Drugs Targeting B-Cells in Autoimmune Diseases PDF Download
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Author: Xavier Bosch
Publisher: Springer Science & Business Media
ISBN: 3034807066
Category : Medical
Languages : en
Pages : 300
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Book Description
This book provides a detailed overview of B-cell directed therapies in patients with rheumatic and systemic autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sjögren syndrome, ANCA-associated vasculitis and cryoglobulinemia. Organ-specific autoimmune diseases are discussed with respect to the use of B-cell directed therapies in neurological autoimmune diseases and autoimmune cytopenias. Situations in which B-cell targeted therapy may be indicated are identified, thereby offering comprehensive support for therapeutic decisions on the basis of the latest published evidence. The book also offers a valuable reference tool for rheumatologists, internists, nephrologists, immunologists, and all specialists involved in the multidisciplinary care of patients with rheumatic and systemic autoimmune diseases.
Author: P. E. Bigazzi
Publisher: CRC Press
ISBN: 9780824785505
Category : Medical
Languages : en
Pages : 328
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Book Description
Surveys the biotechnologically influenced advances in the understanding of systemic autoimmune disorders, highlighting recent research using cell biology and biochemistry, the cloning of immune cells, recombinant DNA, and molecular genetics. Among the topics are the role of complement in inflammatio
Author: Xavier Bosch
Publisher: Springer Science & Business Media
ISBN: 3034807066
Category : Medical
Languages : en
Pages : 300
Get Book Here
Book Description
This book provides a detailed overview of B-cell directed therapies in patients with rheumatic and systemic autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sjögren syndrome, ANCA-associated vasculitis and cryoglobulinemia. Organ-specific autoimmune diseases are discussed with respect to the use of B-cell directed therapies in neurological autoimmune diseases and autoimmune cytopenias. Situations in which B-cell targeted therapy may be indicated are identified, thereby offering comprehensive support for therapeutic decisions on the basis of the latest published evidence. The book also offers a valuable reference tool for rheumatologists, internists, nephrologists, immunologists, and all specialists involved in the multidisciplinary care of patients with rheumatic and systemic autoimmune diseases.
Author: William Stohl
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805578512
Category : Medical
Languages : en
Pages : 321
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Book Description
The understanding of B cell biology has increased and expanded enormously in the last three decades. It is now known that B cells, in addition to just differentiating into antibody-secreting cells, serve many other vital functions. For example, their roles as antigen-presenting cells and cytokine-producing cells as well as effector cells and regulatory cells are well appreciated now. Indeed, the pathologic role of B cells in many autoimmune disorders may be largely autoantibody-independent. Today, the B cell is of considerable interest not only to immunologists but also to mainstream clinicians and scientists. The current volume covers the latest information on the functions of B cells in normal and disease states, and their therapeutic antagonism. Chapters cover cutting-edge topics from the basic to the clinical, including B cells in infection and autoimmunity, CD19-CD21 signal transduction complex, marginal zone B cell physiology and disease, B cell growth and differentiation, their role in rheumatoid arthritis, SLE treatment, the BAFF/APRIL system and B lymphocyte malignancies. This book is recommended reading for cellular and molecular immunologists as well as for rheumatologists, hematologists and clinical immunologists, and all those interested in human diseases in which B cells play an important contributory role.
Author: Peter E. Lipsky
Publisher:
ISBN:
Category :
Languages : en
Pages : 27
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Book Description
Author: Gerald J. Prud'homme
Publisher: Springer
ISBN: 9780306479915
Category : Medical
Languages : en
Pages : 149
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Book Description
Autoimmune diseases are diverse and responsible for considerable morbidity. Their etiology remains largely unknown, and current therapy with anti-inflammatory drugs is prone to adverse effects, and rarely curative. New therapies with anti-cytokine antibodies or receptors are promising, but require frequent administration of expensive protein drugs. Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.
Author: Tasuku Honjo
Publisher: Elsevier
ISBN: 0080479502
Category : Medical
Languages : en
Pages : 629
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Book Description
Molecular Biology of B Cells is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All these developmental and stimulatory processes are described in molecular and genetic terms to give a clear understanding of complex phenotyes. The molecular basis of many diseases due to B cell abnormality is also discussed. This definitive reference is directed at research level immunologists, molecular biologists and geneticists.
Author: Min Yang
Publisher:
ISBN: 9781361276556
Category :
Languages : en
Pages :
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Book Description
This dissertation, "Role of Regulatory B Cells in Autoimmune Disease" by Min, Yang, 杨敏, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Although B cells are well-known for their functions in antibody production and antigen presentation, certain B cell subsets have been recently identified as regulatory B cells to modulate immune responses through cytokine production. However, the microenvironmental factors involved in the induction of regulatory B cells remain largely uncharacterized. B cell-activating factor (BAFF), a member of TNF family cytokines produced by myeloid cells, is a key regulator for B cell maturation and function. However, it remains unknown whether BAFF plays a role in modulating the generation of regulatory B cells and how regulatory B cells suppress autoimmune pathogenesis. In this study, treatment with BAFF significantly increased IL-10-producing B cells in culture of mouse splenic B cells, an effect specifically abrogated by neutralization with TACI-Fc. BAFF-induced IL-10-producing B cells showed a distinct CD1dhiCD5+(B10) phenotype. Phenotypic analysis further indicated that these BAFF-induced B10 cells were marginal-zone (MZ)-like B cells. Interestingly, BAFF treatment in vivo also increased the number of IL-10-producingB cells in splenic MZ regions. Moreover, chromatin immunoprecipitation analysis revealed that BAFF activated the transcription factor AP-1 for binding to IL-10 promoter, demonstrating a novel function for BAFF in inducing IL-10 production. Furthermore, those BAFF-induced B10 cells exhibited significant suppressive effects on CD4+T cell proliferation and Th1 cytokine production in culture. To explore whether these BAFF-induced B10 cells possess a regulatory function in suppressing autoimmune progression in vivo, collagen-induced arthritis (CIA) mouse model was employed. In vitro-expanded B10 cells and other control B cells were intravenously transferred into DBA/1J mice on the day of 2ndcollagen II (CII)-immunization. After adoptive transfer of BAFF-induced B10 cells, CII-immunized mice exhibited a delayed onset of arthritis and substantially reduced severity of clinical symptoms. The pathogenesis of IL-17-producing CD4+T cells (Th17) in the development of arthritis has been well-recognized, which has led me to test the hypothesis whether B10 cells ameliorate the development of arthritis via modulating Th17 cells. During the progression of CIA, IL-10-producing B cells were decreasedwhereasTh17 cells were significantly increased at the acute phase of CIA. Upon transfer of BAFF-induced B10 cells, a substantially reduction ofTh17 cells in both lymphoid organs and inflamed joints were detected. To verify whether B10 cells inhibit Th17 cell generation in culture, CFSE-labeled na've CD4+T cells were cocultured with B10 cells in Th17 cell polarization medium. It was found that B10 cells suppressed Th17 cell differentiation via reducing STAT3 phosphorylation and RORt expression. Although adoptive transfer of Th17 cells triggered the development of CIA in IL-17-/-DBA mice, cotransfer of B10 cells with Th17 cells profoundly delayed the onset of delayed the onset of arthritisand remarkably reduced the infiltration of Th17 cells in synovial fluid. Taken together, I have identified a novel function of BAFF in the induction of IL-10-producing regulatory B cells. My findings that adoptive transfer of BAFF-expanded B10 cells can effectively suppress the development of experimental arthritisin mice via the inhibition of Th17 cell generation may contribute to the development of new therapeutic strategies in t
Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :
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Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author: Kartik Bhamidipati
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Alterations in B cell homeostasis drive pathogenesis of various immune mediated diseases. Breaks in peripheral tolerance allow autoreactive B cells to differentiate in to pathogenic auto-antibody secreting cells. B cells themselves may directly drive pathogenesis through antigen-presentation capabilities and secretion of pro-fibrotic factors. Lastly, the inability of B cells to mount effective responses against pathogens may trigger subsequent inflammatory or autoimmune reactions. In this work, we dissect various ways in which B cells contribute to pathogenesis of inflammatory disease by evaluating their role in three different immune mediated diseases. In chapter 2 we identify a potential regulatory role for B cells in the context of Systemic Lupus Erythematosus (SLE), an autoimmune disease characterized by the pathogenic secretion of anti-nuclear antibodies. We found that CD52 is a B cell regulatory glycoprotein elevated on the surface of B cells in patients and acts to suppress B cell hyperactivity both through its surface expression and through the secretion of a soluble form that can bind receptor Siglec-10. In chapter 3 we describe a population of B cells that is significantly expanded in IgG4-RD, a fibroinflammatory condition characterized by infiltration of IgG4+ plasma cells into tumefactive lesions and the development of storiform fibrosis. The expanded population of B cells was CD21-- and CXCR5+, expressing high levels of pathogenic B cell marker CD11c. Moreover, the frequency of this expanded population correlated with clinical parameters such as IgG4 titers. We observed a tremendous elevation of CXCL13, the ligand for CXCR5, strongly implicating the CXCR5-CXCL13 axis in recruiting B cells to affected tissue, making it a viable therapeutic target. Lastly, in chapter 4 we performed high-dimensional sequencing on B cells from sarcoidosis patients, a disease characterized by spontaneous granuloma formation. Although B cells have not been directly implicated in the inflammation, we observed a less diverse and less mutated B cell receptor repertoire; together, our findings point to the initiation of sarcoidosis after ineffective antibody mediated clearance of pathogen from affected organs. In total, this work sheds novel insights on the role of B cells-- from the initial stages of activation and germinal center recruitment, to the development of a diverse antibody repertoire-- in the context of poorly understood immune mediated conditions and contributes important knowledge for the advancement of better treatments for affected patients.
Author: Christian Boitard
Publisher: Landes Bioscience
ISBN:
Category : Medical
Languages : en
Pages : 288
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Book Description
