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Author: R. W. Hoffmann
Publisher: Springer Science & Business Media
ISBN: 3540792201
Category : Science
Languages : en
Pages : 227
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Book Description
Synthesis is at the core of organic chemistry. In order for compounds to be studied—be it as drugs, materials, or because of their physical properties— they have to be prepared, often in multistep synthetic sequences. Thus, the target compound is at the outset of synthesis planning. Synthesis involves creating the target compound from smaller, readily available building blocks. Immediately, questions arise: From which bui- ing blocks? In which sequence? By which reactions? Nature creates many highly complex “natural products” via reaction cascades, in which an asso- ment of starting compounds present within the cell is transformed by speci c (for each target structure) combinations of modular enzymes in speci c - quences into the target compounds [1, 2]. To mimic this ef ciency is the dream of an ideal synthesis [2]. However, we are at present so far from - alising such a “one-pot” operation that actual synthesis has to be achieved via a sequence of individual discrete steps. Thus, we are left with the task of planning each synthesis individually in an optimal fashion. Synthesis planning must be conducted with regard for certain speci - tions, some of which are due to the structure of the target molecule, and some of which relate to external parameters such as costs, environmental compatibility, or novelty. We will not consider these external aspects in this context. Planning of a synthesis is based on a pool of information regarding chemical reactions that can be executed reliably and in high chemical yield.
Author: R. W. Hoffmann
Publisher: Springer Science & Business Media
ISBN: 3540792201
Category : Science
Languages : en
Pages : 227
Get Book
Book Description
Synthesis is at the core of organic chemistry. In order for compounds to be studied—be it as drugs, materials, or because of their physical properties— they have to be prepared, often in multistep synthetic sequences. Thus, the target compound is at the outset of synthesis planning. Synthesis involves creating the target compound from smaller, readily available building blocks. Immediately, questions arise: From which bui- ing blocks? In which sequence? By which reactions? Nature creates many highly complex “natural products” via reaction cascades, in which an asso- ment of starting compounds present within the cell is transformed by speci c (for each target structure) combinations of modular enzymes in speci c - quences into the target compounds [1, 2]. To mimic this ef ciency is the dream of an ideal synthesis [2]. However, we are at present so far from - alising such a “one-pot” operation that actual synthesis has to be achieved via a sequence of individual discrete steps. Thus, we are left with the task of planning each synthesis individually in an optimal fashion. Synthesis planning must be conducted with regard for certain speci - tions, some of which are due to the structure of the target molecule, and some of which relate to external parameters such as costs, environmental compatibility, or novelty. We will not consider these external aspects in this context. Planning of a synthesis is based on a pool of information regarding chemical reactions that can be executed reliably and in high chemical yield.
Author: E.J. Corey
Publisher: Рипол Классик
ISBN: 5885010811
Category : Science
Languages : en
Pages : 447
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Book Description
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309168392
Category : Science
Languages : en
Pages : 238
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Book Description
Chemistry and chemical engineering have changed significantly in the last decade. They have broadened their scopeâ€"into biology, nanotechnology, materials science, computation, and advanced methods of process systems engineering and controlâ€"so much that the programs in most chemistry and chemical engineering departments now barely resemble the classical notion of chemistry. Beyond the Molecular Frontier brings together research, discovery, and invention across the entire spectrum of the chemical sciencesâ€"from fundamental, molecular-level chemistry to large-scale chemical processing technology. This reflects the way the field has evolved, the synergy at universities between research and education in chemistry and chemical engineering, and the way chemists and chemical engineers work together in industry. The astonishing developments in science and engineering during the 20th century have made it possible to dream of new goals that might previously have been considered unthinkable. This book identifies the key opportunities and challenges for the chemical sciences, from basic research to societal needs and from terrorism defense to environmental protection, and it looks at the ways in which chemists and chemical engineers can work together to contribute to an improved future.
Author: James Hendler
Publisher: Elsevier
ISBN: 0080499449
Category : Computers
Languages : en
Pages : 315
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Book Description
Artificial Intelligence Planning Systems documents the proceedings of the First International Conference on AI Planning Systems held in College Park, Maryland on June 15-17, 1992. This book discusses the abstract probabilistic modeling of action; building symbolic primitives with continuous control routines; and systematic adaptation for case-based planning. The analysis of ABSTRIPS; conditional nonlinear planning; and building plans to monitor and exploit open-loop and closed-loop dynamics are also elaborated. This text likewise covers the modular utility representation for decision-theoretic planning; reaction and reflection in tetris; and planning in intelligent sensor fusion. Other topics include the resource-bounded adaptive agent, critical look at Knoblock's hierarchy mechanism, and traffic laws for mobile robots. This publication is beneficial to students and researchers conducting work on AI planning systems.
Author: Richard Turton
Publisher: Pearson Education
ISBN: 0132459183
Category : Technology & Engineering
Languages : en
Pages : 1562
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Book Description
The Leading Integrated Chemical Process Design Guide: Now with New Problems, New Projects, and More More than ever, effective design is the focal point of sound chemical engineering. Analysis, Synthesis, and Design of Chemical Processes, Third Edition, presents design as a creative process that integrates both the big picture and the small details–and knows which to stress when, and why. Realistic from start to finish, this book moves readers beyond classroom exercises into open-ended, real-world process problem solving. The authors introduce integrated techniques for every facet of the discipline, from finance to operations, new plant design to existing process optimization. This fully updated Third Edition presents entirely new problems at the end of every chapter. It also adds extensive coverage of batch process design, including realistic examples of equipment sizing for batch sequencing; batch scheduling for multi-product plants; improving production via intermediate storage and parallel equipment; and new optimization techniques specifically for batch processes. Coverage includes Conceptualizing and analyzing chemical processes: flow diagrams, tracing, process conditions, and more Chemical process economics: analyzing capital and manufacturing costs, and predicting or assessing profitability Synthesizing and optimizing chemical processing: experience-based principles, BFD/PFD, simulations, and more Analyzing process performance via I/O models, performance curves, and other tools Process troubleshooting and “debottlenecking” Chemical engineering design and society: ethics, professionalism, health, safety, and new “green engineering” techniques Participating successfully in chemical engineering design teams Analysis, Synthesis, and Design of Chemical Processes, Third Edition, draws on nearly 35 years of innovative chemical engineering instruction at West Virginia University. It includes suggested curricula for both single-semester and year-long design courses; case studies and design projects with practical applications; and appendixes with current equipment cost data and preliminary design information for eleven chemical processes–including seven brand new to this edition.
Author: Stanislaus von Moos
Publisher: 010 Publishers
ISBN: 9064506426
Category : Architecture
Languages : en
Pages : 370
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Book Description
Originally published in Germany in 1968, this first comprehensive and critical survey of Le Corbusier's life and work soon became the standard text on the architect and polymath. French, Spanish, English, Japanese and Korean editions followed, but the book has now been out of print for almost two decades. In the meantime, Le Corbusier's archives in Paris have become available for research, resulting in an avalanche of scholarship. Von Moos' critical take and the basic criteria by which the subject is organized and historicized remain surprisingly pertinent in the context of this recent jungle of Corbusier studies. This new, completely revised edition is based on the 1979 version published in English by the MIT Press but offers a substantially updated body of illustrations. Each of the seven chapters is supplemented by a critical survey of recent scholarship on the respective issues. An updated edition of this acclaimed book, an essential read for students of architecture and architectural history.
Author: Barbara Paech
Publisher: Springer
ISBN: 354089778X
Category : Computers
Languages : en
Pages : 215
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Book Description
Wearepleasedtopresenttheproceedingsofthe14thMontereyWorkshop,which tookplaceSeptember10–13,2007inMonterey,CA,USA. Inthispreface,wegive the reader an overview of what took place at the workshop and introduce the contributions in this Lecture Notes in Computer Science volume. A complete introduction to the theme of the workshop, as well as to the history of the Monterey Workshop series, can be found in Luqi and Kordon’s “Advances in Requirements Engineering: Bridging the Gap between Stakeholders’ Needs and Formal Designs” in this volume. This paper also contains the case study that many participants used as a problem to frame their analyses, and a summary of the workshop’s results. The workshop consisted of three keynote talks, three panels, presentations of peer-reviewed papers, as well as presentations of various position papers by the participants. The keynote speakers at this year’s workshop were Daniel Berry, Aravind Joshi, and Lori Clarke. Each of their talks was used to set the tone for the p- sentations and discussions for that particular day. Daniel Berry presented an overview of the needs and challenges of natural language processing in requi- ments engineering, with a special focus on ambiguity in his talk “Ambiguity in Natural Language Requirements. ” Aravind Joshi provided an overview of current natural language processing research in discourse analysis in the talk “Some Recent Developments in Natural Language Processing. ” Finally, Lori Clarke showed how to combine formal requirements speci?cation with natural language processing to cope with the complex domain of medical information processes in “Getting the Details Right.
Author: Christopher Alexander
Publisher: Harvard University Press
ISBN: 9780674627512
Category : Architecture
Languages : en
Pages : 228
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Book Description
"These notes are about the process of design: the process of inventing things which display new physical order, organization, form, in response to function." This book, opening with these words, presents an entirely new theory of the process of design. In the first part of the book, Christopher Alexander discusses the process by which a form is adapted to the context of human needs and demands that has called it into being. He shows that such an adaptive process will be successful only if it proceeds piecemeal instead of all at once. It is for this reason that forms from traditional un-self-conscious cultures, molded not by designers but by the slow pattern of changes within tradition, are so beautifully organized and adapted. When the designer, in our own self-conscious culture, is called on to create a form that is adapted to its context he is unsuccessful, because the preconceived categories out of which he builds his picture of the problem do not correspond to the inherent components of the problem, and therefore lead only to the arbitrariness, willfulness, and lack of understanding which plague the design of modern buildings and modern cities. In the second part, Mr. Alexander presents a method by which the designer may bring his full creative imagination into play, and yet avoid the traps of irrelevant preconception. He shows that, whenever a problem is stated, it is possible to ignore existing concepts and to create new concepts, out of the structure of the problem itself, which do correspond correctly to what he calls the subsystems of the adaptive process. By treating each of these subsystems as a separate subproblem, the designer can translate the new concepts into form. The form, because of the process, will be well-adapted to its context, non-arbitrary, and correct. The mathematics underlying this method, based mainly on set theory, is fully developed in a long appendix. Another appendix demonstrates the application of the method to the design of an Indian village.
Author: Major Chas. J. Smith
Publisher: Pickle Partners Publishing
ISBN: 1786253615
Category : History
Languages : en
Pages : 57
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Book Description
Operational art and the operational level of war became a doctrinal focus for the U.S. Army in the 1980s. This focus led to the development of the elements of operational design. These concepts are not new, and were developed in the interwar period prior to World War II at the staff and war colleges. During this time, however, the military did not doctrinally recognize the operational level or war or operational art. Even though the concepts were not recognized, the intellectual process permeated the officer education system prior to World War II. Clearly, American officers in World War II used something of operational art, including in the planning and execution of the Marianas Campaign. This monograph looks at the question in more detail, by testing the extent to which planners within CENPAC used the elements of operational design in the Marianas Campaign, including end state and objectives, effects, center(s) of gravity, decisive points, direct and indirect action, lines of operation, operational reach, simultaneity and depth, timing and tempo, leverage, balance, anticipation, culmination, and arranging operations. The implication of this study is that as current doctrine evolves, the development, education, and execution of operational concepts in the World War II era continue to be useful.
Author: C.A. Brebbia
Publisher: WIT Press
ISBN: 1784661538
Category : Architecture
Languages : en
Pages : 835
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Book Description
The 8th International Conference on Sustainable Development and Planning is part of a series of biennial conferences on the topic of sustainable regional development which began in Greece in 2003. The papers included in these proceedings report on the latest advances from scientists specialising in the range of subjects included within sustainable development and planning. Planners, environmentalists, architects, engineers, policy makers and economists have to work together in order to ensure that planning and development can meet our present needs without compromising the ability of future generations. The use of modern technologies in planning gives us new potential to monitor and prevent environmental degradation. Problems related to development and planning, which affect both rural and urban areas, are present in all regions of the world and accelerated urbanisation has resulted in both the deterioration of the environment and quality of life. Urban development can also intensify problems faced by rural areas such as forests, mountain regions and coastal areas, which urgently require solutions in order to avoid irreversible damage. The papers in the book cover the following topics: City planning; Regional planning; Rural developments; Sustainability and the built environment; Sustainability indicators; Policies and planning; Environmental planning and management; Energy resources; Cultural heritage; Quality of life; Community planning and resilience; Sustainable solutions in emerging countries; Sustainable tourism; Learning from nature; Transportation Social and political issues and Community planning.
