Studies of Transannular (4+3) Cycloadditions and Application to the Synthesis of (+)-cortistatin A PDF Download
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Author: 陳肇人
Publisher:
ISBN:
Category : Organic cyclic compounds
Languages : en
Pages : 0
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Book Description
Author: 陳肇人
Publisher:
ISBN:
Category : Organic cyclic compounds
Languages : en
Pages : 0
Get Book Here
Book Description
![An Unexpected Transannular [4+2] Cycloaddition During the Total Synthesis of (+)-Norcembrene 5 PDF](https://books.google.com/books/content/images/frontcover/tS7GzQEACAAJ?fife=w80-h100)
Author: Michael Breunig
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Yu Chen (Researcher on chemistry)
Publisher:
ISBN:
Category : Organic cyclic compounds
Languages : en
Pages : 425
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Book Description
![Studies of Intramolecular [4+3]-cycloadditions and Chiral Molecular Clefts PDF](https://books.google.com/books/content/images/frontcover/lXdyHAAACAAJ?fife=w80-h100)
Author: Mehmet Kahraman
Publisher:
ISBN:
Category : Ring formation (Chemistry)
Languages : en
Pages : 450
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Book Description
A new alkylation procedure was developed for the synthesis of E-alkoxyallylic sulfones which were then used as precursors for TiCl$\sb4$-mediated intramolecular (4$+$3) -cycloaddition reactions. Three different approaches were demonstrated for the synthesis of 6,7-fused ring systems via a (4$+$3) -cycloaddition. Unlike (4$+$3) -cycloaddition of allylic alcohols and allylic sulfoxides, alkoxylallylic sulfones gave excellent yields of cycloadducts one of which was used to make a natural product, widdrol. It was shown that functionalized Kagan's ether can be made in either racemic or chiral forms with an improved procedure. It was demonstrated that these functionalized Kagan's ethers can be used to assemble chiral molecular squares in which two corners are Kagan's ether unit and the other two corners are square planar palladium. Similarly, using the newly developed procedure, it was shown that a water soluble molecular tweezer can be made as a potential DNA intercalator.
Author: Gordon W. Gribble
Publisher: Elsevier
ISBN:
Category : Science
Languages : en
Pages : 584
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Book Description
Progress in Heterocyclic Chemistry (PHC), is an annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC). Volumes in the series contain both highlights of the previous year's literature on heterocyclic chemistry and articles on new developing topics of particular interest to heterocyclic chemists. The highlight chapters in Volume 21 are all written by leading researchers in their field and these chapters constitute a systematic survey of the important original material reported in the literature of heterocyclic chemistry in 2008. Additional articles in this volume review 'Biocatalytic approaches to chiral heterocycles' and 'Ring-expanded ('fat') purines and their nucleoside/nucleotide analogues as broad-spectrum therapeutics'. As with previous volumes in the series, Volume 21 will enable academic and industrial chemists, and advanced students, to keep abreast of developments in heterocyclic chemistry in a convenient way. CONTENTS Biocatalytic approaches to chiral heterocycles (Steven J. Collier, Michael A. K. Vogel, Brian J. Wong and Naga K. Modukuru); Ring-expanded ('fat') purines and their nucleoside/nucleotide analogues as broad-spectrum therapeutics (Ramachandra S. Hosmane); Three-membered ring systems (Stephen C. Bergmeier and David J. Lapinsky); Four-membered ring systems (Benito Alcaide and Pedro Almendros); Five-membered ring systems: Thiophenes and Se/Te analogues (Tomasz Janosik and Jan Bergman); pyrroles and benzo analogs (Jonathon S. Russel, Erin T. Pelkey and Sarah J. P. Yoon-Miller); Furans and benzofurans (Xue-Long Hou, Zhen Yang, Kap-Sun Yeung, Henry N.C. Wong); With more than one N atom (Larry Yet); With N and S (Se) atoms (Yong-Jin Wu and Bingwei V. Yang); With O & S (Se, Te) atoms (R. Alan Aitken); With O & N atoms (Stefano Cicchi, Franca M. Cordero, Donatella Giomi); Six-membered ring systems: Pyridine and benzo derivatives (Darrin W. Hopper, Aimee L. Crombie, and Jeremy J. Clemens, and Soojin Kwon); Diazines and benzo derivatives (Amelia Manlove and Michael P. Groziak); Triazines, tetrazines and fused ring polyaza systems (2007) (Dmitry N. Kozhevnikov and Valery N. Kozhevnikov); Triazines, tetrazines and fused ring polyaza systems (2008) (Dmitry N. Kozhevnikov and Valery N. Kozhevnikov); Six-membered ring systems: With O and/or S atoms (John D. Hepworth and B. Mark Heron); Seven-membered rings (Jason A. Smith, Peter P. Molesworth and John H. Ryan); Eight-membered and larger rings (George R. Newkome); Index.
Author: Goutam Brahmachari
Publisher: Elsevier
ISBN: 0128205865
Category : Science
Languages : en
Pages : 642
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Book Description
Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume One: Advanced Synthetic Techniques reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of new chapters. Volume One explores advanced synthetic techniques, with each chapter presenting in-depth coverage of various green protocols for the synthesis of a wide variety of bioactive heterocycles that are classified on the basis of ring-size and/or the presence of heteroatoms. Techniques covered range from high pressure cycloaddition reactions and microwave irradiation to sustainable one-pot domino reactions. This updated edition is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product and green chemistry. Provides fully updated coverage of the field of greener heterocycle synthesis Includes new chapters on varied multicomponent reactions, alongside both traditional and novel approaches Presents information in an accessible style with an emphasis on sustainability
Author: Michael Harmata
Publisher: Academic Press
ISBN: 9780124502840
Category : Science
Languages : en
Pages : 522
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Book Description
This title provides a forum for investigators to discuss their approach to the science and art of organic synthesis in a unique way. There are stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners.
Author: Eric F.V. Scriven
Publisher: Academic Press
ISBN: 0123852366
Category : Science
Languages : en
Pages : 583
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Book Description
Pyridines: From Lab to Production provides a synthetic armory of tools to aid the practicing chemist by reviewing the most reliable historical methods alongside new methods/ Written by scientists who have actually used these in synthesis. By emphasizing tricks and tips to optimize reactions for the best yields and purity, which are often missing from the primary literature, this book provides another dimension for the synthetic chemist. A combined academic and industrial approach evaluates the best methods for different scales of reaction and discusses practical tips (e.g. when to stop a reaction early to maximize purity or when to re-use side products). Chapters also assess whether to make or source starting materials, how to connect them and what are the best synthetic routes. The book is designed to be a stand-alone reference, but also provides cross references to leading reviews and the Comprehensive Heterocyclic Chemistry reference works for those who want to learn more. - Reviews tried and tested practical methods to help the reader select the best method for their research - Includes tips, tricks and hints to enable the reader to get the best yield or cleanest product out of their reaction for synthesising or transforming a pyridine derivative - Written by both academic researchers and industry leaders this provides a unique view of how to get the most out of a reaction no matter what scale you are running this on
Author: Jie Jack Li
Publisher: Springer Science & Business Media
ISBN: 3642340652
Category : Science
Languages : en
Pages : 292
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Book Description
'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.
Author: R. W. Hoffmann
Publisher: Springer Science & Business Media
ISBN: 3540792201
Category : Science
Languages : en
Pages : 227
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Book Description
Synthesis is at the core of organic chemistry. In order for compounds to be studied—be it as drugs, materials, or because of their physical properties— they have to be prepared, often in multistep synthetic sequences. Thus, the target compound is at the outset of synthesis planning. Synthesis involves creating the target compound from smaller, readily available building blocks. Immediately, questions arise: From which bui- ing blocks? In which sequence? By which reactions? Nature creates many highly complex “natural products” via reaction cascades, in which an asso- ment of starting compounds present within the cell is transformed by speci c (for each target structure) combinations of modular enzymes in speci c - quences into the target compounds [1, 2]. To mimic this ef ciency is the dream of an ideal synthesis [2]. However, we are at present so far from - alising such a “one-pot” operation that actual synthesis has to be achieved via a sequence of individual discrete steps. Thus, we are left with the task of planning each synthesis individually in an optimal fashion. Synthesis planning must be conducted with regard for certain speci - tions, some of which are due to the structure of the target molecule, and some of which relate to external parameters such as costs, environmental compatibility, or novelty. We will not consider these external aspects in this context. Planning of a synthesis is based on a pool of information regarding chemical reactions that can be executed reliably and in high chemical yield.
