Author: Colin R. Spencer
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Eighteen polypyridyl ruthenium complexes were synthesized and characterized to test their ability to be new photodynamic compounds (PDCs). Each compound bears oxazo- or imidazo[4,5-f][1,10]phenanthroline ligands with a varying R-group and 2,2-bipyridine and 1,10-phenanthroline ancillary ligands. Biological tests were employed for the complexes to test the potential to be new PDCs, and included DNA photocleavage, DNA binding, and photocytotoxicity. Compounds containing thiophenes as the R-group showed significant DNA damage in the photocleavage assays as well as light toxicity and low dark toxicity in photocytotoxic assays. Compounds with 1,10-phenanthroline ancillary ligands generally showed more DNA photocleavage, unwinding, and binding compared to their 2,2'-bipyridine counterparts. Dinuclear compounds containing the bis(imidazo[4,5-f][1,10]phenanthroline) bridging ligand exhibited the best results for high light toxicity and low dark toxicity, the strongest binding to DNA, and the most potency for DNA photocleavage. As such these compounds are promising candidates for new PDCs and warrant further investigations.
Synthesis and Characterization of Ruthenium Polypyridyl Complexes for Application in Photodynamic Therapy
Author: Colin R. Spencer
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Eighteen polypyridyl ruthenium complexes were synthesized and characterized to test their ability to be new photodynamic compounds (PDCs). Each compound bears oxazo- or imidazo[4,5-f][1,10]phenanthroline ligands with a varying R-group and 2,2-bipyridine and 1,10-phenanthroline ancillary ligands. Biological tests were employed for the complexes to test the potential to be new PDCs, and included DNA photocleavage, DNA binding, and photocytotoxicity. Compounds containing thiophenes as the R-group showed significant DNA damage in the photocleavage assays as well as light toxicity and low dark toxicity in photocytotoxic assays. Compounds with 1,10-phenanthroline ancillary ligands generally showed more DNA photocleavage, unwinding, and binding compared to their 2,2'-bipyridine counterparts. Dinuclear compounds containing the bis(imidazo[4,5-f][1,10]phenanthroline) bridging ligand exhibited the best results for high light toxicity and low dark toxicity, the strongest binding to DNA, and the most potency for DNA photocleavage. As such these compounds are promising candidates for new PDCs and warrant further investigations.
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Eighteen polypyridyl ruthenium complexes were synthesized and characterized to test their ability to be new photodynamic compounds (PDCs). Each compound bears oxazo- or imidazo[4,5-f][1,10]phenanthroline ligands with a varying R-group and 2,2-bipyridine and 1,10-phenanthroline ancillary ligands. Biological tests were employed for the complexes to test the potential to be new PDCs, and included DNA photocleavage, DNA binding, and photocytotoxicity. Compounds containing thiophenes as the R-group showed significant DNA damage in the photocleavage assays as well as light toxicity and low dark toxicity in photocytotoxic assays. Compounds with 1,10-phenanthroline ancillary ligands generally showed more DNA photocleavage, unwinding, and binding compared to their 2,2'-bipyridine counterparts. Dinuclear compounds containing the bis(imidazo[4,5-f][1,10]phenanthroline) bridging ligand exhibited the best results for high light toxicity and low dark toxicity, the strongest binding to DNA, and the most potency for DNA photocleavage. As such these compounds are promising candidates for new PDCs and warrant further investigations.
Synthesis and Characterization of Ruthenium Polypyridyl Complexes for Application in Photodynamic Theraoy
Author: Colin R. Spencer
Publisher:
ISBN:
Category : Photochemistry
Languages : en
Pages : 588
Book Description
Publisher:
ISBN:
Category : Photochemistry
Languages : en
Pages : 588
Book Description
The Synthesis and Characterization of Ruthenium and Osmium Polypyridyl Coordination Complexes as Photosensitizers for Photodynamic Therapy
Author: Leah G. Bennett
Publisher:
ISBN:
Category :
Languages : en
Pages : 207
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 207
Book Description
Ruthenium Complexes
Author: Alvin A. Holder
Publisher: John Wiley & Sons
ISBN: 3527339574
Category : Science
Languages : en
Pages : 344
Book Description
Edited by a team of highly respected researchers combining their expertise in chemistry, physics, and medicine, this book focuses on the use of rutheniumcontaining complexes in artificial photosynthesis and medicine. Following a brief introduction to the basic coordination chemistry of ruthenium complexes and their synthesis in section one, as well as their photophysical and photochemical properties, the authors discuss in detail the major concepts of artificial photosynthesis and mechanisms of hydrogen production and water oxidation with ruthenium in section two. The third section of the text covers biological properties and important medical applications of ruthenium complexes as therapeutic agents or in diagnostic imaging. Aimed at stimulating research in this active field, this is an invaluable information source for researchers in academia, health research institutes and governmental departments working in the field of organometallic chemistry, green and sustainable chemistry as well as medicine/drug discovery, while equally serving as a useful reference also for scientists in industry.
Publisher: John Wiley & Sons
ISBN: 3527339574
Category : Science
Languages : en
Pages : 344
Book Description
Edited by a team of highly respected researchers combining their expertise in chemistry, physics, and medicine, this book focuses on the use of rutheniumcontaining complexes in artificial photosynthesis and medicine. Following a brief introduction to the basic coordination chemistry of ruthenium complexes and their synthesis in section one, as well as their photophysical and photochemical properties, the authors discuss in detail the major concepts of artificial photosynthesis and mechanisms of hydrogen production and water oxidation with ruthenium in section two. The third section of the text covers biological properties and important medical applications of ruthenium complexes as therapeutic agents or in diagnostic imaging. Aimed at stimulating research in this active field, this is an invaluable information source for researchers in academia, health research institutes and governmental departments working in the field of organometallic chemistry, green and sustainable chemistry as well as medicine/drug discovery, while equally serving as a useful reference also for scientists in industry.
Synthesis and Characterization of Novel Ru(II) Dipyrrin Complexes for Use as Photodynamic Therapy Agents in Cancer Treatments
Author: Max Tsao
Publisher:
ISBN:
Category : Characterization
Languages : en
Pages : 41
Book Description
Publisher:
ISBN:
Category : Characterization
Languages : en
Pages : 41
Book Description
Ruthenium Chemistry
Author: Ajay Kumar Mishra
Publisher: CRC Press
ISBN: 1351616501
Category : Science
Languages : en
Pages : 386
Book Description
This book will describe Ruthenium complexes as chemotherapeutic agent specifically at tumor site. It has been the most challenging task in the area of cancer therapy. Nanoparticles are now emerging as the most effective alternative to traditional chemotherapeutic approach. Nanoparticles have been shown to be useful in this respect. However, in view of organ system complicacies, instead of using nanoparticles as a delivery tool, it will be more appropriate to synthesize a drug of nanoparticle size that can use blood transport mechanism to reach the tumor site and regress cancer. Due to less toxicity and effective bio-distribution, ruthenium (Ru) complexes are of much current interest. Additionally, lumiscent Ru-complexes can be synthesized in nanoparticle size and can be directly traced at tissue level. The book will contain the synthesis, characterization, and applications of various Ruthenium complexes as chemotherapeutic agents. The book will also cover the introduction to chemotherapy, classification of Ru- complexes with respect to their oxidation states and geometry, Ruthenium complexes of nano size: shape and binding- selectivity, binding of ruthenium complexes with DNA, DNA cleavage studies and cytotoxicity. The present book will be more beneficial to researchers, scientists and biomedical. Current book will empower specially to younger generation to create a new world of ruthenium chemistry in material science as well as in medicines. This book will be also beneficial to national/international research laboratories, and academia with interest in the area of coordination chemistry more especially to the Ruthenium compounds and its applications.
Publisher: CRC Press
ISBN: 1351616501
Category : Science
Languages : en
Pages : 386
Book Description
This book will describe Ruthenium complexes as chemotherapeutic agent specifically at tumor site. It has been the most challenging task in the area of cancer therapy. Nanoparticles are now emerging as the most effective alternative to traditional chemotherapeutic approach. Nanoparticles have been shown to be useful in this respect. However, in view of organ system complicacies, instead of using nanoparticles as a delivery tool, it will be more appropriate to synthesize a drug of nanoparticle size that can use blood transport mechanism to reach the tumor site and regress cancer. Due to less toxicity and effective bio-distribution, ruthenium (Ru) complexes are of much current interest. Additionally, lumiscent Ru-complexes can be synthesized in nanoparticle size and can be directly traced at tissue level. The book will contain the synthesis, characterization, and applications of various Ruthenium complexes as chemotherapeutic agents. The book will also cover the introduction to chemotherapy, classification of Ru- complexes with respect to their oxidation states and geometry, Ruthenium complexes of nano size: shape and binding- selectivity, binding of ruthenium complexes with DNA, DNA cleavage studies and cytotoxicity. The present book will be more beneficial to researchers, scientists and biomedical. Current book will empower specially to younger generation to create a new world of ruthenium chemistry in material science as well as in medicines. This book will be also beneficial to national/international research laboratories, and academia with interest in the area of coordination chemistry more especially to the Ruthenium compounds and its applications.
Synthesis and Characterization of Ruthenium (II) Polypyridyl Complexes
Author: Youxiang Wang
Publisher:
ISBN:
Category : Diazo compounds
Languages : en
Pages : 190
Book Description
Publisher:
ISBN:
Category : Diazo compounds
Languages : en
Pages : 190
Book Description
Synthesis and Characterization of Photolabile Ruthenium Polypyridyl Crosslinkers with Applications in Soft Materials and Biology
Author: Teresa Rapp
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
Book Description
Since its discovery in 1844, ruthenium has solidified its position as the most widely used transition metal in catalysis and excited state chemistry. Its lower toxicity and relatively low price (compared to other platinum group metals) have enabled many applications of ruthenium coordination compounds. In this dissertation I discuss ruthenium polypyridyl complexes that undergo photoinduced ligand exchange, and how this unique property can be harnessed to develop next-generation smart materials and responsive chemical biology tools. Ru(LL)2X22+ complexes, where LL is a bidentate aromatic heterocycle such as 2,2'-bipyridine, 1,10-phenanthroline, or 2,2'-biquinoline, and X is a pyridine-, nitrile-, sulfur-, or imidazole-based monodentate ligand, have the unique capability to undergo ligand exchange under visible light irradiation. We have harnessed this property to develop a series of visible-light-sensitive photodegradable crosslinkers by choosing X ligands that contain reactive moieties such as alkynes (for copper-mediated azide-alkyne cycloaddition (CuAAC)) or aldehydes (for Schiff base reaction with hydrazines). Ru(bpy)2(3-ethynylpyridine)2 (RuBEP) has been used in CuAAC reactions to circularize azide-terminated oligonucleotides important for gene regulation or transcriptome analysis. Ru(bpy)2 (3-pyridinaldehyde) 2 (RuAldehyde) alternately employed aldehydes to react with hydrazine-modified hyaluronic acid (HA-HYD). The resulting hydrogel was cytocompatible, efficiently degraded with visible light, and well adapted for the storage and delivery of active enzymes via lysine-mediated crosslinking into the hydrogel matrix. Finally, Ru(biq)2(5-hexynenitrile)2 and Ru(bpy) 2(5-hexynenitrile) 2 were developed as crosslinkers to form PEG-based hydrogel, which was subsequently degraded using two different colors of visible light, orange and blue.
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
Book Description
Since its discovery in 1844, ruthenium has solidified its position as the most widely used transition metal in catalysis and excited state chemistry. Its lower toxicity and relatively low price (compared to other platinum group metals) have enabled many applications of ruthenium coordination compounds. In this dissertation I discuss ruthenium polypyridyl complexes that undergo photoinduced ligand exchange, and how this unique property can be harnessed to develop next-generation smart materials and responsive chemical biology tools. Ru(LL)2X22+ complexes, where LL is a bidentate aromatic heterocycle such as 2,2'-bipyridine, 1,10-phenanthroline, or 2,2'-biquinoline, and X is a pyridine-, nitrile-, sulfur-, or imidazole-based monodentate ligand, have the unique capability to undergo ligand exchange under visible light irradiation. We have harnessed this property to develop a series of visible-light-sensitive photodegradable crosslinkers by choosing X ligands that contain reactive moieties such as alkynes (for copper-mediated azide-alkyne cycloaddition (CuAAC)) or aldehydes (for Schiff base reaction with hydrazines). Ru(bpy)2(3-ethynylpyridine)2 (RuBEP) has been used in CuAAC reactions to circularize azide-terminated oligonucleotides important for gene regulation or transcriptome analysis. Ru(bpy)2 (3-pyridinaldehyde) 2 (RuAldehyde) alternately employed aldehydes to react with hydrazine-modified hyaluronic acid (HA-HYD). The resulting hydrogel was cytocompatible, efficiently degraded with visible light, and well adapted for the storage and delivery of active enzymes via lysine-mediated crosslinking into the hydrogel matrix. Finally, Ru(biq)2(5-hexynenitrile)2 and Ru(bpy) 2(5-hexynenitrile) 2 were developed as crosslinkers to form PEG-based hydrogel, which was subsequently degraded using two different colors of visible light, orange and blue.
The Synthesis and Characterisation of Novel Ruthenium (II) Polypyridyl Complexes for Use in Cellular Imaging
Author: Zoe Joseph Stack
Publisher:
ISBN:
Category :
Languages : en
Pages : 163
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 163
Book Description
Synthesis and Characterization of a Series of Ruthenium Polypyridyl Metal Complexes
Author: Mathew Stein
Publisher:
ISBN:
Category : Metal complexes
Languages : en
Pages : 58
Book Description
Publisher:
ISBN:
Category : Metal complexes
Languages : en
Pages : 58
Book Description