in 1938 Van Nostrand's Scientific Encyclopedia, First Edition, was published and welcomed by educators worldwide at a time when what we know today as modern science was just getting underway. The early encyclopedia was well received by students and educators alike during a critical time span when science became established as a major factor in shaping the progress and economy of individual nations and at the global level. A vital need existed for a permanent science reference that could be updated periodically and made conveniently available to audiences that numbered in the millions. The pioneering VNSE met these criteria and continues today as a reliable technical information source for making private and public decisions that present a backdrop of technical alternatives.