Test No. 443: Extended One-Generation Reproductive Toxicity Study PDF Download
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Author: OECD
Publisher: OECD Publishing
ISBN: 9264122559
Category :
Languages : en
Pages : 25
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Book Description
This Test Guideline is designed to provide an evaluation of reproductive and developmental effects that may occur as a result of pre- and postnatal chemical exposure as well as an evaluation of systemic toxicity in pregnant and lactating females and ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264122559
Category :
Languages : en
Pages : 25
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Book Description
This Test Guideline is designed to provide an evaluation of reproductive and developmental effects that may occur as a result of pre- and postnatal chemical exposure as well as an evaluation of systemic toxicity in pregnant and lactating females and ...
Author: Ali S. Faqi
Publisher: Humana Press
ISBN: 9781493972067
Category : Medical
Languages : en
Pages : 314
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Book Description
This meticulous volume covers metabolism and drug-drug interactions during pregnancy, critical periods of developmental toxicology, in vivo and alternative methods to assess potential developmental toxicity for drugs and chemicals, and effects of chemicals on testes and mammary glands. Evaluation of developmental and reproductive toxicology endpoints is an integral part of the safety assessment process for compounds with potential use in women of childbearing age or females that might be exposed during pregnancy as well as men of reproductive potential. The in vivo assessments included here are guideline-driven and are required for submissions for product approval. Written for the Methods in Pharmacology and Toxicology series, this collection includes the kind of detailed implementation advice necessary for success in the lab. Authoritative and practical, Developmental and Reproductive Toxicology is an ideal resource for researchers working in this vital field of study./div
Author: OECD
Publisher: OECD Publishing
ISBN: 9264070966
Category :
Languages : en
Pages : 10
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Book Description
The test substance is administered in graduated doses to several groups of males and females. Males should be dosed for a minimum of four weeks. Females should be dosed throughout the study, so approximately 54 days. This Test Guideline is designed ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264070982
Category :
Languages : en
Pages : 14
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Book Description
The test substance is administered in graduated doses to several groups of males and females. Males should be dosed for a minimum of four weeks; females should be dosed throughout the study (approximately 54 days). Normally, matings “one male to one ...
Author: Tim Marrs
Publisher: Royal Society of Chemistry
ISBN: 1788014049
Category : Medical
Languages : en
Pages : 638
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Book Description
Consumer and environmental protection depend on the careful regulation of all classes of chemicals. Toxicology is the key science used to evaluate safety and so underpins regulatory decisions on chemicals. With the growing body of EU legislation involved in chemical regulation, there is a concomitant need to understand the toxicological principles underlying safety assessments Regulatory Toxicology in the European Union is the first book to cover regulatory toxicology specifically in Europe. It addresses the need for a wider understanding of the principles of regulatory toxicology and their application and presents the relationship between toxicology and legislative processes in regulating chemical commodities across Europe. This title has a broad scope, covering historical and current chemical regulation in Europe, the role of European agencies and institutions, and also the use of toxicology data for important classes of chemicals, including human and veterinary medicines, animal feed and food additives, biocides, pesticides and nanomaterials. This book is therefore extremely pertinent and timely in the toxicology field at present. This book is an essential reference for regulatory authorities, industrialists, academics, undergraduates and postgraduates working within safety and hazards, toxicology, the biological sciences, and the medicinal and pharmaceutical sciences across the European Union.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264067396
Category :
Languages : en
Pages : 26
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Book Description
A developmental neurotoxicity study will provide information on the effects of repeated exposure to a substance during in utero and early postnatal development. The test substance is administered daily, generally orally, to mated females (rats are ...
Author:
Publisher:
ISBN:
Category : Ethylene dichloride
Languages : en
Pages : 224
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Book Description
Author: OECD
Publisher: OECD Publishing
ISBN: 9264070826
Category :
Languages : en
Pages : 14
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Book Description
This Test Guideline for developmental toxicity testing is designed to provide general information concerning the effects of prenatal exposure on the pregnant test animal and on the developing organism. The test substance is normally administered to ...
Author: Andrew G. Mtewa
Publisher: John Wiley & Sons
ISBN: 1119650232
Category : Science
Languages : en
Pages : 444
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Book Description
Focusing on phytochemicals and their potential for drug discovery, this book offers a comprehensive resource on poisonous plants and their applications in chemistry and in pharmacology. Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career
Author:
Publisher:
ISBN:
Category : Freshwater invertebrates
Languages : en
Pages : 150
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Book Description
Sediment contamination is a widespread environmental problem that can potentially pose a threat to a variety of aquatic ecosystems. The sediment test methods in this manual will be used by The United States Environmental Protection Agency (USEPA) to make decisions under a range of statutory authorities concerning such issues as: dredged material disposal, registration of pesticides and toxic substances, superfound site assessment, and assessment and cleanup of hazardous waste treatment, storage, and disposal facilities. The use of uniform sediment testing procedures by USEPA programs is expected to increase data accuracy and precision, facilitate test replication, increase the comparative value of test results, and ultimately, increase the efficiency of regulatory processes requiring sediment tests.
