Synthesis and Characterization of Lipophilic 3,4-hydroxypyridinone Iron (III) Complexes PDF Download
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Author: Megan M. Fitzgerald
Publisher:
ISBN:
Category : Complexes
Languages : en
Pages : 0
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Book Description
Iii Abstract Four N-substituted 3,4-hydroxypyridinone compounds were functionalized with four different aryl substituents with hydrocarbon tails of varying lengths. 3,4-hydroxypyridinone ligands were synthesized, isolated and characterized utilizing 1H-NMR, FT-IR spectroscopy and melting point analysis. These ligands were then used to form Fe(III) complexes. Complexes were characterized using FT-IR spectroscopy, UV-Vis spectroscopy, and decomposition point analysis. In addition to Fe(III) complex characterization, a preliminary X-ray structure of complex Fe(1A)2Cl was collected.
Author: Megan M. Fitzgerald
Publisher:
ISBN:
Category : Complexes
Languages : en
Pages : 0
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Book Description
Iii Abstract Four N-substituted 3,4-hydroxypyridinone compounds were functionalized with four different aryl substituents with hydrocarbon tails of varying lengths. 3,4-hydroxypyridinone ligands were synthesized, isolated and characterized utilizing 1H-NMR, FT-IR spectroscopy and melting point analysis. These ligands were then used to form Fe(III) complexes. Complexes were characterized using FT-IR spectroscopy, UV-Vis spectroscopy, and decomposition point analysis. In addition to Fe(III) complex characterization, a preliminary X-ray structure of complex Fe(1A)2Cl was collected.
Author: David G. Badman
Publisher: Saratoga Group
ISBN: 9781879894204
Category : Medical
Languages : en
Pages : 458
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Book Description
Author: Gregory J. Anderson
Publisher: Springer Science & Business Media
ISBN: 1603274855
Category : Medical
Languages : en
Pages : 705
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Book Description
Iron Physiology and Pathophysiology in Humans provides health professionals in many areas of research and practice with the most up-to-date and well-referenced volume on the importance of iron as a nutrient and its role in health and disease. This important new volume is the benchmark in the complex area of interrelationships between the essentiality of iron, its functions throughout the body, including its critical role in erythropoiesis, the biochemistry and clinical relevance of iron-containing enzymes and other molecules involved in iron absorption, transport and metabolism, he importance of optimal iron status on immune function, and links between iron and the liver, heart, brain and other organs. Moreover, the interactions between genetic and environmental factors and the numerous co-morbidities seen with both iron deficiency and iron overload in at risk populations are clearly delineated so that students as well as practitioners can better understand the complexities of these interactions. Key features of the volume include an in-depth index and recommendations and practice guidelines are included in relevant chapters. The volume contains more than 100 detailed tables and informative figures and up-to-date references that provide the reader with excellent sources of information about the critical role of iron nutrition, optimal iron status and the adverse clinical consequences of altered iron homeostasis. Iron Physiology and Pathophysiology in Humans is an excellent new text as well as the most authoritative resource in the field.
Author: Jason S. Lewis
Publisher: Springer
ISBN: 3319989472
Category : Medical
Languages : en
Pages : 648
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Book Description
This book is a comprehensive guide to radiopharmaceutical chemistry. The stunning clinical successes of nuclear imaging and targeted radiotherapy have resulted in rapid growth in the field of radiopharmaceutical chemistry, an essential component of nuclear medicine and radiology. However, at this point, interest in the field outpaces the academic and educational infrastructure needed to train radiopharmaceutical chemists. For example, the vast majority of texts that address radiopharmaceutical chemistry do so only peripherally, focusing instead on nuclear chemistry (i.e. nuclear reactions in reactors), heavy element radiochemistry (i.e. the decomposition of radioactive waste), or solely on the clinical applications of radiopharmaceuticals (e.g. the use of PET tracers in oncology). This text fills that gap by focusing on the chemistry of radiopharmaceuticals, with key coverage of how that knowledge translates to the development of diagnostic and therapeutic radiopharmaceuticals for the clinic. The text is divided into three overarching sections: First Principles, Radiochemistry, and Special Topics. The first is a general overview covering fundamental and broad issues like “The Production of Radionuclides” and “Basics of Radiochemistry”. The second section is the main focus of the book. In this section, each chapter’s author will delve much deeper into the subject matter, covering both well established and state-of-the-art techniques in radiopharmaceutical chemistry. This section will be divided according to radionuclide and will include chapters on radiolabeling methods using all of the common nuclides employed in radiopharmaceuticals, including four chapters on the ubiquitously used fluorine-18 and a “Best of the Rest” chapter to cover emerging radionuclides. Finally, the third section of the book is dedicated to special topics with important information for radiochemists, including “Bioconjugation Methods,” “Click Chemistry in Radiochemistry”, and “Radiochemical Instrumentation.” This is an ideal educational guide for nuclear medicine physicians, radiologists, and radiopharmaceutical chemists, as well as residents and trainees in all of these areas.
Author: Jonathan L. Sessler
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 480
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Book Description
This book reviews the current diagnostic and therapeutic uses of metal-containing compounds in medicine, as well as the role of metals in disease.
Author: Robert Crichton
Publisher: John Wiley & Sons
ISBN: 1118925629
Category : Medical
Languages : en
Pages : 576
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Book Description
Iron is indispensable for the growth, development and well-being of almost all living organisms. Biological systems from bacteria, fungi and plants to humans have evolved systems for the uptake, utilisation, storage and homeostasis of iron. Its importance for microbial growth makes its uptake systems a natural target for pathogenic microorganisms and parasites. Uniquely, humans suffer from both iron deficiency and iron overload, while the capacity of iron to generate highly reactive free radicals, causing oxidative stress, is associated with a wide range of human pathologies, including many neurodegenerative diseases. Whereas some essential metal ions like copper and zinc are closely linked with iron metabolism, toxic metals like aluminium and cadmium can interfere with iron metabolism. Finally, iron metabolism and homeostasis are key targets for the development of new drugs for human health. The 4th edition of Iron Metabolism is written in a lively style by one of the leaders in the field, presented in colour and covers the latest discoveries in this exciting area. It will be essential reading for researchers and students in biochemistry, molecular biology, microbiology, cell biology, nutrition and medical sciences. Other interested groups include biological inorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism, or of diseases in which iron uptake systems are involved (eg. microbial and fungal infections, cancer, neurodegenerative disorders), and researchers in the pharmaceutical industry interested in developing novel drugs targeting iron metabolism/homeostasis.
Author: Raymond J. Bergeron
Publisher: CRC Press
ISBN: 9780849386794
Category : Medical
Languages : en
Pages : 438
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Book Description
Representing an integration of basic and clinical sciences, this book focuses on new concepts in the design, synthesis, and testing of iron chelators for clinical application. It provides an overview of the pathophysiology of iron metabolism as it relates to the origins of iron-mediated tissue damage, and it clearly outlines successes and shortcomings of current iron chelation therapy in preventing such damage. The book also describes a number of other exciting potential therapeutic applications of iron chelators, such as in the treatment of malaria. Other topics covered include iron coordination chemistry, recent advances in synthetic methods for accessing iron chelators, siderophore models, subcellular iron storage targets, and the possible application of biotechnology in the production of therapeutically useful iron chelators. The book also describes new animal models for evaluating chelators.
Author: Morton P. Friedman
Publisher: Elsevier
ISBN: 0080529275
Category : Psychology
Languages : en
Pages : 403
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Book Description
Cognitive Ecology identifies the richness of input to our sensory evaluations, from our cultural heritage and philosophies of aesthetics to perceptual cognition and judgment. Integrating the arts, humanities, and sciences, Cognitive Ecology investigates the relationship of perception and cognition to wider issues of how science is conducted, and how the questions we ask about perception influence the answers we find. Part One discusses how issues of the human mind are inseparable from the culture from which the investigations arise, how mind and environment co-define experience and actions, and how culture otherwise influences cognitive function. Part Two outlines how philosophical themes of aesthetics have guided psychological research, and discuss the physical and aesthetic perception of music, film, and art. Part Three presents an overview of how the senses interact for sensory evaluation.
Author: Thomas J. Dougherty
Publisher: Springer Science & Business Media
ISBN: 1461414008
Category : Medical
Languages : en
Pages : 1119
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Book Description
This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.
Author: Magdy M. Khalil
Publisher: Springer Nature
ISBN: 3030652459
Category : Medical
Languages : en
Pages : 571
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Book Description
This book provides comprehensive and detailed information on the scientific bases of nuclear medicine, addressing a wide variety of topics and explaining the concepts that underlie many of the investigations and procedures performed in the field. The book is divided into six sections that cover the physics and chemistry of nuclear medicine besides associated quality assurance/quality control procedures; dosimetry and radiation biology; SPECT and PET imaging instrumentation plus CT imaging technology in hybrid modalities; data analysis including image processing, reconstruction, radiomics, image degrading correction techniques, along with image quantitation and kinetic modeling. Within these sections, particular attention is paid to recent developments and the advances in knowledge that have taken place since release of the first edition in 2011. Several entirely new chapters have been included and the remaining chapters, thoroughly updated. Innovations in the ever-expanding field of nuclear medicine are predominantly due to integration of the basic sciences with complex technological advances. This excellently illustrated book on the subject will be of interest to not only nuclear medicine physicists and physicians but also clinical scientists, radiologists, radiopharmacists, medical students and technologists.
