The biochemistry of amyloids in neurodegenerative diseases, volume II PDF Download
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Author: Cláudio M. Gomes
Publisher: Frontiers Media SA
ISBN: 2832529798
Category : Science
Languages : en
Pages : 193
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Book Description
Author: Cláudio M. Gomes
Publisher: Frontiers Media SA
ISBN: 2832529798
Category : Science
Languages : en
Pages : 193
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Book Description
Author: Cláudio M. Gomes
Publisher: Frontiers Media SA
ISBN: 2889742512
Category : Science
Languages : en
Pages : 153
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Book Description
Author: J. Robin Harris
Publisher: Springer Science & Business Media
ISBN: 0387232265
Category : Science
Languages : en
Pages : 416
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Book Description
To understand Alzheimer's disease (AD) is one of the major thrusts of present-day clinical research, strongly supported by more fimdamental cellular, biochemical, immunological and structural studies. It is these latter that receive attention within this book. This compilation of 20 chapters indicates the diversity of work currently in progress and summarizes the current state of knowledge. Experienced authors who are scientifically active in their fields of study have been selected as contributors to this book, in an attempt to present a reasonably complete survey of the field. Inevitably, some exciting topics for one reason or another have not been included, for which we can only apologize. Standardization of terminology is often a problem in science, not least in the Alzheimer field; editorial effort has been made to achieve standardization between the Chapters, but some minor yet acceptable personal / author variation is still present, i. e. P-amyloid/amyloid-P; Ap42/Apl-42/APi. 42! The book commences with a broad survey of the contribution that the range of available microscopical techniques has made to the study of Alzheimer's amyloid plaques and amyloid fibrillogenesis. This chapter also serves as an Introduction to the book, since several of the topics introduced here are expanded upon in later chapters. Also, it is significant to the presence of this chapter that the initial discovery of brain plaques, by Alois Alzheimer, utilized light microscopy, a technique that continues to be extremely valuable in present-day AD research.
Author: Dmitry Kurouski
Publisher: BoD – Books on Demand
ISBN: 1789853818
Category : Medical
Languages : en
Pages : 244
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Book Description
Neurodegenerative diseases are severe, rapidly developing, and currently incurable conditions that result in progressive degeneration and the death of neurons. This causes dementia, movement problems, and essentially loss of personal identity. Amyloids attempts to answer the following questions: (1) why do we develop these severe neurodegenerative diseases? (2) what histological and physiological changes are observed upon development and progression of these diseases? and (3) how can we treat amyloid-associated diseases?
Author: Einar M. Sigurdsson
Publisher: Springer Science & Business Media
ISBN: 1592598749
Category : Science
Languages : en
Pages : 390
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Book Description
A proven collection of readily reproducible techniques for studying amyloid proteins and their involvement in the etiology, pathogenesis, diagnosis, and therapy of amyloid diseases. The contributors provide methods for the preparation of amyloid and its precursors (oligomers and protofibrils), in vitro assays and analytical techniques for their study, and cell culture models and assays for the production of amyloid proteins. Additional chapters present readily reproducible techniques for amyloid extraction from tissue, its detection in vitro and in vivo, as well as nontransgenic methods for developing amyloid mouse models. The protocols follow the successful Methods in Molecular BiologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Author: Dennis J. Selkoe
Publisher: Cold Spring Harbor Perspective
ISBN: 9781936113446
Category : Medical
Languages : en
Pages : 0
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Book Description
Alzheimer disease causes the gradual deterioration of cognitive function, including severe memory loss and impairments in abstraction and reasoning. Understanding the complex changes that occur in the brain as the disease progressesincluding the accumulation of amyloid plaques and neurofibrillary tanglesis critical for the development of successful therapeutic approaches. Written and edited by leading experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine includes contributions covering all aspects of Alzheimer disease, from our current molecular understanding to therapeutic agents that could be used to treat and, ultimately, prevent it. Contributors discuss the biochemistry and cell biology of amyloid -protein precursor (APP), tau, presenilin, -secretase, and apolipoprotein E and their involvement in Alzheimer disease. They also review the clinical, neuropathological, imaging, and biomarker phenotypes of the disease; genetic alterations associated with the disorder; and epidemiological insights into its causation and pathogenesis. This comprehensive volume, which includes discussions of therapeutic strategies that are currently used or under development, is a vital reference for neurobiologists, cell biologists, pathologists, and other scientists pursuing the biological basis of Alzheimer disease, as well as investigators, clinicians, and students interested in its pathogenesis, treatment, and prevention.
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1398
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Book Description
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1398
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Book Description
Author: Claire Lesieur
Publisher: BoD – Books on Demand
ISBN: 9535116177
Category : Science
Languages : en
Pages : 454
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Book Description
Many thanks to the authors for high quality chapters and to the referees for helping improve the manuscripts. The book is interdisciplinary, it covers fields from organic chemistry to mathematics, and raises different aspects of oligomerization. It is a great source of information as every chapter introduces general knowledge and deep details. Mixing communities is to instigate novel ideas and hopefully help looking at oligomerization with new eyes.
Author: John Herbert Growdon
Publisher: Elsevier Health Sciences
ISBN: 075067542X
Category : Medical
Languages : en
Pages : 456
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Book Description
This volume in the Blue Books of Neurology series provides you with rapid access to practical, clinical guidance on the diagnosis and treatment of all forms of dementia, including Alzheimer's disease, dementia with Lewy bodies, Parkinson's disease, and many others. Organized by the most common neurodegenerative diseases, it reflects new insights regarding commonalities among the neurodegenerative diseases, and clusters them according to their dominant molecular pathologic signatures, so you can best treat any dementia you see. Differentiate among various forms of dementia and provide the appropriate management strategy. Correlate neuroimaging with neuropsychological testing to form more accurate diagnoses. Administer the latest approved drugs to improve your patients' brain function. A new two-color design and full-color images throughout helps you access information more easily. New chapters and new authors help you incorporate the latest information and fresh perspectives into your practice.
