Sudden Death in Epilepsy: Basic and Translational Research

Sudden Death in Epilepsy: Basic and Translational Research PDF Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 0

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Book Description
Sudden Death in Epilepsy (SUDEP) is a major cause of death in people with epilepsy, accounting for up to 17% of all deaths. Research interest is exploding, focusing on epidemiology, basic mechanisms, identification of risk factors, and biomarkers. New wearable technologies are approved or in development. These incorporate accelerometers and advanced heart rate detection, which are linked to smart phones. The advent of FDA approved detection devices now allows immediate intervention by family and loved ones. The next frontier for SUDEP remains effective prevention strategies, which will likely include new devices and pharmacologic interventions. This volume is organized into three sections: Basic and Physiologic Mechanisms; Clinical Risk Factors and Inventories; and Very Early Research into Pharmacologic Interventions. It is our hope that this eBook will inform clinicians of key advances in the field, and to foster and stimulate basic and translational research with one purpose: To prevent SUDEP in those at risk.

Sudden Death in Epilepsy: Basic and Translational Research

Sudden Death in Epilepsy: Basic and Translational Research PDF Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 0

Get Book Here

Book Description
Sudden Death in Epilepsy (SUDEP) is a major cause of death in people with epilepsy, accounting for up to 17% of all deaths. Research interest is exploding, focusing on epidemiology, basic mechanisms, identification of risk factors, and biomarkers. New wearable technologies are approved or in development. These incorporate accelerometers and advanced heart rate detection, which are linked to smart phones. The advent of FDA approved detection devices now allows immediate intervention by family and loved ones. The next frontier for SUDEP remains effective prevention strategies, which will likely include new devices and pharmacologic interventions. This volume is organized into three sections: Basic and Physiologic Mechanisms; Clinical Risk Factors and Inventories; and Very Early Research into Pharmacologic Interventions. It is our hope that this eBook will inform clinicians of key advances in the field, and to foster and stimulate basic and translational research with one purpose: To prevent SUDEP in those at risk.

Sudden Unexpected Death in Epilepsy: Bio-markers, Mechanisms, Risk Identification and Prevention

Sudden Unexpected Death in Epilepsy: Bio-markers, Mechanisms, Risk Identification and Prevention PDF Author: Christopher Michael DeGiorgio
Publisher:
ISBN:
Category :
Languages : en
Pages : 0

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Book Description
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Models of Seizures and Epilepsy

Models of Seizures and Epilepsy PDF Author: Asla Pitkänen
Publisher: Academic Press
ISBN: 012804067X
Category : Medical
Languages : en
Pages : 1180

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Book Description
Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals. - Provides a comprehensive reference detailing animal models of epilepsy and seizure - Offers insights on the use of novel technologies that can be applied in experimental epilepsy research - Edited by leading experts in the field that provide not only technical reviews of these models but also conceptual critiques - Comments on the strengths and limitations of various models, including their relationship to clinical phenomenology and their value in developing better understanding and treatments

Epileptic Syndromes in Infancy, Childhood and Adolescence - 5th edition

Epileptic Syndromes in Infancy, Childhood and Adolescence - 5th edition PDF Author: Bureau Michelle
Publisher: John Libbey Eurotext
ISBN: 2742008292
Category : Medical
Languages : en
Pages : 682

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Book Description
The ultimate reference book : the 5th updated edition of the famous “blue guide”. Incluided : A DVD with new sequences completes each chapter! Epileptology changes. The syndromic approach is completed by an etiological approach, based on the major advances in genetics and functional genetics. New entities have found their place, and a purely descriptive, “electroclinical” approach is no longer adapted in many circumstances. The 5th edition of the Blue Guide includes the most recent advances. It was necessary to justify the physiological, epidemiologic, genetic and therapeutic approaches and to consider them in the light of the new classification efforts, which are still in the making. Nevertheless, the description of epileptic syndromes, both classical and recent, remains at the core of this book.

Puzzling Cases of Epilepsy

Puzzling Cases of Epilepsy PDF Author: Dieter Schmidt
Publisher: Elsevier
ISBN: 0080559549
Category : Medical
Languages : en
Pages : 545

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Book Description
Epilepsy is one of the most common neurological disorders, and original observations in the field are often the key to diagnosis and successful treatment. Physicians new to the field as well as seasoned practitioners will benefit from more than one hundred case vignettes that explore the universe of epilepsy as it presents in daily practice. Some of these cases challenge long-held views about epilepsy and others bring the reader to the limits of our understanding of epilepsy, both in clinical and basic science. To improve the interface of clinical and basic science in epilepsy, basic scientists comment on the potential mechanisms underlying clinical observations, and clinicians assess the potential impact of recent results of experiments in the laboratory. Puzzling Cases of Epilepsy highlights the importance that original observations have in inspiring both new treatments and continued research. - Presents unique and challenging case vignettes in epilepsy contributed by eminent physicians in the field - Provides practicing physicians with examples of how baffling cases were handled and solved - A new section provides a translational perspective, with basic scientists discussing the potential mechanisms underlying original clinical observations, and clinical scientists discussing the clinical implications of experiments in the epilepsy laboratory

A Practical Guide to Supporting People with Epilepsy

A Practical Guide to Supporting People with Epilepsy PDF Author: Rebecca Case
Publisher: Springer Nature
ISBN: 3030426750
Category : Medical
Languages : en
Pages : 179

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Book Description
This book is a practical guide, with rationale to supporting people with epilepsy. It encompasses epilepsy guidance such as NICE (2012, revised 2019), The Equality Act (2010), the children and families act (2014), current evidence based-practice, and regulatory organisation standards. It is predominantly aimed at nurses and student nurses, especially, those studying learning disability nursing but also residential, respite and supported living services, schools and family carers, to enable them to offer appropriate and evidence-based support to people with epilepsy of all ages. It is estimated there are approximately 1200 epilepsy related deaths each year in the UK. Many of these are considered to be preventable. High-profile cases have led to an increase in anxiety in people providing services, and greater scrutiny of those services by regulatory bodies. Over the years, the authors have been asked the same questions and witnessed the same misunderstandings and mistakes, by people supporting individuals with epilepsy. So they looked at the common themes and the resources available. It became clear that the information to address these gaps is available, but not easily accessible. There is lots of information in the public domain, however much of it is factual, rather than practical. This book provides practical information and resources with the focus on “what needs to happen”,” how to make it happen” and “who needs to do it”. This book is useful for supporting people with epilepsy wherever they live (both within and outside the United Kingdom).

Electrical Diseases of the Heart

Electrical Diseases of the Heart PDF Author: Ihor Gussak
Publisher: Springer Science & Business Media
ISBN: 1846288541
Category : Medical
Languages : en
Pages : 982

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Book Description
This book provides a unique contemporary and succinct distillation of the current status of recently delineated electrical diseases of the heart, emphasizing their common and diverse clinical features. The latest developments in the field of experimental and clinical cardiac electrophysiology, genetics, pharmacology and interventional therapies of various clinical arrhythmogenic entities are featured and discussed in terms of recent advances in basic and clinical science. The book is divided into seven major parts. Each part consists of chapters (total of 64) dealing with related topics.

Epilepsy Across the Spectrum

Epilepsy Across the Spectrum PDF Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309259533
Category : Medical
Languages : en
Pages : 568

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Book Description
Although epilepsy is one of the nation's most common neurological disorders, public understanding of it is limited. Many people do not know the causes of epilepsy or what they should do if they see someone having a seizure. Epilepsy is a complex spectrum of disorders that affects an estimated 2.2 million Americans in a variety of ways, and is characterized by unpredictable seizures that differ in type, cause, and severity. Yet living with epilepsy is about much more than just seizures; the disorder is often defined in practical terms, such as challenges in school, uncertainties about social situations and employment, limitations on driving, and questions about independent living. The Institute of Medicine was asked to examine the public health dimensions of the epilepsies, focusing on public health surveillance and data collection; population and public health research; health policy, health care, and human services; and education for people with the disorder and their families, health care providers, and the public. In Epilepsy Across the Spectrum, the IOM makes recommendations ranging from the expansion of collaborative epilepsy surveillance efforts, to the coordination of public awareness efforts, to the engagement of people with epilepsy and their families in education, dissemination, and advocacy for improved care and services. Taking action across multiple dimensions will improve the lives of people with epilepsy and their families. The realistic, feasible, and action-oriented recommendations in this report can help enable short- and long-term improvements for people with epilepsy. For all epilepsy organizations and advocates, local, state, and federal agencies, researchers, health care professionals, people with epilepsy, as well as the public, Epilepsy Across the Spectrum is an essential resource.

Experimental Epilepsy

Experimental Epilepsy PDF Author:
Publisher: Elsevier
ISBN: 0080861431
Category : Medical
Languages : en
Pages : 223

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Book Description
Experimental Epilepsy

A Smell of Burning

A Smell of Burning PDF Author: Colin Grant
Publisher: Vintage
ISBN: 9780099597872
Category :
Languages : en
Pages : 256

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Book Description
One day Colin Grant's teenage brother Christopher failed to emerge from the bathroom. His family broke down the door to find him unconscious on the floor. None of their lives were ever the same again. Christopher was diagnosed with epilepsy. A Smell of Burning tells the remarkable story of this strange and misunderstood disorder. How certain people, at a particular moment in their life, start to suffer seizures, often preceded by an aura, of which a smell of burning is one of the most common. For many years epilepsy was associated with mental illness or even possession by devils. People with epilepsy were forbidden to marry or have children. Many became victims of Nazi eugenics programmes. To this day many people with epilepsy - sixty million worldwide - still live in fear of exposure. Grant's book traces the history of the condition and the pioneering doctors whose extraordinary breakthroughs finally helped gain an understanding of how the brain works. He tells the stories of famous people with epilepsy like Julius Caesar, Joan of Arc, Fyodor Dostoevsky and Vincent Van Gogh, and through the tragic tale of his brother, he considers the effect of epilepsy on his own life.