Synthetic Bioactive Morpholine Based 1,3,4-Oxadiazole Scaffolds PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Synthetic Bioactive Morpholine Based 1,3,4-Oxadiazole Scaffolds PDF full book. Access full book title Synthetic Bioactive Morpholine Based 1,3,4-Oxadiazole Scaffolds by Aziz-ur- Rehman. Download full books in PDF and EPUB format.
Author: Aziz-ur- Rehman
Publisher: LAP Lambert Academic Publishing
ISBN: 9783659709548
Category :
Languages : en
Pages : 176
Get Book Here
Book Description
The presented research work comprises of synthesis, spectral analysis and biological screening of some new acetamides/sulfides bearing substituted-1,3,4-Oxadiazole and morpholine moieties. The acetamide, 1,3,4-oxadiazole and morpholine moieties are important functionalities because of their broad range of known pharmacological activities. Synthetic approaches were utilized to synthesize poly-functional compounds. The main intention of the present research work was to design and synthesize some new poly-functional compounds having 1,3,4-oxadiazole and acetamide or 1,3,4-oxadiazole, morpholine and sulfide or 1,3,4-oxadiazole, morpholine and acetamide moieties together in one molecule. It was assumed that 2,5-disubstituted-1,3,4-oxadiazol ring along with the potential morpholine moiety and acetamide/sulfide functionality will enhance the activity of the molecule. Keeping in sight the broad diversity of biological activitites, some of the synthesized compounds were checked for their antibacaterial, hemolytic and antifungal screening. Some of compounds were found to be active and showed interesting results as compared to reference standard drugs.
Author: Aziz-ur- Rehman
Publisher: LAP Lambert Academic Publishing
ISBN: 9783659709548
Category :
Languages : en
Pages : 176
Get Book Here
Book Description
The presented research work comprises of synthesis, spectral analysis and biological screening of some new acetamides/sulfides bearing substituted-1,3,4-Oxadiazole and morpholine moieties. The acetamide, 1,3,4-oxadiazole and morpholine moieties are important functionalities because of their broad range of known pharmacological activities. Synthetic approaches were utilized to synthesize poly-functional compounds. The main intention of the present research work was to design and synthesize some new poly-functional compounds having 1,3,4-oxadiazole and acetamide or 1,3,4-oxadiazole, morpholine and sulfide or 1,3,4-oxadiazole, morpholine and acetamide moieties together in one molecule. It was assumed that 2,5-disubstituted-1,3,4-oxadiazol ring along with the potential morpholine moiety and acetamide/sulfide functionality will enhance the activity of the molecule. Keeping in sight the broad diversity of biological activitites, some of the synthesized compounds were checked for their antibacaterial, hemolytic and antifungal screening. Some of compounds were found to be active and showed interesting results as compared to reference standard drugs.
Author: Rakesh Kumar Sharma
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3110797429
Category : Science
Languages : en
Pages : 414
Get Book Here
Book Description
Carbon-carbon and carbon-heteroatom bond-forming reactions are the backbone of synthetic organic chemistry. Scientists are constantly developing and improving these techniques in order to maximize the diversity of synthetically available molecules. These techniques must be developed in a sustainable manner in order to limit their environmental impact. This book highlights green bond forming reactions for bioactive scaffolds.
Author: Jacques V. Metzger
Publisher:
ISBN:
Category : Thiazoles
Languages : en
Pages : 440
Get Book Here
Book Description
Author: Goutam Brahmachari
Publisher: Royal Society of Chemistry
ISBN: 1782624120
Category : Business & Economics
Languages : en
Pages : 410
Get Book Here
Book Description
Explaining methods for carrying out chemical syntheses without the use of catalysts, this book shows how avoiding catalysts during synthesis can mean less use of toxic chemicals, environmentally damaging chemicals, or endangered elements, and lower costs.
Author: Maria João Matos
Publisher: Mdpi AG
ISBN: 9783036527758
Category : Science
Languages : en
Pages : 416
Get Book Here
Book Description
Coumarins are widely distributed in nature and can be found in a large number of naturally occurring and synthetic bioactive molecules. The unique and versatile oxygen-containing heterocyclic structure makes them a privileged scaffold in Medicinal Chemistry. Many coumarin derivatives have been extracted from natural sources, designed, synthetized, and evaluated on different pharmacological targets. In addition, coumarin-based ion receptors, fluorescent probes, and biological stains are growing quickly and have extensive applications to monitor timely enzyme activity, complex biological events, as well as accurate pharmacological and pharmacokinetic properties in living cells. The extraction, synthesis, and biological evaluation of coumarins have become extremely attractive and rapidly developing topics. A large number of research and review papers have compiled information on this important family of compounds in 2020. Research articles, reviews, communications, and concept papers focused on the multidisciplinary profile of coumarins, highlighting natural sources, most recent synthetic pathways, along with the main biological applications and theoretical studies, were the main focus of this book. The huge and growing range of applications of coumarins described in this book is a demonstration of the potential of this family of compounds in Organic Chemistry, Medicinal Chemistry, and different sciences related to the study of natural products. This book includes 23 articles: 17 original papers and six review papers.
Author: Jason Tierney
Publisher: John Wiley & Sons
ISBN: 1405168447
Category : Science
Languages : en
Pages : 296
Get Book Here
Book Description
The first reports on the application of microwaves in organicsynthesis date back to 1986, but it was not until the recentintroduction of specifically designed and constructed equipment,which countered the safety and reproducibility concerns, thatsynthetic application of microwaves has become established as alaboratory technique. Microwave assisted synthesis is now beingadopted in many industrial and academic laboratories to takeadvantage of the novel chemistry that can be carried out using avariety of organic reaction types. This book demonstrates the underlying principles of microwavedielectric heating and, by reference to a range of organic reactiontypes, it's effective use in synthetic organic chemistry. Toillustrate the impact microwave assisted organic synthesis can haveon chemical research, case studies drawn mainly from thepharmaceutical industry are presented.
Author: Florencio Zaragoza Dörwald
Publisher: John Wiley & Sons
ISBN: 3527604987
Category : Science
Languages : en
Pages : 389
Get Book Here
Book Description
Most syntheses in the chemical research laboratory fail and usually require several attempts before proceeding satisfactorily. Failed syntheses are not only discouraging and frustrating, but also cost a lot of time and money. Many failures may, however, be avoided by understanding the structure-reactivity relationship of organic compounds. This textbook highlights the competing processes and limitations of the most important reactions used in organic synthesis. By allowing chemists to quickly recognize potential problems this book will help to improve their efficiency and success-rate. A must for every graduate student but also for every chemist in industry and academia. Contents: 1 Organic Synthesis: General Remarks 2 Stereoelectronic Effects and Reactivity 3 The Stability of Organic Compounds 4 Aliphatic Nucleophilic Substitutions: Problematic Electrophiles 5 The Alkylation of Carbanions 6 The Alkylation of Heteroatoms 7 The Acylation of Heteroatoms 8 Palladium-Catalyzed C-C Bond Formation 9 Cyclizations 10 Monofunctionalization of Symmetric Difunctional Substrates
Author: K. L. Ameta
Publisher: Springer
ISBN: 8132218507
Category : Science
Languages : en
Pages : 418
Get Book Here
Book Description
The book presents a succinct summary of methods for the synthesis and biological activities of various different-sized bioactive heterocycles using different green chemistry synthetic methodologies, like microwave, ultrasonic, water mediated, ionic liquids, etc. The book also provides an insight of how green chemistry techniques are specific to the bioactive heterocyclic compounds.
Author: Paul Knochel
Publisher: Oxford University Press on Demand
ISBN: 9780198501213
Category : Science
Languages : en
Pages : 354
Get Book Here
Book Description
This valuable and unique text, written by world-renowned researchers, covers the application of these reagents to organic synthesis. The book is written in a clear and concise manner, containing step-by-step experimental procedures, and should be a valuable resource to new postgraduate students and experienced researchers alike.
Author: Aiwen Lei
Publisher: John Wiley & Sons
ISBN: 3527681019
Category : Technology & Engineering
Languages : en
Pages : 240
Get Book Here
Book Description
The first handbook on this emerging field provides a comprehensive overview of transition metal-catalyzed coupling reactions in the presence of an oxidant. Following an introduction to the general concept and mechanism of this reaction class, the team of authors presents chapters on C-C cross-coupling reactions using organometallic partners, C-Heteroatom bond forming reactions via oxidative couplings, and C-H couplings via C-H activation. The text also covers such groundbreaking topics as recent achievements in the fields of C-C and C-X bond formation reactions as well as C-H activation involving oxidative couplings. With its novel and concise approach towards important building blocks in organic chemistry and its focus on synthetic applications, this handbook is of great interest to all synthetic chemists in academia and industry alike.
