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Languages : en
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![Studies of Mammalian Brain Development by Fate Mapping and Mutant Analysis [microform] PDF](https://books.google.com/books/content/images/frontcover/tmb5tgAACAAJ?fife=w80-h100)
Author: Dawn Lenee Zinyk
Publisher: National Library of Canada = Bibliothèque nationale du Canada
ISBN: 9780612413573
Category :
Languages : en
Pages : 308
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Author: Dawn Lenee Zinyk
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Mice lacking 'Engrailed-1' or 'Gli3' exhibit severe brain malformations, demonstrating that these molecules play key roles in mammalian brain development. The mouse 'En' genes are expressed in a band around the embryonic midbrain-hindbrain constriction. This region is involved in patterning of the midbrain and cerebellum and can act as an organizer region to induce midbrain and cerebellar development. Fate-mapping experiments in chick indicate that the cerebellar primordium is located anterior and posterior to the midbrain-hindbrain constriction, whereas midbrain precursors lie more anteriorly. Fate mapping in mice is complicated by the inaccessibility of the postimplantation embryo. I report a new 'in vivo' approach using the Cre/'loxP ' recombination system to map the fate of the mouse midbrain-hindbrain constriction: E9-12 cells originating in the dorsal midbrain-hindbrain constriction contribute significantly to the medial cerebellum. The feasibility of using a recombinase-based lineage-tracing system for fate mapping in mouse is demonstrated. Mice homozygous for a loss-of-function 'Gli3' mutation exhibit defective neural-tube closure in midbrain and forebrain regions, and later exencephaly. I show that: (1) 'Gli3-/-' mutants display transient ectopic 'Sonic hedgehog' (' Shh') expression in early dorsal neural folds, suggesting that Gli3 normally acts there to repress 'Shh' expression, (2) Gli3 is involved in the control of cell proliferation or cell death in the dorsal neural tube of rostral brain structures, and (3) Gli3 restricts ventrolateral expansion of 'Shh' and Shh-responsive gene expression at ventral midline in the brains of E9.5-11.5 embryos. Thus, Gli3 plays a role in the development of both dorsal and ventral neural tube at the rostral level. ' Gli3-/-' embryos were also found to exhibit abdominal heterotaxia, indicating that 'Gli3' is essential for the establishment of gut sidedness. Early somite-stage 'Gli3-/-' embryos exhibit a downregulation of 'nodal' but not ' lefty' expression in left lateral-plate mesoderm, suggesting that ' Gli3' is required for 'nodal' activation downstream of 'lefty' or in a separate pathway of left-right specification. Together, these data support the view that Gli3 genetically acts as both a repressor and activator.
Author: National Academy of Sciences
Publisher: National Academies Press
ISBN: 0309045290
Category : Medical
Languages : en
Pages : 195
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The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309070864
Category : Nature
Languages : en
Pages : 348
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Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Author: Jeffrey Noebels
Publisher: OUP USA
ISBN: 0199746540
Category : Medical
Languages : en
Pages : 1258
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Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
Author: Richard Baldock
Publisher: Academic Press
ISBN: 0128009136
Category : Science
Languages : en
Pages : 343
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Kaufman's Atlas of Mouse Development: With Coronal Sections continues the stellar reputation of the original Atlas by providing updated, in-depth anatomical content and morphological views of organ systems.The publication offers written descriptions of the developmental origins of the organ systems alongside high-resolution images for needed visualization of developmental processes. Matt Kaufman himself has annotated the coronal images in the same clear, meticulous style of the original Atlas. Kaufman's Atlas of Mouse Development: With Coronal Sections follows the original Atlas as a continuation of the standard in the field for developmental biologists and researchers across biological and biomedical sciences studying mouse development. Provides high-resolution images for best visualization of key developmental processes and structures Offers in-depth anatomy and morphological views of organ systems Written descriptions convey developmental origins of the organ systems
Author: Isabelle Godin
Publisher: Springer Science & Business Media
ISBN: 0387335358
Category : Medical
Languages : en
Pages : 188
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This book collects articles on the biology of hematopoietic stem cells during embryonic development, reporting on fly, fish, avian and mammalian models. The text invites a comparative overview of hematopoietic stem cell generation in the different classes, emphasizing conserved trends in development. The book reviews current knowledge on human hematopoietic development and discusses recent breakthroughs of relevance to both researchers and clinicians.
Author: Gerhard Martin Technau
Publisher: Springer Science & Business Media
ISBN: 0387782613
Category : Medical
Languages : en
Pages : 173
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The fruitfly Drosophila melanogaster is an ideal model system to study processes of the central nervous system This book provides an overview of some major facets of recent research on Drosophila brain development.
Author: Edwin Grant Conklin
Publisher:
ISBN:
Category : Embryology
Languages : en
Pages : 186
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