Synaptic Plasticity in the Cerebellum of the Adult Rat Following Complex Motor Skill Acquisition PDF Download
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Author: Jeffrey Allan Kleim
Publisher:
ISBN:
Category :
Languages : en
Pages : 98
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Author: Jeffrey Allan Kleim
Publisher:
ISBN:
Category :
Languages : en
Pages : 98
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Book Description
Author: Paul J. Cordo
Publisher: Cambridge University Press
ISBN: 9780521597050
Category : Medical
Languages : en
Pages : 78
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Book Description
This book is concerned with the involvement of the cerebellum in learning and remembering motor tasks. It is unique in discussing plasticity at both the cellular and at the behavioral level.
Author: Masao Itō
Publisher: Elsevier Science & Technology
ISBN:
Category : Medical
Languages : en
Pages : 348
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Book Description
Hardbound. The present advancement in the brain is characterized by the dichotomy of the molecular approaches to cellular functions in the brain and integrative approaches to the mechanisms of brain functions. This book contains the proceedings of the Uehera Foundation Symposium held in 1996 in Tokyo, which aimed to synthesize the two lines of approaches.The major research strategy employed at the molecular and cellular levels is to pinpoint a molecule, a set of them, a microstructure which is responsible for a cellular function. That undertaken at integrative and functional levels is to comprehend the mechanisms which underlie a system function of the brain. These two strategies will be mutually beneficial, and the need to combine them in brain science will become increasingly important. This monograph, thus, helps envision the future of brain science and is of great interest to researchers, graduate and undergraduate students who want to know the cur
Author: Mark Wolraich
Publisher: Elsevier Health Sciences
ISBN: 032304025X
Category : Psychology
Languages : en
Pages : 994
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Book Description
Based on the Diagnostic and Statistical Manual for Primary Care: Child and Adolescent Version (DSM-PC), this state-of-the-art reference expertly guides you through normal and abnormal development and behavior for all pediatric age groups. See how neurobiological, environmental, and human relationship factors all contribute to developmental and behavioral disorders and know how to best diagnose and treat each patient you see. Accurately identify developmental and behavioral problems using the Diagnostic and Statistical Manual for Primary Care criteria, and evidence-based guidelines. Gain a clear understanding of the "normal" boundaries and variations within specific disorders. Make informed therapeutic decisions with the integration of basic science and practical information and recommendations from the Society of Developmental and Behavioral Pediatrics and the American Academy of Pediatrics. Avoid legal and ethical implications by consulting the Law, Policy, and Ethics chapter. Download the DSM PC criteria from the included CD, as well as tables and illustrations for use in electronic presentations.
Author: Dhakshin Ramanathan
Publisher:
ISBN: 9780549125907
Category :
Languages : en
Pages : 163
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Book Description
We conclude that there are many different neural correlates underlying map plasticity of the motor cortex. In order to utilize this knowledge to enhance recovery following injury, it is essential to understand which neural changes have behavioral and functional relevance. (Abstract shortened by UMI.)
Author: Hwa-Min Francis Hwang
Publisher:
ISBN:
Category :
Languages : en
Pages : 266
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Author: Amber Jo O'Bryant
Publisher:
ISBN:
Category :
Languages : en
Pages : 324
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Book Description
In adult rats, following unilateral stroke-like injury to the motor cortex, there is significant loss of function in the forelimb contralateral to the ischemic damage. In the remaining motor cortex, changes in neuronal activation patterns and connectivity are induced following motor learning and rehabilitation in the brains of adult animals. Rehabilitative training promotes functional recovery of the impaired forelimb following motor cortical strokes; however, its benefits are most efficacious when coupled with other rehabilitative treatments. Multiple lines of evidence suggest that focal cortical electrical stimulation (CS) enhances the effectiveness of rehabilitative training (RT) and promotes changes in neural activation and plasticity in the peri-lesion motor cortex. Specific examples of plastic events include increases in dendritic and synaptic density in the peri-lesion cortex following CS/RT compared to rehabilitative training alone. The objective of these studies was to investigate which conditions, such as timing and method of delivery of CS, when coupled with RT, are most efficacious in promoting neuronal plasticity and functional recovery of the impaired forelimb following ischemic cortical injury in adult animals. The central hypothesis of these dissertation studies is that, following unilateral stroke-like injury, CS improves the functional recovery of the impaired forelimb and promotes neural plasticity in remaining motor cortex when combined with RT. This hypothesis was tested in a series of experiments manipulating post-ischemic behavioral experience with the impaired forelimb. Adult rats were proficient in a motor skill (Single Pellet Retrieval Task) and received ischemic motor cortex lesion that caused impairments in the forelimb. Rats received daily rehabilitative training on a tray reaching task with or without concurrent cortical stimulation. Epidural cortical stimulation, when paired with rehabilitative training, resulted in enhanced reaching performance compared to RT alone when initiated 14 days after lesion. These results were found to be maintained well after the treatment period ended. Rats tested 9-10 months post-rehabilitative training on the single pellet retrieval task continued to have greater reaching performance compared to RT alone. However, delayed onset of rehabilitative training (3 months post-infarct) indicated that CS does not further improve forelimb function compared to RT along. It was further established that CS delivered over the intact skull (transcranial stimulation) of the lesioned motor cortex was not a beneficial adjunct to rehabilitative training. Together these dissertation studies provide insight into the effectiveness and limitations of CS on behavioral recovery. The findings in these studies are likely to be important for understanding how post-stroke behavioral interventions and adjunct therapies could be used to optimize brain reorganization and functional outcome.
Author: Daniel Laskowitz
Publisher: CRC Press
ISBN: 1498766579
Category : Medical
Languages : en
Pages : 388
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Book Description
Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1828
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